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1. 发明授权

US06920353B1 Cardiac pacemaker with adjustable stimulation interval 有权
标题翻译：心脏起搏器可调节刺激间隔
公开(公告)号：US06920353B1
公开(公告)日：2005-07-19
申请号：US09869839
申请日：1999-11-30
申请人： Roland Heinze , Karl Stangl
发明人： Roland Heinze , Karl Stangl
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/365
摘要： A cardiac pacemaker has a pulse generator which emits stimulation pulses which are respectively separated by stimulation intervals and which collectively have an average duration. A modulation device alternatingly shortens and lengthens the stimulation intervals, without changing the average duration. An evaluation unit analyzes signals detected after each stimulation pulse and determines the electric restitution of the heart at the average stimulation interval duration on the basis of a measurement of the duration of the action potential. Changes in a measuring variable, associated with the duration of the action potential, caused by the modulation of the stimulation intervals is determined in a relationship to the average duration of the stimulation interval. This relationship is compared with at least one predetermined value, and the average duration of the stimulation interval is controlled on the basis of this comparison.
摘要翻译：心脏起搏器具有发出刺激脉冲的脉冲发生器，脉冲发生器分别由刺激间隔分开并且共同具有平均持续时间。调制装置交替地缩短和延长刺激间隔，而不改变平均持续时间。评估单元分析在每个刺激脉冲之后检测到的信号，并且基于动作电位的持续时间的测量来确定心脏在平均刺激间隔持续时间的电恢复。与刺激间隔的平均持续时间的关系确定与由刺激间隔的调制引起的动作电位的持续时间相关联的测量变量的变化。将该关系与至少一个预定值进行比较，并且基于该比较来控制刺激间隔的平均持续时间。

2. 发明授权

US5500006A Arrangement, particularly a heart pacemarker, for acquiring a measurement parameter of the heart activity 失效
标题翻译：安排，特别是心脏起搏器，用于获取心脏活动的测量参数
公开(公告)号：US5500006A
公开(公告)日：1996-03-19
申请号：US39190
申请日：1993-06-04
申请人： Roland Heinze
发明人： Roland Heinze
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/3621 , A61N1/36514 , A61N1/3702
摘要： An arrangement, in particular a heart pacemaker, has a measuring device for recording a heart activity measurement parameter. In order to record the measurement parameter in such a way that it is rid of disturbing signals, and can thus be used to evaluate the physiological functions of the heart pacemaker, the arrangement contains switching means which evaluate the signal curve of a measurement parameter during a heart cycle (n+1) as a function of the frequency (f) or duration (t.sub.S) of the previous heart cycle (n).
摘要翻译： PCT No.PCT / EP91 / 01897 371日期：1993年6月4日 102（e）日期1993年6月4日PCT 1991年10月4日PCT PCT。出版物WO92 / 05836 日期为1992年04月16日。一种安排，特别是心脏起搏器，具有用于记录心脏活动测量参数的测量装置。为了记录测量参数，其消除了干扰信号，并且因此可用于评估心脏起搏器的生理功能，该装置包含切换装置，其评估在一个测量参数期间的测量参数的信号曲线心脏周期（n + 1）作为先前心脏周期（n）的频率（f）或持续时间（tS）的函数。

3. 发明授权

US4830488A Measuring instrument for intracardial acquisition of blood oxygen saturation 失效
标题翻译：测量仪器用于血氧饱和度的心内采集
公开(公告)号：US4830488A
公开(公告)日：1989-05-16
申请号：US51857
申请日：1987-05-20
申请人： Roland Heinze , Hakan Elmqvist
发明人： Roland Heinze , Hakan Elmqvist
IPC分类号： A61B5/145 , A61B5/1459 , A61N1/365
CPC分类号： A61N1/36557
摘要： A measuring instrument for obtaining an intracardial signal indicative of blood oxygen saturation, which may be used to control the stimulation frequency of a heart pacemaker, has a measuring probe which contains a light transmitter and a light receiver. The light receiver receives light from the light transmitter reflected by the blood. The light transmitter and the light receiver are connected in parallel to an evaluation circuit via two leads. A constant current source is connected in series with the light transmitter. The current generated by the light receiver, indicative of blood oxygen saturation, can be identified by forming the difference between current flowing in the measuring probe and the constant current. A reference measurement to compensate for factors in the total current resulting from the lead resistances and the measuring probe temperature is not necessary.
摘要翻译：可用于控制心脏起搏器的刺激频率的用于获得指示血氧饱和度的心内信号的测量仪器具有包含光发射器和光接收器的测量探针。光接收器接收来自由血液反射的光发射器的光。光发射器和光接收器通过两根引线并联连接到评估电路。恒流源与光发射器串联连接。由光接收器产生的指示血氧饱和度的电流可以通过形成测量探头中流动的电流与恒定电流之间的差异来识别。用于补偿由导通电阻和测量探头温度导致的总电流中的因素的参考测量不是必需的。

4. 发明授权

US4807632A Measuring instrument for intracardial acquisition of the blood oxygen saturation of a patient for controlling the pacing rate of a heart pacemaker 失效
标题翻译：用于心脏内采集患者血氧饱和度的测量仪器，用于控制心脏起搏器的起搏速率
公开(公告)号：US4807632A
公开(公告)日：1989-02-28
申请号：US52032
申请日：1987-05-19
申请人： Hans D. Liess , Roland Heinze
发明人： Hans D. Liess , Roland Heinze
IPC分类号： G01N33/49 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61N1/365 , G01D18/00
CPC分类号： A61B5/1459 , A61N1/36557
摘要： A measuring instrument for the intracardial acquistion of the blood oxygen saturation of a patient for use in controlling a heart pacemaker implanted in the patient has a measuring probe with a measuring current path which includes a light transmitter and a light receiver which receives light emitted by the light transmitter and reflected by the blood. The measuring probe is connected to an evaluation circuit via two lines. A useful signal measurement and a reference measurement, independent of the blood reflection, are made and the blood oxygen saturation is identified by comparing the two signals. A separate evaluation of the useful signal measurement and the reference signal measurement is enabled by making the useful signal measurement chronologically offset with respect to the reference measurement in one embodiment, or by using the amplitude of the current from the light receiver to make one measurement, and using the voltage amplitude to make the other measurement in another embodiment.
摘要翻译：用于心脏采集患者的血氧饱和度用于控制植入患者的心脏起搏器的测量仪器具有测量电流路径的测量探头，该测量电流路径包括光发射器和接收由光发射器和血液反射。测量探头通过两条线连接到评估电路。进行独立于血液反射的有用的信号测量和参考测量，并通过比较两个信号来识别血氧饱和度。通过使有用信号测量在一个实施例中相对于参考测量按时间顺序偏移，或者通过使用来自光接收器的电流的振幅进行一次测量，可以对有用信号测量和参考信号测量进行单独的评估，并且在另一实施例中使用电压幅度进行另一测量。

5. 发明授权

US4727879A Measurement device for intracardial acquisition of blood oxygen saturation 失效
标题翻译：用于血氧饱和度的心内采集的测量装置
公开(公告)号：US4727879A
公开(公告)日：1988-03-01
申请号：US915675
申请日：1986-10-06
申请人： Hans-Dieter Liess , Roland Heinze
发明人： Hans-Dieter Liess , Roland Heinze
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61N1/365
CPC分类号： A61N1/36557 , A61B5/1459
摘要： A measurement device for frequency control of a heart pacemaker based on the level of blood oxygen saturation contains a measuring probe which includes a light transmitter and a light receiver. The light receiver receives the light emitted by the light transmitter and reflected by the blood. The light transmitter and the light receiver are connected in parallel to an evaluation circuit via two common lines, this evaluation circuit charging the measuring probe with a constant current or with a constant voltage. A resistor is arranged in series with the light receiver. A transistor is arranged parallel to this series circuit, the base thereof being connected to the junction of the resistor and the light receiver. By means of this arrangement, the measurement sensitivity given deposits on the probe is maintained at a higher level. In an alternative embodiment, this can also be achieved using a resistor in series with the light transmitter with a transistor controlled by the light receiver connected in parallel therewith.
摘要翻译：用于基于血氧饱和度的心脏起搏器的频率控制的测量装置包括测量探头，其包括光发射器和光接收器。光接收器接收由光发射器发射并被血液反射的光。光发射器和光接收器通过两条公共线与评估电路并联连接，该评估电路用恒定电流或恒定电压对测量探头充电。电阻器与光接收器串联布置。晶体管被平行于该串联电路设置，其基极连接到电阻器和光接收器的结。通过这种布置，探头上给定的沉积物的测量灵敏度保持在更高的水平。在替代实施例中，这也可以使用与光发射器串联的电阻器来实现，其中晶体管由与其并联连接的光接收器控制。

6. 发明授权

US5133349A Method for adapting the stimulation frequency of a heart pacemaker to the burden of the patient 失效
标题翻译：将心脏起搏器的刺激频率适应到患者的BURDEN的方法
公开(公告)号：US5133349A
公开(公告)日：1992-07-28
申请号：US573032
申请日：1990-08-06
申请人： Roland Heinze
发明人： Roland Heinze
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： During optimization intervals prescribed by the heart pacemaker, the stimulation frequency is periodically changed and an acquisition of a measured value that is dependent on the cardiac minute output is respectively phase-synchronized with the change in stimulation frequency. An identification is thereby made whether the measured value that is dependent on the cardiac minute output changes given the change of the stimulation frequency. A number of curves are stored representing different relationships between a regulating variable, derived from the measured value, and the stimulation frequency. The stimulation frequency of the pacemaker is set based on one of these curves, as selected by an optimization controller to which the regulating variable is supplied. If the change in the measured valued as acquired during the optimization intervals indicates that the currently-selected curve is no longer accurate, the optimization controller selects another curve from among the stored curves which best represents the current relationship between the regulating variable and the stimulation frequency.
摘要翻译： PCT No.PCT / EP89 / 00108 Sec。 371日期1990年8月6日 102（e）日期1990年8月6日PCT提交1989年2月6日PCT公布。出版物WO89 / 06990 日期为1989年8月10日。在由心脏起搏器规定的优化间隔期间，刺激频率周期性地改变，并且取决于心脏分钟输出的测量值的获取与刺激频率的变化分别相位同步。由此确定依赖于心脏分钟输出的测量值是否随着刺激频率的变化而变化。存储多个曲线，其表示从测量值导出的调节变量与刺激频率之间的不同关系。起搏器的刺激频率基于这些曲线之一来设定，由调节变量所提供的优化控制器选择。如果在优化间隔期间获得的测量值的变化表明当前选择的曲线不再准确，则优化控制器从存储的曲线中选择最佳代表调节变量与刺激频率之间的当前关系的另一条曲线。

7. 发明授权

US5058586A Catheter for implantation in the heart, having an integrated measuring probe 失效
标题翻译：用于植入心脏的导管，具有一体化的测量探针
公开(公告)号：US5058586A
公开(公告)日：1991-10-22
申请号：US223027
申请日：1988-07-22
申请人： Roland Heinze
发明人： Roland Heinze
IPC分类号： A61B5/00 , A61N1/05 , A61N1/365
CPC分类号： A61B5/6855 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： A catheter of the type suitable for implantation in a human heart has a catheter tip and a preset curvature spaced along the catheter a distance from the tip. The catheter includes an integrated measuring probe with a measurement window, the measuring probe and window being disposed between the tip and the preset curvature at respective distances from each so that, given the aforementioned location of the catheter tip, it is insured that the measurement window of the probe will not lie against a wall of the heart, which would degrade the operation of the measuring probe, and moreover insures that the measuring probe and measurement window will be disposed at an optimum location for undertaking the desired measurement.
摘要翻译：适于植入人心脏的类型的导管具有导管尖端和沿着导管与尖端间隔一定距离的预设曲率。导管包括具有测量窗口的集成测量探针，测量探针和窗口设置在尖端和预设曲率之间，各自距离处，使得在给定导管尖端的上述位置的情况下，确保测量窗口的探头不会靠在心脏壁上，这会降低测量探头的操作，并且还确保测量探头和测量窗口将被放置在最佳位置进行所需的测量。

8. 发明授权

US4823797A Apparatus and method for impedance measurement of body tissues 失效
标题翻译：用于身体组织阻抗测量的装置和方法
公开(公告)号：US4823797A
公开(公告)日：1989-04-25
申请号：US61547
申请日：1987-06-15
申请人： Roland Heinze , Karl Stangl
发明人： Roland Heinze , Karl Stangl
IPC分类号： A61B5/05 , A61B5/053 , A61B5/08 , A61B5/087 , A61N1/365 , A61N1/36
CPC分类号： A61B5/0535 , A61N1/36521
摘要： An apparatus for impedance measurement of body tissue has a signal source which impresses an electrical signal in body tissue, circuitry for acquiring an impedance signal from the body tissue dependent on the impressed electrical signal, and an evaluation stage for evaluating the impedance signal by filtering higher frequency components and low frequency components from the impedance signal which correspond to the conductance of the tissue. A correction stage corrects the high frequency signal components with the low frequency signal components by eliminating the higher frequency signal components of influences due to changes in the tissue conductance. The corrected signal is supplied at an output of the correction stage.
摘要翻译：用于身体组织的阻抗测量的装置具有施加人体组织中的电信号的信号源，取决于外加电信号从身体组织获取阻抗信号的电路，以及用于通过滤波更高来评估阻抗信号的评估级来自与组织电导相对应的阻抗信号的频率分量和低频分量。校正阶段通过消除由于组织电导的变化引起的影响的较高频率信号分量，来校正具有低频信号分量的高频信号分量。校正信号在校正级的输出端提供。

9. 发明授权

US4805621A Apparatus for measuring impedance of body tissue 失效
标题翻译：用于测量身体组织阻抗的装置
公开(公告)号：US4805621A
公开(公告)日：1989-02-21
申请号：US61549
申请日：1987-06-15
申请人： Roland Heinze , Karl Stangl
发明人： Roland Heinze , Karl Stangl
IPC分类号： A61B5/05 , A61B5/053 , A61B5/08 , A61B5/087 , A61N1/365 , A61N1/00
CPC分类号： A61B5/0535 , A61N1/36521
摘要： An apparatus for measuring the impedance of body tissue has a signal source connected to the tissue to be measured which supplies an electrical signal to the tissue, a unit for acquiring an impedance signal from the body tissue dependent on the electrical signal, and an evaluation stage for the impedance signal. The evaluation stage filters out low frequency signal components corresponding to the conductance of the tissue, and has a signal output to which the signal components which were filtered out are supplied.
摘要翻译：用于测量身体组织的阻抗的装置具有连接到待测组织的信号源，所述信号源向组织提供电信号，用于根据电信号从身体组织获取阻抗信号的单元，以及评估阶段用于阻抗信号。评估级滤除与组织的电导相对应的低频信号分量，并且具有输出被滤出的信号分量的信号输出。

10. 发明授权

US4399820A Process and device for regulating the stimulation frequency of heart pacemakers 失效
标题翻译：调节心脏起搏器刺激频率的过程和装置
公开(公告)号：US4399820A
公开(公告)日：1983-08-23
申请号：US346315
申请日：1982-02-05
申请人： Alexander Wirtzfeld , Roland Heinze , Thomas Bock , Hans D. Liess
发明人： Alexander Wirtzfeld , Roland Heinze , Thomas Bock , Hans D. Liess
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61N1/365 , A61N1/36
CPC分类号： A61N1/36557 , A61B5/1459
摘要： A process and a device for regulating the stimulation frequency of heart pacemakers are disclosed. The process comprises generating with the aid of light emitted by a light-emitting element, reflected by the blood of a patient, and received by a light-receiving element, a current flow which causes, in a measuring probe, an increasing of the current flow at a constant probe voltage or a damping of the probe voltage at constant current flow. Thereafter, one of the possible changing values is measured and the change, with time, is evaluated as a measured quantity proportional to the change, with time, of the blood oxygen saturation, and, as a function of the measured quantity, the stimulation frequency of the heart pacemaker is regulated in such a manner that the greatest possible blood oxygen saturation is always achieved with the lowest stimulation frequency. The device for practicing the invention comprises a measuring probe containing at least one combination of only two active optoelectronic elements, one light-emitting element and one light-receiving element; a control circuit electrically connected to the measuring probe; a stimulation catheter in which the measuring probe is incorporated, and at least two electric lines leading through the stimulation catheter and electrically connecting the measuring probe to the control circuit of the measuring probe.
摘要翻译：公开了一种用于调节心脏起搏器刺激频率的过程和装置。该过程包括借助由发光元件发射的光产生，由患者的血液反射并由光接收元件接收的电流，其在测量探针中引起电流的增加在恒定电流下以恒定的探针电压或探针电压的阻尼流动。此后，测量可能的变化值之一，随时间的变化被评估为与血氧饱和度随时间的变化成比例的测量量，并且作为测量量的函数，刺激频率心脏起搏器的调节方式是以最低的刺激频率始终实现最大可能的血氧饱和度。用于实施本发明的装置包括测量探头，其包含仅两个有源光电元件，一个发光元件和一个光接收元件的至少一个组合; 电连接到所述测量探针的控制电路; 其中结合有测量探针的刺激导管和通过刺激导管的至少两条电线，并将测量探针电连接到测量探针的控制电路。

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