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1. 发明授权

US4784240A Method for using door cycle time in dispatching elevator cars 失效
标题翻译：在电梯轿厢调度中使用门循环时间的方法
公开(公告)号：US4784240A
公开(公告)日：1988-11-15
申请号：US169206
申请日：1988-03-16
申请人： Robert C. MacDonald , Gerald M. Rees , Elsa Abrego , Matthew Martin , Jon Howard , Marjorie J. Polis , Jeffrey W. Blain
发明人： Robert C. MacDonald , Gerald M. Rees , Elsa Abrego , Matthew Martin , Jon Howard , Marjorie J. Polis , Jeffrey W. Blain
IPC分类号： B66B1/18 , B66B1/20 , B66B1/24 , B66B1/46
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/233
摘要： An elevator dispatching method which estimates the time of arrival (ETA) of each car at the floor of a hall call to be assigned. A building profile of average door cycle times per floor, over predetermined periods of the day, is tabulated and used in the ETA calculations, to provide more accurate ETA values and thus a lower average call waiting time.
摘要翻译：一种电梯调度方法，用于估计每个轿厢在要分配的门厅呼叫的楼层处的到达时间（ETA）。在ETA计算中列出并在ETA计算中使用每层楼平均门循环次数的建筑物轮廓，以提供更准确的ETA值，从而降低平均呼叫等待时间。

2. 发明授权

US4782921A Coincident call optimization in an elevator dispatching system 失效
标题翻译：电梯调度系统中的重合调用优化
公开(公告)号：US4782921A
公开(公告)日：1988-11-08
申请号：US168791
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18 , B66B1/20 , B66B1/24
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/233
摘要： A method of optimizing the handling of coincident calls in an elevator system which employs ETA strategy in assigning hall calls to a plurality of elevator cars. The method dynamically biases the ETA value of a car having a car call for the floor of the hall call being assigned, with the bias being applied to favor assignment of the hall call to the car having the coincident car call. The amount of the bias is inversely proportional to the car travel distance between the advanced position (AVP floor) of the elevator car and the floor associated with the hall call (scan floor). The relative effect of the bias is predetermined for each floor by preselection of a constant K used in the bias calculation.
摘要翻译：一种在电梯系统中优化一致呼叫的处理方法，该电梯系统采用ETA策略来向多个电梯轿厢分配门厅呼叫。该方法动态地偏置具有被分配的门厅呼叫的楼层的轿厢呼梯的汽车的ETA值，并且施加偏压以有利于将门厅呼叫分配给具有重合汽车呼叫的汽车。偏置量与电梯轿厢的高级位置（AVP楼层）与门厅呼叫（扫描楼层）相关联的楼层之间的轿厢行驶距离成反比。通过预先选择偏差计算中使用的常数K，预定每个层的偏置的相对影响。

3. 发明授权

US4793443A Dynamic assignment switching in the dispatching of elevator cars 失效
标题翻译：电梯轿厢调度动态分配切换
公开(公告)号：US4793443A
公开(公告)日：1988-12-27
申请号：US168817
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18 , B66B1/20 , B66B1/24
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/233
摘要： A method for assigning hall calls to a plurality of elevator cars on the basis of the estimating the time of arrival (ETA) of each elevator car at the floor of the hall call to be assigned. A new hall call is assigned to the car having the lowest ETA. A previously assigned hall call is reassigned to a car having a lower ETA than the car presently assigned to serve the call when the lower ETA is lower by a value T. The average call waiting time (AWT) is calculated using a selected period of time to tabulate the number of calls and cumulative call waiting time, and this calculated value is compared with the desired AWT for the elevator system. The value of T is changed when the calculated and desired values of ETA have a predetermined relationship.
摘要翻译：基于在要分配的门厅呼叫的楼层估计每个电梯轿厢的到达时间（ETA）的基础上，向多个电梯轿厢分配门厅呼叫的方法。具有最低ETA的汽车分配了一个新的门厅呼叫。先前分配的门厅呼叫被重新分配给具有比目前被分配来服务呼叫的轿厢的ETA低的汽车，当较低的ETA低一个值T时。平均呼叫等待时间（AWT）是使用选定的时间段列出呼叫次数和累积呼叫等待时间，并将该计算值与电梯系统的所需AWT进行比较。当计算的和期望的ETA值具有预定的关系时，T的值被改变。

4. 发明授权

US4875554A Dynamic selection of elevator call assignment scan direction 失效
标题翻译：电梯呼叫分配扫描方向的动态选择
公开(公告)号：US4875554A
公开(公告)日：1989-10-24
申请号：US238941
申请日：1988-08-31
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/20 , B66B1/24
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars (0, 1, N) which biases the assignment process to balance the number of cars serving up and down service directions. Prior to each call assignment update the method determines the number of cars serving each service direction (78, 80, 82). A predetermined relationship (88) between there two numbers is used to determine if up hall calls should be assigned first, or down hall calls (90, 92, 94, 96). The balancing of cars serving the two service directions lowers the average waiting time, and it results in dispersing the cars throughout a building when service subsides, to enable prompt service for newly entered calls without the necessity of moving the cars during periods of low service to be in position for new calls.

5. 发明授权

US4790412A Anti-bunching method for dispatching elevator cars 失效
标题翻译：用于调度电梯轿厢的防ching方法
公开(公告)号：US4790412A
公开(公告)日：1988-12-13
申请号：US169210
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars in an ETA strategy in which up hall calls are scanned upwardly and down calls downwardly. A hall call floor at which the scan has stopped for the purpose of assigning or reassigning a hall call at the floor is called a "scan floor". The floor of the advanced position of the car being considered for assignment is called the "AVP floor". In order to favor the clustering of closely adjacent stops in a given car, and thus minimize car bunching, when a car has an intervening stop between the AVP floor and the scan floor, either the travel distance between the AVP floor and the scan floor, or the travel distance from an intervening stop to the scan floor, is used to develop a dynamic bias for the ETA of the associated car. The dynamic or variable bias is inversely proportional to the travel distance, i.e., the number of floors, between the relevant floors.
摘要翻译：在ETA策略中向多个电梯轿厢分配门厅呼叫的方法，向上和向下扫描向上和向下向上和向下向上扫描向上电梯呼叫。扫描已停止的门厅呼叫楼层是为了在楼层分配或重新分配门厅呼叫而被称为“扫描楼层”。正在考虑分配的汽车的先进位置的地板称为“AVP楼层”。为了有利于在给定轿厢中紧密相邻的停靠点的聚集，并且因此使汽车聚束最小化，当汽车在AVP楼层和扫描楼层之间有中间停止时，AVP楼层与扫描楼层之间的行进距离，或从中间站到扫描楼的行驶距离用于为相关联的汽车的ETA开发动态偏差。动态或可变偏压与相关楼层之间的行进距离，即楼层数成反比。

6. 发明申请

US20090048198A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY SYSTEMS 审中-公开
标题翻译：核酸递送系统的组成和方法
公开(公告)号：US20090048198A1
公开(公告)日：2009-02-19
申请号：US12040977
申请日：2008-03-03
申请人： Rumiana Koynova-Tenchova , Li Wang , Robert C. MacDonald
发明人： Rumiana Koynova-Tenchova , Li Wang , Robert C. MacDonald
IPC分类号： A61K31/7088 , C12N15/64 , A61K47/12 , A61P43/00 , C12N15/88
CPC分类号： A61K31/7088 , A61K9/1272 , A61K9/1274 , A61K48/0025 , C12N15/87 , C12N15/88
摘要： The present invention relates to compositions and methods for use in delivering nucleic acids and other agents into cells and tissues. In particular, the present invention provides lipid mixtures at the gel-liquid crystalline phase transition providing superior lipofection activity for transferring materials into cells and tissues.
摘要翻译：本发明涉及用于将核酸和其它试剂递送到细胞和组织中的组合物和方法。特别地，本发明提供了凝胶 - 液晶相转变时的脂质混合物，为将材料转移到细胞和组织中提供优异的脂转染活性。

7. 发明申请

US20080175893A1 GAS-CONTAINING LIPOSOMES 有权
标题翻译：含气体脂质体
公开(公告)号：US20080175893A1
公开(公告)日：2008-07-24
申请号：US11873256
申请日：2007-10-16
申请人： Shaoling Huang , Robert C. MacDonald , Patrick Kee , David McPherson
发明人： Shaoling Huang , Robert C. MacDonald , Patrick Kee , David McPherson
IPC分类号： A61K9/127 , A61P9/10
CPC分类号： A61K9/127 , A61K9/0009 , A61K9/1277 , A61K9/19 , Y10S977/907
摘要： The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
摘要翻译：本发明提供含气体的脂质体。特别地，本发明提供产生气体在压力下引入气体的含气体脂质体的方法，以及含有大量气体的含气体脂质体（例如，每5mg含气体的气体为10μl气体脂质体）。在某些实施方案中，含气体脂质体含有一氧化氮气体。在一些实施方案中，这种含氧化氮的脂质体用于治疗可由一氧化氮气体治疗的医学病症（例如，内膜增生）。

8. 发明授权

US4511017A Elevator system 失效
标题翻译：电梯系统
公开(公告)号：US4511017A
公开(公告)日：1985-04-16
申请号：US534005
申请日：1983-09-20
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
IPC分类号： B66B1/18 , B66B5/02
CPC分类号： B66B5/02
摘要： An elevator system, and method of operating same, in which emergency back-up service is provided all floors of a building when normal service is degraded, such as due to a dispatcher malfunction, a communication failure between the elevator cars of a bank of cars and a group supervisory controller or dispatcher, failure of the hall call circuits, and the like. When the emergency service is provided, a different initial block of floors is assigned to each elevator car, and as each elevator car completes a round trip its block of assignments are revised in a rotational manner. Thus, all floors are guaranteed service as long as at least one elevator car is operational.
摘要翻译：一种电梯系统及其操作方法，其中当正常服务劣化时，建筑物的所有楼层都提供紧急备用服务，例如由于调度员故障，一排汽车的电梯轿厢之间的通信故障以及组管理控制器或调度员，门厅呼叫电路的故障等。当提供紧急服务时，向每个电梯轿厢分配不同的初始楼层，并且当每个电梯轿厢完成往返时，其轮转方式被修改。因此，只要至少一台电梯轿厢正在运行，所有楼层都能得到保证。

9. 发明授权

US07732420B2 Combinations of transfection lipids exhibiting increased transfection efficiencies 有权
标题翻译：具有提高转染效率的转染脂质的组合
公开(公告)号：US07732420B2
公开(公告)日：2010-06-08
申请号：US10957977
申请日：2004-10-04
申请人： Robert C. MacDonald , Li Wang
发明人： Robert C. MacDonald , Li Wang
IPC分类号： A01N43/04 , A61K31/70 , C12N5/00 , C12N5/02 , G01N33/92
CPC分类号： C12N15/88
摘要： The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.
摘要翻译：本发明提供包含阳离子脂质混合物的优化的转染试剂。特别地，本发明提供了基于鉴定与DNA单独或组合形成复合物（lipoplexes）并显示增强的转染活性的新型阳离子磷脂衍生物的最佳疏水性的DNA递送载体。

10. 发明授权

US5891714A Cationic phospholipids for transfection 失效
标题翻译：用于转染的阳离子磷脂
公开(公告)号：US5891714A
公开(公告)日：1999-04-06
申请号：US470923
申请日：1995-06-06
申请人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
发明人： Gary W. Ashley , Robert C. MacDonald , Miho Shida
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88 , C12N15/63
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： Cationic phospholipids and their use in treating pathogen-associated disease are disclosed. The class of phospholipids comprises the phosphotriester derivatives of phosphoglycerides and sphingolipids. Liposomes comprising one or more of the cationic phospholipids are effective in the lipofection of nuclidic acids and are therefore useful in methods of treating disease.
摘要翻译：公开了阳离子磷脂及其在治疗病原体相关疾病中的用途。磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。包含一种或多种阳离子磷脂的脂质体在核苷酸的脂质转染中是有效的，因此可用于治疗疾病的方法。

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