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1. 发明授权

US5780053A Cationic phospholipids for transfection 失效
公开(公告)号：US5780053A
公开(公告)日：1998-07-14
申请号：US466417
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.

2. 发明授权

US5688958A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5688958A
公开(公告)日：1997-11-18
申请号：US468873
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质体转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们不仅在脂质体转染中有效，而且非常便宜且易于制备。

3. 发明授权

US5686620A Cationic phospholipids for transfection 失效
公开(公告)号：US5686620A
公开(公告)日：1997-11-11
申请号：US522607
申请日：1995-09-01
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.

4. 发明授权

US5661018A Cationic phospholipids for transfection 失效
公开(公告)号：US5661018A
公开(公告)日：1997-08-26
申请号：US470916
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88 , C12N15/66
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.

5. 发明授权

US5651981A Cationic phospholipids for transfection 失效
公开(公告)号：US5651981A
公开(公告)日：1997-07-29
申请号：US220376
申请日：1994-03-29
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.

6. 发明授权

US4793443A Dynamic assignment switching in the dispatching of elevator cars 失效
标题翻译：电梯轿厢调度动态分配切换
公开(公告)号：US4793443A
公开(公告)日：1988-12-27
申请号：US168817
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18 , B66B1/20 , B66B1/24
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/233
摘要： A method for assigning hall calls to a plurality of elevator cars on the basis of the estimating the time of arrival (ETA) of each elevator car at the floor of the hall call to be assigned. A new hall call is assigned to the car having the lowest ETA. A previously assigned hall call is reassigned to a car having a lower ETA than the car presently assigned to serve the call when the lower ETA is lower by a value T. The average call waiting time (AWT) is calculated using a selected period of time to tabulate the number of calls and cumulative call waiting time, and this calculated value is compared with the desired AWT for the elevator system. The value of T is changed when the calculated and desired values of ETA have a predetermined relationship.
摘要翻译：基于在要分配的门厅呼叫的楼层估计每个电梯轿厢的到达时间（ETA）的基础上，向多个电梯轿厢分配门厅呼叫的方法。具有最低ETA的汽车分配了一个新的门厅呼叫。先前分配的门厅呼叫被重新分配给具有比目前被分配来服务呼叫的轿厢的ETA低的汽车，当较低的ETA低一个值T时。平均呼叫等待时间（AWT）是使用选定的时间段列出呼叫次数和累积呼叫等待时间，并将该计算值与电梯系统的所需AWT进行比较。当计算的和期望的ETA值具有预定的关系时，T的值被改变。

7. 发明授权

US4129199A Elevator system 失效
标题翻译：电梯系统
公开(公告)号：US4129199A
公开(公告)日：1978-12-12
申请号：US792289
申请日：1977-04-29
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
IPC分类号： B66B1/20
CPC分类号： B66B1/20
摘要： An elevator system, and method of operating same, which includes a plurality of elevator cars mounted in a building to serve the floors therein. The building includes a special floor, located between the top and bottom floors, from which all calls for elevator service in the up and down directions may be registered. Supervisory control apparatus, which assigns a hall call to a selected elevator car, gives priority to a predetermined service direction from the special floor when hall calls for both the up and down directions coexist therefrom, with the priority direction being responsive to the position of the special floor in the building.
摘要翻译：一种电梯系统及其操作方法，其包括安装在建筑物中以服务于其中的楼层的多个电梯轿厢。该建筑物包括位于顶层和底层之间的特殊楼层，所有上下方向的所有电梯服务电话都可以登记。向所选择的电梯轿厢分配门厅呼叫的监视控制装置，当门厅呼叫上下方向共同存在时，从特殊楼层优先考虑预定的服务方向，优先方向是响应于特大楼层。

8. 发明授权

US06187760B1 Cationic phospholipids for transfection 有权
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US06187760B1
公开(公告)日：2001-02-13
申请号：US09245541
申请日：1999-02-05
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： A01N4304
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to male.
摘要翻译：公开了一类新型的阳离子磷脂及其合成方法。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质体转染中是有效的。这些新型磷脂是特别有吸引力的，因为它们不仅在脂质转染中有效，而且对于男性来说是非常便宜和容易的。

9. 发明授权

US4784240A Method for using door cycle time in dispatching elevator cars 失效
标题翻译：在电梯轿厢调度中使用门循环时间的方法
公开(公告)号：US4784240A
公开(公告)日：1988-11-15
申请号：US169206
申请日：1988-03-16
申请人： Robert C. MacDonald , Gerald M. Rees , Elsa Abrego , Matthew Martin , Jon Howard , Marjorie J. Polis , Jeffrey W. Blain
发明人： Robert C. MacDonald , Gerald M. Rees , Elsa Abrego , Matthew Martin , Jon Howard , Marjorie J. Polis , Jeffrey W. Blain
IPC分类号： B66B1/18 , B66B1/20 , B66B1/24 , B66B1/46
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/233
摘要： An elevator dispatching method which estimates the time of arrival (ETA) of each car at the floor of a hall call to be assigned. A building profile of average door cycle times per floor, over predetermined periods of the day, is tabulated and used in the ETA calculations, to provide more accurate ETA values and thus a lower average call waiting time.
摘要翻译：一种电梯调度方法，用于估计每个轿厢在要分配的门厅呼叫的楼层处的到达时间（ETA）。在ETA计算中列出并在ETA计算中使用每层楼平均门循环次数的建筑物轮廓，以提供更准确的ETA值，从而降低平均呼叫等待时间。

10. 发明授权

US4482032A Elevator emergency control system 失效
标题翻译：电梯应急控制系统
公开(公告)号：US4482032A
公开(公告)日：1984-11-13
申请号：US488340
申请日：1983-04-25
申请人： Emanuel E. Enriquez , Robert C. MacDonald
发明人： Emanuel E. Enriquez , Robert C. MacDonald
IPC分类号： B66B1/46 , B66B5/02 , B66B5/00
CPC分类号： B66B1/468 , B66B5/021 , B66B2201/4646 , B66B2201/4661 , B66B2201/4676
摘要： An emergency control system for use in an elevator system. When an emergency situation arises in an elevator car, an elevator passenger recites a code word. A microphone in the elevator car transforms the vocal signal to an electrical signal, and using a voice-recognition system, the spoken code word is compared with a code word stored in memory. If the spoken code word matches the stored code word, control of the elevator system is switched to an emergency mode. In this mode the elevator car is brought to a predetermined landing and an intercom system providing communication between the elevator car and the guard station is activated. At the predetermined landing, security personnel are available to render assistance to the elevator passenger when the elevator doors open.
摘要翻译：一种用于电梯系统的应急控制系统。当电梯轿厢出现紧急情况时，电梯乘客背着码字。电梯轿厢中的麦克风将声音信号转换为电信号，并且使用语音识别系统将口语码字与存储在存储器中的码字进行比较。如果口语码字与存储的码字匹配，则电梯系统的控制被切换到紧急模式。在这种模式中，电梯轿厢被带到预定的起落架，并且启动了提供电梯轿厢和保护站之间的通信的对讲系统。在预定的着陆点，当电梯门打开时，保安人员可以向电梯乘客提供协助。

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