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1. 发明授权

US07981664B1 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates 有权
标题翻译：用于在多孔板中的微阵列上进行配体结合测定的装置和方法
公开(公告)号：US07981664B1
公开(公告)日：2011-07-19
申请号：US12125685
申请日：2008-05-22
申请人： Shane C Dultz
发明人： Shane C Dultz
IPC分类号： C12M3/00
CPC分类号： B01L3/5085 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/0861 , G01N21/211 , G01N21/253 , G01N21/552 , Y10S436/805 , Y10S436/809
摘要： Each well of a multiwell plate adapted to accept a plurality of biological samples for testing for the presence of analytes in the sample is further adapted herein for immobilizing on the side walls of a well a 3D arrangement of ligand arrays. A well is formed with planar side walls and a stack of sample separators is placed within a well in positions so as to not come in contact with ligand spots in the array(s). The spacing between each pair of adjacent separators in a stack forms a sample chamber in a position corresponding to an array of the 3D arrangement of ligand arrays.
摘要翻译：适于接受用于测试样品中分析物存在的多个生物样品的多孔板的每个孔在本文中进一步适用于固定在阱的配置阵列的3D排列的侧壁上。一个井形成有平面的侧壁，并且一堆样品分离器放置在井内的位置，以便不与阵列中的配体点接触。叠层中每对相邻分离器之间的间隔在对应于配体阵列的3D排列的阵列的位置形成样品室。

2. 发明授权

US08039270B2 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates 有权
标题翻译：用于在多孔板中的微阵列上进行配体结合测定的装置和方法
公开(公告)号：US08039270B2
公开(公告)日：2011-10-18
申请号：US12125735
申请日：2008-05-22
申请人： Shane C Dultz , David Ralin
发明人： Shane C Dultz , David Ralin
IPC分类号： G01N33/543
CPC分类号： G01N21/211 , G01N21/253 , G01N33/54373 , G01N2021/212 , G02B5/045 , Y10S436/805 , Y10S436/809
摘要： Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.
摘要翻译：用于在样品中的分析物和由从配体的平面反射的光束产生的消逝场中的配体阵列之间的成像结合事件的椭圆偏光测量系统适用于通常使用的多孔板结构。在一个示例中，棱镜阵列的膜被固定到板的下侧，每个棱镜阵列与阱对准，并且将配体阵列固定在孔的（平面）底表面上。棱镜阵列可以形成为薄膜并且与板的底表面并列，或者棱镜阵列可以与多孔板的板底一体地形成。

3. 发明申请

US20110157693A1 BIOLOGICAL TESTING WITH SAWTOOTH-SHAPED PRISMS 有权
标题翻译：生物测试与SAWTOOTH形状的PRISMS
公开(公告)号：US20110157693A1
公开(公告)日：2011-06-30
申请号：US12650327
申请日：2009-12-30
申请人： Shane C. Dultz , David Ralin
发明人： Shane C. Dultz , David Ralin
IPC分类号： G02B21/34 , G01N21/01 , B32B5/00
CPC分类号： G01N21/552 , B01L3/5027 , B01L3/508 , B01L3/5085 , G01N21/05 , G01N21/253 , G01N33/54373 , G01N2021/0346 , Y10T428/24777
摘要： In one embodiment, an apparatus is provided for testing for the presence of analytes in a sample. The apparatus comprises a source of light directed at the bottom surface of a substrate to achieve total internal reflection and to generate an evanescent field. An array of capture elements is immobilized on the top surface of the substrate. The bottom surface of the substrate is configured as a sawtooth (in cross section), the “teeth” aligned with the rows or the columns in the array. The outer faces of the sawtooth “prisms” are non-parallel to the substrate top surface, and specific requirements are imposed on the prism light-entrance face, and the substrate thickness and refractive index.
摘要翻译：在一个实施例中，提供了用于测试样品中分析物的存在的装置。该装置包括指向基板的底表面的光源，以实现全内反射并产生渐逝场。捕获元件的阵列被固定在基板的顶表面上。衬底的底表面被配置为锯齿形（横截面），“齿”与阵列中的行或列对准。锯齿状“棱镜”的外表面与基板顶面不平行，对棱镜光入射面，基板厚度和折射率有特殊要求。

4. 发明授权

US07867783B2 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates 有权
标题翻译：用于在多孔板中的微阵列上进行配体结合测定的装置和方法
公开(公告)号：US07867783B2
公开(公告)日：2011-01-11
申请号：US11677674
申请日：2007-02-22
申请人： Shane C. Dultz , Jeffrey C. Travis , David Ralin
发明人： Shane C. Dultz , Jeffrey C. Travis , David Ralin
IPC分类号： G01N33/543
CPC分类号： C40B60/12 , C40B30/04 , G01N21/552 , G01N2021/212 , Y10S436/809
摘要： An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.
摘要翻译：提供了一种用于实时，无标签成像和定位位置阵列处的绑定事件的装置和方法。来自多孔板的孔的平面侧壁的全内反射被用于在固定在壁上的配体图案的平面中产生消逝场。实施例包括对单个孔的单个壁的成像和多个分析物检测和定量，以及多个孔的同时成像和多个分析物检测和定量。

5. 发明授权

US07799558B1 Ligand binding assays on microarrays in closed multiwell plates 有权
标题翻译：封闭式多孔板中微阵列的配体结合分析
公开(公告)号：US07799558B1
公开(公告)日：2010-09-21
申请号：US11752056
申请日：2007-05-22
申请人： Shane C. Dultz
发明人： Shane C. Dultz
IPC分类号： G01N33/543
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00509 , B01J2219/00596 , B01J2219/00662 , B01J2219/00704 , B01J2219/00725 , B01L3/50853 , B01L2300/0636 , B01L2400/086 , G01N21/552 , Y10S436/809
摘要： Multiwell plates commonly used for immunoassay are increased in capacity and adapted for ease and speed of testing by forming a plurality of solid posts in each well of a plate. The posts and plate material and the dimensions of the posts are chosen to allow the immobilization of ligand patterns on an exterior wall of a post in a well and to permit a collimated beam of light directed to the post in a direction to achieve total internal reflection from a wall to generate an evanescent field in the plane of the ligands immobilized on the exterior wall of the post. The reflected light carries an image of localized intensity variations due to binding events between the ligand patterns and analytes in a sample introduced into a well. A cover plate seals the wells and provides for through holes for introducing sample material to the wells.
摘要翻译：通常用于免疫测定的多孔板通过在板的每个孔中形成多个固体柱而增加容量并适于测试的容易性和速度。柱和板材的尺寸和柱的尺寸被选择为允许将配体图案固定在井的柱的外壁上并且允许在朝向柱的方向上的准直光束以实现全内反射从壁上产生在固定在柱的外壁上的配体的平面中的消逝场。由于引入井中的样品中的配体图案和分析物之间的结合事件，反射光携带局部强度变化的图像。盖板密封井，并提供用于将样品材料引入井的通孔。

6. 发明申请

US20080216334A1 Apparatus and Method for Mapping Hair Metric 有权
标题翻译：用于测量头发指标的装置和方法
公开(公告)号：US20080216334A1
公开(公告)日：2008-09-11
申请号：US11682763
申请日：2007-03-06
申请人： Jae P. Pak , William R. Rassman , Shane C. Dultz , David Ralin
发明人： Jae P. Pak , William R. Rassman , Shane C. Dultz , David Ralin
IPC分类号： A61B5/103
CPC分类号： A61B5/1072 , A61B5/448
摘要： Apparatus for determining the status of hair bulk in an area of a scalp is operative to provide a metric over a sufficiently large area to permit revisiting with only negligible misalignment error. Accurate re-measurement of hair status in accurately identified areas produces a reliable metric for determining degree of hair loss and or the effectiveness of treatment.
摘要翻译：用于确定头皮区域中头发体积的状态的装置可操作以在足够大的区域上提供度量以允许重新访问，只有可忽略的未对准误差。在准确识别的区域中准确地重新测量头发状态产生用于确定脱发程度和/或治疗有效性的可靠度量。

7. 发明申请

US20090290157A1 APPARATUS AND METHOD FOR PERFORMING LIGAND BINDING ASSAYS ON MICROARRAYS IN MULTIWELL PLATES 有权
标题翻译：用于在多层板中进行微阵列配准测定的装置和方法
公开(公告)号：US20090290157A1
公开(公告)日：2009-11-26
申请号：US12125735
申请日：2008-05-22
申请人： Shane C. Dultz , David Ralin
发明人： Shane C. Dultz , David Ralin
IPC分类号： G01J9/00 , G02B5/04 , G02B5/136
CPC分类号： G01N21/211 , G01N21/253 , G01N33/54373 , G01N2021/212 , G02B5/045 , Y10S436/805 , Y10S436/809
摘要： Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.
摘要翻译：用于在样品中的分析物和由从配体的平面反射的光束产生的消逝场中的配体阵列之间的成像结合事件的椭圆偏光测量系统适用于通常使用的多孔板结构。在一个示例中，棱镜阵列的膜被固定到板的下侧，每个棱镜阵列与阱对准，并且将配体阵列固定在孔的（平面）底表面上。棱镜阵列可以形成为薄膜并且与板的底表面并列，或者棱镜阵列可以与多孔板的板底一体地形成。

8. 发明申请

US20080207463A1 APPARATUS AND METHOD FOR PERFORMING LIGAND BINDING ASSAYS ON MICROARRAYS IN MULTIWELL PLATES 有权
标题翻译：用于在多层板中进行微阵列配准测定的装置和方法
公开(公告)号：US20080207463A1
公开(公告)日：2008-08-28
申请号：US11677674
申请日：2007-02-22
申请人： Shane C. Dultz , Jeffrey C. Travis , David Ralin
发明人： Shane C. Dultz , Jeffrey C. Travis , David Ralin
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： C40B60/12 , C40B30/04 , G01N21/552 , G01N2021/212 , Y10S436/809
摘要： An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.
摘要翻译：提供了一种用于实时，无标签成像和定位位置阵列处的绑定事件的装置和方法。来自多孔板的孔的平面侧壁的全内反射被用于在固定在壁上的配体图案的平面中产生消逝场。实施例包括对单个孔的单个壁的成像和多个分析物检测和定量，以及多个孔的同时成像和多个分析物检测和定量。

9. 发明授权

US08355133B2 Biological testing with sawtooth-shaped prisms 有权
标题翻译：用锯齿形棱镜进行生物试验
公开(公告)号：US08355133B2
公开(公告)日：2013-01-15
申请号：US12650327
申请日：2009-12-30
申请人： Shane C. Dultz , David Ralin
发明人： Shane C. Dultz , David Ralin
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , B01L3/5027 , B01L3/508 , B01L3/5085 , G01N21/05 , G01N21/253 , G01N33/54373 , G01N2021/0346 , Y10T428/24777
摘要： In one embodiment, an apparatus is provided for testing for the presence of analytes in a sample. The apparatus comprises a source of light directed at the bottom surface of a substrate to achieve total internal reflection and to generate an evanescent field. An array of capture elements is immobilized on the top surface of the substrate. The bottom surface of the substrate is configured as a sawtooth (in cross section), the “teeth” aligned with the rows or the columns in the array. The outer faces of the sawtooth “prisms” are non-parallel to the substrate top surface, and specific requirements are imposed on the prism light-entrance face, and the substrate thickness and refractive index.
摘要翻译：在一个实施例中，提供了用于测试样品中分析物的存在的装置。该装置包括指向基板的底表面的光源，以实现全内反射并产生渐逝场。捕获元件的阵列被固定在基板的顶表面上。衬底的底表面被配置为锯齿形（横截面），齿与阵列中的行或列对齐。锯齿形棱镜的外表面与基板顶面不平行，对棱镜光入射面和基板厚度及折射率有特殊要求。

10. 发明授权

US07863037B1 Ligand binding assays on microarrays in closed multiwell plates 有权
标题翻译：封闭式多孔板中微阵列的配体结合分析
公开(公告)号：US07863037B1
公开(公告)日：2011-01-04
申请号：US11696369
申请日：2007-04-04
申请人： Shane C. Dultz
发明人： Shane C. Dultz
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S436/809
摘要： Multiwell plates commonly used for immunoassay are increased in capacity and adapted for ease and speed of testing by forming a plurality of solid posts in each well of a plate. The posts and plate material and the dimensions of the posts are chosen to allow the immobilization of ligand patterns on an exterior wall of a post in a well and to permit a collimated beam of light directed to the post in a direction to achieve total internal reflection from a wall to generate an evanescent field in the plane of the ligands immobilized on the exterior wall of the post. The reflected light carries an image of localized intensity variations due to binding events between the ligand patterns and analytes in a sample introduced into a well. A cover plate seals the wells and provides for through holes for introducing sample material to the wells.
摘要翻译：通常用于免疫测定的多孔板通过在板的每个孔中形成多个固体柱而增加容量并适于测试的容易性和速度。柱和板材的尺寸和柱的尺寸被选择为允许将配体图案固定在井的柱的外壁上并且允许在朝向柱的方向上的准直光束以实现全内反射从壁上产生在固定在柱的外壁上的配体的平面中的消逝场。由于引入井中的样品中的配体图案和分析物之间的结合事件，反射光携带局部强度变化的图像。盖板密封井，并提供用于将样品材料引入井的通孔。

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