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1. 发明授权

US5329021A Process for the production of pure vinyl pyrrolidone 失效
标题翻译：生产纯乙烯基吡咯烷酮的方法
公开(公告)号：US5329021A
公开(公告)日：1994-07-12
申请号：US81947
申请日：1993-02-04
申请人： Jeffrey M. Cohen , Russell B. Biss
发明人： Jeffrey M. Cohen , Russell B. Biss
IPC分类号： C07D207/26 , C07D207/267
CPC分类号： C07D207/267
摘要： This invention relates to a process for the purification of a crude liquid N-vinylpyrrolidone product which comprises (I) product rectification by (a) subjecting said crude product containing at least 0.3 weight % of impurities to a temperature of between about 1.degree. and 5.degree. below the freezing point of said crude liquid to form a vinyl pyrrolidone crystalline phase and a liquid residue phase in a first crystallization step; (b) separating said liquid phase from said crystalline phase; (c) allowing said separated crystalline phase to warm gradually so as to liquify said crystals and (d) subjecting the liquified crystals of vinyl pyrrolidone to between 1 and 3 additional crystallization steps, each carried out by gradually cooling the liquified vinyl pyrrolidone to a temperature above that of the preceding crystallization step up to a temperature of 14.4.degree. C. so as to form additional vinyl pyrrolidone crystalline and liquid residue phases with separation of vinyl pyrrolidone crystals and liquid residue phases and liquification of vinyl pyrrolidone crystals between each additional recrystallization step, recovery of N-vinyl-pyrrolidone product from the final crystallization step and (II) collecting said separated liquid residues from each crystallization step and subjecting them, sequentially, individually or collectively, to fractional crystallization in order to recover additional amounts of purified vinyl pyrrolidone product. The present process is capable of achieving up to 99.999% purity of vinyl pyrrolidone in about 98% recovery.
摘要翻译：本发明涉及纯液体N-乙烯基吡咯烷酮产物的纯化方法，该方法包括（I）通过（a）将含有至少0.3重量％杂质的所述粗产物处理至约1至5℃的温度来进行产物精馏 DEG低于所述粗液体的凝固点，以在第一结晶步骤中形成乙烯基吡咯烷酮结晶相和液体残余相; （b）从所述结晶相分离所述液相; （c）使所述分离的结晶相逐渐温热以使所述晶体液化，和（d）使乙烯基吡咯烷酮的液化晶体经受1至3个另外的结晶步骤，每个结晶步骤通过将液化的乙烯基吡咯烷酮逐渐冷却至温度高于上述结晶步骤的温度至14.4℃，以便在每次附加的重结晶步骤之间分离乙烯基吡咯烷酮晶体和液体残余相并乙烯基吡咯烷酮晶体的液化形成另外的乙烯基吡咯烷酮结晶和液体残余相，从最终结晶步骤回收N-乙烯基 - 吡咯烷酮产物，和（II）从每个结晶步骤收集所述分离的液体残余物，并依次单独或共同地对其进行分级结晶，以便回收额外量的纯化的乙烯基吡咯烷酮产物。本方法能够以约98％的回收率实现高达99.999％的乙烯基吡咯烷酮纯度。

2. 发明授权

US5183901A Urea-hydrogen peroxide-polyvinylpyrrolidone 失效
标题翻译：尿素 - 过氧化氢 - 聚乙烯吡咯烷酮
公开(公告)号：US5183901A
公开(公告)日：1993-02-02
申请号：US825359
申请日：1992-01-24
申请人： Robert B. Login , John J. Merianos , Russell B. Biss , Paul Garelick
发明人： Robert B. Login , John J. Merianos , Russell B. Biss , Paul Garelick
IPC分类号： A61K8/22 , A61K8/81 , A61Q11/00 , C01B15/037 , C11D3/37 , C11D3/39
CPC分类号： A61K8/8176 , A61K8/22 , A61Q11/00 , C01B15/037 , C11D3/3776 , C11D3/394 , C11D3/3945
摘要： Urea-hydrogen peroxide-polyvinylpyrrolidone (PVP) in the form of a free-flowing powder is stable against decomposition in water and alcohol solvents. The product is obtained by spraying an aqueous solution of urea-hydrogen peroxide onto a fluidized bed of PVP and drying; it contains about 5%-20% by weight H.sub.2 O.sub.2 and less than about 5% water. The urea-hydrogen peroxide solution is applied onto the fluidized PVP bed at a predetermined rate, suitably about 0.5-30 g of solution/minute/kg PVP in the bed, and, preferably, about 1-3 g/min/kg PVP.
摘要翻译：以自由流动的粉末形式的尿素 - 过氧化氢 - 聚乙烯吡咯烷酮（PVP）在水和醇溶剂中是分解的。通过将尿素 - 过氧化氢水溶液喷雾到PVP的流化床上并干燥获得产物; 它含有约5％-20％重量的H 2 O 2和小于约5％的水。将脲 - 过氧化氢溶液以预定速率施加到流化PVP床上，合适地在床中约0.5-30g溶液/分/ kg PVP，优选约1-3g / min / kg PVP。

3. 发明授权

US5077047A Process for producing PVP-H2O2 products in the form of free-flowing powders 失效
标题翻译：以自由流动的粉末形式生产PVP-H2O2产品的方法
公开(公告)号：US5077047A
公开(公告)日：1991-12-31
申请号：US683467
申请日：1991-04-08
申请人： Russell B. Biss , Jeffrey Cohen , John J. Merianos , Paul D. Taylor
发明人： Russell B. Biss , Jeffrey Cohen , John J. Merianos , Paul D. Taylor
IPC分类号： A61K8/22 , A61K8/81 , A61K31/79 , A61K33/40 , A61Q17/00 , A61Q19/00 , C01B15/01 , C01B15/037
CPC分类号： A61K8/02 , A61K31/79 , A61K33/40 , A61K8/22 , A61K8/8176 , A61Q17/005 , A61Q19/00 , C01B15/01 , C01B15/037 , A61K2800/52 , Y10T428/2982
摘要： A process for the production of PVP-H.sub.2 O.sub.2 products in the form of free-flowing powders is described in which a fluidized bed maintained at a reaction temperature of about room temperature to 60.degree. C. is contacted with finely divided droplets of a 30 to 85% by weight aqueous H.sub.2 O.sub.2 solution. Preferably the fluidized bed temperature is about 35.degree.-45.degree. C., a 50-70% H.sub.2 O.sub.2 solution is used, and the feed rate of introduction of the H.sub.2 O.sub.2 solution is about 5-50 g/minute/kg PVP present. The PVP-H.sub.2 O.sub.2 product preferably contains about 15-24%, preferably 18-22%, H.sub.2 O.sub.2 (1:1 molar ratio) and less than about 5% water.
摘要翻译：描述了以自由流动的粉末形式生产PVP-H 2 O 2产物的方法，其中保持在约室温至60℃的反应温度的流化床与30至85℃的细分散液滴接触重量％H 2 O 2水溶液。优选地，流化床温度为约35°-45℃，使用50-70％的H 2 O 2溶液，并且H 2 O 2溶液的进料速率为约5-50g /分钟/ kg存在的PVP。 PVP-H 2 O 2产物优选含有约15-24％，优选18-22％的H 2 O 2（1:1摩尔比）和小于约5％的水。

4. 发明授权

US5645859A Process for producing an alpha or beta-hydroxy acid-vinylpyrrolidone polymer, copolymer or graft polymer complex in the form of free-flowing powders having a high acid loading 失效
标题翻译：用于生产具有高酸负载的自由流动粉末形式的α或β-羟基酸 - 乙烯基吡咯烷酮聚合物，共聚物或接枝聚合物复合物的方法
公开(公告)号：US5645859A
公开(公告)日：1997-07-08
申请号：US537566
申请日：1995-10-02
申请人： Ratan K. Chaudhuri , Russell B. Biss , John J. Merianos
发明人： Ratan K. Chaudhuri , Russell B. Biss , John J. Merianos
IPC分类号： A61K8/365 , A61K8/368 , A61K8/81 , A61K8/91 , A61K9/14 , A61K47/48 , A61Q19/00
CPC分类号： A61K8/91 , A61K47/48176 , A61K8/365 , A61K8/368 , A61K8/8176 , A61K8/8182 , A61Q19/00 , A61K2800/75 , A61Q19/08
摘要： A process is provided for making a free-flowing powder of a complex of an alpha-hydroxy acid (AHA) and/or a beta-hydroxy acid (BHA) and a vinylpyrrolidone (PVP) polymer, copolymer or graft polymers, as the complexing agent, at high acid loadings, preferably 20-60% by weight. The presence of VP polymers, copolymers or graft polymers in the complex reduces the skin irritation effect of the acid when applied to the skin of the user. The process involves applying an aqueous solution or slurry of the acid to PVP, and, substantially immediately thereafter, evaporating the water to form a free-flowing powder of the complex of the acid and VP polymers, copolymers or graft polymers.
摘要翻译：提供了一种制备自由流动的α-羟基酸（AHA）和/或β-羟基酸（BHA）和乙烯基吡咯烷酮（PVP）聚合物，共聚物或接枝聚合物的络合物的粉末作为络合物的方法试剂，在高酸负载下，优选20-60重量％。复合物中VP聚合物，共聚物或接枝聚合物的存在降低了施用于使用者皮肤时酸的皮肤刺激作用。该方法包括将酸的水溶液或浆液施用于PVP，并且基本上立即蒸发水以形成酸和VP聚合物，共聚物或接枝聚合物的络合物的自由流动的粉末。

5. 发明授权

US5206385A Urea-hydrogen peroxide-polyvinylpyrrolidone process 失效
标题翻译：尿素 - 过氧化氢 - 聚乙烯吡咯烷酮工艺
公开(公告)号：US5206385A
公开(公告)日：1993-04-27
申请号：US908107
申请日：1992-07-02
申请人： Robert B. Login , John J. Merianos , Russell B. Biss , Paul Garelick
发明人： Robert B. Login , John J. Merianos , Russell B. Biss , Paul Garelick
IPC分类号： A01N59/00 , A61K8/22 , A61K8/42 , A61K8/81 , A61Q5/08 , A61Q11/00 , C01B15/037 , C11D3/37 , C11D3/39
CPC分类号： C11D3/3945 , A01N59/00 , A61K8/22 , A61K8/42 , A61K8/8176 , A61Q11/00 , A61Q5/08 , C01B15/037 , C11D3/3776 , C11D3/394
摘要： Urea-hydrogen peroxide-polyvinylpyrrolidone (PVP) in the form of a free-flowing powder is stable against decomposition in water and alcohol solvents. The product is obtained by spraying an aqueous solution of urea-hydrogen peroxide onto a fluidized bed of PVP and drying; it contains about 5%-20% by weight H.sub.2 O.sub.2 and less than about 5% water. The urea-hydrogen peroxide solution is applied onto the fluidized PVP bed at a predetermined rate, suitably about 0.5-30 g of solution/minute/kg PVP in the bed, and, preferably, about 1-3 g/min/kg PVP.
摘要翻译：以自由流动粉末形式的尿素 - 过氧化氢 - 聚乙烯吡咯烷酮（PVP）在水和醇溶剂中是分解的。通过将尿素 - 过氧化氢水溶液喷雾到PVP的流化床上并干燥获得产物; 它含有约5％-20％重量的H 2 O 2和小于约5％的水。将脲 - 过氧化氢溶液以预定速率施加到流化PVP床上，合适地在床中约0.5-30g溶液/分/ kg PVP，优选约1-3g / min / kg PVP。

6. 发明授权

US5177113A Free-standing, porous foam PVP:H.sub.2 O.sub.2 product 失效
标题翻译：独立的多孔泡沫PVP：H2O2产品
公开(公告)号：US5177113A
公开(公告)日：1993-01-05
申请号：US883617
申请日：1992-03-04
申请人： Russell B. Biss , Jeffrey M. Cohen , John J. Merianos , Paul D. Taylor
发明人： Russell B. Biss , Jeffrey M. Cohen , John J. Merianos , Paul D. Taylor
IPC分类号： A01N59/00 , A61K8/22 , A61K8/81 , A61K31/79 , A61K33/40 , A61Q17/00 , A61Q19/00 , C01B15/01 , C11D3/39
CPC分类号： A61Q17/005 , A01N59/00 , A61K31/79 , A61K33/40 , A61K8/22 , A61K8/8176 , A61Q19/00 , C01B15/01 , C11D3/394 , C11D3/3945 , A61K2800/57
摘要： A free-standing, porous foam product comprising an integral network of PVP molecules hydrogen-bonded to H.sub.2 O.sub.2 molecules, optionally including a water-soluble gelling agent; e.g. hydroxyethyl cellulose; in an amount up to 60% by weight of the product, its PVP content being about 25-90% by weight of the product, and the H.sub.2 O.sub.2 content being about 5-24% by weight. In the absence of a gelling agent, the product has a bulk density of about 0.3 to about 0.5 g/cc and a porosity of about 60-70%. When a gelling agent is present in the product, its bulk density and porosity of the product is substantially reduced and, accordingly, it has a more foam-like structure and appearance.
摘要翻译：一种独立的多孔泡沫产品，包括与H 2 O 2分子氢键合的PVP分子的整体网络，任选地包括水溶性胶凝剂; 例如羟乙基纤维素; 其量高达产品的60重量％，其PVP含量为产物重量的约25-90重量％，H 2 O 2含量为约5-24重量％。在没有胶凝剂的情况下，该产品具有约0.3至约0.5g / cc的堆积密度和约60-70％的孔隙率。当产品中存在胶凝剂时，产品的体积密度和孔隙率显着降低，因此具有更多的泡沫状结构和外观。

7. 发明授权

US5972329A Fixative polymers 失效
标题翻译：固定聚合物
公开(公告)号：US5972329A
公开(公告)日：1999-10-26
申请号：US34574
申请日：1998-03-04
申请人： Jui-Chang Chuang , Jenn S. Shih , Russell B. Biss
发明人： Jui-Chang Chuang , Jenn S. Shih , Russell B. Biss
IPC分类号： A61K8/04 , A61K8/81 , A61K9/12 , A61K31/78 , A61Q5/06 , C08F2/20 , C08F4/04 , C08F4/38 , C08F6/10 , C08F218/08 , C08F218/14 , C08F220/54 , C08F222/16
CPC分类号： A61Q5/06 , A61K31/78 , A61K8/046 , A61K8/8158 , A61K8/8164 , C08F218/08 , C08F218/10 , C08F220/56 , C08F222/16 , C08F222/18
摘要： An improved hydrocarbon tolerant, aerosol hair spray resin composition includes a fixative polymer which is a tetrapolymer consisting essentially of (1) vinyl acetate, (2) vinyl neodecanoate or vinyl neononanoate, (3) monoisobutyl maleate and (4) N-t-butyl acrylamide, N-t-octyl acrylamide, or isobornyl (meth)acrylate, in a molar ratio from 10:10:15:1 to 26:1:15:1, preferably in a molar ratio of 12.5:7.5:15:1, exhibits advantageous small spray particle size, short tack and drying times, and hydrolytic stability, which are the desired performance characteristics on hair.
摘要翻译：改进的耐烃气溶胶喷发树脂组合物包括一种固定聚合物，它是一种基本上由（1）乙酸乙烯酯，（2）新癸酸乙烯酯或新戊酸乙烯酯组成的四元共聚物，（3）马来酸单异丁酯和（4）N叔丁基丙烯酰胺，辛基丙烯酰胺或（甲基）丙烯酸异冰片酯，摩尔比为10：10：15：1至26：1：15：1，优选摩尔比为12.5：7.5：15：1，喷雾粒度，短粘性和干燥时间以及水解稳定性，这是头发上所需的性能特征。

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