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1. 发明申请

US20090193530A1 Animals, cells and methods for production of detectably-labeled antibodies 审中-公开
标题翻译：用于产生可检测标记抗体的动物，细胞和方法
公开(公告)号：US20090193530A1
公开(公告)日：2009-07-30
申请号：US12316433
申请日：2008-12-12
申请人： Sanford M. Simon , Yu Chen
发明人： Sanford M. Simon , Yu Chen
IPC分类号： A01K67/027 , C12N15/85 , C12N5/06 , C07K16/18
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K16/26 , C07K16/40 , C07K2317/52 , C07K2319/00 , C07K2319/60 , C12N2510/02
摘要： Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.
摘要翻译：提供了遗传修饰的哺乳动物和免疫细胞，其能够产生或分泌可检测标记的免疫球蛋白分子，作为其基因组中至少一个免疫球蛋白基因的遗传修饰的结果，使得编码可检测蛋白质或肽的融合多核苷酸和存在免疫球蛋白组分分子。

2. 发明授权

US5851789A Methods and agents for measuring and controlling multidrug resistance 失效
标题翻译：用于测量和控制多药耐药性的方法和试剂
公开(公告)号：US5851789A
公开(公告)日：1998-12-22
申请号：US535995
申请日：1995-09-29
申请人： Sanford M. Simon , Melvin M. S. Schindler
发明人： Sanford M. Simon , Melvin M. S. Schindler
IPC分类号： G01N33/50 , C12Q1/18 , C12Q1/02 , G01N21/80 , G01N31/00
CPC分类号： G01N33/5011
摘要： The predominant effect of pH change on multidrug resistance (MDR) independent of active drug efflux has been demonstrated in tumor cells through studies of the drugs doxorubicin and daunomycin. Specifically, the distribution of both drugs was monitored in fibroblasts and myeloma cells to examine the role of pH in drug partitioning. The invention comprises in one aspect the treatment of MDR by administering a therapeutically effective amount of a pH modulator. Diagnostic utilities are contemplated and extend to drug discovery assays and methods for measuring monitoring the status of the onset or development of pH-related conditions such as MDR, as well as the measurement of intracellular drug accumulation. Therapeutic compositions include a composition comprising a pH modulator alone or in combination with the dose-limited therapeutic agent(s), and a pharmaceutically acceptable excipient, are also contemplated.
摘要翻译：通过研究药物多柔比星和道诺霉素，已经在肿瘤细胞中证明了pH变化对多药耐药性（MDR）的主要影响，与活性药物流出无关。具体来说，在成纤维细胞和骨髓瘤细胞中监测两种药物的分布，以检查pH在药物分配中的作用。本发明在一个方面包括通过施用治疗有效量的pH调节剂治疗MDR。诊断实用程序被考虑并且扩展到药物发现测定和用于测量监测pH相关条件如MDR的发作或发展的状态以及细胞内药物积累的测量的方法。治疗组合物还包括包含单独或与剂量受限治疗剂组合的pH调节剂和药学上可接受的赋形剂的组合物。

3. 发明申请

US20130064762A1 METHODS OF DETECTING AND TREATING CANCERS USING AUTOANTIBODIES 审中-公开
标题翻译：使用自动诊断检测和治疗癌症的方法
公开(公告)号：US20130064762A1
公开(公告)日：2013-03-14
申请号：US13611599
申请日：2012-09-12
申请人： Sanford M. Simon
发明人： Sanford M. Simon
IPC分类号： G01N33/574 , G01N21/64 , A61K49/16 , A61K49/00 , A61K51/10
CPC分类号： G01N33/5743 , G01N21/6428 , G01N21/6458 , G01N33/57415 , G01N33/57434
摘要： This invention generally relates to a method of identifying pre-neoplastic or neoplastic tissue of a mammal by utilizing autoantibodies that detect the pre-neoplastic or neoplastic tissue. Also described herein are methods of killing pre-neoplastic or neoplastic tissue by either binding toxins to autoantibodies that detect the pre-neoplastic or neoplastic tissue or introducing toxin-conjugated molecules that can in turn recognize the autoantibodies already bound to the pre-neoplastic or neoplastic tissue.
摘要翻译：本发明一般涉及通过利用检测前肿瘤或肿瘤组织的自身抗体鉴定哺乳动物前肿瘤或肿瘤组织的方法。本文还描述了通过将毒素结合到检测前肿瘤或肿瘤组织或引入毒素缀合的分子的自身抗体来杀死前肿瘤或肿瘤组织的方法，所述毒素缀合的分子又可以识别已经结合于前肿瘤或肿瘤的自身抗体组织。

4. 发明申请

US20100205679A9 Animals, cells and methods for production of detectably-labeled antibodies 审中-公开
标题翻译：用于产生可检测标记抗体的动物，细胞和方法
公开(公告)号：US20100205679A9
公开(公告)日：2010-08-12
申请号：US12316433
申请日：2008-12-12
申请人： Sanford M. Simon , Yu Chen
发明人： Sanford M. Simon , Yu Chen
IPC分类号： A01K67/027 , C12N15/85 , C12N5/06 , C07K16/18
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K16/26 , C07K16/40 , C07K2317/52 , C07K2319/00 , C07K2319/60 , C12N2510/02
摘要： Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.
摘要翻译：提供了遗传修饰的哺乳动物和免疫细胞，其能够产生或分泌可检测标记的免疫球蛋白分子，作为其基因组中至少一个免疫球蛋白基因的遗传修饰的结果，使得编码可检测蛋白质或肽的融合多核苷酸和存在免疫球蛋白组分分子。

5. 发明授权

US06204067B1 Methods of identifying modulators of the estrogen receptor 失效
标题翻译：识别雌激素受体调节剂的方法
公开(公告)号：US06204067B1
公开(公告)日：2001-03-20
申请号：US09335457
申请日：1999-06-17
申请人： Sanford M. Simon , Melvin S. Schindler , Yu Chen
发明人： Sanford M. Simon , Melvin S. Schindler , Yu Chen
IPC分类号： G01N3122
CPC分类号： G01N21/6428 , G01N21/80 , G01N33/743 , G01N2021/6439 , G01N2333/723 , G01N2500/00 , Y10T436/173845
摘要： The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the corresponding side-effects.
摘要翻译：本发明公开了他莫昔芬介导的酸化抑制机制。然后将该机制信息用于设计鉴定化合物的方法，该化合物将具有没有相应副作用的他莫昔芬的药效。

6. 发明授权

US6132958A Fluorescent bead for determining the temperature of a cell and methods of use thereof 失效
标题翻译：用于确定细胞温度的荧光珠及其使用方法
公开(公告)号：US6132958A
公开(公告)日：2000-10-17
申请号：US320874
申请日：1999-05-27
申请人： Sanford M. Simon
发明人： Sanford M. Simon
IPC分类号： G01N33/52 , C12Q1/00
CPC分类号： G01N33/52 , Y10S435/968
摘要： The invention discloses a fluorescent bead that can be used for determining the temperature and/or metabolic state of a single cell contained in a cell/tissue sample. The fluorescent bead contains at least one temperature-sensitive fluorophore. The invention also includes methods of monitoring cellular metabolism and methods of diagnosing abnormal metabolism of a cell.
摘要翻译：本发明公开了一种可用于测定细胞/组织样品中包含的单细胞的温度和/或代谢状态的荧光珠。荧光珠包含至少一个温度敏感的荧光团。本发明还包括监测细胞代谢的方法和诊断细胞异常代谢的方法。

7. 发明授权

US07091396B1 Animals, cells and methods for production of detectably-labeled antibodies 失效
公开(公告)号：US07091396B1
公开(公告)日：2006-08-15
申请号：US09982120
申请日：2001-10-17
申请人： Sanford M. Simon , Yu Chen
发明人： Sanford M. Simon , Yu Chen
IPC分类号： A01K67/027 , A01K67/033 , C12N15/63 , C12N5/06 , C12N5/10
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K2317/52 , C07K2319/00 , C07K2319/60
摘要： Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

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