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1. 发明授权

US06387398B1 Process for producing cosmetic and pharmaceutical formulations, and products comprising same 失效
标题翻译：用于生产化妆品和药物制剂的方法以及包含其的产品
公开(公告)号：US06387398B1
公开(公告)日：2002-05-14
申请号：US09365033
申请日：1999-08-02
申请人： Jürgen Vollhardt , Nisha Malkan , Robert P. Manzo
发明人： Jürgen Vollhardt , Nisha Malkan , Robert P. Manzo
IPC分类号： A61K9127
CPC分类号： A61Q17/005 , A61K8/046 , A61K8/14 , A61K8/34 , A61K8/732 , A61K9/127 , A61Q1/06 , A61Q13/00 , A61Q15/00 , A61Q19/00 , Y10S977/907 , Y10S977/926
摘要： Cosmetic or pharmaceutical formulations such as (a) anhydrous cosmetic stick formulations and (b) anhydrous aerosol spray formulations, comprising an organic dispersion medium having particles dispersed therein, which particles are preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, modified starch, and optionally a hydrocolloid gum such as maltodextrin.
摘要翻译：化妆品或药物制剂，例如（a）无水化妆品棒制剂和（b）无水气溶胶喷雾制剂，其包含其中分散有颗粒的有机分散介质，该颗粒优选通过包括喷雾干燥脂质体包封的活性物质试剂，改性淀粉和任选的水胶体胶如麦芽糖糊精。

2. 发明授权

US6045823A Process for producing solid anhydrous composition, and pharmaceutical and cosmetic products comprising same 失效
标题翻译：制备固体无水组合物的方法，以及包含其的药物和化妆品
公开(公告)号：US6045823A
公开(公告)日：2000-04-04
申请号：US120269
申请日：1998-07-22
申请人： Jurgen Vollhardt , Robert P. Manzo , Nisha Malkan
发明人： Jurgen Vollhardt , Robert P. Manzo , Nisha Malkan
IPC分类号： A61K8/04 , A61K8/14 , A61K8/34 , A61K8/73 , A61K9/127 , A61K9/133 , A61Q1/06 , A61Q13/00 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61K91/127 , A61K7/00 , A61K7/027 , A61K7/32
CPC分类号： A61Q17/005 , A61K8/046 , A61K8/14 , A61K8/34 , A61K8/732 , A61K9/127 , A61Q1/06 , A61Q13/00 , A61Q15/00 , A61Q19/00 , Y10S977/907 , Y10S977/926
摘要： Anhydrous cosmetic stick formulations such as lip balms, lipsticks, and underarm deodorant or antiperspirant sticks, comprising an organic matrix having particles homogeneously dispersed therein, which particles are preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, modified starch, and optionally a hydrocolloid gum such as maltodextrin.
摘要翻译：无水化妆棒配方如唇膏，唇膏，腋下除臭剂或止汗棒，包含均匀分散有颗粒的有机基质，该颗粒优选通过包括喷雾干燥脂质体包封的活性剂，改性淀粉，和任选的水胶体胶如麦芽糖糊精。

3. 发明授权

US06083529A Liposome encapsulated active agent dry powder composition 失效
标题翻译：脂质体包封活性剂干粉组合物
公开(公告)号：US06083529A
公开(公告)日：2000-07-04
申请号：US59320
申请日：1998-04-13
申请人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
发明人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
IPC分类号： A61K8/14 , A61K8/73 , A61K9/127 , A61K9/133 , A61K9/14 , A61Q1/12
CPC分类号： A61K8/14 , A61K8/732 , A61K9/127 , A61K9/146 , A61Q1/12 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： A stable dry powder skin care powder having prolonged and controlled release properties, useful as baby powders, body talcs, deodorizing powders, OTC eczema preparations, foot powders, anti-fungal powders, etc. The dry powder is preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, starch and maltodextrin. The particle is designed so that activity of, e.g., an anti-inflammatory agent such as Dragosantol.RTM. can be specifically triggered by skin conditions, such as moisture, for optimal timing of delivery.
摘要翻译：具有延长和控制释放性能的稳定的干粉护肤粉，可用作婴儿粉末，身体滑石，除臭粉末，OTC湿疹制剂，足部粉末，抗真菌粉末等。干燥粉末优选通过包括喷雾混合脂质体包裹的活性剂，淀粉和麦芽糖糊精。该颗粒被设计成使得例如Dragosantol TM等抗炎剂的活性可以由皮肤状况例如水分特异性触发，以达到最佳的递送时间。

4. 发明授权

US6013524A Living air freshener 失效
标题翻译：生活空气清新剂
公开(公告)号：US6013524A
公开(公告)日：2000-01-11
申请号：US8772
申请日：1998-01-19
申请人： Gary Friars , Robert P. Manzo , Gary Titus
发明人： Gary Friars , Robert P. Manzo , Gary Titus
IPC分类号： A01G9/10 , A01G9/16 , A01G13/04 , C12N5/00 , A01G9/02 , A01G31/02
CPC分类号： A01G13/04 , A01G2009/1093
摘要： A living air freshener comprising a dwarf flowering plant such as a miniature rose plant rooted in a transparent or non-transparent growth medium in a transparent vessel, with a natural or artificial fragrance composition added directly to the growth medium or to a second compartment in said vessel. The invention also concerns a sealed package for shipping and displaying the living air freshener, which package can be easily opened to activate and/or release fragrance.
摘要翻译：一种生活空气清新剂，其包含侏儒开花植物，例如在透明容器中植根于透明或非透明生长培养基中的微型玫瑰植物，天然或人造香料组合物直接添加至所述生长培养基或所述第二隔室船只。本发明还涉及用于运输和展示生活空气清新剂的密封包装，该包装可以容易地打开以启动和/或释放香味。

5. 发明授权

US5256328A Liquid toilet bowl cleaner and sanitizer containing halogen donating nanoparticles 失效
标题翻译：含有卤素纳米颗粒的液体马桶清洁剂和消毒剂
公开(公告)号：US5256328A
公开(公告)日：1993-10-26
申请号：US991449
申请日：1992-12-16
申请人： James W. Cavanagh , Robert P. Manzo
发明人： James W. Cavanagh , Robert P. Manzo
IPC分类号： C11D3/395 , C11D3/48 , C11D7/54 , C11D17/08
CPC分类号： C11D3/3956
摘要： The present invention is directed to a liquid toilet bowl cleaning and sanitizing composition comprising an aqueous dispersion of particles of at least one halogen donating compound wherein said particles have a surface modifier absorbed on the surface thereof in an amount sufficient nanometers (nm). The compositions of the present invention can contain other conventional ingredients in toilet bowl cleaning compositions such as enzymes, surfactants, perfumes, dyes and other similar ingredients. In a preferred embodiment the composition contains:0.2-10.0 Weight percent surfactant;35.0-75.0 Weight percent halogen donating nanoparticles;1.0-7.0 Weight percent dye;0-3.0 Weight percent alkali;0.05-0.5 Weight percent fragrance; and20.0-40.0 Weight percent water.
摘要翻译：本发明涉及一种液体马桶清洁和消毒组合物，其包含至少一种供体化合物的颗粒的水性分散体，其中所述颗粒具有在其表面上以足够的纳米（nm）的量吸收的表面改性剂。本发明的组合物可以在马桶清洁组合物如酶，表面活性剂，香料，染料和其它类似成分中含有其它常规成分。在优选的实施方案中，组合物含有：0.2-10.0重量百分比的表面活性剂; 35.0-75.0重量百分比的卤素供体纳米颗粒; 1.0-7.0重量百分比染料; 0-3.0重量百分比碱; 0.05-0.5重量百分比香料; 和20.0-40.0重量百分比的水。

6. 发明授权

US6106849A Water soluble dry foam personal care product 失效
标题翻译：水溶性干泡沫个人护理产品
公开(公告)号：US6106849A
公开(公告)日：2000-08-22
申请号：US10246
申请日：1998-01-21
申请人： Nisha Malkan , Gary Friars , Robert P. Manzo
发明人： Nisha Malkan , Gary Friars , Robert P. Manzo
IPC分类号： A61K8/73 , A61Q5/02 , A61Q5/12 , A61Q9/02 , A61Q17/04 , A61Q19/10 , C11D3/22 , C11D17/00 , A61K9/10 , A61K47/36
CPC分类号： C11D3/0094 , A61K8/73 , A61Q17/04 , A61Q19/10 , A61Q5/02 , A61Q5/12 , A61Q9/02 , C11D17/0047 , C11D17/006 , C11D3/222 , A61K2800/56
摘要： A "single-use" personal care product designed to replace conventional single use products such as small bars of soap, mini-bottles of shampoo, etc. A water soluble foamed polymer structure, such as produced by freeze drying acemannan derived from aloe vera, serves as the carrier for the personal care active ingredient, and provides the bulk to the structure. The dry foamed product has high void volume, good dimensional stability, high surface area, dissolves easily and completely upon exposure to water and hand mechanical action, and leaves no adverse residue on the skin. The product does not require bottling or complex wrapping, and is much more economical and environmentally friendly than the conventional single use products it replaces. The product can be conveniently carried in a purse or pocket, so that a consumer need never be without his/her favorite personal care products.
摘要翻译：一种“一次性”个人护理产品，旨在取代常规的单一用途产品，如小肥皂皂，迷你瓶洗发水等。水溶性发泡聚合物结构，如通过冷冻干燥来自芦荟的acemannan，作为个人护理活性成分的载体，并为结构提供散装。干燥的发泡产品具有高空隙体积，良好的尺寸稳定性，高表面积，暴露于水和手部机械作用下容易和完全溶解，并且不会在皮肤上留下不良残留物。该产品不需要装瓶或复杂的包装，并且比其替代的常规单一使用产品更经济和环保。该产品可以方便地携带在钱包或口袋中，使得消费者不需要没有他/她最喜欢的个人护理产品。

7. 发明授权

US07349857B2 Process for formulating a customized skin care product 有权
标题翻译：制定定制护肤品的方法
公开(公告)号：US07349857B2
公开(公告)日：2008-03-25
申请号：US10409843
申请日：2003-04-09
申请人： Robert P. Manzo
发明人： Robert P. Manzo
IPC分类号： G06Q10/00 , C12Q1/00
CPC分类号： A45D44/00 , A45D40/00 , A45D2044/007 , A61B5/0059 , A61B5/411 , A61B5/442 , A61B5/444 , B22F9/04 , B22F9/12 , C01P2004/61 , C01P2004/84 , C01P2006/60 , C09C1/62 , C23C14/0005 , G06F19/00 , G06Q50/22
摘要： The invention relates to a method and a process of determining individual skin structure and function at a point in time for the purpose of determining and formulating skin care products that remedy the deficiencies observed in the skin. Objective and repeatable dermal biometric instrumentation techniques can be used to measure skin moisture content, sebum content, firmness and elasticity properties, skin thickness, transepidermal water loss, skin pH and to perform a photo analysis of the face with UV and visible light. By customizing the skin care products, the individually added active ingredients can be controlled, the diluents can be modified, dermal penetration rates can be controlled, the surfactant systems can be adjusted, and the stability of the product can be controlled. To prevent the loss of active materials in the product, the skin care product is manufactured for an individual consumer and is only sold in a quantity of a three months supply. Additionally, a variety of ingredients can be combined that a mass produced product cannot contain due to stability/compatibility issues. This invention overcomes the limitations in formulating skin products for the mass market by providing a product designed with objective biometric data and created for the specific clinical condition of an individual's skin.
摘要翻译：本发明涉及一种确定个体皮肤结构和功能的方法和方法，以确定和配制护肤产品，以补救皮肤中观察到的缺陷。可以使用客观和可重复的皮肤生物识别技术来测量皮肤含水量，皮脂含量，坚实度和弹性，皮肤厚度，经皮水分流失，皮肤pH值，并用紫外线和可见光进行脸部照片分析。通过定制皮肤护理产品，可以控制单独添加的活性成分，可以改变稀释剂，可以控制皮肤渗透速率，调节表面活性剂体系，可以控制产品的稳定性。为了防止产品中活性物质的损失，护肤品是为个人消费者制造的，只能以三个月的供应量出售。另外，由于稳定性/兼容性问题，大量生产的产品不能包含多种成分。本发明克服了为大众市场配制皮肤产品的局限性，提供了设计有客观生物特征数据的产品，并为个人皮肤的特定临床状况而创建。

8. 发明授权

US5783211A Liposome encapsulated active agent dry powder composition 失效
公开(公告)号：US5783211A
公开(公告)日：1998-07-21
申请号：US962906
申请日：1997-11-03
申请人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
发明人： Robert P. Manzo , Jurgen Vollhardt , Nisha Malkan , Gary Friars
IPC分类号： A61K8/14 , A61K8/73 , A61K9/127 , A61K9/133 , A61K9/14 , A61Q1/12
CPC分类号： A61K8/14 , A61K8/732 , A61K9/127 , A61K9/146 , A61Q1/12 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： A stable dry powder skin care powder having prolonged and controlled release properties, useful as baby powders, body talcs, deodorizing powders, OTC eczema preparations, foot powders, anti-fungal powders, etc. The dry powder is preferably prepared by a process comprising spray-drying a mixture of liposome encapsulated active agent, starch and maltodextrin. The particle is designed so that activity of, e.g., an anti-inflammatory agent such as Dragosantol.RTM. can be specifically triggered by skin conditions, such as moisture, for optimal timing of delivery.

9. 发明授权

US5736505A Non-alcoholic perfume or cologne 失效
标题翻译：非酒精香水或古龙水
公开(公告)号：US5736505A
公开(公告)日：1998-04-07
申请号：US706119
申请日：1996-08-30
申请人： Robert P. Manzo , Diane M. Kennedy
发明人： Robert P. Manzo , Diane M. Kennedy
IPC分类号： A61K8/39 , A61Q13/00 , A61K7/46
CPC分类号： A61Q13/00 , A61K8/39
摘要： A non-alcoholic fragrance carrier with good fragrance solubility, product stability and clarity, and silky, non-tacky rub out when applied to the skin. Glycereth-7-triacetate is used for solubilization of fragrance oil into a non-alcohol water system. The ultimate fragrance carrier product is, e.g., a perfume or cologne composition, and contains a reduced overall surfactant level and reduced overall solids level. The composition thus minimizes the use of ingredients which tend to adversely affect evaporation rates, skin feel, rub-out time, and product turbidity.
摘要翻译：非酒精香料载体，具有良好的香味溶解度，产品稳定性和透明度，并且当应用于皮肤时，丝滑，无粘性擦除。 Glycereth-7-三醋酸酯用于将香料油溶解成非醇水系统。最终的香料载体产品是例如香水或古龙水组合物，并且包含降低的总体表面活性剂水平和降低的总固体含量。因此，组合物最小化倾向于不利地影响蒸发速率，皮肤感觉，擦除时间和产品浊度的成分的使用。

10. 发明授权

US5460742A Aqueous acidic hard surface cleaner with abrasive 失效
标题翻译：水性酸性硬表面清洁剂与磨料
公开(公告)号：US5460742A
公开(公告)日：1995-10-24
申请号：US64293
申请日：1993-05-18
申请人： James W. Cavanagh , Robert P. Manzo
发明人： James W. Cavanagh , Robert P. Manzo
IPC分类号： C11D1/72 , C11D1/75 , C11D1/825 , C11D1/90 , C11D1/94 , C11D3/12 , C11D3/20 , C11D17/00 , C11D3/14 , C11D3/30 , C11D3/33
CPC分类号： C11D1/94 , C11D1/825 , C11D17/003 , C11D3/124 , C11D3/128 , C11D3/2082 , C11D1/72 , C11D1/75 , C11D1/90
摘要： Aqueous acidic thixotropic hard surface cleaning formulations, having a viscosity of 2000 to 10,000 centipoise containing on a weight to weight basis:(a) 0.5 to 6.0 percent of hydrated aluminum silicate that is substantially free of inert mineral impurities;(b) 0.1 to 3.0 percent of an amphoteric material or a highly alkoxylated block copolymer;(c) 0.1 to 5.0 percent of a nonionic surfactant selected from the group consisting of polyoxyethylene derivatives of higher alcohols and polyethylene glycol ethers of linear alcohol;(d) sufficient acid to establish a pH in the range 0.9 to 3.5;(e) 5.0 to 50.0 percent of an abrasive;(f) 1.0 to 5.0 percent of a cleaning solvent; and(g) sufficient deionized water to make 100 percent.
摘要翻译：水性酸性触变性硬表面清洁剂，其粘度为2000至10,000厘泊，其重量为基重：（a）基本上不含惰性矿物杂质的水合硅酸铝的0.5-6.0％（b）0.1〜3.0％的两性材料或高度烷氧基化的嵌段共聚物; （c）0.1〜5.0％的选自高级醇的聚氧乙烯衍生物和直链醇的聚乙二醇醚的非离子表面活性剂; （d）足够的酸以建立0.9至3.5的pH值; （e）5.0〜50.0％的磨料; （f）1.0〜5.0％的清洗溶剂; 和（g）足够的去离子水使100％。

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