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1. 发明申请

US20050266149A1 Method and apparatus for depositing material onto a surface 失效
标题翻译：用于将材料沉积到表面上的方法和设备
公开(公告)号：US20050266149A1
公开(公告)日：2005-12-01
申请号：US11120042
申请日：2005-04-29
申请人： Eric Henderson , Juntao Xu , Michael Lynch , Curtis Mosher , Janice Huff , Saju Nettikadan
发明人： Eric Henderson , Juntao Xu , Michael Lynch , Curtis Mosher , Janice Huff , Saju Nettikadan
IPC分类号： A61L2/00 , B01L3/02 , B05B7/06 , B05C1/00 , B05D3/00
CPC分类号： B01L3/0244 , B01J2219/00387 , B01J2219/00659 , B01L3/0248 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2300/10 , B01L2400/02 , B01L2400/0406
摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam having an aperture defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2 mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.
摘要翻译：本发明的一些实施例提供了一种装置和方法，其中材料从具有限定在其中的孔的细长梁沉积在表面上，通过该孔通过被动吸附来移动材料。细长梁基本上可以在其整个长度上基本上是平面的，可以在沉积过程中相对于表面以锐角定向，并且可以具有不大于约2mm的长度。在一些实施例中，孔可以是细长的，可以从材料储存器延伸到短于细长梁的终端的位置或者通过细长梁的终端，并且可以具有延伸穿过细长梁的厚度的部分光束。

2. 发明申请

US20120088694A1 CELL ASSAY METHODS AND ARTICLES 审中-公开
标题翻译：细胞测定方法和文章
公开(公告)号：US20120088694A1
公开(公告)日：2012-04-12
申请号：US13251786
申请日：2011-10-03
申请人： Saju Nettikadan , John Michael Collins , Alexander B. Smetana , Paul Leon Stiles
发明人： Saju Nettikadan , John Michael Collins , Alexander B. Smetana , Paul Leon Stiles
IPC分类号： C40B40/04 , C40B50/14 , B82Y15/00
CPC分类号： G01N33/5008
摘要： Versatile, efficient cell assays which can be prepared with use of nanolithography and can be used to test nanomaterials, pharmaceuticals, toxins, and the like. For example, a method comprising: depositing at least one first composition comprising at least one cell adhesion material on at least one substrate to form a pattern which forms an interior space on the substrate within the pattern, depositing in the interior space on the substrate at least one second composition, different from the first, comprising at least one material adapted to affect or potentially affect cell function. Tip-based deposition and direct-write methods can be used for deposition at nanoscale and sub-cellular resolutions. Nanoscopic and atomic force microscope tips can be used. Multiplexing can be carried out.
摘要翻译：可以使用纳米光刻技术制备的多功能，高效的细胞测定法，可用于测试纳米材料，药物，毒素等。例如，一种方法包括：将至少一种包含至少一种细胞粘附材料的第一组合物沉积在至少一个基底上以形成在图案内的衬底上形成内部空间的图案，在衬底上的内部空间中沉积不同于第一组合物的至少一种组合物包含适于影响或潜在地影响细胞功能的至少一种材料。基于尖端的沉积和直接写入方法可用于以纳米尺度和亚细胞分辨率沉积。可以使用纳米镜和原子力显微镜尖端。可以进行多路复用。

3. 发明申请

US20110014436A1 METHODS FOR FORMING HYDROGELS ON SURFACES AND ARTICLES FORMED THEREBY 审中-公开
标题翻译：表面形成水凝胶的方法及其形成方法
公开(公告)号：US20110014436A1
公开(公告)日：2011-01-20
申请号：US12835681
申请日：2010-07-13
申请人： Paul Leon STILES , Saju Nettikadan , Tung Suet Ruby Lam , Jae-Won Jang
发明人： Paul Leon STILES , Saju Nettikadan , Tung Suet Ruby Lam , Jae-Won Jang
IPC分类号： C09D11/10 , C09D11/14 , B05D5/00 , B32B3/10
CPC分类号： G03F7/0002 , Y10T428/24802
摘要： Methods for forming hydrogels on substrates, including patterned hydrogels. One method comprises providing at least one nanoscopic tip, coating the tip with at least one ink composition, and depositing the ink composition onto at least one substrate, wherein the ink composition comprises at least one hydrogel precursor, the hydrogel precursor adapted to form a hydrogel. The precursor can be converted to the hydrogel after patterning. The ink composition can comprise at least two polymers and can be functionalized. The amount of the polymers and the amount of functionalization can be tuned. Also provided are articles formed from the methods, methods for using the articles, ink compositions and related kits.
摘要翻译：在基材上形成水凝胶的方法，包括图案化水凝胶。一种方法包括提供至少一个纳米级尖端，用至少一种油墨组合物涂覆所述尖端，以及将所述油墨组合物沉积在至少一个底物上，其中所述油墨组合物包含至少一种水凝胶前体，所述水凝胶前体适于形成水凝胶。图案化后，可以将前体转化为水凝胶。油墨组合物可以包含至少两种聚合物并且可以被官能化。可以调节聚合物的量和官能化的量。还提供了由方法，使用制品的方法，油墨组合物和相关试剂盒形成的制品。

4. 发明申请

US20050239193A1 Device and method of use for detection and characterization of microorganisms and microparticles 审中-公开
标题翻译：用于微生物和微粒的检测和表征的装置和方法
公开(公告)号：US20050239193A1
公开(公告)日：2005-10-27
申请号：US10977551
申请日：2004-10-29
申请人： Eric Henderson , Saju Nettikadan , Curtis Mosher , James Johnson
发明人： Eric Henderson , Saju Nettikadan , Curtis Mosher , James Johnson
IPC分类号： C12M1/26 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/70 , G01N33/48 , G01N33/50 , G01N33/68 , G01Q30/04 , G01Q60/00 , G06F19/00
CPC分类号： G01N33/56983 , C12M41/36 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N33/552 , G01N33/6854 , G01Q70/18 , C12Q2565/518 , C12Q2527/127 , C12Q2521/107
摘要： The present invention includes a method and apparatus for the detection of a microorganism or microparticle.
摘要翻译：本发明包括用于检测微生物或微粒的方法和装置。

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