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    • 4. 发明授权
    • Process for the preparation of 10-methoxycarbamazepine
    • 制备10-甲氧基氨基甲脒的方法
    • US06670472B2
    • 2003-12-30
    • US10269084
    • 2002-10-09
    • Shahid Akhtar AnsariRavindra BhatAshok Krishna Kulkarni
    • Shahid Akhtar AnsariRavindra BhatAshok Krishna Kulkarni
    • C07D22322
    • C07D223/26C07D223/28Y02P20/582
    • A process for the preparation of 10-methoxycarbamazepine, an important intermediate in the preparation of 10-oxo-10, 11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide(oxcarbazepine) from 10-methoxy-5H-dibenz(b,f)azepine(10-methoxyiminostilbene), is disclosed, which process comprises reacting 10-methoxyiminostilbene with cyanic acid (HOCN) in the presence of a mild acidic reagent in a solvent. Also disclosed is an improved method for the hydrolysis of 10-methoxycarbamazepine to oxcarbazepine, which method comprises carrying out the hydrolysis in a biphasic system chosen such that the oxcarbazepine is substantially insoluble in both phases, whereas the by-products or impurities are soluble in at least one of the phases. The oxcarbazepine thereby prepared is an anticonvulsant, and has been proposed for use as an anti-epileptical agent in the treatment of AIDS-related neural disorders, and for the treatment of Parkinson's disease and/or Parkinsonian syndromes.
    • 制备10-甲氧基氨基马西平的方法,10-甲氧基-5-氨基甲酰胺,10-氧代-10-二氢-5H-二苯并(b,f)吖庚因-5-甲酰胺(奥卡西平),10-甲氧基-5H- 二苯并(b,f)吖庚因(10-甲氧基亚氨基芪),该方法包括在温和酸性试剂存在下在溶剂中使10-甲氧基亚氨基芪与氰酸(HOCN)反应。 还公开了一种用于将10-甲氧基氨基甲脒水解成奥卡西平的改进方法,该方法包括在选择的双相系统中进行水解,使得奥卡西平基本上不溶于两相,而副产物或杂质可溶于 至少有一个阶段。 由此制备的奥卡西平是抗惊厥药,并且已被提出用作抗癫痫剂用于治疗AIDS相关的神经障碍,并用于治疗帕金森病和/或帕金森综合征。
    • 7. 发明授权
    • Resource profile adjustment for pre-fetching of assets to user equipment
    • 用于将资产预取给用户设备的资源配置文件调整
    • US08787882B2
    • 2014-07-22
    • US12964578
    • 2010-12-09
    • Shahid Akhtar
    • Shahid Akhtar
    • H04L12/58H04M1/725
    • H04L67/30G06F17/30902H04L67/04H04W8/18H04W28/06H04W28/26
    • Systems and methods are disclosed for adjusting resource profiles which are used by user equipment (UE) to pre-fetch assets from content providers. In one embodiment, a recommender system receives a resource profile from a UE. The resource profile indicates content providers that have assets for the UE to download in advance during a pre-fetch operation. The resource profile also defines a percentage of UE resources allocated to each of the content providers for downloading the assets during the pre-fetch operation. The recommender system then adjusts the percentages of the UE resources in the resource profile for the end user to generate an updated resource profile for the end user, and transmits the updated resource profile to the UE for use in one or more subsequent pre-fetch operations.
    • 公开了用于调整用户设备(UE)从内容提供商预取资产的资源简档的系统和方法。 在一个实施例中,推荐器系统从UE接收资源简档。 资源配置文件指示在预取操作期间具有用于UE预先下载的资产的内容提供商。 资源简档还定义了在预取操作期间分配给每个内容提供商的用于下载资产的UE资源的百分比。 推荐系统然后调整终端用户的资源简档中的UE资源的百分比,以便为最终用户生成更新的资源简档,并且将更新的资源简档发送给UE以用于一个或多个后续预取操作 。