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1. 发明申请

US20140024610A1 NANOPARTICLES LOADED WITH CHEMOTHERAPEUTIC ANTITUMORAL DRUG 有权
标题翻译：用化学治疗药物装载的纳米颗粒
公开(公告)号：US20140024610A1
公开(公告)日：2014-01-23
申请号：US14009021
申请日：2012-03-30
申请人： Emilia Pisani , Sophie Lebel-Binay , Valérie Polard
发明人： Emilia Pisani , Sophie Lebel-Binay , Valérie Polard
IPC分类号： A61K9/00 , A61K9/51 , A61K31/704
CPC分类号： A61K9/0019 , A61K9/19 , A61K9/5138 , A61K9/5161 , A61K31/704 , A61K47/6951 , B82Y5/00
摘要： The invention relates to new therapeutic approaches for treating cancer, in particular hepatocellular carcinoma, with Nanoparticules loaded with a chemotherapeutic antitumoral agent. In particular, it relates to the treatment of cancer by administration of said Nanoparticules by intravenous infusion for at least 2 hours in order to prevent toxicological side effects and increase the benefit/risk ratio of the treatment.
摘要翻译：本发明涉及用载有化疗抗肿瘤剂的纳米颗粒治疗癌症，特别是肝细胞癌的新的治疗方法。特别地，涉及通过静脉内输注给予所述纳米棒剂至少2小时以治疗癌症，以防止毒理学副作用并增加治疗的益处/风险比。

2. 发明申请

US20060292553A1 Method for study of the genetic and functional variability of HIV and kit for using it 审中-公开
标题翻译：研究HIV遗传和功能变异性的方法及其使用方法
公开(公告)号：US20060292553A1
公开(公告)日：2006-12-28
申请号：US11073972
申请日：2005-03-07
申请人： Sophie Lebel-Binay , Elisabeth Dam , Luc Boblet , Dominique Costantini
发明人： Sophie Lebel-Binay , Elisabeth Dam , Luc Boblet , Dominique Costantini
IPC分类号： C12Q1/70 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/703
摘要： A method of analyzing a sample possibly containing an HIV virus, including a) extracting viral RNA in a biological sample that possibly contains an HIV virus; b) reverse transcription of the RNA obtained of (a) and amplification with a first pair of primers to obtain an amplified product of reverse transcription including all or part of at least two successive genes of a genome of an HIV virus; and one or both of c) and d): c) sequencing the amplified product of (b) to establish a genotype of HIV virus present in the sample and identify mutations that may be present in the amplified product; d1) amplifying the product of (b) with a second pair of primers complementary to the first pair of (b) and capable of generating an amplification product that can be inserted by homologous recombination into a retroviral vector that is defective in a region corresponding to the amplified product; d2) homologously recombining the product of (d1) with the defective vector; d3) functionally analyzing the viral proteins coded by all or part of the at least two successive genes of the product of (d1); and d4) measuring replicating capacity of recombinant viruses of (d2) in the presence or in the absence of at least one active substance.
摘要翻译：分析可能含有HIV病毒的样品的方法，包括a）在可能含有HIV病毒的生物样品中提取病毒RNA; b）用（a）获得的RNA的逆转录和用第一对引物扩增以获得包括HIV病毒基因组的全部或部分至少两个连续基因的逆转录的扩增产物; 和c）和d）中的一个或两个：c）对（b）的扩增产物进行测序以建立存在于样品中的HIV病毒的基因型并鉴定可能存在于扩增产物中的突变; d1）用与第一对（b）互补的第二对引物扩增（b）的产物，并且能够产生可以通过同源重组插入的扩增产物到对应于扩增产物; d2）将（d1）的产物与缺陷载体同源重组; d3）功能性分析由（d1）的产物的全部或部分至少两个连续基因编码的病毒蛋白; 和d4）在存在或不存在至少一种活性物质的情况下测量（d2）重组病毒的复制能力。

3. 发明授权

US09763874B2 Nanoparticles loaded with chemotherapeutic antitumoral drug 有权
公开(公告)号：US09763874B2
公开(公告)日：2017-09-19
申请号：US14009021
申请日：2012-03-30
申请人： Emilia Pisani , Sophie Lebel-Binay , Valérie Polard
发明人： Emilia Pisani , Sophie Lebel-Binay , Valérie Polard
IPC分类号： A61K31/704 , A61K9/19 , B82Y5/00 , A61K9/00 , A61K9/51 , A61K47/48
CPC分类号： A61K9/0019 , A61K9/19 , A61K9/5138 , A61K9/5161 , A61K31/704 , A61K47/6951 , B82Y5/00
摘要： The invention relates to new therapeutic approaches for treating cancer, in particular hepatocellular carcinoma, with Nanoparticules loaded with a chemotherapeutic antitumoral agent. In particular, it relates to the treatment of cancer by administration of said Nanoparticules by intravenous infusion for at least 2 hours in order to prevent toxicological side effects and increase the benefit/risk ratio of the treatment.

4. 发明申请

US20110207685A1 Oral Formulations of Chemotherapeutic Agents 审中-公开
标题翻译：化学治疗剂口服制剂
公开(公告)号：US20110207685A1
公开(公告)日：2011-08-25
申请号：US13057835
申请日：2009-08-06
申请人： David Bonnafous , Guy Cave , Assia Dembri , Sophie Lebel-Binay , Gilles Ponchel , Emilienne Soma
发明人： David Bonnafous , Guy Cave , Assia Dembri , Sophie Lebel-Binay , Gilles Ponchel , Emilienne Soma
IPC分类号： A61K31/704 , A61K31/4745 , A61K31/337 , A61P35/00 , B82Y5/00
CPC分类号： A61K31/4745 , A61K9/146 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to new oral formulations of chemotherapeutic agents, their process of preparation as well as their therapeutic uses. More specifically, said invention is related to nanoparticles comprising at least one chemotherapeutic agents as an active ingredient, at least one polymer and at least one cyclic oligosaccharide capable of complexing said camptothecin derivative, said nanoparticles being for therapeutic oral administration.
摘要翻译：本发明涉及化学治疗剂的新口服制剂，其制备方法及其治疗用途。更具体地说，本发明涉及包含至少一种作为活性成分的化学治疗剂，至少一种聚合物和能够络合所述喜树碱衍生物的至少一种环状寡糖的纳米颗粒，所述纳米颗粒用于治疗性口服给药。

5. 发明申请

US20100197769A1 PLASMID CONTAINING A SEQUENCE ENCODING A DISINTEGRIN DOMAIN OF METARGIDIN (RDD) 审中-公开
标题翻译：含有编码METARGIDIN（RDD）的消毒区的序列的PLASMID
公开(公告)号：US20100197769A1
公开(公告)日：2010-08-05
申请号：US12529947
申请日：2008-03-05
申请人： Celine Bouquet , Sophie Lebel Binay
发明人： Celine Bouquet , Sophie Lebel Binay
IPC分类号： A61K31/711 , C12N15/74 , C12N1/21 , C12N5/10 , C12N15/64 , G01N33/574 , A61P35/00
CPC分类号： C12N9/6489 , A61K38/00 , C12N15/85 , C12N2710/16122 , C12N2710/16132 , C12N2830/60
摘要： The invention relates to a pORT plasmid containing a sequence encoding all or part of a disintegrin domain of metargidin (RDD) or a derivative thereof under the control of strong cytomegalovirus promoter, in particular a plasmid having the sequence shown in SEQ ID NO:2.
摘要翻译：本发明涉及一种pORT质粒，其含有在强巨细胞病毒启动子，特别是具有SEQ ID NO：2所示序列的质粒中编码全部或部分脱甲基蛋白（RDD）或其衍生物的整合素结构域的序列。

6. 发明申请

US20060194217A1 Method of genotyping and phenotyping hepatitis B viruses resistant to antiviral molecules 审中-公开
标题翻译：对抗病毒分子抗性的乙型肝炎病毒的基因分型和表型分析方法
公开(公告)号：US20060194217A1
公开(公告)日：2006-08-31
申请号：US11077359
申请日：2005-03-11
申请人： Fabien Zoulim , Luc Barraud , Sandra Durantel , Sophie Lebel-Binay , David Durantel , Christian Trepo
发明人： Fabien Zoulim , Luc Barraud , Sandra Durantel , Sophie Lebel-Binay , David Durantel , Christian Trepo
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/706
摘要： The invention provides a method of preparation of HBV genomic amplicons which makes it possible, using the same amplicon obtained from a patient, to evaluate HBV strains resistant to antiviral agents by analysing, their genotype, their phenotype and their replicative capacity. The method of the invention guarantees to obtain the closest in vitro replication capability compared to the in vivo replication and ensures that the influences of all the mutations present on a viral genome are taken into account when evaluating the drug sensitivity and the replicative capacity.
摘要翻译：本发明提供了一种制备HBV基因组扩增子的方法，其使用从患者获得的相同扩增子可以通过分析其基因型及其表型及其复制能力来评估对抗病毒药物有抗性的HBV病毒株。本发明的方法保证与体内复制相比获得最接近的体外复制能力，并且确保当评估药物敏感性和复制能力时，考虑病毒基因组上存在的所有突变的影响。

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