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1. 发明授权

US08125637B2 Optical beam spectrometer with movable lens 有权
标题翻译：具有可移动镜头的光束光谱仪
公开(公告)号：US08125637B2
公开(公告)日：2012-02-28
申请号：US12268419
申请日：2008-11-10
申请人： Keith T. Carron , Mark Watson , Shane Buller
发明人： Keith T. Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/06 , G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0272 , G01J3/44
摘要： A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.
摘要翻译：描述了一种分光系统，其将激发光束的焦点中的至少一个提供到样本上，用于收集分光信号的光谱系统的光学系统的自动聚焦和/或样品的表面积上的激发强度的平均值。

2. 发明申请

US20050248758A1 Raman spectrometer 有权
标题翻译：拉曼光谱仪
公开(公告)号：US20050248758A1
公开(公告)日：2005-11-10
申请号：US10859372
申请日：2004-06-01
申请人： Keith Carron , Mark Watson , Shane Buller
发明人： Keith Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J2003/4424 , G01N21/65 , G01N2201/0221 , G01N2201/0612 , G01N2201/0813
摘要： A system, method and apparatus for taking a Raman spectrum of a sample is disclosed. In one embodiment, for example, an integrated Raman spectrometer is provided. In another embodiment, a portable Raman spectrometer is provided. In another embodiment, a Raman spectrometer is provided comprising a collimated beam tube for transmitting excitation radiation to an external optical system, such as a microscope, a telescope or a camera lens. In another embodiment, a method for correcting a Raman spectrum for background interference is provided. In yet another embodiment, a method for rejecting fluorescence in a Raman spectrometer is provided. A chemical reactor comprising a built-in Raman detector for monitoring a chemical reaction in a reaction chamber of the reactor is also provided.
摘要翻译：公开了一种用于获取样品的拉曼光谱的系统，方法和装置。在一个实施例中，例如，提供了一种集成的拉曼光谱仪。在另一个实施例中，提供了便携式拉曼光谱仪。在另一个实施例中，提供拉曼光谱仪，其包括用于将激发辐射传输到诸如显微镜，望远镜或相机透镜的外部光学系统的准直束管。在另一实施例中，提供了用于校正背景干扰的拉曼光谱的方法。在另一个实施方案中，提供了一种用于在拉曼光谱仪中排除荧光的方法。还提供了一种包括用于监测反应器的反应室中的化学反应的内置拉曼检测器的化学反应器。

3. 发明申请

US20130316467A1 SPECTROSCOPIC ASSAYS AND TAGGING 审中-公开
标题翻译：光谱测定和标记
公开(公告)号：US20130316467A1
公开(公告)日：2013-11-28
申请号：US13819316
申请日：2011-08-30
申请人： Keith Carron , Shane Buller , Mark Watson
发明人： Keith Carron , Shane Buller , Mark Watson
IPC分类号： G01N21/65
CPC分类号： G01J3/4406 , G01J3/06 , G01J3/44 , G01J2003/062 , G01J2003/064 , G01N21/65 , G01N21/658 , G01N33/536 , G01N33/54313 , G01N33/54373 , G01N2201/0612
摘要： A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.
摘要翻译：提供光谱测定。该测定包括：构型成在溶液内移动的动力颗粒，所述动力颗粒包含用于选择性结合靶分析物的第一分析物结合试剂; 以及光谱报告颗粒，其被配置为响应于由光谱仪询问而提供预定的光谱信号，所述光谱报告颗粒包含用于选择性地结合靶分析物的第二分析物结合试剂，其中所述运动颗粒和所述光谱报告颗粒被配置以通过第一和第二分析物结合试剂在目标分析物存在下提供夹心测定。

4. 发明申请

US20120162642A1 Spectrometer 有权
标题翻译：光谱仪
公开(公告)号：US20120162642A1
公开(公告)日：2012-06-28
申请号：US13221899
申请日：2011-08-31
申请人： Mark Watson , Shane Buller , Keith Carron
发明人： Mark Watson , Shane Buller , Keith Carron
IPC分类号： G01J3/443
CPC分类号： G01J3/4406 , G01J3/06 , G01J3/44 , G01J2003/062 , G01J2003/064 , G01N21/65 , G01N21/658 , G01N33/54313 , G01N33/54373 , G01N2201/0612
摘要： A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable minor, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.
摘要翻译：提供光谱仪。在一个实施方案中，例如，光谱仪包括激发源，聚焦透镜，可移动次要器件和致动器组件。聚焦透镜适于聚焦来自激发源的入射光束。致动器组件适于控制可移动镜以将聚焦的入射光束移动穿过样品的表面。

5. 发明申请

US20090135417A1 OPTICAL BEAM SPECTROMETER 有权
标题翻译：光束光谱仪
公开(公告)号：US20090135417A1
公开(公告)日：2009-05-28
申请号：US12268419
申请日：2008-11-10
申请人： Keith T. Carron , Mark Watson , Shane Buller
发明人： Keith T. Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0272 , G01J3/44
摘要： A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.
摘要翻译：描述了一种分光系统，其将激发光束的焦点中的至少一个提供到样本上，用于收集分光信号的光谱系统的光学系统的自动聚焦和/或样品的表面积上的激发强度的平均值。

6. 发明授权

US08988678B2 Spectrometer 有权
标题翻译：光谱仪
公开(公告)号：US08988678B2
公开(公告)日：2015-03-24
申请号：US13221899
申请日：2011-08-31
申请人： Mark Watson , Shane Buller , Keith Carron
发明人： Mark Watson , Shane Buller , Keith Carron
IPC分类号： G01J3/00 , G01J3/06 , G01J3/44 , G01N21/65
CPC分类号： G01J3/4406 , G01J3/06 , G01J3/44 , G01J2003/062 , G01J2003/064 , G01N21/65 , G01N21/658 , G01N33/54313 , G01N33/54373 , G01N2201/0612
摘要： A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable mirror, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.
摘要翻译：提供光谱仪。在一个实施方案中，例如，光谱仪包括激发源，聚焦透镜，可移动反射镜和致动器组件。聚焦透镜适于聚焦来自激发源的入射光束。致动器组件适于控制可移动镜以将聚焦的入射光束移动穿过样品的表面。

7. 发明申请

US20120154801A1 Spectrometer 有权
标题翻译：光谱仪
公开(公告)号：US20120154801A1
公开(公告)日：2012-06-21
申请号：US13161485
申请日：2011-06-15
申请人： Keith Carron , Mark Watson , Shane Buller
发明人： Keith Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/44
CPC分类号： G01J3/0237 , G01J3/0208 , G01J3/44 , G01J3/4412 , G01N21/65
摘要： A spectroscopic system is provided. In one embodiment, the spectroscopic system comprises a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector, wherein the optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector; a calibration detector adapted to determine a set point of the adjustable dispersing element; and a source synchronization component adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided. In one embodiment, the method comprises determining a set point along a path of an adjustable dispersing element, wherein the set point corresponds to a position of the dispersing element where a calibration signal of a spectrometer is detected at a calibration sensor of the spectrometer; adjusting the position of the dispersing element along the path by a predetermined offset measurement from the set point; and directing at least a portion of a spectroscopic signal from the dispersing element to a spectroscopic signal detector of the spectrometer.
摘要翻译：提供光谱系统。在一个实施例中，分光系统包括适于提供照明光束的光源; 光学系统，其适于向样本提供照射束并从样本接收光谱信号，并将光谱信号引导到至少一个单通道检测器，其中该光学系统包括用于引导一个或多个光谱特征的至少一个单通道检测器; 校准检测器，适于确定可调分散元件的设定点; 以及源同步部件，其适于使所述光源和所述至少一个单通道检测器的操作同步。还提供了校准分光器的分散元件的方法。在一个实施例中，该方法包括确定沿着可调分散元件的路径的设定点，其中该设定点对应于在该分光器的校准传感器处检测到该光谱仪的校准信号的分散元件的位置; 沿着路径将分散元件的位置从设定点调整预定的偏移测量值; 并将来自分散元件的至少一部分光谱信号引导到光谱仪的光谱信号检测器。

8. 发明授权

US10684172B2 Spectroscopic assays and tagging 有权
公开(公告)号：US10684172B2
公开(公告)日：2020-06-16
申请号：US13819316
申请日：2011-08-30
申请人： Keith Carron , Shane Buller , Mark Watson
发明人： Keith Carron , Shane Buller , Mark Watson
IPC分类号： G01N33/536 , G01J3/44 , G01N33/543 , G01N21/65 , G01J3/06
摘要： A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.

9. 发明授权

US08867033B2 Spectrometer 有权
标题翻译：光谱仪
公开(公告)号：US08867033B2
公开(公告)日：2014-10-21
申请号：US13161485
申请日：2011-06-15
申请人： Keith Carron , Mark Watson , Shane Buller
发明人： Keith Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/28 , G01J3/44 , G01J3/02 , G01N21/65
CPC分类号： G01J3/0237 , G01J3/0208 , G01J3/44 , G01J3/4412 , G01N21/65
摘要： A spectroscopic system including a light source adapted to provide a beam of illumination; an optical system adapted to provide the beam of illumination to a sample and receive a spectroscopy signal from the sample and direct the spectroscopy signal to at least one single channel detector is provided. The optical system comprises an adjustable dispersing element for directing one or more spectral features of the spectroscopy signal to the at least one single channel detector. A calibration detector is adapted to determine a set point of the adjustable dispersing element; and a source synchronization component is adapted to synchronize an operation of the light source and the at least one single channel detector. A method of calibrating a dispersing element of a spectrometer is also provided.
摘要翻译：一种分光系统，包括适于提供照明光束的光源; 提供了一种光学系统，其适于向样本提供照射束并从样本接收光谱信号，并将光谱信号指向至少一个单通道检测器。光学系统包括用于将光谱信号的一个或多个光谱特征引导到至少一个单通道检测器的可调分散元件。校准检测器适于确定可调分散元件的设定点; 并且源同步组件适于同步光源和至少一个单通道检测器的操作。还提供了校准分光器的分散元件的方法。

10. 发明授权

US08373856B2 Optical beam spectrometer with movable lens 有权
标题翻译：具有可移动镜头的光束光谱仪
公开(公告)号：US08373856B2
公开(公告)日：2013-02-12
申请号：US13286181
申请日：2011-10-31
申请人： Keith T. Carron , Mark Watson , Shane Buller
发明人： Keith T. Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0272 , G01J3/44
摘要： A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.
摘要翻译：描述了一种分光系统，其将激发光束的焦点中的至少一个提供到样本上，用于收集分光信号的光谱系统的光学系统的自动聚焦和/或样品的表面积上的激发强度的平均值。

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