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1. 发明授权

US08703740B2 Composition for preventing adhesion 有权
标题翻译：用于防止粘附的组合物
公开(公告)号：US08703740B2
公开(公告)日：2014-04-22
申请号：US13131996
申请日：2009-11-25
申请人： Il Hwan Cho , Sei Kwang Hahn , Eui Jin Hwang , Jang Sik Shin , Junseok Yeom
发明人： Il Hwan Cho , Sei Kwang Hahn , Eui Jin Hwang , Jang Sik Shin , Junseok Yeom
IPC分类号： A61K31/728
CPC分类号： A61K31/722 , A61K31/728
摘要： The present invention relates to a composition for preventing tissue adhesion which comprising a bio-compatible hyaluronic acid and a polymer compound. More specifically, the invention is a composition containing hyaluronic acid which has not been modified by a chemical crosslinking or other chemical modification a method for preparing the same, and a composition for adhesion prevention with superior efficacy.The composition of the present invention for preventing adhesion exhibits a physical barrier function and a new adhesion prevention function whereby thrombus formation, which is the basis of adhesion, is inhibited. Unlike conventional compositions which simply mix polymeric substances that function as physical barriers, the present invention performs a more effective role as a physical barrier by undergoing decomposition, absorption and excretion after a certain period inside a human body, does not interfere with healing of scars following surgery, and exhibits superior effects since application to areas of surgery is convenient.
摘要翻译：本发明涉及一种用于预防组织粘连的组合物，其包含生物相容性透明质酸和高分子化合物。更具体地说，本发明是含有未被化学交联或其它化学改性改性的透明质酸的组合物及其制备方法，以及具有优异功效的粘着防止用组合物。用于防止粘附的本发明的组合物显示出物理屏障功能和新的粘附防止功能，其中作为粘附基础的血栓形成被抑制。不同于简单地混合作为物理屏障的聚合物质的常规组合物，本发明通过在人体内经过一定时间后经历分解，吸收和排泄而作为物理屏障起到更有效的作用，不影响瘢痕愈合手术，并且表现出优异的效果，因为应用于手术领域是方便的。

2. 发明申请

US20130253170A1 HYALURONIC ACID-PROTEIN CONJUGATE AND METHOD FOR PREPARING SAME 有权
标题翻译：羟丙酸蛋白结合物及其制备方法
公开(公告)号：US20130253170A1
公开(公告)日：2013-09-26
申请号：US13992988
申请日：2011-12-05
申请人： Sei Kwang Hahn , Jeong A. Yang , Seung Kyu Yoon , Won Hee Hur , Ki Tae Park , Hye Min Kim , Hyun Tae Jung
发明人： Sei Kwang Hahn , Jeong A. Yang , Seung Kyu Yoon , Won Hee Hur , Ki Tae Park , Hye Min Kim , Hyun Tae Jung
IPC分类号： C07K14/56
CPC分类号： C07K14/56 , A61K31/726 , A61K31/728 , A61K38/191 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K47/36 , A61K47/61 , C07K14/525 , C07K14/565 , C07K14/57 , C07K17/10
摘要： An HA-protein conjugate in which an HA-aldehyde derivative, in which an aldehyde group is introduced to a hyaluronic acid or a salt thereof, is conjugated to the N-terminus of a protein, and a method for preparing the same are provided. The HA-protein conjugate includes a protein drug exhibiting an excellent bioconjugation efficiency and long-term medicinal effects, and has excellent protein drug activities since the hyaluronic acid is specifically conjugated to the N-terminus of the protein. Also, since liver-targeting properties of the hyaluronic acid can be freely controlled by changing an aldehyde substitution rate of the HA-aldehyde derivative, the HA-protein conjugate can be effectively used as a protein drug for treating liver diseases, and also be useful in enabling long-term medicinal effects of a protein drug required to bypass the liver. Accordingly, the HA-protein conjugate can be effectively used for a drug delivery system of proteins.
摘要翻译：提供其中将醛基引入透明质酸或其盐的HA-醛衍生物与蛋白质的N末端缀合的HA-蛋白质缀合物及其制备方法。 HA蛋白结合物包括显示出优异的生物共轭效率和长期药用作用的蛋白质药物，并且由于透明质酸与蛋白质的N末端特异性缀合，因此具有优异的蛋白质药物活性。此外，由于可以通过改变HA醛衍生物的醛取代率来自由地控制透明质酸的肝靶向性，因此HA蛋白结合物可以有效地用作治疗肝脏疾病的蛋白质药物，并且也是有用的能够使旁路肝脏所需的蛋白质药物具有长期的药效。因此，HA蛋白结合物可以有效地用于蛋白质的药物递送系统。

3. 发明授权

US08318856B2 Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid 有权
标题翻译：包含PEI和透明质酸的缀合物的核酸递送系统
公开(公告)号：US08318856B2
公开(公告)日：2012-11-27
申请号：US12733061
申请日：2008-04-04
申请人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
发明人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
IPC分类号： C08B37/00 , C08G63/48 , C08G63/91 , A61K48/00
CPC分类号： A61K47/61 , A61K47/59
摘要： The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
摘要翻译：本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。

4. 发明授权

US08183229B2 Bone filling complex and method for fabricating the same 有权
标题翻译：骨填充复合体及其制造方法
公开(公告)号：US08183229B2
公开(公告)日：2012-05-22
申请号：US12438628
申请日：2007-08-27
申请人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
发明人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
IPC分类号： A61K31/70 , C07H5/04
CPC分类号： A61L27/46 , A61F2/28 , A61L2430/02 , C08L5/08
摘要： Provided is a bone filling complex and method of preparing the same. The bone filling complex includes a matrix including a hydrogel-type hyaluronic acid derivative; and a bone derivative filling the matrix For example, the bone filling complex can be used to regenerate an injured alveolar bone.
摘要翻译：提供骨填充复合物及其制备方法。骨填充复合物包括包含水凝胶型透明质酸衍生物的基质; 和填充基质的骨衍生物例如，骨填充复合物可用于再生受损的牙槽骨。

5. 发明申请

US20100322378A1 X-RAY ABLATION OF HYALURONAN HYDROGELS 有权
标题翻译： HYALURONAN HYDROGELS的X射线吸收
公开(公告)号：US20100322378A1
公开(公告)日：2010-12-23
申请号：US12487862
申请日：2009-06-19
申请人： So Eun Chang , Byung Mook Weon , Jung Ho Je , Jun Seok Yeom , Sei Kwang Hahn
发明人： So Eun Chang , Byung Mook Weon , Jung Ho Je , Jun Seok Yeom , Sei Kwang Hahn
IPC分类号： G21K5/00
CPC分类号： G21K5/00 , C08B37/0072 , C08J3/075 , C08J3/28 , C08J2305/08 , C08L5/08 , G21K5/04
摘要： Disclosed is a method for ablating hyaluronan-based hydrogels with X-rays, the method comprising the steps of: (a) preparing hyaluronan-based hydrogels; and (b) performing X-ray irradiation to the hyaluronan-based hydrogels to induce a degradation of the hyaluronan-based hydrogels by a gel-to-sol transition during the X-ray irradiation. Disclosed is also a method for fabricating three-dimensional microchannels of hyaluronan hydrogels with a finely tunable X-ray ablation technique.
摘要翻译：公开了一种利用X射线消融透明质酸的水凝胶的方法，所述方法包括以下步骤：（a）制备透明质酸水凝胶; 和（b）对透明质酸水凝胶进行X射线照射，以在X射线照射期间通过凝胶 - 溶胶转变诱导透明质酸类水凝胶的降解。还公开了一种用精细可调X射线消融技术制造透明质酸水凝胶的三维微通道的方法。

6. 发明申请

US20100261245A1 LONG ACTING FORMULATION OF BIOPHARMACEUTICAL 有权
标题翻译：生物医学的长期制定
公开(公告)号：US20100261245A1
公开(公告)日：2010-10-14
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译：本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。

7. 发明授权

US09017712B2 Filler composition for tissue reinforcement 有权
标题翻译：用于组织增强的填料组合物
公开(公告)号：US09017712B2
公开(公告)日：2015-04-28
申请号：US13809432
申请日：2011-07-11
申请人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
发明人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
IPC分类号： A61K8/73 , A61Q19/08 , A61K31/167 , A61L27/20 , A61L27/52 , C08B37/08 , C08J3/075 , C08L5/08 , A61L27/54
CPC分类号： A61K8/735 , A61K31/167 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.
摘要翻译：本发明涉及用于组织增强的填充剂组合物，包括透明质酸和亚烷基二胺交联的水凝胶。填充剂组合物显示组织增强所需的正性物理性质，例如生物相容性和溶胀能力，以及有益效果，因为它们长时间保留在体内。

8. 发明授权

US08575332B2 Crosslinked polysaccharide microparticles and method for their preparation 有权
标题翻译：交联多糖微粒及其制备方法
公开(公告)号：US08575332B2
公开(公告)日：2013-11-05
申请号：US10579032
申请日：2004-11-15
申请人： Sei Kwang Hahn , Tsuyoshi Shimoboji
发明人： Sei Kwang Hahn , Tsuyoshi Shimoboji
IPC分类号： C08B37/00 , A61K9/50 , A61K9/62
CPC分类号： A61K9/1652 , A61K9/0019 , A61K9/0024 , A61K9/1694 , C08B37/00 , C08B37/0072 , C08J3/12 , C08J3/24 , C08J2305/08
摘要： The present invention provides long-acting sustained-release formulations of drugs such as proteins or peptides, which are injectable, completely biodegradable and safe, as well as ensuring efficient encapsulation of the drugs such as proteins or peptides without inhibiting their biological activity. It is possible to achieve injectable sustained-release formulations that ensure efficient encapsulation and long-term sustained release of drugs such as proteins or peptides while retaining their biological activity, when a solution containing a drug and a polysaccharide derivative such as hyaluronic acid having a crosslinkable functional group(s) or a salt thereof is dehydrated in microparticulate form starting from a dilute state, where crosslinking proceeds slowly, to reach a concentration which facilitates crosslinking, to thereby cause crosslinking reaction during concentration, so that the drug is encapsulated into the crosslinked polysaccharide to give drug-carrying microparticles.
摘要翻译：本发明提供了可注射，完全可生物降解和安全的药物（例如蛋白质或肽）的长效缓释制剂，以及确保药物如蛋白质或肽的有效包封而不抑制其生物学活性。当含有药物和多糖衍生物如具有交联性的透明质酸的溶液时，可以实现可注射的持续释放制剂，其确保药物如蛋白质或肽的药物的有效包封和长期持续释放，同时保持其生物学活性官能团或其盐以稀释状态从微细状态脱水，其中交联缓慢进行以达到促进交联的浓度，从而在浓缩期间引起交联反应，使得药物被包封到交联的多糖以产生载药微粒。

9. 发明授权

US08247493B2 Long acting formulation of biopharmaceutical 有权
标题翻译：长效配方的生物制药
公开(公告)号：US08247493B2
公开(公告)日：2012-08-21
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译：本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。

10. 发明申请

US20110237542A1 COMPOSITION FOR PREVENTING ADHESION 有权
标题翻译：防止粘合剂的组合物
公开(公告)号：US20110237542A1
公开(公告)日：2011-09-29
申请号：US13131996
申请日：2009-11-25
申请人： Il Hwan Cho , Sei Kwang Hahn , Eui Jin Hwang , Jang Sik Shin , Junseok Yeom
发明人： Il Hwan Cho , Sei Kwang Hahn , Eui Jin Hwang , Jang Sik Shin , Junseok Yeom
IPC分类号： A61K31/728 , A61P17/02
CPC分类号： A61K31/722 , A61K31/728
摘要： The present invention relates to a composition for preventing tissue adhesion which comprising a bio-compatible hyaluronic acid and a polymer compound. More specifically, the invention is a composition containing hyaluronic acid which has not been modified by a chemical crosslinking or other chemical modification a method for preparing the same, and a composition for adhesion prevention with superior efficacy.The composition of the present invention for preventing adhesion exhibits a physical barrier function and a new adhesion prevention function whereby thrombus formation, which is the basis of adhesion, is inhibited. Unlike conventional compositions which simply mixpolymeric substances that function as physical barriers, the present invention performs a more effective role as a physical barrier by undergoing decomposition, absorption and excretion after a certain period inside a human body, does not interfere with healing of scars following surgery, and exhibits superior effects since application to areas of surgery is convenient.
摘要翻译：本发明涉及一种用于预防组织粘连的组合物，其包含生物相容性透明质酸和高分子化合物。更具体地说，本发明是含有未被化学交联或其它化学改性改性的透明质酸的组合物及其制备方法，以及具有优异功效的防粘组合物。用于防止粘附的本发明的组合物显示出物理屏障功能和新的粘附防止功能，其中作为粘附基础的血栓形成被抑制。不同于简单地混合作为物理障碍物的混合物质的常规组合物，本发明通过在人体内经过一定时间后经历分解，吸收和排泄而作为物理屏障起到更有效的作用，不影响手术后瘢痕愈合，并且表现出优异的效果，因为应用于手术领域是方便的。

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