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1. 发明申请

US20160313163A1 METHOD AND CONTROL DEVICE FOR DETERMINING A GAS CONSUMPTION OF A GAS-POWERED ENGINE 审中-公开
标题翻译：用于确定燃气发动机的燃气消耗的方法和控制装置
公开(公告)号：US20160313163A1
公开(公告)日：2016-10-27
申请号：US15134111
申请日：2016-04-20
申请人： Stefan PETERS , Günter HEIDER , Thomas KREMSER
发明人： Stefan PETERS , Günter HEIDER , Thomas KREMSER
IPC分类号： G01F9/00
CPC分类号： G01F9/001 , F02D19/028 , F02D19/029 , F02D19/0628 , F02D41/0027 , F02D2200/0406 , F02D2200/0414 , F02D2200/0611 , F02D2200/0625 , F02D2200/703 , Y02T10/32 , Y02T10/36
摘要： A method for determining a gas consumption of a gas-powered gas engine or a gas-powered dual-fuel engine. The engine is operated under actual operating conditions, and the actual gas consumption of the engine is acquired under the actual operating conditions. A target gas consumption of the engine to be anticipated under target operating conditions is calculated depending on the actual gas consumption and depending on discrepancies between the actual operating conditions and the target operating conditions.
摘要翻译：一种用于确定气体燃料发动机或燃气动力双燃料发动机的气体消耗量的方法。发动机在实际运行条件下运行，发动机的实际燃气消耗在实际运行条件下获得。目标运行条件下预计发动机的目标燃气消耗量根据实际燃气消耗量计算，并取决于实际运行状况与目标运行条件之间的差异。

2. 发明授权

US09133904B2 Torsional vibration damper 有权
标题翻译：扭转振动阻尼器
公开(公告)号：US09133904B2
公开(公告)日：2015-09-15
申请号：US14115254
申请日：2012-03-27
申请人： Andreas Kranz , Dietmar Heidingsfeld , Dietmar Ritterbecks , Stefan Peters
发明人： Andreas Kranz , Dietmar Heidingsfeld , Dietmar Ritterbecks , Stefan Peters
IPC分类号： F16F15/12 , F16F15/121 , F16F15/131 , F16F15/134
CPC分类号： F16F15/121 , F16F15/131 , F16F15/13438 , F16F15/13453 , F16F15/13492 , Y10T74/2131
摘要： A torsional vibration damper has a drive-side transmission element; a damping device having a plurality of energy accumulators; a driven-side transmission element configured to be rotationally deflected coaxial to the drive-side transmission element and which is connected to the drive-side transmission element via the damping device; and sliding elements arranged in one of the drive-side transmission element and driven-side transmission element so as to be movable in a circumferential direction. The sliding elements have: (i) circumferential projections for the energy accumulators, these circumferential projections being directed toward adjacent sliding elements, and/or (ii) penetration spaces for circumferential projections provided at the adjacent sliding element. The energy accumulators are supported at the sliding elements, the sliding elements having in sequence in an axial direction at least one circumferential projection and/or at least one penetration space at their circumferential side which faces a sliding element adjacent in the circumferential direction.
摘要翻译：扭转振动阻尼器具有驱动侧传动元件; 具有多个蓄能器的阻尼装置; 被驱动侧传动元件，被配置为与驱动侧传动元件同轴地旋转偏转，并且经由阻尼装置连接到驱动侧传动元件; 以及布置在驱动侧传动元件和从动侧传动元件中的一个中的滑动元件，以便能够在圆周方向上移动。滑动元件具有：（i）用于蓄能器的周向突起，这些周向突起指向相邻的滑动元件，和/或（ii）设置在相邻滑动元件处的周向突起的穿透空间。蓄能器被支撑在滑动元件处，滑动元件沿轴向依次沿着圆周方向的至少一个周向突起和/或它们的圆周侧上的至少一个穿透空间，其面向与圆周方向相邻的滑动元件。

3. 发明授权

US09115093B2 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity 有权
标题翻译：取代的双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途
公开(公告)号：US09115093B2
公开(公告)日：2015-08-25
申请号：US14184817
申请日：2014-02-20
申请人： Christian Gnamm , Thorsten Oost , Stefan Peters , Klaus Rudolf
发明人： Christian Gnamm , Thorsten Oost , Stefan Peters , Klaus Rudolf
IPC分类号： C07D239/70 , C07D403/12 , C07D401/12 , A61K31/517 , A61P19/02 , C07D239/82 , C07D401/04 , C07D403/06 , C07D407/06 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/06 , C07D471/04 , C07D487/04 , C07D493/10 , C07D498/04 , C07D498/10 , C07D405/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D413/12 , C07D417/06 , C07D487/10 , C07D491/10
CPC分类号： C07D239/82 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , C07D493/10 , C07D498/04 , C07D498/10
摘要： This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
摘要翻译：本发明涉及式1的取代双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途，含有它们的药物组合物及其用于治疗和/或预防肺，胃肠和泌尿生殖疾病，炎性疾病的药物的方法的皮肤和眼睛以及其他自身免疫性和过敏性疾病，同种异体移植排斥和肿瘤疾病。

4. 发明授权

US08859580B2 Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use 有权
标题翻译：苯并吡喃和相关支架的芳基和杂芳基羰基衍生物，含有这些化合物的药物及其应用
公开(公告)号：US08859580B2
公开(公告)日：2014-10-14
申请号：US12742680
申请日：2008-11-14
申请人： Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
发明人： Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
IPC分类号： C07D221/26 , C07D417/06 , C07D401/06 , C07D471/08 , C07D498/08 , C07D413/14 , C07D413/06 , C07D405/06 , C07D401/14 , C07D451/06 , C07D403/06
CPC分类号： C07D221/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D451/06 , C07D471/08 , C07D498/08
摘要： The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
摘要翻译：本发明涉及由式I定义的化合物，其中R 1至R 3，X，m，n和o基团如权利要求1中所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

5. 发明申请

US20130324514A1 INDANYLOXYPHENYLCYCLOPROPANECARBOXYLIC ACIDS 有权
标题翻译：间苯二酚类环戊二烯酸
公开(公告)号：US20130324514A1
公开(公告)日：2013-12-05
申请号：US13900121
申请日：2013-05-22
申请人： Dieter HAMPRECHT , Sara FRATTINI , Iain LINGARD , Stefan PETERS
发明人： Dieter HAMPRECHT , Sara FRATTINI , Iain LINGARD , Stefan PETERS
IPC分类号： A61K31/425 , A61K31/4196 , A61K31/416 , A61K31/40 , A61K31/382 , A61K31/341 , A61K31/277 , A61K31/192 , C07D275/02 , C07D249/08 , C07D231/56 , C07D207/48 , C07D205/04 , C07D335/02 , C07D307/20 , C07C255/54 , C07C317/46 , C07C235/68 , C07C61/39 , A61K45/06 , A61K31/397
CPC分类号： A61K31/425 , A61K31/192 , A61K31/277 , A61K31/341 , A61K31/382 , A61K31/397 , A61K31/40 , A61K31/416 , A61K31/4196 , A61K45/06 , C07C61/39 , C07C62/34 , C07C67/31 , C07C67/347 , C07C69/757 , C07C235/20 , C07C235/42 , C07C235/68 , C07C255/54 , C07C317/18 , C07C317/20 , C07C317/46 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D207/48 , C07D209/08 , C07D213/30 , C07D213/84 , C07D215/14 , C07D217/02 , C07D231/56 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D275/02 , C07D307/20 , C07D309/12 , C07D333/38 , C07D335/02
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
摘要翻译：本发明涉及通式I的化合物，其中R1，R2，R3，m和n基团如权利要求1中所定义，其具有有价值的药理学性质，特别是与GPR40受体结合并调节其活性。该化合物适用于治疗和预防可受该受体影响的疾病，如代谢疾病，特别是2型糖尿病。此外，本发明涉及可用于合成式I化合物的新中间体。

6. 发明申请

US20130289074A1 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS 有权
公开(公告)号：US20130289074A1
公开(公告)日：2013-10-31
申请号：US13869144
申请日：2013-04-24
申请人： Frank HIMMELSBACH , Matthias ECKHARDT , Elke LANGKOPF , Stefan PETERS
发明人： Frank HIMMELSBACH , Matthias ECKHARDT , Elke LANGKOPF , Stefan PETERS
IPC分类号： C07D307/80 , A61K45/06 , A61K31/443 , A61K31/343 , C07D405/12
CPC分类号： C07D307/80 , A61K31/343 , A61K31/443 , A61K45/06 , C07D405/12 , A61K2300/00
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

7. 发明授权

US08497281B2 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline 有权
标题翻译：六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
公开(公告)号：US08497281B2
公开(公告)日：2013-07-30
申请号：US12940387
申请日：2010-11-05
申请人： Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
发明人： Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
IPC分类号： C07D401/06 , A61K31/352
CPC分类号： C07D221/10 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
摘要翻译：本发明涉及由式I定义的化合物，其中变量R1，R2，R3，R4和m如权利要求1所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

8. 发明申请

US20110269791A1 Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use 有权
标题翻译：苯并呋喃和相关支架的脂环族羧酸衍生物，含有这些化合物的药物及其应用
公开(公告)号：US20110269791A1
公开(公告)日：2011-11-03
申请号：US12991722
申请日：2009-05-12
申请人： Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz
发明人： Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz
IPC分类号： A61K31/439 , A61K31/4985 , A61P3/10 , A61K31/397 , A61P3/00 , A61P3/06 , C07D471/04 , C07D221/26
CPC分类号： C07D221/26 , C07D221/22 , C07D401/06 , C07D401/08 , C07D401/12 , C07D405/06 , C07D405/12 , C07D471/18 , C07D491/08 , C07D491/18
摘要： The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
摘要翻译：本发明涉及由式（I）定义的化合物，其中基团A，B，X，m，n和o如权利要求1中所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

9. 发明授权

US07713961B2 Substituted 1,2-ethylenediamines, methods for preparing them and uses thereof 有权
标题翻译：取代的1,2-乙二胺，其制备方法和用途
公开(公告)号：US07713961B2
公开(公告)日：2010-05-11
申请号：US11278059
申请日：2006-03-30
申请人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
发明人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
IPC分类号： A61K31/54 , A61K31/505 , A61K31/535 , C07D295/00 , C07C239/00 , A61K31/16 , C07D285/16 , C07D279/00
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1—X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译：本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 15，A，B，L，i以及X 1 -X 4如在说明书和权利要求书中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病。

10. 发明申请

US20080293680A1 Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II 审中-公开
标题翻译：用于治疗阿尔茨海默病的取代乙烷-1,2-二胺Ⅱ
公开(公告)号：US20080293680A1
公开(公告)日：2008-11-27
申请号：US11997449
申请日：2006-08-01
申请人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
发明人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
IPC分类号： A61K31/65 , C07D213/02 , A61K31/44 , C07C229/02 , A61K31/19 , C07C237/00 , A61K31/164 , C12N9/99 , A61P25/00 , C07D401/02 , A61K31/4439 , A61K31/355 , A61K31/445 , A61K31/473 , A61K31/55
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如说明书和权利要求中所定义，以及其用于治疗或预防阿尔茨海默病和其它类似物疾病

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