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1. 发明授权

US06764648B1 Robotic microchannel bioanalytical instrument 有权
标题翻译：机器人微通道生物分析仪器
公开(公告)号：US06764648B1
公开(公告)日：2004-07-20
申请号：US09556897
申请日：2000-04-20
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N3500
CPC分类号： G01N27/44704 , B01L3/5027 , B01L99/00 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437 , Y10T436/11 , Y10T436/110833 , Y10T436/25 , Y10T436/2575
摘要： A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.
摘要翻译：具有多个微通道的基板可移动地与其他可移动物体一起展开，其中可移动物体将样品载入微通道，刺激分子迁移，读取迁移结果，去除和替换基底，并准备新的运行。其他目的包括用于接合和移动衬底的夹持器，适于安装到用于电迁移的微通道中的细线的电极阵列，以及用于读取迁移结果的扫描检测器。建立了一系列自动操作，使得一个接一个的衬底可以移动到位置，装载样品，刺激分子迁移，用光束读取，然后移除并用新鲜的底物代替。

2. 发明授权

US06787111B2 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis 有权
标题翻译：用于生物分析的微芯片中填充和清洁通道和入口的装置和方法
公开(公告)号：US06787111B2
公开(公告)日：2004-09-07
申请号：US09737675
申请日：2000-12-13
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J2219/0099 , B01L3/5027 , B01L99/00 , G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437
摘要： An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
摘要翻译：公开了一种用于填充和清洁微芯片衬底的通道和入口的装置。将包括管阵列的装置的装置插入到微芯片的每个入口端口中。该装置的管阵列包括由多个真空管包围的多个压力管。与此同时，诸如基质或洗涤剂的加压溶液被引入到微芯片上的共同的开口中，通过使用该装置的压头喷射器提供通向微芯片的微通道的通道。当将基质或洗涤溶液泵送通过微芯片衬底的共同的开口和微通道时，将洗涤溶液泵送通过多个压力管，并且通过围绕多个压力管的多个真空管将一切都抽真空。选择各种储存的溶液并通过适当的阀驱动使其流动。该过程可以通过使用适当的阀门和控制硬件/软件手动或容易地进行自动化。

3. 发明授权

US06627446B1 Robotic microchannel bioanalytical instrument 失效
标题翻译：机器人微通道生物分析仪器
公开(公告)号：US06627446B1
公开(公告)日：2003-09-30
申请号：US09109676
申请日：1998-07-02
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44704 , B01L3/5027 , B01L99/00 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437 , Y10T436/11 , Y10T436/110833 , Y10T436/25 , Y10T436/2575
摘要： A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.
摘要翻译：具有多个微通道的基板可移动地与其他可移动物体一起展开，其中可移动物体将样品载入微通道，刺激分子迁移，读取迁移结果，去除和替换基底，并准备新的运行。其他目的包括用于接合和移动衬底的夹持器，适于安装到用于电迁移的微通道中的细线的电极阵列，以及用于读取迁移结果的扫描检测器。建立了一系列自动操作，使得一个接一个的衬底可以移动到位置，装载样品，刺激分子迁移，用光束读取，然后移除并用新鲜的底物代替。

4. 发明申请

US20120213667A1 AUTOMATED MICRO-VOLUME ASSAY SYSTEM 审中-公开
标题翻译：自动微量测定系统
公开(公告)号：US20120213667A1
公开(公告)日：2012-08-23
申请号：US13236316
申请日：2011-09-19
申请人： David J. Roach , Tom W. Yang , Roger A. O'Neill , Robert T. Loder, JR. , Peter B. Vander Horn
发明人： David J. Roach , Tom W. Yang , Roger A. O'Neill , Robert T. Loder, JR. , Peter B. Vander Horn
IPC分类号： G01N35/10
CPC分类号： F16L41/00 , G01N35/04 , G01N35/1065 , G01N2035/1034 , G01N2035/1039 , G01N2035/1051 , G01N2035/1062 , Y10T137/0318 , Y10T137/85938 , Y10T436/11 , Y10T436/119163 , Y10T436/2575
摘要： An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run. Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.
摘要翻译：描述了用于放置用于毛细管内部的材料测定的材料的站的自动测定系统和用于操纵毛细管的自动化夹具。该系统包括分离和固定站，其中毛细管内部发生反应，并且检测到来自毛细血管反应的光摄取的检测器站。来自毛细血管的光摄取可以显示为线图或类似于熟悉的Western凝胶印迹的假凝胶图像的列。自动化控制系统具有用户界面，通过该界面，操作员可以选择运行协议并定义要在协议运行中使用的样本和试剂的位置。在设置之后，控制系统将使自动化系统执行协议，然后以选定的显示格式显示结果。

5. 发明授权

US5424841A Apparatus for measuring spatial distribution of fluorescence on a substrate 失效
标题翻译：用于测量衬底上荧光的空间分布的装置
公开(公告)号：US5424841A
公开(公告)日：1995-06-13
申请号：US069150
申请日：1993-05-28
申请人： Ezra Van Gelder , Bee C. Liang , Richard F. Johnston , Robert T. Loder, Jr.
发明人： Ezra Van Gelder , Bee C. Liang , Richard F. Johnston , Robert T. Loder, Jr.
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6441
摘要： A fluorescence detection scanner and method employing a fiberoptic collector, positioned adjacent to the scanning plane of the excitation beam, with a light collecting surface which is oriented to reject back-scattered excitation light from the incident surface of the sample support. The scanning plane of the excitation beam is off normal relative to the incident surface of the sample support and the light collecting surface is located within the area defined by the resulting acute angle of incidence. The light collecting surface is angled away from the location at which the incident excitation beam intersects the surface of the sample support so that back-scattered excitation light does not enter the optical fibers. The orientation of the light collector results in a four to five-fold decrease in excitation-light background without attenuation of the fluorescence emitted by the sample. Long-pass interference filters, selected to reject the excitation wavelength, are located at the input and output surfaces of the fiberoptic light collector to further reduce background excitation light. Multiple fluorophores are discriminated by sequentially scanning the sample with a different interchangeable narrow bandpass filter for each fluorophore. Internal fluorescence standards in the sample are used to determine filter efficiencies for each label in each filter image and the quantity of each fluorophore is computed by linear analysis. Increased detector sensitivity allows linear quantitation of multiple fluorophores in the femto-mole range.
摘要翻译：一种荧光检测扫描器和采用与激发光束的扫描平面相邻的光纤收集器的方法，该光收集表面被定向成阻止来自样品支架的入射表面的反向散射的激发光。激发光束的扫描平面相对于样品支架的入射表面正常，并且光收集表面位于由所产生的锐角入射限定的区域内。光收集表面远离入射激发光束与样品支架表面相交的位置成角度，使得后向散射的激发光不进入光纤。光收集器的取向导致激发光背景下降4-5倍，而不会使样品发射的荧光发生衰减。被选择以抑制激发波长的长通干涉滤光器位于光纤集光器的输入和输出表面，以进一步减少背景激发光。通过用每个荧光团的不同可互换的窄带通滤光器顺序扫描样品来区分多个荧光团。使用样品中的内部荧光标准来确定每个过滤图像中每个标记的过滤效率，并且通过线性分析计算每个荧光团的量。增加的检测器灵敏度允许在毫微微摩尔范围内的多个荧光团的线性定量。

6. 发明授权

US4949290A Method and apparatus for defining test sequences for a signal measurement system 失效
标题翻译：用于定义信号测量系统的测试序列的方法和装置
公开(公告)号：US4949290A
公开(公告)日：1990-08-14
申请号：US178036
申请日：1988-04-05
申请人： William T. Pike , Robert T. Loder, Jr.
发明人： William T. Pike , Robert T. Loder, Jr.
IPC分类号： G01R27/28 , G01R15/00 , G01R27/04 , G01R31/00 , G01R31/28 , G01R31/319
CPC分类号： G01R27/04 , G01R31/2834 , G01R31/31912
摘要： A signal measurement system with softkey menus for enabling a user to select a desired test setup, including selection of test measurement for a device. The signal measurement system prompts the user with a set of displayed softkey selections via a user interface to step the user through the setup process. Preferably, a signal processing unit (or analyzer) included in the signal measurement system incorporates the user interface in firmware to aid the user in entering a test sequence for the device to be tested. The analyzer preferably displays the softkey menus on a cathode ray tube included in the analyzer to guide the user. The user is guided through the test sequencing procedure by depressing softkeys. A set of softkey labels (softkey menu) is presented on the display of the analyzer by the firmware for each step in the test sequencing series. As each step of a desired test sequence is entered by the user, the step is displayed on the CRT. Also, the displayed steps are preferably overlaid on data measured in accordance with the test sequence.

7. 发明授权

US08021611B2 Automated micro-volume assay system 有权
标题翻译：自动微量测定系统
公开(公告)号：US08021611B2
公开(公告)日：2011-09-20
申请号：US11401699
申请日：2006-04-10
申请人： David J. Roach , Tom W. Yang , Roger A. O'Neill , Robert T. Loder, Jr. , Peter B. Vander Horn
发明人： David J. Roach , Tom W. Yang , Roger A. O'Neill , Robert T. Loder, Jr. , Peter B. Vander Horn
IPC分类号： B01L9/06 , B01L9/00
CPC分类号： F16L41/00 , G01N35/04 , G01N35/1065 , G01N2035/1034 , G01N2035/1039 , G01N2035/1051 , G01N2035/1062 , Y10T137/0318 , Y10T137/85938 , Y10T436/11 , Y10T436/119163 , Y10T436/2575
摘要： An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run. Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.
摘要翻译：描述了用于放置用于毛细管内部的材料测定的材料的站的自动测定系统和用于操纵毛细管的自动化夹具。该系统包括分离和固定站，其中毛细管内部发生反应，并且检测到来自毛细血管反应的光摄取的检测器站。来自毛细血管的光摄取可以显示为线图或类似于熟悉的Western凝胶印迹的假凝胶图像的列。自动化控制系统具有用户界面，通过该界面，操作员可以选择运行协议并定义要在协议运行中使用的样本和试剂的位置。在设置之后，控制系统将使自动化系统执行协议，然后以选定的显示格式显示结果。

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