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1. 发明授权

US06605741B2 Synthetic method of &agr;-ketol unsaturated fatty acids 失效
标题翻译： α-酮醇不饱和脂肪酸的合成方法
公开(公告)号：US06605741B2
公开(公告)日：2003-08-12
申请号：US10110239
申请日：2002-04-10
申请人： Yoshihiro Yokokawa , Koji Kobayashi , Shosuke Yamamura
发明人： Yoshihiro Yokokawa , Koji Kobayashi , Shosuke Yamamura
IPC分类号： C07L32100
CPC分类号： C07C51/373 , Y02P20/55 , C07C59/90
摘要： The present invention provides an efficient synthetic method of &agr;-ketol unsaturated fatty acid having a double bond at a &bgr;-position to the ketone group thereof. It comprises the steps of: preparing compound (4) by reacting monosubstituted acetylene (2) with epoxide (3); and preparing &agr;-ketol unsaturated fatty acid (1) from said compound (4) as shown in Reaction Formula 1: wherein R1 represents an alkyl group of 1-18 carbon atoms or an aliphatic hydrocarbon group of 2-18 carbon atoms having 1-5 double or triple bonds at given positions; R2 represents a protecting group for a hydroxyl group; R3 represents a protecting group for a carboxyl group; R is identical to R1 or, when R1 has one or more triple bonds, represents an aliphatic hydrocarbon group in which each triple bond of R1 is converted to a double bond; and A represents an alkylene group of 1-18 carbon atoms.
摘要翻译：本发明提供了在与酮基的β-位具有双键的α-酮醇不饱和脂肪酸的有效合成方法。它包括以下步骤：通过使单取代乙炔（2）与环氧化物（3）反应制备化合物（4）; 和由反应式1所示的所述化合物（4）制备α-酮醇不饱和脂肪酸（1）：其中R1表示1-18个碳原子的烷基或具有1- 在给定位置5个双重或三重键; R2表示羟基的保护基; R3表示羧基的保护基; R与R1相同，或者当R1具有一个或多个三键时，表示R1的每个三键转化为双键的脂族烃基; A表示1-18个碳原子的亚烷基。

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