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1. 发明申请

US20090263407A1 Cationic Lipids and Uses Thereof 审中-公开
标题翻译：阳离子脂质及其用途
公开(公告)号：US20090263407A1
公开(公告)日：2009-10-22
申请号：US12425254
申请日：2009-04-16
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
IPC分类号： A61K47/18 , C07D207/08 , C07D317/26 , C07D317/28 , C07C229/34 , C07C217/48 , C07C217/28 , A61K47/22 , A61K31/7088 , A61K31/7105 , A61K39/00 , A61K38/02
CPC分类号： C07D207/08 , A61K9/1271 , A61K9/1272 , C07C205/43 , C07C217/28 , C07C235/08 , C07C271/16 , C07D211/22 , C07D233/54 , C07D241/12 , C07D243/08 , C07D265/30 , C07D317/28 , C07D403/04
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
摘要翻译：公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。

2. 发明申请

US20100104629A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
公开(公告)号：US20100104629A1
公开(公告)日：2010-04-29
申请号：US12557294
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , A61K39/00 , A61K38/02 , A61K31/7088 , A61K47/22 , A61K47/18 , C07D207/08 , C07D317/28 , C07D317/26 , C07C229/34 , C07C217/48 , C07C217/28
CPC分类号： A61K9/1272 , C07C205/43 , C07C217/28 , C07C229/34 , C07C235/08 , C07C271/16 , C07D207/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/22 , C07D213/74 , C07D233/54 , C07D233/60 , C07D239/22 , C07D241/12 , C07D243/08 , C07D265/30 , C07D295/088 , C07D295/108 , C07D317/18 , C07D317/28 , C07D403/04 , C07D405/06
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

3. 发明申请

US20100099738A1 POLYETHYLENE GLYCOL LIPID CONJUGATES AND USES THEREOF 审中-公开
标题翻译：聚乙烯甘油脂糖浆及其用途
公开(公告)号：US20100099738A1
公开(公告)日：2010-04-22
申请号：US12556836
申请日：2009-09-10
申请人： Todd M. Hansen , Robert D. Hubbard , Leiming Li , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Todd M. Hansen , Robert D. Hubbard , Leiming Li , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K31/711 , C07C53/126 , C07C229/00 , C07D207/04 , A61K31/215 , A61K31/40 , A61P43/00
CPC分类号： A61K47/6907
摘要： Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
摘要翻译：公开了聚乙二醇（PEG）脂质偶联物，聚乙二醇（PEG） - 脂质缀合物的药物递送系统，其制备方法和使用它们治疗疾病的方法。

4. 发明申请

US20100063135A1 POLYETHYLENE GLYCOL LIPID CONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：US20100063135A1
公开(公告)日：2010-03-11
申请号：US12556886
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , William E. Kohlbrenner , Leiming Li , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , William E. Kohlbrenner , Leiming Li , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K31/7105 , C07C229/00 , C07F9/02 , C07C233/01 , C07H21/02 , C07K17/00 , A61K31/56 , A61K31/225 , A61K31/40
CPC分类号： A61K9/0019 , A61K9/0004 , A61K9/1271 , A61K9/1272 , A61K31/225 , A61K31/40 , A61K31/7105
摘要： Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

5. 发明申请

US20100055168A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
公开(公告)号：US20100055168A1
公开(公告)日：2010-03-04
申请号：US12557188
申请日：2009-09-10
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Aparna V. Sarthy , Yu Shen , Lu Tian , Carol K. Wada , Xiaobin Zhao
IPC分类号： A61K9/127 , C07C229/00 , A61K47/14 , A61K38/16 , A61K31/7088 , A61K38/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , C07C45/29 , C07C45/515 , C07C205/43 , C07C217/28 , C07C219/06 , C07C235/08 , C07C271/16 , C07D295/088 , C07D317/04 , C12N15/88 , C07C47/277 , C07C49/255 , C07C49/175
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

6. 发明授权

US08067409B2 Protein kinase inhibitors 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US08067409B2
公开(公告)日：2011-11-29
申请号：US12274834
申请日：2008-11-20
申请人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
发明人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
IPC分类号： C07D513/04 , A61K31/425
CPC分类号： C07D513/04
摘要： Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译：公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

7. 发明申请

US20100076055A1 Cationic Lipids and Uses Thereof 审中-公开
标题翻译：阳离子脂质及其用途
公开(公告)号：US20100076055A1
公开(公告)日：2010-03-25
申请号：US12425266
申请日：2009-04-16
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
IPC分类号： A61K31/7105 , C07C229/04 , A61K31/711 , A61P43/00
CPC分类号： A61K31/00 , A61K9/1272 , C07C217/28 , C07C219/06 , C07C233/18 , C07C235/08 , C07C271/16
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
摘要翻译：公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。

8. 发明申请

US20090285881A1 CATIONIC LIPIDS AND USES THEREOF 审中-公开
标题翻译：阳离子脂肪及其用途
公开(公告)号：US20090285881A1
公开(公告)日：2009-11-19
申请号：US12425198
申请日：2009-04-16
申请人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
发明人： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
IPC分类号： A61K9/127 , C11C3/00 , A61K31/16 , A61K31/265 , C07C229/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/16 , A61K31/265 , C07C45/29 , C07C45/515 , C07C205/43 , C07C217/28 , C07C219/06 , C07C235/08 , C07C271/16 , C07D295/088 , C07D317/04 , C12N15/88 , C07C47/277 , C07C49/255 , C07C49/175
摘要： Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
摘要翻译：公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。

9. 发明授权

US06562782B1 Oligocycloalkanoid compounds and methods of use 失效
标题翻译：寡核苷酸类化合物及其使用方法
公开(公告)号：US06562782B1
公开(公告)日：2003-05-13
申请号：US09568403
申请日：2000-05-10
申请人： Benjamin L. Miller , Robert D. Hubbard
发明人： Benjamin L. Miller , Robert D. Hubbard
IPC分类号： A61K31015
CPC分类号： A61K31/405 , A61K31/015 , A61K31/198 , Y02A50/411 , Y02A50/414 , Y02A50/423
摘要： The present invention related to an oligocycloalkanoid compound comprising formula (I) wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O—, carbonyl, oxygen, or sulfur; X and Y are independently hydrogen, hydroxy, alkyl, or in combination an electrophilic group; and R1 through R10 are independently hydrogen, hydroxy, alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, N-, S-, or O-heterocycles, fused or multi-ring aryl with or without hetero ring members, arylalkyl, arylalkenyl, arylalkynyl, alkylphenyl, alkenylphenyl, alkynylphenyl, alkoxy, alkenyloxy, alkynyloxy, substituted or unsubstituted aryloxy, substituted or unsubstituted arylalkoxy, alkylacyl, alkenylacyl, alkynylacyl, arylacyl, aroyl, alkylaroyl, aminoaroyl, aminoalkylacyl, aminoalkyl, aminoalkenyl, aminoalkynyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, dialkylamino, dialkenylamino, dialkynylamino, arylalkylamino, arylalkenylamino, imino, alkylimino, alkenylimino, alkynylimino, arylimino, thiol, sulfoxide, alkyl sulfonamide, alkenyl sulfonamide, alkynyl sulfonamide, aryl sulfonamide, alkyl sulfonate ester, alkenyl sulfonate ester, alkynyl sulfonate ester, aryl sulfonate ester, amino acid, or polypeptide, with at least one of R1 through R4 and at least one of R7 through R10 being other than hydrogen. Also disclosed are a pharmaceutical composition including an oligocycloalkanoid compound of the present invention, and methods of using such compounds or compositions for treating a bacterial infection, inhibiting or treating septic shock, treating a disease caused by bacterial endotoxin, and inhibiting the activity of cathepsin K.
摘要翻译：本发明涉及包含式（I）的寡核苷酸化合物，其中m，n和o独立地为0至2的整数; A1至A10独立地为直链，亚烷基，亚烷基-O-，羰基，氧或硫; X和Y独立地是氢，羟基，烷基或者亲电基团的组合; R 1至R 10独立地为氢，羟基，烷基，烯基，炔基，取代或未取代的芳基，N-，S-或O-杂环，具有或不具有杂环成员的稠合或多环芳基，芳基烷基，芳基烯基，芳基炔基烷基苯基，烯基苯基，炔基苯基，烷氧基，烯氧基，炔氧基，烷氧基，烯氧基，炔氧基，取代或未取代的芳氧基，取代或未取代的芳基烷氧基，烷基酰基，链烯基酰基，炔酰基，芳基酰基，芳酰基，烷酰基，氨基酰基，氨基烷基酰基，氨基烷基，氨基烯基，氨基炔基，氨基，烷基氨基，炔基氨基，芳基氨基，二烷基氨基，二烷基氨基，二炔基氨基，芳基烷基氨基，芳基烯基氨基，亚氨基，烷基亚氨基，烯基亚氨基，炔基亚氨基，芳基亚氨基，硫醇，亚砜，烷基磺酰胺，烯基磺酰胺，炔基磺酰胺，芳基磺酰胺，烷基磺酸酯，链烯基磺酸酯，炔基磺酸酯，芳基磺酸酯，氨基酸或多肽，与至少一个R1至R4和至少一个 R7至R10不是氢。还公开了包含本发明的低聚核糖类化合物的药物组合物，以及使用这些化合物或组合物治疗细菌感染，抑制或治疗败血性休克，治疗细菌内毒素引起的疾病和抑制组织蛋白酶K的活性的方法。

10. 发明申请

US20090253723A1 PROTEIN KINASE INHIBITORS 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20090253723A1
公开(公告)日：2009-10-08
申请号：US12274834
申请日：2008-11-20
申请人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
发明人： Nwe Y. Ba-Maung , Randy L. Bell , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Robert D. Hubbard , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang
IPC分类号： A61K31/506 , C07D239/42 , A61P35/00
CPC分类号： C07D513/04
摘要： Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译：公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

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