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1. 发明授权

US07915254B2 Biologically active methylene blue derivatives 有权
标题翻译：生物活性亚甲蓝衍生物
公开(公告)号：US07915254B2
公开(公告)日：2011-03-29
申请号：US12078805
申请日：2008-04-04
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
IPC分类号： A61K31/54
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R1, R2, R3 and R4 each independently is an optionally -substituted linear, branched or cyclic hydrocarbon group, or R1 and R2 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring or R3 and R4 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which —NR1R2 and —NR3R4 are the same and are selected from —N(CH3)2 or —N(CH2CH3)2; and exposing the area to light to activate the compound.
摘要翻译：本发明涉及光动力学治疗的方法和诱导光毒性作用的方法，其包括向有待治疗的区域施用有效量的下式化合物，其中R 1，R 2，R 3和R 4各自独立地为任选的取代的直链，支链或环状烃基，或者R 1和R 2与它们所连接的N原子一起形成任选取代的5-，6-或7-元环，或者R 3和R 4与它们连接形成任选取代的5-，6-或7-元环; 而XP-是抗衡阴离子，P为1,2或3; 除了-NR 1 R 2和-NR 3 R 4相同并且选自-N（CH 3）2或-N（CH 2 CH 3）2的化合物之外）并将该区域曝光以激活化合物。

2. 发明授权

US07407953B2 Wound healing 失效
标题翻译：伤口愈合
公开(公告)号：US07407953B2
公开(公告)日：2008-08-05
申请号：US11723523
申请日：2007-03-20
申请人： Stanley Beames Brown , Cassandra Clare O'Grady
发明人： Stanley Beames Brown , Cassandra Clare O'Grady
IPC分类号： C07D279/28 , A61K31/5415 , A61P17/00
CPC分类号： C09B5/60 , C07D279/28
摘要： A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound of Formula (1) to a wound site or the skin, and optionally exposing the wound site or skin to light.
摘要翻译：用于促进伤口愈合的吩噻嗪鎓化合物，组合物和药物以及通过向伤口部位或皮肤施用或施用式（1）的吩噻嗪鎓化合物，以及任选地暴露伤口部位或皮肤亮起

3. 发明授权

US07276494B2 Photosensitisers 失效
标题翻译：光敏剂
公开(公告)号：US07276494B2
公开(公告)日：2007-10-02
申请号：US10393783
申请日：2003-03-21
申请人： Stanley Beames Brown , Andrea Lucille Bell , John Griffiths , Jack Schofield
发明人： Stanley Beames Brown , Andrea Lucille Bell , John Griffiths , Jack Schofield
IPC分类号： A61K31/40 , A61K31/555 , A61B10/00 , C07B47/00 , C07F5/10
CPC分类号： A61K41/0071 , A61K41/0076
摘要： A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a photosensitising chromophoric system, a sulphonamido functionality and a carboxy functionality. The compounds used in the present invention are photosensitisers in PDT in vivo, and show phototoxic activity in vitro. The compounds are used to treat pre-cancerous conditions, cancer, ophthalmological disease, vascular problems, arteriosclerosis and restenosis and autoimmune diseases, skin diseases and other benign conditions, and for anti-microbial treatments.
摘要翻译：在PDT中用作光敏剂的化合物，在癌症疫苗生产中的光化学内化或医学病症的诊断或检测中，具有光敏发色体系，磺酰胺官能团和羧基官能团的化合物。本发明中使用的化合物是体内PDT中的光敏剂，体外显示光毒性活性。这些化合物用于治疗癌前病症，癌症，眼科疾病，血管问题，动脉硬化和再狭窄以及自身免疫疾病，皮肤病和其他良性病症，以及抗微生物治疗。

4. 发明申请

US20080275033A1 BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES 失效
标题翻译：生物活性甲基蓝衍生物
公开(公告)号：US20080275033A1
公开(公告)日：2008-11-06
申请号：US12141747
申请日：2008-06-18
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
IPC分类号： A61K31/5415
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： A phenothiazinium compound of Formula (I) wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH3)2 or —N(CH2CH3)2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells.
摘要翻译：式（I）的吩噻嗪鎓化合物其中：A和B各自独立地是其中R'和R“各自独立地是直链，支链或环状烃基，或者R'和R”与其中的N原子一起它们连接形成任选取代的5-，6-或7-元环; 并且其中P 是抗衡阴离子，P是1,2或3; 除了其中A和B均为-N（CH 3）2 - 或-N（CH 2 CH 2） 3 ，用于需要去除，失活或杀死不想要的组织或细胞的治疗。

5. 发明申请

US20080261960A1 Biologically active methylene blue derivatives 有权
标题翻译：生物活性亚甲蓝衍生物
公开(公告)号：US20080261960A1
公开(公告)日：2008-10-23
申请号：US12078805
申请日：2008-04-04
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
IPC分类号： A61K31/5415 , A61P31/04 , A61P31/10 , A01P1/00 , A01P3/00 , A01N43/84
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a phenothiazinium compound of Formula (I): wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH3)2 or —N(CH2CH3)2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells. The invention also relates to compositions comprising the compounds of Formula I, to selected compounds of Formula I, use of the compounds of Formula I as medicaments and as a PDT agent or a photodiagnostic agent, a conjugate or composite formed between a compound of Formula I and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated.The compounds are biologically active photosensitisers which are strongly photocytotoxic and have application in the areas of photodynamic therapy (PDT), as well as for the diagnosis and detection of medical conditions and related uses in photochemical internalisation, in the production of cancer vaccines, in the treatment and prevention of microbial infections and in photodisinfection or photosterilisation.
摘要翻译：本发明涉及式（I）的吩噻嗪鎓化合物：其中：A和B各自独立地是其中R'和R“各自独立地是直链，支链或环状烃基，或者R'和R”在一起与它们所连接的N原子形成任选取代的5-，6-或7-元环; 并且其中X-P-P为抗衡阴离子，P为1,2或3; 除了其中A和B均为-N（CH 3）2 - 或-N（CH 2 CH 2） 3 ，用于需要去除，失活或杀死不想要的组织或细胞的治疗。本发明还涉及包含式I化合物的组合物，所选择的式I化合物，式I化合物用作药物和作为PDT剂或光诊断剂，在式I化合物之间形成的缀合物或复合物和聚合物; 以及用于对液体进行灭菌的方法，其中流体在其被照射时通过共轭物或复合物。这些化合物是具有强烈光细胞毒性并且在光动力疗法（PDT）领域中的应用的生物活性光敏剂，以及用于诊断和检测光化学内化中的医学病症和相关用途，在癌症疫苗的生产中治疗和预防微生物感染和光消毒或光化学。

6. 发明申请

US20080268033A1 BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES 失效
标题翻译：生物活性甲基蓝衍生物
公开(公告)号：US20080268033A1
公开(公告)日：2008-10-30
申请号：US12171121
申请日：2008-07-10
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
IPC分类号： A61K9/127 , A61K31/5415
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a phenothiazinium compound of Formula (I): wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH3)2 or —N(CH2CH3)2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells. The invention also relates to compositions comprising the compounds of Formula I, to selected compounds of Formula I, use of the compounds of Formula I as medicaments and as a PDT agent or a photodiagnostic agent, a conjugate or composite formed between a compound of Formula I and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated.
摘要翻译：本发明涉及式（I）的吩噻嗪鎓化合物：其中：A和B各自独立地是其中R'和R“各自独立地是直链，支链或环状烃基，或者R'和R”在一起与它们所连接的N原子形成任选取代的5-，6-或7-元环; 并且其中P 是抗衡阴离子，P是1,2或3; 除了其中A和B均为-N（CH 3）2 - 或-N（CH 2 CH 2） 3 ，用于需要去除，失活或杀死不想要的组织或细胞的治疗。本发明还涉及包含式I化合物的组合物，所选择的式I化合物，式I化合物用作药物和作为PDT剂或光诊断剂，在式I化合物之间形成的缀合物或复合物和聚合物; 以及用于对液体进行灭菌的方法，其中流体在其被照射时通过共轭物或复合物。

7. 发明申请

US20120302557A1 BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES 审中-公开
标题翻译：生物活性甲基蓝衍生物
公开(公告)号：US20120302557A1
公开(公告)日：2012-11-29
申请号：US13453855
申请日：2012-04-23
申请人： Stanley Beames BROWN , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
发明人： Stanley Beames BROWN , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , Richard George Tunstall , David John Howard Roberts , David Ian Vernon
IPC分类号： A61K31/5415 , A61P31/00
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R1, R2, R3 and R4 each independently is an optionally-substituted linear, branched or cyclic hydrocarbon group, or R1 and R2 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring or R3 and R4 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which —NR1R2 and —NR3R4 are the same and are selected from —N(CH3)2 or —N(CH2CH3)2; and exposing the area to light to activate the compound.
摘要翻译：本发明涉及光动力学治疗的方法和诱导光毒性作用的方法，其包括向有待治疗的区域施用有效量的下式化合物，其中R 1，R 2，R 3和R 4各自独立地为任选的取代的直链，支链或环状烃基，或R 1和R 2与它们所连接的N原子一起形成任选取代的5-，6-或7-元环，或者R 3和R 4与它们所在的N原子一起形成连接形成任选取代的5-，6-或7-元环; 而XP-是抗衡阴离子，P为1,2或3; 除了-NR 1 R 2和-NR 3 R 4相同并且选自-N（CH 3）2或-N（CH 2 CH 3）2的化合物之外）并将该区域曝光以激活化合物。

8. 发明授权

US08188074B2 Biologically active methylene blue derivatives 有权
标题翻译：生物活性亚甲蓝衍生物
公开(公告)号：US08188074B2
公开(公告)日：2012-05-29
申请号：US12149996
申请日：2008-05-12
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
IPC分类号： A61K31/54
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： The present invention relates to a composition which includes a moiety of formula wherein R1, R2, R3 and R4 each represent n-pentyl, and to a method of sterilizing a su fluid using same.
摘要翻译：本发明涉及一种组合物，其包含其中R 1，R 2，R 3和R 4各自表示正戊基的下式的部分，以及使用它们对su流体进行灭菌的方法。

9. 发明申请

US20110028459A1 Wound Healing 审中-公开
标题翻译：伤口愈合
公开(公告)号：US20110028459A1
公开(公告)日：2011-02-03
申请号：US12899365
申请日：2010-10-06
申请人： Stanley Beames Brown , Cassandra Clare O'Grady
发明人： Stanley Beames Brown , Cassandra Clare O'Grady
IPC分类号： A61K31/5415 , A61Q19/00 , A61P17/02 , A61P17/00
CPC分类号： C09B5/60 , C07D279/28
摘要： A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound to a wound site or the skin, and optionally exposing the wound site or skin to light.
摘要翻译：吩噻嗪鎓化合物，用于促进伤口愈合的组合物和药物以及通过向伤口部位或皮肤施用或施用吩噻嗪鎓化合物，以及任选地将伤口部位或皮肤暴露于光而促进伤口愈合或化妆品用途的方法。

10. 发明授权

US07855197B2 Biologically active methylene blue derivatives 失效
标题翻译：生物活性亚甲蓝衍生物
公开(公告)号：US07855197B2
公开(公告)日：2010-12-21
申请号：US12141747
申请日：2008-06-18
申请人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
发明人： Stanley Beames Brown , Cassandra Claire O'Grady , John Griffiths , Kirste Joanne Mellish , David Ian Vernon
IPC分类号： A61K31/54
CPC分类号： A61K49/003 , A61K8/4986 , A61K41/0057 , A61L2/0029 , A61L2/0082 , A61L2/08 , A61L2/232 , A61Q11/00 , C07D279/18
摘要： A phenothiazinium compound of Formula (I) wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where XP− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH3)2 or —N(CH2CH3)2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells.
摘要翻译：式（I）的吩噻嗪鎓化合物其中：A和B各自独立地是其中R'和R“各自独立地是直链，支链或环状烃基，或者R'和R”与它们所在的N原子一起连接形成任选取代的5-，6-或7-元环; 而XP-是抗衡阴离子，P为1,2或3; 除了其中A和B都是-N（CH 3）2或-N（CH 2 CH 3）2）的化合物，其用于需要去除，失活或杀死不想要的组织或细胞的处理中。

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