专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11833220B2 Artificial multi-antigen fusion protein and preparation and use thereof 有权
公开(公告)号：US11833220B2
公开(公告)日：2023-12-05
申请号：US15536428
申请日：2015-12-15
申请人： OXFORD VACMEDIX UK LTD. , Shisong Jiang
发明人： Shisong Jiang , Xiaobing Xia , Hanghai Ding
IPC分类号： A61K39/02 , A61K39/12 , C07K19/00 , C12N5/0783 , A61K47/68 , A61K39/118 , C12N15/70 , C12Q1/686 , A61K39/39 , C07K2/00 , C07K16/00
CPC分类号： A61K47/6849 , A61K39/02 , A61K39/118 , A61K39/12 , A61K47/6855 , C07K19/00 , C12N5/0636 , C12N15/70 , C12Q1/686 , A61K39/39 , C07K2/00 , C07K16/00 , C12N2501/505
摘要： Provided are an artificial multi-antigen fusion protein and a preparation method thereof. The fusion protein can effectively stimulate CD8+T and CD4+ T cell immunities, and can be applied to immunodiagnostics or serve as a prophylactic or therapeutic vaccine.

2. 发明授权

US09382546B2 Process for making oligopeptides 有权
标题翻译：制备寡肽的方法
公开(公告)号：US09382546B2
公开(公告)日：2016-07-05
申请号：US12298835
申请日：2007-04-30
申请人： Shisong Jiang , Ruth Ruprecht
发明人： Shisong Jiang , Ruth Ruprecht
IPC分类号： A61K38/00 , C12N15/62 , C07K14/005
CPC分类号： C12N15/62 , C07K14/005 , C07K2319/50 , C12N2740/16322
摘要： There is described a method of synthesizing a family of oligopeptides of predetermined amino acid sequence, which together make up from 7 amino acids to the complete amino acid sequence of a target protein, which comprises: synthesizing a nucleic acid construct which codes for a fusion protein composed of overlapping peptides derived from the desired portion of the target protein, interspersed with regions which code for protease cleavage sites, expressing the nucleic acid construct in a suitable expression vector, harvesting the fusion protein corresponding to the nucleic acid sequence, and digesting the fusion protein with a protease selective for the cleavage sites to generate the oligopeptides. The oligopeptides may be generated in vitro or in vitro and may be used as vaccines against viral infections and in epitope mapping. MGGKWSKSSVVGWPAVRERMIEGRVGWPAVRERMRRAEPAADGVIEGRRRA EPAADGVGAVSRDLEKHIEGRGAVSRDLEKHGAITSSNTAAIEGRGAITSS NTAATNADCAWLEAIEGRTNADCAWLEAQEEEEVGFPVIEGRQEEEEVGFP VTPQVPLRPMTIEGRTPQVPLRPMTYKAAVDLSHFIEGRYKAAVDLSHFLK EKGGLEGLIEGRLKEKGGLEGLIHSQRRQDILIEGRIHSQRRQDILDLWIY HTQGYIEGRDLWIYHTQGYFPDWQNYTPEIEGRFPDWQNYTPEPGVRYPLT FGIEGRPGVRYPLTFGWCY
摘要翻译：描述了一种合成预定氨基酸序列的寡肽家族的方法，其由7个氨基酸组成，与靶蛋白的完整氨基酸序列组成，其包括：合成编码融合蛋白的核酸构建体由衍生自靶蛋白的所需部分的重叠肽组成，散布有编码蛋白酶切割位点的区域，在合适的表达载体中表达核酸构建体，收获对应于核酸序列的融合蛋白，并消化融合物具有选择性地用于切割位点以产生寡肽的蛋白质。寡肽可以在体外或体外产生，并且可以用作抗病毒感染和表位作图的疫苗。 MGGKWSKSSVVGWPAVRERMIEGRVGWPAVRERMRRAEPAADGVIEGRRRA EPAADGVGAVSRDLEKHIEGRGAVSRDLEKHGAITSSNTAAIEGRGAITSS NTAATNADCAWLEAIEGRTNADCAWLEAQEEEEVGFPVIEGRQEEEEVGFP VTPQVPLRPMTIEGRTPQVPLRPMTYKAAVDLSHFIEGRYKAAVDLSHFLK EKGGLEGLIEGRLKEKGGLEGLIHSQRRQDILIEGRIHSQRRQDILDLWIY HTQGYIEGRDLWIYHTQGYFPDWQNYTPEIEGRFPDWQNYTPEPGVRYPLT FGIEGRPGVRYPLTFGWCY

3. 发明申请

US20120082643A1 Compositions and Methods for Modulating a Cytotoxic T Lymphocyte Immune Response 审中-公开
标题翻译：用于调节细胞毒性T淋巴细胞免疫应答的组合物和方法
公开(公告)号：US20120082643A1
公开(公告)日：2012-04-05
申请号：US13180459
申请日：2011-07-11
申请人： RUTH M. RUPRECHT , SHISONG JIANG
发明人： RUTH M. RUPRECHT , SHISONG JIANG
IPC分类号： A61K39/39 , A61K39/21 , A61K39/07 , A61K39/12 , A61K39/29 , A61K39/155 , A61K39/015 , A61K39/085 , A61K39/112 , A61K39/108 , A61K39/08 , A61K39/10 , A61K39/215 , A61P37/04 , A61P31/18 , A61P31/14 , A61P35/00 , A61P31/04 , A61P33/06 , A61K39/00
CPC分类号： C07K14/005 , A61K38/10 , A61K39/12 , A61K39/155 , A61K39/21 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , C07K14/235 , C07K14/245 , C07K14/31 , C07K14/32 , C07K14/33 , C07K14/445 , C12N2710/24143 , C12N2740/15022 , C12N2740/15034 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2760/14122 , C12N2760/16322 , C12N2760/18522 , C12N2760/18534 , C12N2770/20022 , C12N2770/24222 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/478
摘要： The present invention provides compositions and methods for the treatment and prevention of immune disorders.
摘要翻译：本发明提供了用于治疗和预防免疫疾病的组合物和方法。

4. 发明申请

US20190144517A1 PROTEIN FOR NEUTRALIZING PROGRAMMED NECROCYTOSIS PROMOTION ANTIBODY, AND APPLICATION OF PROTEIN 审中-公开
公开(公告)号：US20190144517A1
公开(公告)日：2019-05-16
申请号：US15779282
申请日：2016-11-25
申请人： Shisong JIANG , Wenshu LU
发明人： Shisong JIANG , Wenshu LU
IPC分类号： C07K14/525 , A61K9/00 , A61P19/02 , A61P29/00 , A61M1/14 , A61M1/36
摘要： Provided is polypeptide which derives from wild type TNF á and inhibits necrocytosis. The polypeptide contains 10-200 amino acid residues and a sequence QLVVPSE. Also provided is a pharmaceutical composition containing polypeptide. The polypeptide and the pharmaceutical composition containing the polypeptide are capable of inhibiting necrocytosis, thereby being used for treating inflammatory diseases.

5. 发明申请

US20190062417A1 ANTIBODY FACILITATING PROGRAMMED NECROSIS OF CELLS AND APPLICATION THEREOF 审中-公开
公开(公告)号：US20190062417A1
公开(公告)日：2019-02-28
申请号：US15745624
申请日：2016-07-18
申请人： Shisong JIANG , Wenshu LU
发明人： Shisong JIANG , Wenshu LU
IPC分类号： C07K16/24 , G01N33/68 , G01N33/564
摘要： The present invention provides an antibody facilitating programmed necrosis of cells. The antibody can cause programmed necrosis of cells in the presence of tumor necrosis factor (TNF). Therefore, an inhibitor for the antibody can be used in the treatment of inflammatory diseases. Further, the present invention provides the application of the antibody facilitating programmed necrosis of cells in the inflammatory disease prognosis.

6. 发明申请

US20170340751A1 ARTIFICIAL MULTI-ANTIGEN FUSION PROTEIN AND PREPARATION AND USE THEREOF 审中-公开
公开(公告)号：US20170340751A1
公开(公告)日：2017-11-30
申请号：US15536428
申请日：2015-12-15
申请人： Shisong JIANG , OXFORD VACMEDIX UK LTD.
发明人： Shisong JIANG , Xiaobing XIA , Hanghai DING
IPC分类号： A61K47/68 , C12N5/0783 , C12Q1/68 , C12N15/70 , C07K2/00 , C07K16/00 , A61K39/39
CPC分类号： A61K47/6849 , A61K39/02 , A61K39/118 , A61K39/12 , A61K39/39 , A61K47/6855 , C07K2/00 , C07K16/00 , C07K19/00 , C12N5/0636 , C12N15/70 , C12N2501/505 , C12Q1/686
摘要： Provided are an artificial multi-antigen fusion protein and a preparation method thereof. The fusion protein can effectively stimulate CD8+T and CD4+ T cell immunities, and can be applied to immunodiagnostics or serve as a prophylactic or therapeutic vaccine.

7. 发明申请

US20100291061A1 PROCESS FOR MAKING OLIGOPEPTIDES 有权
标题翻译：制备寡核苷酸的方法
公开(公告)号：US20100291061A1
公开(公告)日：2010-11-18
申请号：US12298835
申请日：2007-04-30
申请人： Shisong Jiang
发明人： Shisong Jiang
IPC分类号： A61K31/7088 , C12P21/02 , C07K2/00 , C12N15/11 , A61K38/48 , A61K38/02 , C12Q1/68 , A61P31/12
CPC分类号： C12N15/62 , C07K14/005 , C07K2319/50 , C12N2740/16322
摘要： There is described a method of synthesising a family of oligopeptides of predetermined amino acid sequence, which together make up from 7 amino acids to the complete amino acid sequence of a target protein, which comprises: synthesising a nucleic acid construct which codes for a fusion protein composed of overlapping peptides derived from the desired portion of the target protein, interspersed with regions which code for protease cleavage sites, expressing the nucleic acid construct in a suitable expression vector, harvesting the fusion protein corresponding to the nucleic acid sequence, and digesting the fusion protein with a protease selective for the cleavage sites to generate the oligopeptides. The oligopeptides may be generated in vitro or in vitro and may be used as vaccines against viral infections and in epitope mapping.
摘要翻译：描述了一种合成预定氨基酸序列的寡肽家族的方法，其由7个氨基酸组成，与靶蛋白的完整氨基酸序列组成，其包括：合成编码融合蛋白的核酸构建体由衍生自靶蛋白的所需部分的重叠肽组成，散布有编码蛋白酶切割位点的区域，在合适的表达载体中表达核酸构建体，收获对应于核酸序列的融合蛋白，并消化融合物具有选择性地用于切割位点以产生寡肽的蛋白质。寡肽可以在体外或体外产生，并且可以用作抗病毒感染和表位作图的疫苗。

8. 发明申请

US20050249742A1 Compositions and methods for modulating a cytotoxic T lymphocyte immune response 审中-公开
标题翻译：用于调节细胞毒性T淋巴细胞免疫应答的组合物和方法
公开(公告)号：US20050249742A1
公开(公告)日：2005-11-10
申请号：US11022562
申请日：2004-12-22
申请人： Ruth Ruprecht , Shisong Jiang
发明人： Ruth Ruprecht , Shisong Jiang
IPC分类号： A61K38/10 , A61K39/155 , A61K39/21 , C07K14/08 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/165 , C07K14/18 , C07K14/235 , C07K14/245 , C07K14/31 , C07K14/32 , C07K14/33 , C07K14/445 , A61K39/385 , A61K39/00
CPC分类号： C07K14/005 , A61K38/10 , A61K39/12 , A61K39/155 , A61K39/21 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , C07K14/235 , C07K14/245 , C07K14/31 , C07K14/32 , C07K14/33 , C07K14/445 , C12N2710/24143 , C12N2740/15022 , C12N2740/15034 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2760/14122 , C12N2760/16322 , C12N2760/18522 , C12N2760/18534 , C12N2770/20022 , C12N2770/24222 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/478
摘要： The present invention provides compositions and methods for the treatment and prevention of immune disorders.
摘要翻译：本发明提供了用于治疗和预防免疫疾病的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式