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    • 9. 发明申请
    • Device for collection and assay of oral fluids
    • 用于收集和测定口腔液的装置
    • US20070116597A1
    • 2007-05-24
    • US11653916
    • 2007-01-17
    • Ronald MinkAndrew GoldsteinRobert Bohannon
    • Ronald MinkAndrew GoldsteinRobert Bohannon
    • B01L3/00
    • A61B10/0051A61B2010/0006G01N30/90Y10S435/974Y10S436/81Y10T436/25
    • A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
    • 公开了一种用于将含水流体从口腔收集和输送到用于测试的侧向色谱条的装置。 侧向色谱条放置在限定在壳体中的空腔内并沿其延伸。 提供至少一个侧向色谱条的检查位置,以便检查侧向色谱条上的选定位点以便测试结果。 多孔芯材料在一端从外壳突出到外壳的收集位置,并在另一端与侧向色谱条连通。 多孔芯材料具有颗粒结构,颗粒吸附口腔液体,以将流体从嘴部输送到侧向色谱条而无需实质吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积,并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径,防止从侧向色谱条带逆向流入口腔。 咬合板联接到壳体并且可插入患者的牙齿之间,以将多孔芯放置在口腔中以收集口腔液体。 咬合板通常通过牙齿的咬合力(优选地为臼齿和/或双尖牙)保持在适当的位置,以将多孔芯放置在口腔空间中。 在测试装置处于口中时,通过观察侧向色谱条即可得到结果。