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1. 发明授权

US4757133A Physiologically active peptide 失效
标题翻译：生理活性肽
公开(公告)号：US4757133A
公开(公告)日：1988-07-12
申请号：US35125
申请日：1987-04-06
申请人： Osamu Ito , Shinro Tachibana
发明人： Osamu Ito , Shinro Tachibana
IPC分类号： A61K38/00 , A61K38/22 , A61P9/12 , A61P11/08 , C07K14/00 , C07K14/575 , C07K7/10
CPC分类号： C07K14/57563 , A61K38/00 , Y02P20/55 , Y10S930/17
摘要： A peptide is novel and useful for the bronchodilative activity and the hypotensive activity, having the following structure: ##STR1## (wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, Lys-Arg-OH, or Lys-NH.sub.2 when X is Met, or Y is Lys-NH.sub.2, Lys-OH, or Lys-Arg-OH when X is Leu).
摘要翻译： His具有以下结构：His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys- Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn- + TR Ser-Ile-Leu-Asn-Gly-Y（其中X为Met或Leu; Y为OH，Lys-OH，当X为Met时，OH，Lys-Arg-OH或Lys-NH 2，或当X为Leu时，Y为Lys-NH2，Lys-OH或Lys-Arg-OH）。

2. 发明授权

US4551273A Analgesic peptide and process for the preparation thereof 失效
标题翻译：止痛肽及其制备方法
公开(公告)号：US4551273A
公开(公告)日：1985-11-05
申请号：US575804
申请日：1984-01-31
申请人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
发明人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
IPC分类号： C07K14/655 , A61K38/00 , A61P25/04 , C07C231/02 , C07K7/08 , C07K14/575 , C07K14/665 , C07C103/52
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.
摘要翻译：具有一级结构的新型肽：N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2（其中D. Ile和D.Leu分别表示D-Ile和D-Leu残基，氨基酸的其它缩写代表每个L-氨基酸残基，Me表示甲基），其在外周施用时显示出显着的镇痛作用。还公开了通过固相法制备其方法。

3. 发明授权

US4822774A Physiologically active peptide 失效
标题翻译：生理活性肽
公开(公告)号：US4822774A
公开(公告)日：1989-04-18
申请号：US177998
申请日：1988-04-05
申请人： Osamu Ito , Shinro Tachibana
发明人： Osamu Ito , Shinro Tachibana
IPC分类号： A61K38/00 , A61K38/22 , A61P9/12 , A61P11/08 , C07K14/00 , C07K14/575 , A61K37/02
CPC分类号： C07K14/57563 , A61K38/00 , Y02P20/55 , Y10S930/17
摘要： A peptide is novel and useful for the bronchodilative activity and the hypotensive activity, having the following structure:His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys -Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Gly-Y(wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, Lys-Arg-OH, or Lys-NH.sub.2 when X is Met, or Y is Lys-NH.sub.2, Lys-OH, or Lys-Arg-OH when X is Leu).

4. 发明授权

US4707468A Polypeptide 失效
公开(公告)号：US4707468A
公开(公告)日：1987-11-17
申请号：US796390
申请日：1985-11-08
申请人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
发明人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
IPC分类号： C07K1/14 , A61K38/00 , A61K38/08 , A61P25/04 , C07K7/06 , C07K14/665 , C07K14/675 , C07K7/12
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A represents a D-amino acid, Gly or Sar provided that when the D-amino acid is D-Cys, it is bonded with L-Cys or D-Cys in position 5 through a S--S bond to effect intramolecular ring closure, B represents L-Phe or D-Phe in which the benzene ring may be substituted or an .alpha.-N-alkyl derivative thereof, C represents an L-amino acid, D-Cys or an .alpha.-N-alkyl derivative thereof, D and E each represent an L- or D-basic amino acid or an .alpha.-N-alkyl derivative thereof, F represents a group of the formula --OR.sup.3 (in which R.sup.3 is H or a lower alkyl group), a group of the formula: ##STR2## (in which R.sup.4 and R.sup.5 are the same or different and each represents H or a lower alkyl group), a group of the formula: --G--OR.sup.6 (in which G is an L- or D-amino acid or Gly or an .alpha.-N-alkyl derivative thereof and R.sup.6 represents H or a lower alkyl group), a group of the formula: ##STR3## (in which G is as defined above and R.sup.7 and R.sup.8 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--L--Arg--OR.sup.9 or --G--D--Arg--OR.sup.9 (in which G is as defined above and R.sup.9 represents H or a lower alkyl group or a group of the formula: ##STR4## (in which G is as defined above and R.sup.10 and R.sup.11 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--J--OR.sup.12 in which G is defined as above, J is a neutral amono acid group or an acidic amino acid group and R.sup.12 is hydrogen or a lower alkyl group; or a group of the formula: --G--Arg--M--OR.sup.13 in which M is D-amino acid group and R.sup.13 is hydrogen or a lower alkyl group, provided that all of the amino acids constituting the polypeptide of the above formula do not represent at the same time an L-amino acid of the general formula: ##STR5## (in which R represents a group corresponding to a structural formula of an amino acid deprived of a group of the formula: ##STR6## or pharmacologically acceptable salts of them.

5. 发明授权

US4481138A Heptadecapeptide 失效
标题翻译：七肽
公开(公告)号：US4481138A
公开(公告)日：1984-11-06
申请号：US400324
申请日：1982-07-21
申请人： Shinro Tachibana , Kengo Araki , Shizuko Ohya , Seiji Yoshida
发明人： Shinro Tachibana , Kengo Araki , Shizuko Ohya , Seiji Yoshida
IPC分类号： C07K7/08 , A61K35/38 , A61K38/00 , A61P25/04 , C07K1/20 , C07K14/575 , C07K14/655 , C07K14/675 , C07C103/52
CPC分类号： C07K14/675 , A61K38/00
摘要： A substance having opiate and analgesic activity is obtained from swine duodenum. The opioid substance of the present invention comprises a heptadecapeptide having the following primary amino acid structure: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln.
摘要翻译：从十二指肠获得具有鸦片和止痛活性的物质。本发明的阿片样物质包含具有以下伯氨基酸结构的十七肽：Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn- Gln。

6. 发明授权

US3940480A Process for production of stabilized powdery secretin preparation by lyophilization 失效
标题翻译：通过冻干生产稳定的粉末分泌素制剂的方法
公开(公告)号：US3940480A
公开(公告)日：1976-02-24
申请号：US354883
申请日：1973-04-26
申请人： Eiichi Suenaga , Shinro Tachibana , Nagayasu Sato
发明人： Eiichi Suenaga , Shinro Tachibana , Nagayasu Sato
IPC分类号： A61K9/14 , A61K9/19 , A61K38/00 , A61K38/22 , A61K47/16 , A61K37/00
CPC分类号： A61K38/2235 , A61K47/183 , A61K9/19
摘要： Stabilized powdery secretin preparation wherein secretin is carried on an adequate amount of alanine serving as excipient and weighing material, which is produced by lyophilization of an aqueous solution of secretin in the presence of alanine, the product being useful for therapeutic treatment of diseases and for diagnosis of disorders in digestive tracts such as pancreas and gallbladder.
摘要翻译：稳定化的粉末分泌素制剂，其中分泌胰蛋白质携带足量的丙氨酸作为赋形剂和称重物质，其通过在丙氨酸存在下冻干分泌素水溶液而产生，该产品可用于治疗疾病和诊断的消化道疾病如胰腺和胆囊。

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