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1. 发明申请

US20160206761A9 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents 审中-公开
标题翻译：可重构的微球组合物可用作超声波对比剂
公开(公告)号：US20160206761A9
公开(公告)日：2016-07-21
申请号：US13712192
申请日：2012-12-12
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

2. 发明申请

US20090274628A1 RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS 审中-公开
标题翻译：可重复使用的微波组合物作为超声对比剂
公开(公告)号：US20090274628A1
公开(公告)日：2009-11-05
申请号：US12329202
申请日：2008-12-05
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K9/10 , A61K9/1647 , A61K9/1658 , A61K9/19 , A61K9/5052 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K47/10 , A61K47/183 , A61K47/26 , A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugars) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

3. 发明授权

US06776761B2 Hollow microspheres with controlled fragility for medical use 有权
标题翻译：具有受控脆弱性的中空微球用于医疗用途
公开(公告)号：US06776761B2
公开(公告)日：2004-08-17
申请号：US10225252
申请日：2002-08-20
申请人： Thomas B. Ottoboni , E. Glenn Tickner , Robert E. Short , Ronald K. Yamamoto
发明人： Thomas B. Ottoboni , E. Glenn Tickner , Robert E. Short , Ronald K. Yamamoto
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B5/4839 , A61B8/04 , A61B8/06 , A61K9/0009 , A61K9/5073 , A61K41/0028 , A61K49/223
摘要： A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness to microbubble diameter is substantially similar across the population of microbubbles. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
摘要翻译：描述了一种用于超声成像的组合物，其具有受控脆性的微泡群体。微泡包括外壳和中空芯。壳体厚度与微泡直径的比例在微泡群体上基本相似。描述了使用这种组合物对流体填充腔，容器或组织进行成像的方法。

4. 发明授权

US06193951B1 Microparticles useful as ultrasonic contrast agents 失效
标题翻译：微粒可用作超声造影剂
公开(公告)号：US06193951B1
公开(公告)日：2001-02-27
申请号：US09070474
申请日：1998-04-30
申请人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
发明人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
IPC分类号： A61B813
CPC分类号： A61K49/223 , A61K41/0028 , A61K47/6925 , A61K49/225
摘要： Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
摘要翻译：提供了微粒，其包括生物相容性材料的外层的外壳和可生物降解的聚合物的内层。微粒的核心含有用于药物递送的气体，液体或固体，或用作超声造影成像的造影剂。微粒能够通过受试者的毛细管系统。

5. 发明申请

US20140161726A1 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents 审中-公开
标题翻译：可重构的微球组合物可用作超声波对比剂
公开(公告)号：US20140161726A1
公开(公告)日：2014-06-12
申请号：US13712192
申请日：2012-12-12
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

6. 发明申请

US20120052016A1 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents 有权
标题翻译：可重构的微球组合物可用作超声波对比剂
公开(公告)号：US20120052016A1
公开(公告)日：2012-03-01
申请号：US13252743
申请日：2011-10-04
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22 , B67D7/00
CPC分类号： A61K49/223 , A61K9/10 , A61K9/1647 , A61K9/1658 , A61K9/19 , A61K9/5052 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K47/10 , A61K47/183 , A61K47/26 , A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

7. 发明申请

US20090081130A1 MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS AND FOR DELIVERY OF DRUGS INTO THE BLOODSTREAM 审中-公开
标题翻译：微量元素作为超声对比剂和用于将药物输送到血液中
公开(公告)号：US20090081130A1
公开(公告)日：2009-03-26
申请号：US12329305
申请日：2008-12-05
申请人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
发明人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K41/0028 , A61K47/6925 , A61K49/225
摘要： Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
摘要翻译：提供了微粒，其包括生物相容性材料的外层的外壳和可生物降解的聚合物的内层。微粒的核心含有用于药物递送的气体，液体或固体，或用作超声造影成像的造影剂。微粒能够通过受试者的毛细管系统。

8. 发明授权

US06919068B2 Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging 失效
标题翻译：制备用于回波成像的气体填充聚合物基质微粒的方法
公开(公告)号：US06919068B2
公开(公告)日：2005-07-19
申请号：US10150449
申请日：2002-05-17
申请人： Robert E. Short
发明人： Robert E. Short
IPC分类号： A61K49/22 , B01J13/02 , A61B8/00 , A61K9/50 , B01F17/00
CPC分类号： A61K49/223 , B01J13/02
摘要： A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation. The resulting porous microparticles can receive a gas and be used as an ultrasound contrast agent.
摘要翻译：提供了一种制备具有聚合物基体内部的充气多孔微粒的方法，其可用作超声回声造影剂。形成水包油悬浮液，两相冷冻，然后通过升华除去水和非水冷冻相。所得到的多孔微粒可以接受气体并用作超声造影剂。

9. 发明授权

US5278194A Environmentall dispersible syntactic foam 失效
标题翻译：环境可分散的复合泡沫
公开(公告)号：US5278194A
公开(公告)日：1994-01-11
申请号：US36915
申请日：1993-03-25
申请人： E. Glenn Tickner , Robert E. Short
发明人： E. Glenn Tickner , Robert E. Short
IPC分类号： B01J13/12 , B65D65/46 , C08J9/32
CPC分类号： C08J9/32 , B01J13/12 , B65D65/46 , Y02W90/13 , Y10S521/916
摘要： A syntactic foam product having a desired configuration is set forth. The product comprises a plurality of rigid gas filled bubbles arranged in the desired configuration. The bubbles are defined by respective individual and discrete substantially spherical shells preferably formed of a biodegradable shell material. The shells abut one another. They define open spaces where they are not abutting. Attaching material attaches the abutting shells to one another. The open spaces between the shells are not filled by the attaching material. The attaching material is environmentally degradable. It releases the bubbles under ambient conditions after a selected time interval. The shells are in contact with their surroundings and can relatively rapidly biodegrade.
摘要翻译：阐述了具有所需结构的复合泡沫产品。该产品包括以所需构造排列的多个刚性气体填充气泡。气泡由相应的个体和离散的基本上为球形的壳体限定，优选由可生物降解的壳材料形成。壳彼此靠拢。它们定义了不邻接的空位。附着材料将相邻的壳体相互连接起来。壳体之间的开放空间未被附着材料填充。附着材料是环境可降解的。在选定的时间间隔后，它会在环境条件下释放气泡。壳体与其周围环境接触并能相对快速地生物降解。

10. 发明授权

US4691762A Personal temperature control system 失效
标题翻译：个人温控系统
公开(公告)号：US4691762A
公开(公告)日：1987-09-08
申请号：US839737
申请日：1986-03-14
申请人： William Elkins , Eugene W. Connell , Robert E. Short
发明人： William Elkins , Eugene W. Connell , Robert E. Short
IPC分类号： A61F7/00 , A61F7/02 , A62B17/00
CPC分类号： A61F7/02 , A41D13/0053 , A62B17/005 , A61F2007/0001 , A61F2007/0054 , A61F2007/0086 , Y10S165/046
摘要： A personal temperature control system including a first heat exchanger adapted to be worn as a garment and a second heat exchanger adapted to interact with a temperature source, the first and second heat exchangers being interconnected through a pump and reservoir unit. The first heat exchanger together with the pump and reservoir are portable and in one embodiment the second heat exchanger is constructed to be fully portable. Specific devices including automatic quick release couplings interconnect the first heat exchanger to the second heat exchanger through the pump and reservoir. The fabrication of the first heat exchanger in helmet and vest portions is disclosed together with a control display unit housing the pump and reservoir and including an adjustable flow valve connected in parallel with the second heat exchanger. A preferred embodiment of the adjustable flow valve provides non-linear change in rate of flow upon adjustment.
摘要翻译：一种个人温度控制系统，包括适于作为服装穿着的第一热交换器和适于与温度源相互作用的第二热交换器，所述第一和第二热交换器通过泵和储存器单元相互连接。第一热交换器与泵和储存器一起是便携式的，并且在一个实施例中，第二热交换器被构造为完全便携式。包括自动快速释放联轴器的特定装置通过泵和储存器将第一热交换器与第二热交换器互连。头盔和背心部分中的第一热交换器的制造与容纳泵和容器的控制显示单元一起公开，并且包括与第二热交换器并联连接的可调节流量阀。可调节流量阀的优选实施例在调节时提供流量的非线性变化。

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