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1. 发明授权

US06670472B2 Process for the preparation of 10-methoxycarbamazepine 失效
标题翻译：制备10-甲氧基氨基甲脒的方法
公开(公告)号：US06670472B2
公开(公告)日：2003-12-30
申请号：US10269084
申请日：2002-10-09
申请人： Shahid Akhtar Ansari , Ravindra Bhat , Ashok Krishna Kulkarni
发明人： Shahid Akhtar Ansari , Ravindra Bhat , Ashok Krishna Kulkarni
IPC分类号： C07D22322
CPC分类号： C07D223/26 , C07D223/28 , Y02P20/582
摘要： A process for the preparation of 10-methoxycarbamazepine, an important intermediate in the preparation of 10-oxo-10, 11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide(oxcarbazepine) from 10-methoxy-5H-dibenz(b,f)azepine(10-methoxyiminostilbene), is disclosed, which process comprises reacting 10-methoxyiminostilbene with cyanic acid (HOCN) in the presence of a mild acidic reagent in a solvent. Also disclosed is an improved method for the hydrolysis of 10-methoxycarbamazepine to oxcarbazepine, which method comprises carrying out the hydrolysis in a biphasic system chosen such that the oxcarbazepine is substantially insoluble in both phases, whereas the by-products or impurities are soluble in at least one of the phases. The oxcarbazepine thereby prepared is an anticonvulsant, and has been proposed for use as an anti-epileptical agent in the treatment of AIDS-related neural disorders, and for the treatment of Parkinson's disease and/or Parkinsonian syndromes.
摘要翻译：制备10-甲氧基氨基马西平的方法，10-甲氧基-5-氨基甲酰胺，10-氧代-10-二氢-5H-二苯并（b，f）吖庚因-5-甲酰胺（奥卡西平），10-甲氧基-5H- 二苯并（b，f）吖庚因（10-甲氧基亚氨基芪），该方法包括在温和酸性试剂存在下在溶剂中使10-甲氧基亚氨基芪与氰酸（HOCN）反应。还公开了一种用于将10-甲氧基氨基甲脒水解成奥卡西平的改进方法，该方法包括在选择的双相系统中进行水解，使得奥卡西平基本上不溶于两相，而副产物或杂质可溶于至少有一个阶段。由此制备的奥卡西平是抗惊厥药，并且已被提出用作抗癫痫剂用于治疗AIDS相关的神经障碍，并用于治疗帕金森病和/或帕金森综合征。

2. 发明申请

US20120232476A1 STEERING SYSTEM AND A CATCHER SYSTEM 有权
标题翻译：转向系统和捕获系统
公开(公告)号：US20120232476A1
公开(公告)日：2012-09-13
申请号：US13508560
申请日：2010-11-08
申请人： Ravindra Bhat , Dennis Erwin Bos , Antonius Maria Rijken , Michel Gerardus Pardoel , Sait Izmit
发明人： Ravindra Bhat , Dennis Erwin Bos , Antonius Maria Rijken , Michel Gerardus Pardoel , Sait Izmit
IPC分类号： A61M25/092 , B65H51/10
CPC分类号： A61M25/0113 , A61B1/00147 , A61B8/12 , A61B8/42 , A61B34/30 , A61B2034/301 , A61M25/09041
摘要： A steering system (30) comprises two radially oppositely arranged drive wheels (1; 3) for steering a tubular object (5) positioned between the drive wheels (1; 3). The drive wheels (1; 3) each have a wheel rotation axis (40; 42) and each include a plurality of rollers (7) distributed around the wheel rotation axis (40; 42). The rollers (7) are rotatably arranged, each roller having a roller rotation axis (44) and an outer drive face (58) concavely vaulted in a direction corresponding to its roller rotation axis (44). The roller rotation axis (44) is obliquely oriented in relation to the wheel rotation axis (40; 42) and the rollers (7) of each drive wheel (1; 3) form together a steering periphery for the tubular object (5). The steering system enables continues rotation of a tubular object without danger that the object will lose the contact with the rollers. The steering system (30) may be incorporated in a catheter system which comprises a catheter (5).
摘要翻译：转向系统（30）包括两个径向相对布置的驱动轮（1; 3），用于转向位于驱动轮（1; 3）之间的管状物体（5）。驱动轮（1; 3）各自具有车轮旋转轴线（40; 42），并且每个包括围绕车轮旋转轴线（40; 42）分布的多个辊子（7）。辊（7）可旋转地布置，每个辊具有在与其辊旋转轴线（44）对应的方向上凹入地弯曲的辊旋转轴线（44）和外驱动面（58）。辊旋转轴（44）相对于车轮旋转轴线（40; 42）倾斜定向，并且每个驱动轮（1; 3）的辊（7）一起形成用于管状物体（5）的转向周边。转向系统能够持续地旋转管状物体，而不会危及物体将失去与辊的接触。转向系统（30）可以结合在包括导管（5）的导管系统中。

3. 发明申请

US20120085078A1 GUIDANCE CHAIN FOR GUIDING CABLES OR OTHER LINES IN A MEDICAL DIAGNOSTIC APPARATUS 有权
标题翻译：在医疗诊断设备中指导电缆或其他线路的指导链
公开(公告)号：US20120085078A1
公开(公告)日：2012-04-12
申请号：US13375636
申请日：2010-06-21
申请人： Antonius Maria Rijken , Martinus Antonius Maria Cuppen , Ravindra Bhat , Arthur Robert Van ES
发明人： Antonius Maria Rijken , Martinus Antonius Maria Cuppen , Ravindra Bhat , Arthur Robert Van ES
IPC分类号： F16G13/00
CPC分类号： H02G3/0475 , A61B6/4441 , A61B6/4488 , A61B6/56 , F16G13/16
摘要： The invention relates to a guidance chain (18; 118; 218; 318; 418; 518, 618) for guiding a connection line (20; 120; 220; 320; 420), such as a cable, electrical cable, fiber glass cable, water line, gas line or fluid line, between parts (12, 13) of a medical diagnostic apparatus (10) which are moved relative to each other, the guidance chain comprising plural chain elements (19; 119; 219; 319; 419), wherein consecutive chain elements are moveable relative to each other about a respective imaginary or real rotation axis for realizing a folding movement of the guidance chain, wherein the guidance chain is constructed such that it has an pre-set curvature in an unfolded state, and the radial extensions of the rotation axes are originating from substantially the same point in a folded state of the guidance chain. Further, the invention relates to a medical diagnostic apparatus (10) having such a guidance chain.
摘要翻译：本发明涉及用于引导连接线（20; 120; 220; 320; 420）的引导链（18; 118; 218; 318; 418; 518,618），例如电缆，电缆，玻璃纤维电缆（10）的部件（12,13）之间相互相对移动的引导链，所述引导链包括多个链条元件（19; 119; 219; 319; 419 ），其中连续的链条元件围绕相应的假想或实际旋转轴线相对于彼此可移动，以实现引导链的折叠运动，其中引导链被构造成使其具有处于展开状态的预设曲率，并且旋转轴的径向延伸源自引导链的折叠状态的基本上相同的点。此外，本发明涉及具有这种引导链的医疗诊断装置（10）。

4. 发明授权

US08769922B2 Guidance chain for guiding cables or other lines in a medical diagnostic apparatus 有权
标题翻译：用于在医疗诊断仪器中引导电缆或其他线路的导向链
公开(公告)号：US08769922B2
公开(公告)日：2014-07-08
申请号：US13375636
申请日：2010-06-21
申请人： Antonius Maria Rijken , Martinus Antonius Maria Cuppen , Ravindra Bhat , Arthur Robert Van Es
发明人： Antonius Maria Rijken , Martinus Antonius Maria Cuppen , Ravindra Bhat , Arthur Robert Van Es
IPC分类号： F16G13/16 , F16G13/02
CPC分类号： H02G3/0475 , A61B6/4441 , A61B6/4488 , A61B6/56 , F16G13/16
摘要： A guidance chain for guiding a connection line, such as a cable, electrical cable, fiber glass cable, water line, gas line or fluid line, between parts of a medical diagnostic apparatus which are moved relative to each other, includes plural chain elements, where consecutive chain elements are moveable relative to each other about a respective imaginary or real rotation axis for realizing a folding movement of the guidance chain. The guidance chain is constructed such that it has a pre-set curvature in an unfolded state, and the radial extensions of the rotation axes are originating from substantially the same point in a folded state of the guidance chain.
摘要翻译：在医疗诊断装置的相对于彼此移动的部分之间引导诸如电缆，电缆，玻璃纤维电缆，水线，气体管线或流体管线之类的连接线的引导链包括多个链条元件，其中连续的链元件围绕相应的虚拟或实际旋转轴线可相对于彼此移动，以实现引导链的折叠运动。引导链构造成使其在展开状态下具有预设的曲率，并且旋转轴的径向延伸源自引导链的折叠状态的基本上相同的点。

5. 发明申请

US20080201849A1 Patient Handling System Whereby a patient Table Top Can Move Over a Table Base 有权
标题翻译：病人处理系统病人桌面可以在桌子底部移动
公开(公告)号：US20080201849A1
公开(公告)日：2008-08-28
申请号：US11817694
申请日：2006-03-07
申请人： Arthur Robert Van Es , Ravindra Bhat
发明人： Arthur Robert Van Es , Ravindra Bhat
IPC分类号： A61G13/00
CPC分类号： A61B6/0457
摘要： A patient handling system comprising a table top (6) for carrying a lying patient (8). The table top (6) is supported by a table base (1) and the table top (6) can move in longitudinal direction over said table base (1) so that at least a part of the table top (6) can be displaced to a position away from said table base (1). At least a portion (1;4) of said table base (1), to which portion (1;4) the table top (6) is movably attached, can be displaced in substantially said longitudinal direction in which the table top (6) can move. Thereby, said table top (6) can be displaced in longitudinal direction over a distance which is larger than the length of the table top (6).
摘要翻译：一种患者处理系统，包括用于承载躺卧患者（8）的台面（6）。台面（6）由台座（1）支撑，桌面（6）能够在所述台座（1）上沿纵向移动，使台面（6）的至少一部分能够移位到远离所述台座（1）的位置。所述台架（1）的至少一部分（1; 4）可移动地连接到桌面（6）的部分（1; 4）上，）可以移动。因此，所述桌面（6）可以在长度方向上移动一个比台面（6）的长度大的距离。

6. 发明授权

US09420983B2 System for quantification of neovasculature in CT volumes 有权
标题翻译： CT体积新血管系统定量系统
公开(公告)号：US09420983B2
公开(公告)日：2016-08-23
申请号：US12739833
申请日：2008-10-29
申请人： Lyubomir Zagorchev , Andrew Buckler , Ravindra Bhat , Dennis E. Bos
发明人： Lyubomir Zagorchev , Andrew Buckler , Ravindra Bhat , Dennis E. Bos
IPC分类号： G06K9/00 , A61B6/00 , A61B6/03 , G06F19/00 , G06T7/60
CPC分类号： A61B6/503 , A61B6/035 , A61B6/504 , A61B6/508 , A61B6/583 , G06F19/00 , G06T7/62 , G06T2207/10081 , G06T2207/30048 , G06T2207/30096 , G06T2207/30101 , G16H40/63
摘要： When quantifying neo-vasculature growth measured using a CT scanner (10), a known blood voxel is identified and adjoining voxels are compared thereto by a quantifier (52) to determine whether they are blood voxels, in order to grow a 3D image of the blood vessels. A removable Hounsfield calibration phantom (56) is positioned in a subject support (12) and concurrently scanned with the subject during each scan, and a Hounsfield unit calibrator (54) automatically calibrates acquired CT data to the phantom. A transport system comprising a plurality of movement-arresting locations facilitates cheaply and repeatably locking a CT detector (20), in six degrees of movement, at a plurality of locations in the scanner gantry.
摘要翻译：当使用CT扫描器（10）量化新血管生长时，识别已知的血液体素，并且通过量词（52）将相邻的体素与其进行比较，以确定它们是否是血液体素，以便生长所述血液体素的三维图像血管可拆卸的Hounsfield校准体模（56）定位在受试者支架（12）中，并且在每次扫描期间与受试者同时扫描，并且Hounsfield单位校准器（54）自动地将所获取的CT数据校准到体模。包括多个运动阻止位置的运输系统有助于在扫描机台架的多个位置处以六个运动方式便宜且可重复地锁定CT检测器（20）。

7. 发明申请

US20100266190A1 SYSTEM FOR QUANTIFICATION OF NEOVASCULATURE IN CT VOLUMES 有权
标题翻译： CT体内定量新生血管系统
公开(公告)号：US20100266190A1
公开(公告)日：2010-10-21
申请号：US12739833
申请日：2008-10-29
申请人： Lyubomir Zagorchev , Andrew Buckler , Ravindra Bhat , Dennis E. Bos
发明人： Lyubomir Zagorchev , Andrew Buckler , Ravindra Bhat , Dennis E. Bos
IPC分类号： G06K9/00
CPC分类号： A61B6/503 , A61B6/035 , A61B6/504 , A61B6/508 , A61B6/583 , G06F19/00 , G06T7/62 , G06T2207/10081 , G06T2207/30048 , G06T2207/30096 , G06T2207/30101 , G16H40/63
摘要： When quantifying neo-vasculature growth measured using a CT scanner (10), a known blood voxel is identified and adjoining voxels are compared thereto by a quantifier (52) to determine whether they are blood voxels, in order to grow a 3D image of the blood vessels. A removable Hounsfield calibration phantom (56) is positioned in a subject support (12) and concurrently scanned with the subject during each scan, and a Hounsfield unit calibrator (54) automatically calibrates acquired CT data to the phantom. A transport system comprising a plurality of movement-arresting locations facilitates cheaply and repeatably locking a CT detector (20), in six degrees of movement, at a plurality of locations in the scanner gantry.
摘要翻译：当使用CT扫描器（10）量化新血管生长时，识别已知的血液体素，并且通过量词（52）将相邻的体素与其进行比较，以确定它们是否是血液体素，以便生长所述血液体素的三维图像血管可拆卸的Hounsfield校准体模（56）定位在受试者支架（12）中，并且在每次扫描期间与受试者同时扫描，并且Hounsfield单位校准器（54）自动地将所获取的CT数据校准到体模。包括多个运动阻止位置的运输系统有助于在扫描机台架的多个位置处以六个运动方式便宜且可重复地锁定CT检测器（20）。

8. 发明授权

US07810187B2 Patient handling system whereby a patient table top can move over a table base 有权
标题翻译：患者台面可以在桌子底座上移动的患者处理系统
公开(公告)号：US07810187B2
公开(公告)日：2010-10-12
申请号：US11817694
申请日：2006-03-07
申请人： Arthur Robert Van Es , Ravindra Bhat
发明人： Arthur Robert Van Es , Ravindra Bhat
IPC分类号： A61B6/04 , A61G13/02
CPC分类号： A61B6/0457
摘要： A patient handling system comprising a table top (6) for carrying a lying patient (8). The table top (6) is supported by a table base (1) and the table top (6) can move in longitudinal direction over said table base (1) so that at least a part of the table top (6) can be displaced to a position away from said table base (1). At least a portion (1;4) of said table base (1), to which portion (1;4) the table top (6) is movably attached, can be displaced in substantially said longitudinal direction in which the table top (6) can move. Thereby, said table top (6) can be displaced in longitudinal direction over a distance which is larger than the length of the table top (6).
摘要翻译：一种患者处理系统，包括用于承载躺卧患者（8）的台面（6）。台面（6）由台座（1）支撑，桌面（6）能够在所述台座（1）上沿纵向移动，使台面（6）的至少一部分能够移位到远离所述台座（1）的位置。所述台架（1）的至少一部分（1; 4）可移动地连接到桌面（6）的部分（1; 4）上，）可以移动。因此，所述桌面（6）可以在长度方向上移动一个比台面（6）的长度大的距离。

9. 发明申请

US20120106701A1 MOTOR ASSISTED MANUALLY CONTROLLED MOVEMENT ASSEMBLY, X-RAY SYSTEM COMPRISING THE SAME, METHOD AND USE 有权
标题翻译：电机辅助的手动控制运动组件，包括其的X射线系统，方法和使用
公开(公告)号：US20120106701A1
公开(公告)日：2012-05-03
申请号：US13319343
申请日：2010-04-19
申请人： Gerrit Jan Meek , Ravindra Bhat , Antonius Maria Rijken
发明人： Gerrit Jan Meek , Ravindra Bhat , Antonius Maria Rijken
IPC分类号： H05G1/02 , F16H7/02 , G01N23/04 , F16H37/06
CPC分类号： A61B6/4482 , A61B6/0457 , A61B6/4405 , A61B6/4441 , A61B6/4464 , A61B6/4476 , A61B6/5276 , H05G1/02 , H05G1/08 , Y10T74/19051
摘要： A motor assisted movement assembly 2 is provided comprising a motor arrangement 3, which motor arrangement 3 may assist a manually controlled movement of a first structural element 5 relative to a second structural element 6. A motor element 3a of the motor arrangement 3 is adapted to detect a manual indication of a desired movement of the second structural element 6 relative to the first structural element 5 with the motor arrangement 3 being adapted to assist, e.g. support the movement by providing an additional force.
摘要翻译：提供了一种电动机辅助移动组件2，其包括电动机装置3，该电动机装置3可辅助第一结构元件5相对于第二结构元件6的手动控制的运动。电动机装置3的电动机元件3a适于检测第二结构元件6相对于第一结构元件5的期望运动的手动指示，马达装置3适于辅助，例如通过提供额外的力来支持运动。

10. 发明授权

US09492131B2 Motor assisted manually controlled movement assembly, X-ray system comprising the same, method and use 有权
标题翻译：电动辅助手动控制运动组件，X射线系统包括相同的方法和用途
公开(公告)号：US09492131B2
公开(公告)日：2016-11-15
申请号：US13319343
申请日：2010-04-19
申请人： Gerrit Jan Meek , Ravindra Bhat , Antonius Maria Rijken
发明人： Gerrit Jan Meek , Ravindra Bhat , Antonius Maria Rijken
IPC分类号： A61B6/00 , H05G1/02 , H05G1/08 , A61B6/04
CPC分类号： A61B6/4482 , A61B6/0457 , A61B6/4405 , A61B6/4441 , A61B6/4464 , A61B6/4476 , A61B6/5276 , H05G1/02 , H05G1/08 , Y10T74/19051
摘要： A motor assisted movement assembly 2 is provided comprising a motor arrangement 3, which motor arrangement 3 may assist a manually controlled movement of a first structural element 5 relative to a second structural element 6. A motor element 3a of the motor arrangement 3 is adapted to detect a manual indication of a desired movement of the second structural element 6 relative to the first structural element 5 with the motor arrangement 3 being adapted to assist, e.g. support the movement by providing an additional force.
摘要翻译：提供了一种电动机辅助移动组件2，其包括电动机装置3，该电动机装置3可辅助第一结构元件5相对于第二结构元件6的手动控制的运动。电动机装置3的电动机元件3a适于检测第二结构元件6相对于第一结构元件5的期望运动的手动指示，马达装置3适于辅助，例如通过提供额外的力来支持运动。

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