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1. 发明授权

US06764648B1 Robotic microchannel bioanalytical instrument 有权
标题翻译：机器人微通道生物分析仪器
公开(公告)号：US06764648B1
公开(公告)日：2004-07-20
申请号：US09556897
申请日：2000-04-20
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N3500
CPC分类号： G01N27/44704 , B01L3/5027 , B01L99/00 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437 , Y10T436/11 , Y10T436/110833 , Y10T436/25 , Y10T436/2575
摘要： A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.
摘要翻译：具有多个微通道的基板可移动地与其他可移动物体一起展开，其中可移动物体将样品载入微通道，刺激分子迁移，读取迁移结果，去除和替换基底，并准备新的运行。其他目的包括用于接合和移动衬底的夹持器，适于安装到用于电迁移的微通道中的细线的电极阵列，以及用于读取迁移结果的扫描检测器。建立了一系列自动操作，使得一个接一个的衬底可以移动到位置，装载样品，刺激分子迁移，用光束读取，然后移除并用新鲜的底物代替。

2. 发明授权

US06787111B2 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis 有权
标题翻译：用于生物分析的微芯片中填充和清洁通道和入口的装置和方法
公开(公告)号：US06787111B2
公开(公告)日：2004-09-07
申请号：US09737675
申请日：2000-12-13
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J2219/0099 , B01L3/5027 , B01L99/00 , G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437
摘要： An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
摘要翻译：公开了一种用于填充和清洁微芯片衬底的通道和入口的装置。将包括管阵列的装置的装置插入到微芯片的每个入口端口中。该装置的管阵列包括由多个真空管包围的多个压力管。与此同时，诸如基质或洗涤剂的加压溶液被引入到微芯片上的共同的开口中，通过使用该装置的压头喷射器提供通向微芯片的微通道的通道。当将基质或洗涤溶液泵送通过微芯片衬底的共同的开口和微通道时，将洗涤溶液泵送通过多个压力管，并且通过围绕多个压力管的多个真空管将一切都抽真空。选择各种储存的溶液并通过适当的阀驱动使其流动。该过程可以通过使用适当的阀门和控制硬件/软件手动或容易地进行自动化。

3. 发明授权

US06627446B1 Robotic microchannel bioanalytical instrument 失效
标题翻译：机器人微通道生物分析仪器
公开(公告)号：US06627446B1
公开(公告)日：2003-09-30
申请号：US09109676
申请日：1998-07-02
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44704 , B01L3/5027 , B01L99/00 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437 , Y10T436/11 , Y10T436/110833 , Y10T436/25 , Y10T436/2575
摘要： A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.
摘要翻译：具有多个微通道的基板可移动地与其他可移动物体一起展开，其中可移动物体将样品载入微通道，刺激分子迁移，读取迁移结果，去除和替换基底，并准备新的运行。其他目的包括用于接合和移动衬底的夹持器，适于安装到用于电迁移的微通道中的细线的电极阵列，以及用于读取迁移结果的扫描检测器。建立了一系列自动操作，使得一个接一个的衬底可以移动到位置，装载样品，刺激分子迁移，用光束读取，然后移除并用新鲜的底物代替。

4. 发明授权

US06551839B2 Method of merging chemical reactants in capillary tubes 有权
标题翻译：将化学反应物并入毛细管中的方法
公开(公告)号：US06551839B2
公开(公告)日：2003-04-22
申请号：US09770412
申请日：2001-01-25
申请人： Stevan B. Jovanovich , Gregory J. Ronan , David J. Roach , Richard F. Johnston
发明人： Stevan B. Jovanovich , Gregory J. Ronan , David J. Roach , Richard F. Johnston
IPC分类号： G01N110
CPC分类号： G01N35/1097 , B01L3/5025 , B01L3/561 , B01L3/565 , B01L2200/026 , B01L2300/0838 , B01L2400/0406 , B01L2400/0622 , B01L2400/0644 , G01N30/20 , G01N30/24 , G01N30/6039 , G01N30/6078 , G01N2030/8827 , G02B6/3504 , G02B6/3558 , G02B6/381 , G02B6/3818 , G02B6/3825 , G02B6/3851 , G02B6/3854 , G02B6/3869 , G02B6/3877 , G02B6/3878 , G02B6/3887 , G02B6/3894 , G02B6/403 , Y10T137/86549 , Y10T436/143333 , Y10T436/2575
摘要： A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment. Connection of a plurality of macroscale pumps enables push-pull fluid motion, with routing, in a capillary system formed by a plurality of fibers coupled by switches, connectors and routers. Chemical reactions, separations and analysis may be carried out with microliter volumes or smaller.
摘要翻译：毛细阀，连接器和路由器，其中一个或多个圆柱形纤维（其可以是毛细管，堵塞的毛细管，光纤等）包括至少一个毛细管，其包含在终止于第一面的第一束纤维中。还包含一个或多个包括至少一个毛细管的纤维的第二圆柱形纤维束终止于邻接第一面的第二面。紧固件或适配器将构件与面对齐地保持在彼此偏置的对准中。多个宏观泵的连接使得能够通过布线在由被开关，连接器和路由器耦合的多个光纤形成的毛细管系统中的推挽流体运动。化学反应，分离和分析可以用微升体积或更小的量进行。

5. 发明授权

US06190616B1 Capillary valve, connector, and router 失效
标题翻译：毛细管阀，连接器和路由器
公开(公告)号：US06190616B1
公开(公告)日：2001-02-20
申请号：US08927645
申请日：1997-09-11
申请人： Stevan B. Jovanovich , Gregory J. Ronan , David J. Roach , Richard F. Johnston
发明人： Stevan B. Jovanovich , Gregory J. Ronan , David J. Roach , Richard F. Johnston
IPC分类号： G01N120
CPC分类号： G01N35/1097 , B01L3/5025 , B01L3/561 , B01L3/565 , B01L2200/026 , B01L2300/0838 , B01L2400/0406 , B01L2400/0622 , B01L2400/0644 , G01N30/20 , G01N30/24 , G01N30/6039 , G01N30/6078 , G01N2030/8827 , G02B6/3504 , G02B6/3558 , G02B6/381 , G02B6/3818 , G02B6/3825 , G02B6/3851 , G02B6/3854 , G02B6/3869 , G02B6/3877 , G02B6/3878 , G02B6/3887 , G02B6/3894 , G02B6/403 , Y10T137/86549 , Y10T436/143333 , Y10T436/2575
摘要： A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first cylindrical bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment, allowing relative rotation of the two cylindrical bundles which terminate in rotatable ferrules. Various functions achieved by rotation include a zero dead volume slide valve, a fluid router and a manifold. The fibers in each sleeve are preferably of uniform size for close symmetrical packing, but could be of disparate sizes, allowing connection of macroscale tubes to capillary tubes. A single connector member may be attached by a fastener to a reservoir or other macroscale device to bring one or more capillary tubes into fluid communication with a macroscale device. A plurality of fibers in one ferrule could allow dispensing of fluid from a single fiber in the other ferrule so that a single fiber could feed a plurality of wells through the plurality of fibers. Connection of a plurality of macroscale pumps enables push-pull fluid motion, with routing, in a capillary system formed by a plurality of fibers coupled by switches, connectors and routers. Chemical reactions, separations and analysis may be carried out with microliter volumes and smaller.
摘要翻译：一种毛细阀，连接器和路由器，其中一个或多个圆柱形纤维（其可以是毛细管，堵塞的毛细管，光纤等）包括至少一个毛细管，其包含在第一圆柱形纤维束中，其终止于第一面。还包含一个或多个包括至少一个毛细管的纤维的第二圆柱形纤维束终止于邻接第一面的第二面。紧固件或适配器将构件以与相对偏压对准的面保持在一起，允许两个圆柱形束的相对旋转，其终止于可旋转的套圈中。通过旋转实现的各种功能包括零死体积滑阀，流体路由器和歧管。每个套管中的纤维优选地具有均匀的尺寸以用于紧密对称的包装，但是可以具有不同的尺寸，允许宏观尺管连接到毛细管。单个连接器构件可以通过紧固件附接到储存器或其他宏观尺寸装置以使一个或多个毛细管与宏观尺寸装置流体连通。一个套圈中的多个纤维可以允许从另一个套圈中的单个纤维分配流体，使得单个纤维可以通过多个纤维供给多个孔。多个宏观泵的连接使得能够通过布线在由被开关，连接器和路由器耦合的多个光纤形成的毛细管系统中的推挽流体运动。化学反应，分离和分析可以用微升体积和更小的方式进行。

6. 发明授权

US06423536B1 Low volume chemical and biochemical reaction system 有权
标题翻译：低体积化学和生化反应体系
公开(公告)号：US06423536B1
公开(公告)日：2002-07-23
申请号：US09577199
申请日：2000-05-23
申请人： Stevan B. Jovanovich , David J. Roach , Andrew G. Hadd , Bo E. R. Hellman
发明人： Stevan B. Jovanovich , David J. Roach , Andrew G. Hadd , Bo E. R. Hellman
IPC分类号： C12M136
CPC分类号： C12Q1/6869 , B01J2219/00286 , B01J2219/00369 , B01J2219/00511 , B01J2219/00585 , B01J2219/00691 , B01J2219/00702 , B01J2219/00722 , B01L3/5025 , B01L7/52 , B01L2300/0838 , B01L2300/1844 , B01L2400/0409 , B01L2400/0487 , C12Q1/6806 , C12Q1/6834 , C40B40/06 , C40B60/14 , Y10S435/809 , Y10T436/113332 , Y10T436/143333 , Y10T436/2575 , C12Q2565/518 , C12Q2535/101 , C12Q2527/125
摘要： A method and device for preparing nanoscale reactions. An automated system utilizes an array of reaction chambers. The ends of the chambers are temporarily sealed with deformable membranes and reactions effected by incubation or temperature cycling. Reaction mixtures may be assembled by using the reaction containers to meter reaction components. After the reaction is finished, the reaction containers may be dispensed onto a substrate and the reaction products analyzed. An automated transfer device may be used for automated transport of the reaction container array or other transportable elements.
摘要翻译：一种制备纳米级反应的方法和装置。一个自动化系统利用一系列反应室。腔室的末端用可变形膜临时密封，并通过孵育或温度循环进行反应。可以通过使用反应容器来组装反应混合物以测量反应组分。反应完成后，将反应容器分配到基材上并分析反应产物。自动转移装置可以用于反应容器阵列或其他可运输元件的自动运输。

7. 发明授权

US08672532B2 Microfluidic methods 有权
标题翻译：微流控方法
公开(公告)号：US08672532B2
公开(公告)日：2014-03-18
申请号：US12642665
申请日：2009-12-18
申请人： Stevan B. Jovanovich , William D. Nielsen , Michael Van Nguyen
发明人： Stevan B. Jovanovich , William D. Nielsen , Michael Van Nguyen
IPC分类号： B01F5/06
CPC分类号： B01F5/06 , B01F11/0045 , B01F13/0059 , F16K99/0001 , F16K99/0015 , F16K99/0036 , F16K99/0046 , F16K99/0059 , Y10T137/0318 , Y10T137/87153 , Y10T137/877
摘要： This invention provides microfluidic devices that comprise a fluidics layer having microfluidic channels and one or more regulating layers that regulate the movement of fluid in the channels. The microfluidic devices can be used to mix one or more fluids. At least a portion of the fluidics layer can be isolated from the regulating layer, for example in the form of a shelf. Such isolated portions can be used as areas in which the temperature of liquids is controlled. Also provided are instruments including thermal control devices into which the microfluidic device is engaged so that the thermal control device controls temperature in the isolated portion, and a movable magnetic assembly including magnets with shields so that a focused magnetic field can be applied to or withdrawn from the isolated portion or any other portion of the microfluidic device. Also provided are methods of mixing fluids. The methods include stacking a plurality of alternating boluses of different liquids in a microfluidic channel, and moving the stacked boluses through the channel. In another method, the boluses are moved into a diaphragm valve having a volume able to accommodate several boluses, and then pumping the liquids out of the valve.
摘要翻译：本发明提供了微流体装置，其包括具有微流体通道的流体层和调节通道中的流体运动的一个或多个调节层。微流体装置可以用于混合一种或多种流体。流体层的至少一部分可以与调节层隔离，例如以搁板的形式。这种隔离部分可以用作控制液体温度的区域。还提供了包括热控制装置的仪器，其中微流体装置被接合到其中，使得热控制装置控制隔离部分中的温度，以及可移动磁性组件，其包括具有屏蔽的磁体，使得可以将聚焦磁场施加到或从微流体装置的隔离部分或任何其它部分。还提供了混合流体的方法。这些方法包括在微流体通道中堆叠多个不同液体的交替喷射，并且通过通道移动堆叠的推注。在另一种方法中，将大团块移动到具有能够容纳多次喷射的体积的隔膜阀中，然后将液体泵出阀。

8. 发明授权

US08388908B2 Fluidic devices with diaphragm valves 有权
标题翻译：带隔膜阀的流体装置
公开(公告)号：US08388908B2
公开(公告)日：2013-03-05
申请号：US12789186
申请日：2010-05-27
申请人： Iuliu I. Blaga , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
发明人： Iuliu I. Blaga , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , F16K99/0001 , F16K2099/0073 , Y10T137/0318 , Y10T137/2224 , Y10T137/87716 , Y10T156/10 , Y10T436/11 , Y10T436/2575
摘要： This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.
摘要翻译：本发明提供具有低故障率的隔膜阀的流体装置，特别是微流体装置。通过抑制膜片到诸如阀座，阀室和流体通道和管道的功能表面的粘附来实现低故障率。实现这一点的一种方法是提供面向隔膜，特别是阀座的暴露表面，其具有低能材料，例如贵金属，全氟化聚合物，自组装单层，硬金刚石，类金刚石碳或金属氧化物。在其他实施例中，阀设置有脊，并且隔膜用粘合剂材料粘附到流体或致动层。

9. 发明申请

US20160016140A1 Integrated Analysis System 有权
标题翻译：综合分析系统
公开(公告)号：US20160016140A1
公开(公告)日：2016-01-21
申请号：US14804675
申请日：2015-07-21
申请人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
发明人： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
IPC分类号： B01J19/00 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，库构建，扩增和测序。集成分析可以在一个或多个流体连接的模块中进行。一个或多个模块可以由计算机控制和/或自动化。可以对组织样品，临床样品或环境样品进行综合分析。集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

10. 发明申请

US20100303687A1 FLUIDIC DEVICES WITH DIAPHRAGM VALVES 有权
标题翻译：带透气阀的流体装置
公开(公告)号：US20100303687A1
公开(公告)日：2010-12-02
申请号：US12789186
申请日：2010-05-27
申请人： Iuliu I. BLAGA , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
发明人： Iuliu I. BLAGA , Stevan B. Jovanovich , Boris Kobrin , Ezra Van Gelder
IPC分类号： B01J8/00 , B81B3/00 , F15C3/04 , G05D7/00 , B32B37/02 , B32B38/10 , B32B38/00
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , F16K99/0001 , F16K2099/0073 , Y10T137/0318 , Y10T137/2224 , Y10T137/87716 , Y10T156/10 , Y10T436/11 , Y10T436/2575
摘要： This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.
摘要翻译：本发明提供具有低故障率的隔膜阀的流体装置，特别是微流体装置。通过抑制膜片到诸如阀座，阀室和流体通道和管道的功能表面的粘附来实现低故障率。实现这一点的一种方法是提供面向隔膜，特别是阀座的暴露表面，其具有低能材料，例如贵金属，全氟化聚合物，自组装单层，硬金刚石，类金刚石碳或金属氧化物。在其他实施例中，阀设置有脊，并且隔膜用粘合剂材料粘附到流体或致动层。

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