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1. 发明公开

US20240182508A1 AMPHIPATHIC COMPOUND, PREPARATION METHOD THEREFOR, AND SURFACTANT COMPOSITION COMPRISING SAME 审中-公开
公开(公告)号：US20240182508A1
公开(公告)日：2024-06-06
申请号：US18283016
申请日：2022-04-11
申请人： Sang Hyun PYO
发明人： Sang Hyun PYO
IPC分类号： C07H15/256 , C09K23/56
CPC分类号： C07H15/256 , C09K23/56
摘要： The present invention relates to an amphipathic compound, a preparation method therefor, and a surfactant composition comprising same and, specifically, to a compound selected from the group consisting of steviol monoglycoside-acid, steviol monoglycoside-ester, and steviol monoglycoside-amide, a preparation method therefor, and a surfactant composition comprising at least one of these compounds.

2. 发明申请

US20070112207A1 METHOD FOR SEPARATION AND PURIFICATION OF 13-DEHYDROXYBACCATIN III AND 10-DEACETYLPACLITAXEL FROM TAXANS-CONTAINING MATERIALS 有权
标题翻译：从含TAXANS的材料中分离和纯化13-脱乙酰氨基三乙酸和10-脱乙酰壳多糖的方法
公开(公告)号：US20070112207A1
公开(公告)日：2007-05-17
申请号：US11560005
申请日：2006-11-15
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
IPC分类号： C07D305/12
CPC分类号： C07D305/14
摘要： This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of paclitaxel and/or docetaxel that are anticancer agents.
摘要翻译：本发明涉及一种从紫杉烷类物质如紫杉属物种中有效分离和纯化纯度高达90％或更高纯度，优选99.5％或更高纯度的13-脱羟基浆果赤霉素III和10-脱乙酰紫杉醇的方法，因此获得的高纯度的13-脱羟基浆果赤霉素III和10-脱乙酰紫杉醇可以用作作为抗癌剂的紫杉醇和/或多西紫杉醇的半合成前体。

3. 发明申请

US20140235875A1 METHOD FOR PRODUCING CYCLIC CARBONATES 审中-公开
标题翻译：生产循环碳酸盐的方法
公开(公告)号：US20140235875A1
公开(公告)日：2014-08-21
申请号：US14117470
申请日：2012-05-14
申请人： Rajni Hatti-Kaul , Sang-Hyun Pyo
发明人： Rajni Hatti-Kaul , Sang-Hyun Pyo
IPC分类号： C07D319/06 , C07D317/36 , C07C68/06
CPC分类号： C07D319/06 , B01J21/063 , B01J21/08 , B01J23/18 , C07C68/06 , C07D317/36 , C07C69/96
摘要： Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkyl carbonates or diphenyl carbonates. This invention was developed to produce linear or cyclic carbonates with or without using catalysts. Polyol compounds were reacted with carbonates such as dimethyl carbonate and diethyl carbonate to produce the corresponding linear and/or cyclic carbonate.
摘要翻译：作为用于无异氰酸酯的聚氨酯和聚碳酸酯的潜在单体的直链或环状碳酸酯由多元醇和碳酸二烷基酯或碳酸二苯酯制备。本发明被开发用于生产具有或不具有催化剂的线性或环状碳酸酯。多元醇化合物与碳酸盐如碳酸二甲酯和碳酸二乙酯反应生成相应的直链和/或环状碳酸酯。

4. 发明授权

US08633326B2 Method for preparing taxane derivatives 有权
标题翻译：紫杉烷衍生物的制备方法
公开(公告)号：US08633326B2
公开(公告)日：2014-01-21
申请号：US13262936
申请日：2009-12-03
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C07D407/00 , C07D493/00
CPC分类号： C07D305/14 , Y02P20/55
摘要： Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
摘要翻译：提供了一种紫杉烷衍生物的制备方法，其包括：使作为侧链的保护基的苯基异丝氨酸衍生物或其异构体的混合物与浆果赤霉素III衍生物或10-脱乙酰基浆果赤霉素III衍生物得到异构体的混合物; 通过色谱分离异构体; 并进行选择性分离的异构体的立体化学结构的回归，其适用于以高产率大规模生产紫杉烷衍生物。

5. 发明申请

US20050154218A1 Method for purification of paclitaxel from paclitaxel-containing materials 有权
标题翻译：从含紫杉醇的材料中纯化紫杉醇的方法
公开(公告)号：US20050154218A1
公开(公告)日：2005-07-14
申请号：US11028487
申请日：2004-12-30
申请人： Sang-Hyun Pyo , Moon-Suk Kim , Jin-Suk Cho , Bong-Kyu Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Moon-Suk Kim , Jin-Suk Cho , Bong-Kyu Song , Ho-Joon Choi
IPC分类号： C07D305/14 , C07D35/12
CPC分类号： C07D305/14
摘要： This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield.
摘要翻译：本发明涉及从含紫杉醇的材料中纯化紫杉醇的方法。该方法包括以下步骤：（a）用有机溶剂萃取含有紫杉醇的材料，得到提取物，浓缩提取物; （b）将浓缩物与不与水混合的有机溶剂加入以分离有机溶剂相，然后浓缩; （c）使浓缩物进行正相色谱以获得洗脱液; （d）将洗脱液溶解在丙酮或二氯甲烷中，然后加入戊烷或己烷以形成沉淀物; 和（e）使沉淀物进行高效液相色谱。根据本发明的方法，可以容易地从具有高收率的紫杉属植物获得纯度超过99.5％的紫杉醇。

6. 发明授权

US08163940B2 Method for preparation of amorphous, anhydrous crystalline or hydrated crystalline docetaxel 有权
标题翻译：无定形，无水结晶或水合结晶多西紫杉醇的制备方法
公开(公告)号：US08163940B2
公开(公告)日：2012-04-24
申请号：US12159812
申请日：2006-11-02
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
IPC分类号： C07D305/00 , C07D407/00
CPC分类号： C07D305/14
摘要： This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
摘要翻译：本发明涉及一种制备具有无定形，无水结晶或水合晶体结构的多西紫杉醇的方法。根据本发明，通过使用溶剂沉淀法，胶体形成法等可以高产率制备高纯度无定形，无水结晶或水合结晶多西紫杉醇。

7. 发明授权

US07259268B2 Method for purification of paclitaxel from paclitaxel-containing materials 有权
标题翻译：从含紫杉醇的材料中纯化紫杉醇的方法
公开(公告)号：US07259268B2
公开(公告)日：2007-08-21
申请号：US11028487
申请日：2004-12-30
申请人： Sang-Hyun Pyo , Moon-Suk Kim , Jin-Suk Cho , Bong-Kyu Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Moon-Suk Kim , Jin-Suk Cho , Bong-Kyu Song , Ho-Joon Choi
IPC分类号： C07D305/00 , C07D407/00 , C07D493/00
CPC分类号： C07D305/14
摘要： This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield.
摘要翻译：本发明涉及从含紫杉醇的材料中纯化紫杉醇的方法。该方法包括以下步骤：（a）用有机溶剂萃取含有紫杉醇的材料，得到提取物，浓缩提取物; （b）将浓缩物与不与水混合的有机溶剂加入以分离有机溶剂相，然后浓缩; （c）使浓缩物进行正相色谱以获得洗脱液; （d）将洗脱液溶解在丙酮或二氯甲烷中，然后加入戊烷或己烷以形成沉淀物; 和（e）使沉淀物进行高效液相色谱。根据本发明的方法，可以容易地从具有高收率的紫杉属植物获得纯度超过99.5％的紫杉醇。

8. 发明授权

US06713611B2 Method for removing endotoxin from the samples containing basic protein 失效
标题翻译：从含有碱性蛋白质的样品中去除内毒素的方法
公开(公告)号：US06713611B2
公开(公告)日：2004-03-30
申请号：US09948491
申请日：2001-09-06
申请人： Sang-Hyun Pyo , Heung-Bok Park , Jin-Eon So , Jin-Hyun Kim , Seung-Suh Hong , Hyun-Soo Lee
发明人： Sang-Hyun Pyo , Heung-Bok Park , Jin-Eon So , Jin-Hyun Kim , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C07K118
CPC分类号： C07K1/18
摘要： The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the surfactant to solution containing the basic protein obtained from the recombinant microorganism and mixing the resultant, of loading the resultant solution on the cation exchange column, washing the cation exchange column with solution which does not contain surfactant, and eluting the basic protein of interest from the cation exchange column.
摘要翻译：本发明涉及从含有碱性蛋白质的溶液中除去内毒素的方法。更具体地说，本发明的方法包括以下步骤：将表面活性剂加入含有由重组微生物获得的碱性蛋白质的溶液中，并将所得溶液混合，将所得溶液装载到阳离子交换柱上，用溶液洗涤阳离子交换柱其不含表面活性剂，并从阳离子交换柱洗脱出所需的碱性蛋白质。

9. 发明授权

US09546147B2 Method for producing cyclic carbonates 有权
标题翻译：环状碳酸酯的制备方法
公开(公告)号：US09546147B2
公开(公告)日：2017-01-17
申请号：US14117470
申请日：2012-05-14
申请人： Rajni Hatti-Kaul , Sang-Hyun Pyo
发明人： Rajni Hatti-Kaul , Sang-Hyun Pyo
IPC分类号： B01J23/18 , B01J21/08 , B01J21/06 , C07D319/06 , C07D317/36 , C07C68/06
CPC分类号： C07D319/06 , B01J21/063 , B01J21/08 , B01J23/18 , C07C68/06 , C07D317/36 , C07C69/96
摘要： Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkyl carbonates or diphenyl carbonates. This invention was developed to produce linear or cyclic carbonates with or without using catalysts. Polyol compounds were reacted with carbonates such as dimethyl carbonate and diethyl carbonate to produce the corresponding linear and/or cyclic carbonate.
摘要翻译：作为用于无异氰酸酯的聚氨酯和聚碳酸酯的潜在单体的直链或环状碳酸酯由多元醇和碳酸二烷基酯或碳酸二苯酯制备。本发明被开发用于生产具有或不具有催化剂的线性或环状碳酸酯。多元醇化合物与碳酸盐如碳酸二甲酯和碳酸二乙酯反应生成相应的直链和/或环状碳酸酯。

10. 发明申请

US20090018353A1 METHOD FOR PREPARATION OF AMORPHOUS, ANHYDROUS CRYSTALLINE OR HYDRATED CRYSTALLINE DOCETAXEL 有权
标题翻译：无定形晶体或水合物晶体的制备方法
公开(公告)号：US20090018353A1
公开(公告)日：2009-01-15
申请号：US12159812
申请日：2006-11-02
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Bong-Kyu Song , Ho-Joon Choi
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
摘要翻译：本发明涉及一种制备具有无定形，无水结晶或水合晶体结构的多西紫杉醇的方法。根据本发明，通过使用溶剂沉淀法，胶体形成法等可以高产率制备高纯度无定形，无水结晶或水合结晶多西紫杉醇。

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