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1. 发明授权

US09345806B2 Manufacture of medical implants 有权
标题翻译：医疗植入物的制造
公开(公告)号：US09345806B2
公开(公告)日：2016-05-24
申请号：US12303348
申请日：2007-06-07
申请人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
发明人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
IPC分类号： A61L27/14 , A61L28/00 , A61L29/04 , A61L31/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture cola medical implant, said process comprising: reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及制造可乐医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97 [混合物（M）]与用于生产热塑性弹性体的合适的反应物; 模制如此获得的热塑性弹性体以产生医用植入物的至少一部分。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被降低的生物流体的化学品提取的医用植入物。

2. 发明申请

US20100227983A1 Manufacture of medical implants 有权
标题翻译：医疗植入物的制造
公开(公告)号：US20100227983A1
公开(公告)日：2010-09-09
申请号：US12303348
申请日：2007-06-07
申请人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
发明人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
IPC分类号： C08G63/91 , C08G65/34 , C08G71/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture cola medical implant, said process comprising: reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及制造可乐医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97 [混合物（M）]与用于生产热塑性弹性体的合适的反应物; 模制如此获得的热塑性弹性体以产生医用植入物的至少一部分。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被生物流体减少的化学品提取的医用植入物。

3. 发明授权

US06649222B1 Modulated plasma glow discharge treatments for making superhydrophobic substrates 失效
标题翻译：用于制造超疏水底物的调制等离子体辉光放电处理
公开(公告)号：US06649222B1
公开(公告)日：2003-11-18
申请号：US09786085
申请日：2001-02-28
申请人： Riccardo D'Agostino , Italo Corzani , Pietro Favia , Ritalba Lamendola , Gianfranco Palumbo
发明人： Riccardo D'Agostino , Italo Corzani , Pietro Favia , Ritalba Lamendola , Gianfranco Palumbo
IPC分类号： C08J718
CPC分类号： B05D1/62 , B05D5/083 , C03C17/22 , C03C17/32 , C03C23/006 , C03C2217/282 , C03C2218/153 , C23C16/30 , C23C16/515
摘要： A method for treating substrates including the steps of: providing a substrate; exposing said substrate to a plasma glow discharge in the presence of a fluorocarbon gas; maintaining said gas at a pressure between about 50 mTorr and about 400 mTorr; generating said plasma as a modulated glow discharge; pulsing said discharge at an on time of 1-500 milliseconds; pulsing said glow at an off time of 1-1000 milliseconds; maintaining said plasma glow discharge at a power density of 0.02-10 watts/cm2; and applying a hydrophobic coating to said substrate.
摘要翻译：一种处理衬底的方法，包括以下步骤：提供衬底;在碳氟化合物气体存在下将所述衬底暴露于等离子体辉光放电;将所述气体保持在约50mTorr至约400mTorr之间的压力;产生所述等离子体为调制辉光放电;在1-500毫秒的开启时脉冲所述放电;在1-1000毫秒的关闭时间脉冲发光;将所述等离子体辉光放电维持在0.02-10瓦特/平方厘米的功率密度; 并将疏水涂层施加到所述基底。

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