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1. 发明授权

US08323683B2 Flavoring of drug-containing chewing gums 有权
标题翻译：调味含药口香糖
公开(公告)号：US08323683B2
公开(公告)日：2012-12-04
申请号：US11131561
申请日：2005-05-18
申请人： Seema Mody , Gregory Koll
发明人： Seema Mody , Gregory Koll
IPC分类号： A24B15/16 , A24B15/00 , A23G4/00 , A23G4/08
CPC分类号： A61K9/0058
摘要： A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.
摘要翻译：一种口香糖，其包含至少一种具有芯的活性药物成分（API），其上施用至少一个内部聚合物膜涂层，此后施加至少一个外部硬涂层。优选的API是尼古丁。调味剂可以并入到核心，至少一个内部聚合物膜涂层和/或至少一个外部硬质涂层中。形成的牙龈表现出持久的调味剂效果，并导致涂层中的调味剂与核心中的调味剂的统称，从而（a）避免了化学或药物不相容性的问题涂层中的核心和调味剂中的API和（b）实现API和非活性赋形剂的释放的增加的控制。

2. 发明申请

US20070269519A1 Whitening products 审中-公开
标题翻译：美白产品
公开(公告)号：US20070269519A1
公开(公告)日：2007-11-22
申请号：US11821217
申请日：2007-06-21
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen (Jane) Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen (Jane) Zhang
IPC分类号： A61K8/02 , A61K8/22 , A61K8/73
CPC分类号： A61Q11/00 , A61K8/0208 , A61K8/22 , A61K8/927
摘要： This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegrable films.
摘要翻译：本发明一般涉及具有屏障以及受控崩解性质的膜，更具体地说涉及受控的水可分解膜。

3. 发明申请

US20050196358A1 Film products having controlled disintegration properties 审中-公开
公开(公告)号：US20050196358A1
公开(公告)日：2005-09-08
申请号：US11086517
申请日：2005-03-22
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
IPC分类号： A61K8/02 , A61K8/22 , A61K8/92 , A61K9/00 , A61K9/70 , A61Q11/00 , A61K7/20
CPC分类号： A61K8/02 , A61K8/22 , A61K8/25 , A61K8/37 , A61K8/375 , A61K8/927 , A61K8/987 , A61K9/0056 , A61Q11/00
摘要： This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegratable films.

4. 发明申请

US20080003248A1 Whitening products 审中-公开
标题翻译：美白产品
公开(公告)号：US20080003248A1
公开(公告)日：2008-01-03
申请号：US11821157
申请日：2007-09-11
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen (Jane) Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen (Jane) Zhang
IPC分类号： A61K8/02 , A61K8/22 , A61Q11/00
CPC分类号： A61K8/0208 , A61K8/22 , A61K8/927 , A61Q11/00
摘要： This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegrable films.
摘要翻译：本发明一般涉及具有屏障以及受控崩解性质的膜，更具体地说涉及受控的水可分解膜。

5. 发明申请

US20050196355A1 Film products having controlled disintegration properties 审中-公开
标题翻译：具有控制崩解性能的胶片制品
公开(公告)号：US20050196355A1
公开(公告)日：2005-09-08
申请号：US10792362
申请日：2004-03-03
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
IPC分类号： A61K8/02 , A61K8/22 , A61K8/92 , A61K9/00 , A61K9/70 , A61Q11/00 , A61K7/20
CPC分类号： A61K8/02 , A61K8/22 , A61K8/25 , A61K8/37 , A61K8/375 , A61K8/927 , A61K8/987 , A61K9/0056 , A61Q11/00
摘要： This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegratable films.
摘要翻译：本发明一般涉及具有屏障和受控的崩解性能的膜，更具体地说涉及受控的水可分解膜。

6. 发明申请

US20050196348A1 Stabilized peroxide compositions 审中-公开
标题翻译：稳定的过氧化物组合物
公开(公告)号：US20050196348A1
公开(公告)日：2005-09-08
申请号：US10792370
申请日：2004-03-03
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
IPC分类号： A61K9/68 , A61K7/20
CPC分类号： A61Q11/00 , A61K8/0208 , A61K8/22 , A61K8/733 , A61K8/96
摘要： This invention relates to a stabilized, oral composition, and more particularly, to such composition comprising peroxide compounds.
摘要翻译：本发明涉及稳定的口服组合物，更具体地说，涉及包含过氧化物化合物的组合物。

7. 发明申请

US20060275344A1 Flavoring of drug-containing chewing gums 有权
标题翻译：调味含药口香糖
公开(公告)号：US20060275344A1
公开(公告)日：2006-12-07
申请号：US11131561
申请日：2005-05-18
申请人： Seema Mody , Gregory Koll
发明人： Seema Mody , Gregory Koll
IPC分类号： A61K47/00
CPC分类号： A61K9/0058
摘要： A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.
摘要翻译：一种口香糖，其包含至少一种具有芯的活性药物成分（API），其上施用至少一个内部聚合物膜涂层，此后施加至少一个外部硬涂层。优选的API是尼古丁。调味剂可以并入到核心，至少一个内部聚合物膜涂层和/或至少一个外部硬质涂层中。形成的牙龈表现出持久的调味剂效果，并导致涂层中的调味剂与核心中的调味剂的统称，从而（a）避免了化学或药物不相容性的问题涂层中的核心和调味剂中的API和（b）实现API和非活性赋形剂的释放的增加的控制。

8. 发明申请

US20050196350A1 Stabilized peroxide compositions 审中-公开
公开(公告)号：US20050196350A1
公开(公告)日：2005-09-08
申请号：US11030845
申请日：2005-01-07
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
IPC分类号： A61K9/68 , A61K7/20
CPC分类号： A61Q11/00 , A61K8/0208 , A61K8/22 , A61K8/733 , A61K8/96
摘要： This invention relates to a stabilized, oral composition, and more particularly, to such composition comprising peroxide compounds.

9. 发明申请

US20080220029A1 Fast-dissolving/disintegrating film preparation having high proportion of active 审中-公开
标题翻译：具有高比例活性的快溶/崩解膜制剂
公开(公告)号：US20080220029A1
公开(公告)日：2008-09-11
申请号：US11714007
申请日：2007-03-05
申请人： Charlene Ng , Seema Mody , Josh Ghaim
发明人： Charlene Ng , Seema Mody , Josh Ghaim
IPC分类号： A61L15/16 , A61K8/02
CPC分类号： A61K9/0056 , A61K9/7007 , A61K31/09 , A61K31/165 , A61K31/167 , A61K31/192 , A61K31/405 , A61K31/616 , A61K33/26 , A61K47/36
摘要： The invention provides a fast-dissolving or fast-disintegrating film preparation having a high proportion (i.e., at least about 40%) of active agent(s) and related methods for its preparation. In one embodiment, the active agent is a pharmaceutical and the film comprises between about 10% and about 40% pullulan as a primary or sole water-soluble polymer.
摘要翻译：本发明提供具有高比例（即至少约40％）活性剂及其制备方法的快速溶解或快速崩解的膜制剂。在一个实施方案中，活性剂是药物，并且该膜包含作为主要或唯一水溶性聚合物的约10％至约40％的支链淀粉。

10. 发明申请

US20050196357A1 Film products having controlled disintegration properties 审中-公开
公开(公告)号：US20050196357A1
公开(公告)日：2005-09-08
申请号：US11030846
申请日：2005-01-07
申请人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
发明人： Constantine Georgiades , Seema Mody , Andre Soshinsky , Zhen Zhang
IPC分类号： A61K8/02 , A61K8/22 , A61K8/92 , A61K9/00 , A61K9/70 , A61Q11/00 , A61K7/20
CPC分类号： A61K8/02 , A61K8/22 , A61K8/25 , A61K8/37 , A61K8/375 , A61K8/927 , A61K8/987 , A61K9/0056 , A61Q11/00
摘要： This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegratable films.

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