专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050119471A1 Sequence analysis of the tetravalent rotavirus vaccine 失效
标题翻译：四价轮状病毒疫苗的序列分析
公开(公告)号：US20050119471A1
公开(公告)日：2005-06-02
申请号：US10505818
申请日：2003-02-19
申请人： Deborah Buonagurio , Alice Georgiu , Robert Lerch , Bruce Mason , Shridhara Murthy , Ruth Rappaport , Mohinder Sidhu , Stephen Udem , Timothy Zamb
发明人： Deborah Buonagurio , Alice Georgiu , Robert Lerch , Bruce Mason , Shridhara Murthy , Ruth Rappaport , Mohinder Sidhu , Stephen Udem , Timothy Zamb
IPC分类号： A61K39/00 , C07K14/14 , C12N7/04 , C12Q1/70 , C07H21/04 , C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N2720/12322 , C12N2720/12362 , C12Q1/701
摘要： Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus: human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules.
摘要翻译：公开了分离的核酸分子，其包含来自恒河猴轮状病毒（RRV）的基因片段或三种恒河猴中的一种：人重配病毒，包括具有选自以下的序列的分离的核酸分子：SEQ ID NO：1-14 和包含编码具有选自SEQ ID NO：15-28的序列的蛋白质的分离的核酸分子，以及分离的核酸分子的变体。

2. 发明授权

US6060280A Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins 失效
标题翻译：编码牛呼吸道合胞病毒免疫原性蛋白的核苷酸序列
公开(公告)号：US6060280A
公开(公告)日：2000-05-09
申请号：US118148
申请日：1993-09-08
申请人： Gail W. Wertz , Robert Lerch
发明人： Gail W. Wertz , Robert Lerch
IPC分类号： A61K39/155 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/395 , A61P11/00 , A61P31/12 , A61P37/04 , C07K14/00 , C07K14/01 , C07K14/115 , C07K14/135 , C07K16/00 , C07K16/08 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/01 , C12R1/645 , C12R1/91 , C12R1/93 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/569 , G01N33/577 , C12P21/06 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2760/18522
摘要： The present invention relates to recombinant DNA molecules which encode bovine respiratory syncytial (BRS) virus proteins, to BRS virus proteins, and peptides and to recombinant BRS virus vaccines produced therefrom. It is based, in part, on the cloning of substantially full length cDNAs which encode the entire BRS virus C, F, and N proteins. According to particular embodiments of the invention, DNA encoding a BRS virus protein or peptide may be used to diagnose BRS virus infection, or, alternatively, may be inserted into an expression vector, including, but not limited to, vaccinia virus as well as bacterial, yeast, insect, or other vertebrate vectors. These expression vectors may be utilized to produce the BRS virus protein or peptide in quantity; the resulting substantially pure viral peptide or protein may be incorporated into subunit vaccine formulations or may be used to generate monoclonal or polyclonal antibodies which may be utilized in diagnosis of BRS virus infection or passive immunization. In additional embodiments, BRS virus protein sequence provided by the invention may be used to produce synthetic peptides or proteins which may be utilized in subunit vaccines,or polyclonal or monoclonal antibody production. Alternatively, a nonpathogenic expression vector containing the genes, parts of the genes, any combination of the genes, or parts thereof may itself be utilized as a recombinant virus vaccine.
摘要翻译：本发明涉及编码牛呼吸道合胞体（BRS）病毒蛋白质，BRS病毒蛋白质的重组DNA分子，以及由其产生的重组BRS病毒疫苗。其部分基于克隆编码整个BRS病毒C，F和N蛋白的基本上全长的cDNA。根据本发明的具体实施方案，编码BRS病毒蛋白或肽的DNA可用于诊断BRS病毒感染，或者可以将其插入到表达载体中，包括但不限于痘苗病毒以及细菌，酵母，昆虫或其他脊椎动物载体。这些表达载体可以用来量产BRS病毒蛋白或肽; 所得到的基本上纯的病毒肽或蛋白质可以并入亚单位疫苗制剂中，或可用于产生可用于诊断BRS病毒感染或被动免疫的单克隆或多克隆抗体。在另外的实施方案中，本发明提供的BRS病毒蛋白质序列可用于产生可用于亚单位疫苗或多克隆或单克隆抗体产生的合成肽或蛋白质。或者，含有基因，部分基因，基因的任何组合或其部分的非致病性表达载体本身可以用作重组病毒疫苗。

3. 发明授权

US06730305B1 Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins 失效
标题翻译：编码牛呼吸道合胞病毒免疫原性蛋白的核苷酸序列
公开(公告)号：US06730305B1
公开(公告)日：2004-05-04
申请号：US09567458
申请日：2000-05-08
申请人： Gail W. Wertz , Robert Lerch
发明人： Gail W. Wertz , Robert Lerch
IPC分类号： A61K39155
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5256 , C12N2710/24143 , C12N2760/18522 , C12N2760/18534
摘要： The present invention relates to recombinant DNA molecules which encode bovine respiratory syncytial (BRS) virus proteins, to BRS virus proteins, and peptides and to recombinant BRS virus vaccines produced therefrom. It is based, in part, on the cloning of substantially full length cDNAs which encode the entire BRS virus G, F, and N proteins. According to particular embodiments of the invention, DNA encoding a BRS virus protein or peptide may be used to diagnose BRS virus infection, or, alternatively, may be inserted into an expression vector, including, but not limited to, vaccinia virus as well as bacterial, yeast, insect, or other vertebrate vectors. These expression vectors may be utilized to produce the BRS virus protein or peptide in quantity; the resulting substantially pure viral peptide or protein may be incorporated into subunit vaccine formulations or may be used to generate monoclonal or polyclonal antibodies which may be utilized in diagnosis of BRS virus infection or passive immunization. In additional embodiments, BRS virus protein sequence provided by the invention may be used to produce synthetic peptides or proteins which may be utilized in subunit vaccines, or polyclonal or monoclonal antibody production. Alternatively, a nonpathogenic expression vector containing the genes, parts of the genes, any combination of the genes, or parts thereof may itself be utilized as a recombinant virus vaccine.
摘要翻译：本发明涉及编码牛呼吸道合胞体（BRS）病毒蛋白质，BRS病毒蛋白质的重组DNA分子，以及由其产生的重组BRS病毒疫苗。其部分基于克隆编码整个BRS病毒G，F和N蛋白的基本上全长的cDNA。根据本发明的具体实施方案，编码BRS病毒蛋白或肽的DNA可用于诊断BRS病毒感染，或者可以将其插入到表达载体中，包括但不限于痘苗病毒以及细菌，酵母，昆虫或其他脊椎动物载体。这些表达载体可以用来量产BRS病毒蛋白或肽; 所得到的基本上纯的病毒肽或蛋白质可以并入亚单位疫苗制剂中，或可用于产生可用于诊断BRS病毒感染或被动免疫的单克隆或多克隆抗体。在另外的实施方案中，本发明提供的BRS病毒蛋白质序列可用于产生可用于亚单位疫苗或多克隆或单克隆抗体产生的合成肽或蛋白质。或者，含有基因，部分基因，基因的任何组合或其部分的非致病性表达载体本身可以用作重组病毒疫苗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式