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1. 发明授权

US09167979B2 Atomic magnetometer sensor array magnetic resonance imaging systems and methods 有权
标题翻译：原子磁力计传感器阵列磁共振成像系统及方法
公开(公告)号：US09167979B2
公开(公告)日：2015-10-27
申请号：US12265785
申请日：2008-11-06
申请人： Frank M. Skidmore , Mark Davidson , Russell S. Donda
发明人： Frank M. Skidmore , Mark Davidson , Russell S. Donda
IPC分类号： A61B5/05 , A61B5/04 , A61B5/00 , G01R33/035 , A61B5/11
CPC分类号： A61B5/04009 , A61B5/04008 , A61B5/11 , A61B5/6814 , A61B2562/02 , A61B2562/046 , G01R33/0354
摘要： Devices disclosed according to various embodiments use one or more arrays of atomic magnetometers to directly detection of relaxation of magnetic field induced subatomic precession within a target specimen. The disclosed devices and methods relate to application of utilization of a magnetic sensor with unique properties requiring changes in design, allowing new functions, and requiring alternative analysis methodologies. Various embodiments are also directed to methods for obtaining and processing magnetic signals. These methods may take advantage of the unique spatial arrangement of the atomic magnetometers and the capacity sensors to be used in either a scalar or a vector mode. Various embodiments have advantages over current techniques utilized for imaging of anatomical and non-anatomical structures. Such advantages may include, for example: development of a wearable, portable array, lower power consumption, potential wafer-level fabrication, the potential for development of a more rapid signal, decreased need for development of strong magnetic fields, and lower cost allowing wider availability.
摘要翻译：根据各种实施例公开的装置使用一个或多个原子磁力计阵列来直接检测靶标样品内磁场诱导的亚原子进动的弛豫。所公开的设备和方法涉及具有需要设计变化，允许新功能以及需要备选分析方法的独特性质的磁传感器的应用。各种实施例还涉及用于获得和处理磁信号的方法。这些方法可以利用原子磁力计和容量传感器在标量或向量模式中使用的独特的空间排列。各种实施例具有优于目前用于解剖和非解剖结构成像的技术的优点。这样的优点可以包括例如：可穿戴便携式阵列的开发，更低的功耗，潜在的晶圆级制造，开发更快速的信号的可能性，减少对强磁场开发的需求，并且降低成本，允许更宽可用性。

2. 发明授权

US06613278B1 Tissue pooling process 有权
标题翻译：组织汇集过程
公开(公告)号：US06613278B1
公开(公告)日：2003-09-02
申请号：US09390174
申请日：1999-09-07
申请人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms , John Bianchi
发明人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms , John Bianchi
IPC分类号： H61L200
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译：本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少植入抗原性。

3. 发明申请

US20120143018A1 PORTABLE TOUCHLESS VITAL SIGN ACQUISITION DEVICE 审中-公开
标题翻译：便携式无线标牌采集设备
公开(公告)号：US20120143018A1
公开(公告)日：2012-06-07
申请号：US13145279
申请日：2010-01-19
申请人： Frank M. Skidmore , Mark Davidson , Russell S. Donda
发明人： Frank M. Skidmore , Mark Davidson , Russell S. Donda
IPC分类号： A61B7/04 , A61B5/01 , A61B5/02 , A61B5/05
CPC分类号： A61B5/02 , A61B5/04007 , A61B7/04
摘要： Disclosed herein is a non-contact MCG is anticipated as one embodiment. Additionally, a non-contact stethoscope, thermal sensor, or MCG could be utilized singly or in combination with each other, or included singly or together in other medical devices such as a fluoroscope, For example, a handheld, portable instrument comprising a non-contact stethoscope without a magnetometer or thermal sensor can provide a measure of acoustic signals without contacting a subject, while a non-contact thermal sensor as a single device can provide a rapid contactless temperature of a subject
摘要翻译：本文公开了一种非接触MCG作为一个实施例。此外，非接触式听诊器，热传感器或MCG可以单独使用或者彼此组合使用，或者单独地或一起包括在诸如荧光镜的其它医疗设备中。例如，包括非接触式听诊器，没有磁力计或热传感器的接触式听诊器可以提供声学信号的测量而不接触受试者，而作为单个装置的非接触式热传感器可以提供受试者的快速非接触温度

4. 发明授权

US06290718B1 Luminal graft, stent or conduit made of cortical bone 失效
标题翻译：腔内移植物，支架或由皮质骨制成的导管
公开(公告)号：US06290718B1
公开(公告)日：2001-09-18
申请号：US09017472
申请日：1998-02-02
申请人： Jamie M. Grooms , Russell S. Donda
发明人： Jamie M. Grooms , Russell S. Donda
IPC分类号： A61F206
CPC分类号： A61L27/3804 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/065 , A61F2002/30059 , A61F2250/0039 , A61L27/3608 , A61L27/3683 , A61L31/005
摘要： This invention relates to implants useful as stents for opening or strengthening biological conduits, or as grafts or conduits for replacing or connecting portions of biological tissues having a lumen. Accordingly, the implants of this invention may be applied in portions of the peripheral and coronary vascular system, biliary, urinary, esophageal, digestive, ocular, tracheal, bronchial, reproductive, and neural systems. The implant comprises a segment of bone having a lumen through at least a part thereof, and wherein at least a portion of the implant is demineralized so as to be pliable.
摘要翻译：本发明涉及可用作打开或加强生物管道的支架的植入物，或用于替换或连接具有内腔的生物组织的部分的移植物或导管。因此，本发明的植入物可以应用于周边和冠状动脉血管系统，胆汁，尿液，食管，消化，眼，气管，支气管，生殖和神经系统的部分。植入物包括具有通过其至少一部分的内腔的骨段，并且其中植入物的至少一部分被软化以便是柔韧的。

5. 发明授权

US07153518B2 Processed soft tissue for topical or internal application 有权
公开(公告)号：US07153518B2
公开(公告)日：2006-12-26
申请号：US10228558
申请日：2002-08-27
申请人： John F. Wironen , Chris Seid , Rebecca Jaw , Thien Doan , Gregg Ritter , Russell S. Donda
发明人： John F. Wironen , Chris Seid , Rebecca Jaw , Thien Doan , Gregg Ritter , Russell S. Donda
IPC分类号： A61F2/10 , A61K9/10 , A61K35/36
CPC分类号： A61L27/3834 , A61L15/225 , A61L15/40 , A61L15/44 , A61L24/0005 , A61L24/0015 , A61L24/0094 , A61L26/0057 , A61L26/0066 , A61L26/0095 , A61L27/362 , A61L27/3683 , A61L27/48 , A61L27/54 , A61L2300/402 , A61L2300/404 , A61L2300/412 , A61L2300/414 , Y10S424/13 , C08L5/00 , C08L89/00 , C08L89/06
摘要： Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.

6. 发明授权

US06652818B1 Implant sterilization apparatus 有权
标题翻译：种植体灭菌装置
公开(公告)号：US06652818B1
公开(公告)日：2003-11-25
申请号：US09378527
申请日：1999-08-20
申请人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms
发明人： C. Randal Mills , John F. Wironen , Sean Hanstke , Russell S. Donda , Jamie M. Grooms
IPC分类号： A61L200
CPC分类号： A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译：本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少植入抗原性。

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