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1. 发明授权

US07601502B2 Prime boost vaccine for the protection of equines against equine influenza 有权
标题翻译：用于保护马类马流感的主要增效疫苗
公开(公告)号：US07601502B2
公开(公告)日：2009-10-13
申请号：US12092164
申请日：2006-10-27
申请人： Saskia van de Zande
发明人： Saskia van de Zande
IPC分类号： C12Q1/68
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55577 , C12N2760/16134
摘要： The present invention is concerned with vaccinating equines against the equine influenza virus (EIV). It has now been found that adequate protection against equine influenza in equines can be achieved when vaccination with a live equine influenza vaccine (prime) is followed by vaccination with an inactivated influenza vaccine (boost), wherein the two shots are given no longer than 8 weeks apart.
摘要翻译：本发明涉及马匹与马流感病毒（EIV）接种疫苗。现在已经发现，当用活马疹流感疫苗（初始）接种疫苗之后，用灭活的流感疫苗接种疫苗（升压），可以实现对马中的马流感的充分保护，其中两次射击不超过8次相隔数周。

2. 发明申请

US20100233208A1 Methods of Treating and Preventing Neurological Symptoms Caused by Avian Reovirus and Novel Associated Characteristics 审中-公开
标题翻译：治疗和预防禽流感病毒和新型相关特征引起的神经症状的方法
公开(公告)号：US20100233208A1
公开(公告)日：2010-09-16
申请号：US12786906
申请日：2010-05-25
申请人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
发明人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
IPC分类号： A61K39/15 , C12N7/00 , A61P31/12 , A61P37/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , C12N2720/12034
摘要： Embodiments of the present invention generally relate to novel methods for the treatment and/or prevention of neurological symptoms caused by an avian reovirus, enteric reovirus strain (ERS), and associated characteristics. Other embodiments generally comprise and immunogenic composition or vaccine comprising an ERS for the treatment and/or prevention of neurological symptoms.
摘要翻译：本发明的实施方案通常涉及用于治疗和/或预防由禽呼肠孤病毒，肠道呼肠孤病毒毒株（ERS）引起的神经症状以及相关特征的新方法。其它实施方案通常包含用于治疗和/或预防神经症状的ERS的免疫原性组合物或疫苗。

3. 发明申请

US20080292659A1 Prime Boost Vaccine for the Protection of Equines Against Equine Influenza 有权
标题翻译：保护马来流感流感疫苗
公开(公告)号：US20080292659A1
公开(公告)日：2008-11-27
申请号：US12092164
申请日：2006-10-27
申请人： Saskia Van De Zande
发明人： Saskia Van De Zande
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55577 , C12N2760/16134
摘要： The present invention is concerned with vaccinating equines against the equine influenza virus (EIV).It has now been found that adequate protection against equine influenza in equines can be achieved when vaccination with a live equine influenza vaccine (prime) is followed by vaccination with an inactivated influenza vaccine (boost), wherein the two shots are given no longer than 8 weeks apart.The present invention therefore provides a method for vaccination of animals against equine influenza, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated equine influenza virus, followed by a vaccination with a (boost) vaccine comprising an inactivated equine influenza virus, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine. Preferably the two shots are given no longer than 8 weeks apart, for example, between 3-6 weeks apart, preferably between 4-6 weeks apart.
摘要翻译：本发明涉及马匹与马流感病毒（EIV）接种疫苗。现在已经发现，当用活马疹流感疫苗（初始）接种疫苗之后，用灭活的流感疫苗接种疫苗（升压），可以实现对马中的马流感的充分保护，其中两次射击不超过8次相隔数周。因此，本发明提供了一种针对马流感疫苗接种动物的方法，其中首先用包含减毒马流感病毒的（初级）疫苗接种动物，然后用包含灭活马流感病毒的（加强）疫苗接种疫苗，并且其中所述增强疫苗在所述主要疫苗之后不超过8周施用。优选地，两次射击不超过8周，例如间隔3-6周，优选间隔4-6周。

4. 发明申请

US20080014216A1 Prime -boost vaccine for the protection of equines against viral infection 有权
标题翻译：用于保护马免受病毒感染的初始疫苗
公开(公告)号：US20080014216A1
公开(公告)日：2008-01-17
申请号：US11743492
申请日：2007-05-02
申请人： Saskia van de Zande
发明人： Saskia van de Zande
IPC分类号： A61K39/295 , A61K39/145 , A61K39/245
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55577 , C12N2760/16134
摘要： It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated vaccine (boost) for the same virus, wherein the two shots are given no longer than 8 weeks apart. The invention therefore provides a method for vaccination of equines against infection with an equine viral pathogen, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated form of the pathogen, followed by a vaccination with a (boost) vaccine comprising the same pathogen in inactivated form, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine. The method of the invention is especially useful for vaccination against viral infections such as infections with EIV and/or EHV-1/EHV-4. Especially for EIV, it has been found that when equines are vaccinated with such a prime-boost vaccine regimen according to the invention, the equines are protected against clinical signs after a challenge with a virulent EIV.
摘要翻译：已经发现，当用活病毒疫苗（初始）接种疫苗之后，用相同病毒的灭活疫苗（增强）接种疫苗后，可以实现对马中的病毒感染的充分保护，其中两次照射不再相隔8周。因此，本发明提供了一种针对马病毒病原体感染马的疫苗接种方法，其中动物首先用包含减毒形式的病原体的（初级）疫苗接种疫苗，然后用（加强）疫苗接种疫苗，其包含相同的灭活形式的病原体，并且其中所述加强疫苗在所述主要疫苗之后不超过8周施用。本发明的方法对于针对病毒感染例如EIV和/或EHV-1 / EHV-4感染是特别有用的。特别是对于EIV，已经发现，当使用根据本发明的初始 - 加强疫苗方案接种马时，在用有毒EIV攻击后，马被保护免受临床症状。

5. 发明授权

US07601500B2 Prime-boost vaccine for the protection of equines against viral infection 有权
标题翻译：用于保护马免受病毒感染的Prime-boost疫苗
公开(公告)号：US07601500B2
公开(公告)日：2009-10-13
申请号：US11743492
申请日：2007-05-02
申请人： Saskia van de Zande
发明人： Saskia van de Zande
IPC分类号： C12Q1/68
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55511 , A61K2039/55577 , C12N2760/16134
摘要： It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated vaccine (boost) for the same virus, wherein the two shots are given no longer than 8 weeks apart.The invention therefore provides a method for vaccination of equines against infection with an equine viral pathogen, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated form of the pathogen, followed by a vaccination with a (boost) vaccine comprising the same pathogen in inactivated form, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine.The method of the invention is especially useful for vaccination against viral infections such as infections with EIV and/or EHV-1/EHV-4.Especially for EIV, it has been found that when equines are vaccinated with such a prime-boost vaccine regimen according to the invention, the equines are protected against clinical signs after a challenge with a virulent EIV.
摘要翻译：已经发现，当用活病毒疫苗（初始）接种疫苗之后，用相同病毒的灭活疫苗（增强）接种疫苗后，可以实现对马中的病毒感染的充分保护，其中两次照射不再相隔8周。因此，本发明提供了一种针对马病毒病原体感染马的疫苗接种方法，其中动物首先用包含减毒形式的病原体的（初级）疫苗接种疫苗，然后用（加强）疫苗接种疫苗，其包含相同的灭活形式的病原体，并且其中所述加强疫苗在所述主要疫苗之后不超过8周施用。本发明的方法对于针对病毒感染例如EIV和/或EHV-1 / EHV-4感染是特别有用的。特别是对于EIV，已经发现，当使用根据本发明的初始 - 加强疫苗方案接种马时，在用有毒EIV攻击后，马被保护免受临床症状。

6. 发明授权

US07736847B2 Methods of treating and preventing neurological symptoms caused by avian reovirus and novel associated characteristics 失效
标题翻译：治疗和预防禽呼肠孤病毒引起的神经症状及新型相关特征的方法
公开(公告)号：US07736847B2
公开(公告)日：2010-06-15
申请号：US10526706
申请日：2003-10-09
申请人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
发明人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
IPC分类号： C12Q1/70 , A61K39/15
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , C12N2720/12034
摘要： Embodiments of the present invention generally relate to novel methods for the treatment and/or prevention of neurological symptoms caused by an avian reovirus, enteric reovirus strain (ERS), and associated characteristics. Other embodiments generally comprise an immunogenic composition or vaccine comprising an ERS for the treatment and/or prevention of neurological symptoms.
摘要翻译：本发明的实施方案通常涉及用于治疗和/或预防由禽呼肠孤病毒，肠道呼肠孤病毒毒株（ERS）引起的神经症状以及相关特征的新方法。其他实施方案通常包含免疫原性组合物或疫苗，其包含用于治疗和/或预防神经症状的ERS。

7. 发明申请

US20080213304A1 Methods of Treating and Preventing Neurological Symptons Caused by Avian Reovirus and Novel Associated Characteristics 失效
标题翻译：治疗和预防禽流感病毒和新型相关特征引起的神经性交配素的方法
公开(公告)号：US20080213304A1
公开(公告)日：2008-09-04
申请号：US10526706
申请日：2003-10-09
申请人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
发明人： Saskia van de Zande , Rudolf George Hein , Donald Eugene Roessler , Gwenllyan F. Slacum , Karen L. Jensen , Phyllis A. Lynch
IPC分类号： A61K39/15 , A61P25/00 , C12N7/02 , C12N7/01
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , C12N2720/12034
摘要： Embodiments of the present invention generally relate to novel methods for the treatment and/or prevention of neurological symptoms caused by an avian reovirus, enteric reovirus strain (ERS), and associated characteristics. Other embodiments generally comprise and immunogenic composition or vaccine comprising an ERS for the treatment and/or prevention of neurological symptoms.
摘要翻译：本发明的实施方案通常涉及用于治疗和/或预防由禽呼肠孤病毒，肠道呼肠孤病毒毒株（ERS）引起的神经症状以及相关特征的新方法。其它实施方案通常包含用于治疗和/或预防神经症状的ERS的免疫原性组合物或疫苗。

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