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1. 发明授权

US06234996B1 Integrated inflation/deflation device and method 失效
标题翻译：综合通货膨胀/通货紧缩手段及方法
公开(公告)号：US06234996B1
公开(公告)日：2001-05-22
申请号：US09338375
申请日：1999-06-23
申请人： Celso J. Bagaoisan , George Tsai , Samuel L. Omaleki , Roy Leguidleguid , Gholam-Reza Zadno-Azizi
发明人： Celso J. Bagaoisan , George Tsai , Samuel L. Omaleki , Roy Leguidleguid , Gholam-Reza Zadno-Azizi
IPC分类号： A61M2900
CPC分类号： A61M25/10182 , A61M5/31505 , A61M5/31566 , A61M5/31586 , A61M25/1018 , A61M25/10185 , A61M25/104 , A61M39/06 , A61M2005/14573
摘要： An integrated inflation/deflation device provides easy, precise delivery of a small amount of fluid for proper inflation of a low volume surgical balloon and similarly provides easy and fast deflation of the balloon. A preferred embodiment includes a low volume syringe and large syringe mounted together within a housing. A port in the low volume syringe is in communication with the large syringe barrel. The low volume syringe plunger is controlled by a knob disposed on the housing. The large syringe is used to prime the surgical balloon system, including a catheter, and the low volume syringe delivers a precise, predetermined volume of fluid to inflate the balloon. The low volume syringe is also used to deflate the balloon. Preferably, indicia on the housing adjacent the knob direct the required rotation of the knob to deliver the correct volume of fluid to be injected to match a balloon of a given size and shape so that the balloon is properly inflated.
摘要翻译：综合的充气/放气装置提供了容易，精确地输送少量流体以适当地膨胀低容量手术气囊，并且类似地提供了气囊的容易和快速的放气。一个优选的实施例包括一个低容量的注射器和安装在一个壳体内的大型注射器。低体积注射器中的端口与大型注射器筒连通。低体积注射器柱塞由设置在壳体上的旋钮控制。大型注射器用于灌注外科气囊系统，包括导管，并且低体积注射器输送精确的预定体积的流体以使气囊膨胀。低体积注射器也用于使气囊放气。优选地，邻近旋钮的壳体上的标记指示旋钮的所需旋转以输送要注射的正确体积的流体以匹配给定尺寸和形状的气囊，使得气囊适当地充气。

2. 发明授权

US06500147B2 Flexible catheter 有权
标题翻译：柔性导管
公开(公告)号：US06500147B2
公开(公告)日：2002-12-31
申请号：US09253591
申请日：1999-02-22
申请人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
发明人： Samuel L. Omaleki , Isaac J. Kim , Jefferey C. Bleam , Juan T. Domingo , Andres D. Tomas , Celso J. Bagaoisan
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/0054 , A61M25/09 , A61M25/09033 , A61M2025/0098 , A61M2025/09008 , A61M2025/09183 , A61M2025/1079 , A61M2025/1093
摘要： A balloon catheter having improved flexibility in and about its distal end is provided. The flexibility of the catheter is determined in part by improving the properties of a wire or catheter located within the area where the balloon is mounted. In one aspect of the present invention, connecting wires extend through the balloon from the distal end of a catheter body to the proximal end of a core wire. The core wire extends distally away from the connecting wires and the catheter body. In another aspect of the present invention, a core wire is provided having a proximal end extending within the balloon into the catheter tubular body but is not mounted therein. This allows the proximal end of the core wire to “float” within the tubular body, such that when the catheter is advanced through the vasculature of a patient, the core wire may move longitudinally within the tubular body. In another aspect of the present invention, the balloon is mounted over a tubular body which is configured to give the catheter longitudinal flexibility.
摘要翻译：提供了具有在其远端中及其远端具有改进的柔性的球囊导管。导管的灵活性部分地通过改进位于安装气球的区域内的线或导管的性质来确定。在本发明的一个方面，连接线从导管主体的远端延伸穿过球囊到芯线的近端。芯线远离连接线和导管主体延伸。在本发明的另一方面，提供了一种芯线，其具有在气囊内延伸到导管管状体中但未安装在其中的近端。这允许芯线的近端在管状体内“漂浮”，使得当导管前进通过患者的脉管系统时，芯线可以在管状体内纵向移动。在本发明的另一方面，气囊被安装在管状体上，该管状体被配置成给予导管的纵向柔性。

3. 发明授权

US06338709B1 Intravascular radiation therapy device and method of use 失效
标题翻译：血管内放射治疗装置及其使用方法
公开(公告)号：US06338709B1
公开(公告)日：2002-01-15
申请号：US09026103
申请日：1998-02-19
申请人： Richard P. Geoffrion , Gholam Reza Zadno-Azizi , Samuel L. Omaleki
发明人： Richard P. Geoffrion , Gholam Reza Zadno-Azizi , Samuel L. Omaleki
IPC分类号： A61N500
CPC分类号： A61N5/1002 , A61N2005/1003 , A61N2005/1005 , A61N2005/1021
摘要： A radiation delivering catheter is positioned away from the walls of the vessel to be treated, e.g. at a stenosis site, so that the radiation flux impacting the walls is more uniform. In one embodiment, one or more balloons are used, and in another, one or more expandable structures. In other embodiments, a radiation source residing within a balloon is shielded from the vessel walls when the balloon is not inflated, but exposes the vessel walls to radiation when the balloon is inflated.
摘要翻译：辐射输送导管被定位成远离待治疗的血管的壁，例如，在狭窄处，使得影响壁的辐射通量更均匀。在一个实施例中，使用一个或多个气囊，而在另一个实施例中，一个或多个可膨胀结构。在其他实施例中，当球囊未膨胀时，驻留在球囊内的辐射源与血管壁屏蔽，但当气囊膨胀时，将血管壁暴露于辐射。

4. 发明授权

US06355016B1 Catheter core wire 有权
标题翻译：导管芯线
公开(公告)号：US06355016B1
公开(公告)日：2002-03-12
申请号：US09253971
申请日：1999-02-22
申请人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
发明人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/09 , A61M25/09033 , A61M2025/09175 , A61M2025/1093 , C22F1/006
摘要： Disclosed herein is an improved core wire for use in a medical catheter. In one aspect, a tapering core wire is incorporated into the distal end of a catheter. The catheter has a tubular body. Both ends of an inflatable balloon are mounted to the tubular body. The core wire extends from the distal end of the tubular body. In one embodiment, substantially all of the taper of the core wire occurs in the extending portion of the core wire over a length of at least 15 mm but no more than 60 mm. In another aspect, a core wire with a shapeable tip and method of manufacturing the same are provided. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本文公开了一种用于医疗导管的改进的芯线。在一个方面，锥形芯线被并入导管的远端。导管具有管状体。可充气气囊的两端安装在管状体上。芯线从管状体的远端延伸。在一个实施例中，芯线的基本上所有的锥形在芯线的延伸部分中发生长度至少为15mm但不大于60mm。另一方面，提供了具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

5. 发明授权

US06228072B1 Shaft for medical catheters 失效
公开(公告)号：US06228072B1
公开(公告)日：2001-05-08
申请号：US09026105
申请日：1998-02-19
申请人： Samuel L. Omaleki , Roy Leguidleguid , Ketan P. Muni
发明人： Samuel L. Omaleki , Roy Leguidleguid , Ketan P. Muni
IPC分类号： A61M2500
CPC分类号： A61M25/1036 , A61M25/104 , A61M2025/0046 , A61M2025/1079
摘要： Several improvements are provided in the design of a catheter shaft to reduce costs and improve performance. In one aspect, a small notch is fabricated into a catheter tube by a nonlaser process such as electric discharge machining (EDM) or mechanical grinding. This notch in the catheter tube is necessary for fluid communication between the catheter lumen and a balloon or other element in communication with the tube. Use of a nonlaser process reduces the costs of fabrication while ensuring a high degree of structure integrity. In another aspect, a method is provided to produce a nonuniform polymer coating on a catheter shaft to reduce friction and to maintain a catheter with a low profile. In another aspect, the catheter is provided with a radiopaque marker which is more visible and is more effective at identifying the location of a balloon. The marker is moved closer to a distal balloon by placing it within an adhesive taper adjacent the balloon.

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