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1. 发明授权

US6126649A Steerable catheter with external guidewire as catheter tip deflector 有权
标题翻译：可导向导管，外导管作为导管尖端导流器
公开(公告)号：US6126649A
公开(公告)日：2000-10-03
申请号：US329386
申请日：1999-06-10
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61M25/01 , A61M25/09
CPC分类号： A61M25/0138 , A61M25/0147 , A61B2017/22041 , A61B2017/22045 , A61M2025/0177
摘要： A steerable catheter in which a guidewire can serve a dual purpose of deflecting a bendable element at a distal end of the steerable catheter and as a guidewire to facilitate the placement of a working catheter within the vascular system. The guidewire is adapted to be slidingly received within routing eyelets or the like where one of such eyelets is disposed at a distal end of the bendable element and another near the proximal end thereof. The guidewire can be readily advanced in the distal direction relative to the steerable catheter, but tensioning of the guidewire at its proximal end serves to deflect and bend the bendable element.
摘要翻译：可导向的导管，其中导丝可以用于在可操纵导管的远端处偏转可弯曲元件的双重目的，并且用作导丝，以便于在血管系统内放置工作导管。导丝适于滑动地容纳在布置孔眼等内，其中这些孔眼之一设置在可弯曲元件的远端，另一个靠近其近端。导丝可以相对于可导向导管在远端方向上容易地前进，但是导丝在其近端处的张紧用于使可弯曲元件偏转和弯曲。

2. 发明授权

US06949087B2 Apparatus with weeping tip and method of use 失效
公开(公告)号：US06949087B2
公开(公告)日：2005-09-27
申请号：US10855026
申请日：2004-05-26
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

3. 发明授权

US06241710B1 Hypodermic needle with weeping tip and method of use 失效
标题翻译：皮下注射针头及其使用方法
公开(公告)号：US06241710B1
公开(公告)日：2001-06-05
申请号：US09468688
申请日：1999-12-20
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

4. 发明授权

US06855132B2 Apparatus with weeping tip and method of use 失效
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US06855132B2
公开(公告)日：2005-02-15
申请号：US10342023
申请日：2003-01-14
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

5. 发明授权

US06645143B2 Pressure/temperature/flow monitor device for vascular implantation 失效
公开(公告)号：US06645143B2
公开(公告)日：2003-11-11
申请号：US09961564
申请日：2001-09-20
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61B500
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/413 , A61B5/6882 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical monitoring apparatus designed to be implanted in the vascular system is capable of sensing and transmitting via a telemetry link to an external monitor both pressure and temperature information. An internally or externally powered microcircuit component is supported on a stent-like structure and adapted to be placed in the vascular system. Placement in the ventricular septum permits measurement of pressure and temperature in the left ventricle without introducing thrombus generating materials in the left ventricle.

6. 发明授权

US06547769B2 Catheter apparatus with weeping tip and method of use 失效
标题翻译：导管器具有eping嘴和使用方法
公开(公告)号：US06547769B2
公开(公告)日：2003-04-15
申请号：US09829022
申请日：2001-04-09
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

7. 发明授权

US07252654B2 Apparatus with weeping tip and method of use 有权
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US07252654B2
公开(公告)日：2007-08-07
申请号：US11218700
申请日：2005-09-02
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M5/32 , A61M25/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

8. 发明授权

US06605061B2 Catheter for drug injection in cardiovascular system 失效
标题翻译：心血管系统药物注射导管
公开(公告)号：US06605061B2
公开(公告)日：2003-08-12
申请号：US09880575
申请日：2001-06-13
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61M5178
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/008 , A61M25/0084 , A61M2025/009
摘要： A catheter for injecting medicants into the endocardium, myocardium or other portions of the cardiovascular system is presented where the catheter has apertures therein for ejection and retraction of a needle. The catheter is designed for the apertures in the catheter to press against the tissue to be injected in the heart while the heart is beating. A needle for inserting a prescribed dose of a medicant is ejected through the aperture and a plunger, pump, or diaphragm is moved to deliver a dose of the medicant to tissue adjacent the aperture. By use of the catheter gene therapy, wherein a small does of a gene are injected into the endocardium of the right or left ventricle, can be used to grow new blood vessels in the injected area of a damaged heart. The apertures in the catheter can be spaced at a prescribed distance for the dosage of medicant to form a precise pattern of injections in the area to be treated. The catheters may be used for any treatments of a human or animal patient where injections are required in the heart, veins or arteries of the cardiovascular system.
摘要翻译：提供用于将药剂注射到心内膜，心肌或心血管系统的其它部分的导管，其中导管在其中具有孔，用于针的弹出和缩回。该导管被设计用于在心脏跳动时将导管中的孔压在组织上以被注射到心脏中。用于插入规定剂量的药剂的针通过孔排出，移动柱塞，泵或隔膜以将剂量的药剂递送到邻近孔的组织。通过使用其中将小的基因注入右心室或左心室的导管基因治疗可用于在损伤的心脏的注射区域中生长新的血管。导管中的孔可以间隔规定的距离，用于药物的剂量以在待治疗的区域中形成精确的注射模式。导管可用于需要在心血管系统的心脏，静脉或动脉中注射的人或动物患者的任何治疗。

9. 发明授权

US06309350B1 Pressure/temperature/monitor device for heart implantation 有权
标题翻译：用于心脏植入的压力/温度/监测装置
公开(公告)号：US06309350B1
公开(公告)日：2001-10-30
申请号：US09416661
申请日：1999-10-12
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61B500
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/413 , A61B5/6882 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical monitoring apparatus designed to be implanted in the vascular system is capable of sensing and transmitting via a telemetry link to an external monitor both pressure and temperature information. An internally or externally powered microcircuit component is supported on a stent-like structure and adapted to be placed in the vascular system. Placement in the ventricular septum permits measurement of pressure and temperature in the left ventricle without introducing thrombus generating materials in the left ventricle.
摘要翻译：设计成植入血管系统的医疗监测装置能够通过遥测链路感测和传输压力和温度信息到外部监视器。内部或外部供电的微电路部件支撑在支架状结构上并适于放置在血管系统中。置入心室隔膜允许测量左心室的压力和温度，而不会在左心室内引入血栓产生物质。

10. 发明授权

US06293958B1 Catheter having flow diffusing tip 失效
标题翻译：导管具有流动扩散尖端
公开(公告)号：US06293958B1
公开(公告)日：2001-09-25
申请号：US09123807
申请日：1998-07-27
申请人： David Berry , David R. Holmes , Robert S. Schwartz , Robert A. VanTassel
发明人： David Berry , David R. Holmes , Robert S. Schwartz , Robert A. VanTassel
IPC分类号： A61M2900
CPC分类号： A61M25/0075 , A61M2025/0076
摘要： An intravascular catheter having a flow diffusing distal tip includes a plurality of cuts formed through the tubular wall thereof so as to define a plurality of generally U-shaped flaps, the flaps being disposed in at least one and preferably two axially displaced bands. When contrast fluid or the like is injected under pressure into the proximal end of the catheter, the flow of the liquid exits the openings in which the plurality of flaps are hinged, causing the flaps to vibrate and effectively eliminate any tendency for the contrast media to be expelled as a jet from the open distal end of the catheter. Having an open distal end allows the catheter to be passed over a guidewire.
摘要翻译：具有流动扩散远侧末端的血管内导管包括通过其管状壁形成的多个切口，以便限定多个大致U形的翼片，翼片设置在至少一个且优选两个轴向移位的带中。当在压力下将对比液或类似物注入导管的近端时，液体的流动离开多个翼片铰接的开口，导致襟翼振动并有效地消除造影剂对作为射流从导管的开放远端排出。具有开放的远端允许导管穿过导丝。

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