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1. 发明申请

US20120020940A1 ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：抗菌肽
公开(公告)号：US20120020940A1
公开(公告)日：2012-01-26
申请号：US13120392
申请日：2009-09-24
申请人： Jörg Durner , Christian Lindermayr , Ruth Brack-Werner
发明人： Jörg Durner , Christian Lindermayr , Ruth Brack-Werner
IPC分类号： A61K35/12 , C07H21/00 , C12N15/63 , C12P21/02 , A61K38/10 , A61K35/74 , A61K31/7088 , C12N1/21 , C12N1/19 , C12N5/10 , A01N63/00 , A61K35/66 , A01N63/04 , A01N37/18 , A61P31/04 , A01P1/00 , A61P31/22 , A61P31/14 , C07K7/08
CPC分类号： A61K38/00
摘要： The present invention relates to a peptide comprising or consisting of the following amino acid sequence: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12 (formula II), wherein A0 is a hydrophobic amino acid residue or is absent; A1, A4, A7, A8, A12 each are a hydrophobic amino acid residue; and A2, A6, A9, A10 each are a basic amino acid residue; A5 is an alanine or a basic amino acid residue; A3, A11 each are a basic amino acid residue, or a hydrophobic amino acid residue; or a peptidomimetic thereof; wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, isoleucine, valine, methionine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial and/or antiviral activity. Furthermore, the invention relates to a nucleic acid molecule encoding the peptide of the invention, a vector comprising the nucleic acid molecule as well as a host cell comprising the nucleic acid molecule or the vector. The present invention also relates to a method for producing the peptide of the invention, a composition as well as to the peptide or peptidomimetic of the invention for use in treating infectious diseases.
摘要翻译：本发明涉及包含以下氨基酸序列或由以下氨基酸序列组成的肽：A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12（式II），其中A0为疏水性氨基酸残基或不存在; A1，A4，A7，A8，A12分别为疏水性氨基酸残基; A2，A6，A9，A10分别为碱性氨基酸残基; A5是丙氨酸或碱性氨基酸残基; A3，A11各自为碱性氨基酸残基或疏水性氨基酸残基; 或其拟肽; 其中所述碱性氨基酸残基选自精氨酸，赖氨酸和组氨酸; 其中所述疏水性氨基酸残基选自亮氨酸，丙氨酸，异亮氨酸，缬氨酸，甲硫氨酸和苯丙氨酸; 并且其中所述肽或肽模拟物具有抗微生物和/或抗病毒活性。此外，本发明涉及编码本发明的肽的核酸分子，包含核酸分子的载体以及包含核酸分子或载体的宿主细胞。本发明还涉及本发明的肽的制备方法，本发明的肽或肽模拟物的组合物以及用于治疗感染性疾病的方法。

2. 发明申请

US20080161199A1 Fusion Proteins and Methods for Determining Protein-Protein-Interactions in Living Cells and Cell Lysates, Nucleic Acids Encoding these Fusion Proteins, as well as Vectors and Kits Containing These 审中-公开
标题翻译：用于确定活细胞和细胞裂解物中的蛋白质相互作用的融合蛋白质和方法，编码这些融合蛋白的核酸，以及含有这些融合蛋白的载体和试剂盒
公开(公告)号：US20080161199A1
公开(公告)日：2008-07-03
申请号：US11793161
申请日：2005-12-22
申请人： Horst Wolff , Andrea Brebeck , Manja Ziegler , Ruth Brack-Werner
发明人： Horst Wolff , Andrea Brebeck , Manja Ziegler , Ruth Brack-Werner
IPC分类号： C40B30/10 , C12Q1/02
CPC分类号： C07K14/43595 , C07K2319/00 , C12N15/62 , G01N33/542 , G01N33/582
摘要： The present invention refers to inventive fusion proteins, to a method for detecting protein-protein-interactions in living cells and cell lysates using these inventive fusion proteins. The present invention also refers to a screening method for identifying compounds suitable to modify, i.e. inhibit or enhance, protein-protein-interaction using these fusion proteins. Additionally a method for detecting cells is disclosed comprising an unknown protein that interacts with a known protein. Along with the inventive fusion proteins used for these methods encoding nucleic acids, corresponding vectors and host cells transfected accordingly are disclosed herewith.
摘要翻译：本发明涉及本发明的融合蛋白，涉及使用这些本发明的融合蛋白检测活细胞和细胞裂解物中的蛋白质 - 蛋白质相互作用的方法。本发明还涉及用于鉴定适合于使用这些融合蛋白修饰，即抑制或增强蛋白质 - 蛋白质相互作用的化合物的筛选方法。另外，公开了一种用于检测细胞的方法，其包括与已知蛋白质相互作用的未知蛋白质。随着本文公开了用于编码核酸的这些方法的本发明融合蛋白，相应的载体和相应转染的宿主细胞。

3. 发明授权

US07183047B2 Reporter gene construct for the detection of HIV Rev and HIV Tat 失效
标题翻译：报告基因构建用于检测艾滋病毒感染和艾滋病毒
公开(公告)号：US07183047B2
公开(公告)日：2007-02-27
申请号：US10176010
申请日：2002-06-20
申请人： Ruth Brack-Werner , Markus Neumann , Horst Wolff , Volker Erfle
发明人： Ruth Brack-Werner , Markus Neumann , Horst Wolff , Volker Erfle
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/68 , C12N15/33
CPC分类号： C07K14/005 , C07K2319/00 , C12N15/85 , C12N2740/16322 , C12N2830/50
摘要： The present invention relates to a reporter gene construct for the detection of the HIV Rev and HIV Tat proteins. Furthermore, the invention relates to a functionality test method for Rev and Rev fusion proteins prepared in a recombinant manner, a method of screening for sequences of different origin for their activity as an instability element, a method of screening for sequences which cause the transport out of the nucleus into the cytoplasm by binding to cellular or other viral shuttle proteins, as well as to a method for the detection of HIV-infected cells. The reporter gene construct according to the present invention, after it has been introduced into cells, in the presence of HIV Rev and HIV Tat proteins results in the formation of reporter proteins which may be used for quantitative/qualitative detection of the HIV Rev and HIV Tat proteins.
摘要翻译：本发明涉及用于检测HIV Rev和HIV Tat蛋白的报告基因构建体。此外，本发明涉及以重组方式制备的Rev和Rev融合蛋白的功能性测试方法，筛选不稳定序列的不同来源的序列作为不稳定性元件的活性的方法，筛选引起转运的序列的方法通过与细胞或其他病毒穿梭蛋白结合而进入细胞质，以及用于检测HIV感染细胞的方法。根据本发明的报道基因构建体在其被引入细胞之后，在HIV Rev和HIV Tat蛋白的存在下导致报告蛋白的形成，其可用于HIV Rev和HIV的定量/定性检测 Tat蛋白。

4. 发明申请

US20110294721A1 ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：抗菌肽
公开(公告)号：US20110294721A1
公开(公告)日：2011-12-01
申请号：US13120402
申请日：2009-09-24
申请人： Jörg Durner , Christian Lindermayr , Ruth Brack-Werner
发明人： Jörg Durner , Christian Lindermayr , Ruth Brack-Werner
IPC分类号： A61K38/10 , C07K14/435 , A61P31/04 , A61P31/12 , C07H21/04 , C12P21/00 , A61P31/22 , A61P31/14 , A61P31/20 , C12N15/63 , C12N1/21 , C07K7/08 , A61K38/17
CPC分类号： A61K38/00
摘要： The present invention relates to a peptide comprising or consisting of a sequence of formula I A-B-C-D-E-F-G-H-I (formula I), wherein A is a peptide consisting of three or four basic amino acid residues; B is a peptide consisting of two to four hydrophobic amino acid residues; C is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; D is a peptide consisting of two hydrophobic amino acid residues; E is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; F is a peptide consisting of three amino acid residues selected from the group consisting of glycine and hydrophobic amino acid residues; G is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; H is a peptide consisting of two or three amino acid residues selected from the group consisting of serine and hydrophobic amino acid residues; I is a peptide consisting of two to four basic amino acid residues; or a peptidomimetic thereof, wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, isoleucine, valine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial and/or antiviral activity. Furthermore, the invention relates to a nucleic acid molecule encoding the peptide of the invention, a vector comprising the nucleic acid molecule as well as a host cell comprising the nucleic acid molecule or the vector. The present invention also relates to a method for producing the peptide of the invention, a composition comprising the peptide or peptidomimetic of the invention as well as to the peptide or peptidomimetic of the invention for use in treating infectious diseases.
摘要翻译：本发明涉及包含式I A-B-C-D-E-F-G-H-I（式I）的序列或由其组成的肽，其中A是由三个或四个碱性氨基酸残基组成的肽; B是由2至4个疏水性氨基酸残基组成的肽; C是选自疏水和碱性氨基酸残基的氨基酸残基; D是由两个疏水性氨基酸残基组成的肽; E是选自疏水和碱性氨基酸残基的氨基酸残基; F是由选自甘氨酸和疏水性氨基酸残基的三个氨基酸残基组成的肽; G是选自疏水和碱性氨基酸残基的氨基酸残基; H是由选自丝氨酸和疏水性氨基酸残基的两个或三个氨基酸残基组成的肽; I是由2-4个碱性氨基酸残基组成的肽; 或其肽模拟物，其中所述碱性氨基酸残基选自精氨酸，赖氨酸和组氨酸; 其中所述疏水性氨基酸残基选自亮氨酸，丙氨酸，异亮氨酸，缬氨酸和苯丙氨酸; 并且其中所述肽或肽模拟物具有抗微生物和/或抗病毒活性。此外，本发明涉及编码本发明的肽的核酸分子，包含核酸分子的载体以及包含核酸分子或载体的宿主细胞。本发明还涉及本发明的肽的制备方法，包含本发明的肽或肽模拟物的组合物以及用于治疗感染性疾病的本发明的肽或肽模拟物。

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