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1. 发明授权

US09351972B2 Compounds as respiratory stimulants for treatment of breathing control disorders or diseases 有权
标题翻译：作为呼吸兴奋剂的化合物，用于治疗呼吸控制障碍或疾病
公开(公告)号：US09351972B2
公开(公告)日：2016-05-31
申请号：US13306349
申请日：2011-11-29
申请人： Scott L. Dax , Richard Woodward , Sean Peng
发明人： Scott L. Dax , Richard Woodward , Sean Peng
IPC分类号： C07D251/70 , C07D403/12 , C07D401/12 , C07D405/14 , C07D409/12 , C07D498/08 , C07D413/04 , A61K31/505 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/5355 , A61K31/57 , A61K45/06 , C07D251/66 , C07D401/14 , C07D405/12 , C07D487/04 , C07D498/06
CPC分类号： A61K31/53 , A61K31/505 , A61K31/519 , A61K31/522 , A61K31/5355 , A61K31/57 , A61K45/06 , A61M16/0465 , A61M16/06 , C07D239/50 , C07D251/66 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D487/04 , C07D498/06
摘要： The present invention includes a composition comprising a compound, such as a 2,4,6-triamino-1,3,5-triazine, 2,4,6-triaminopyrimidine, 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine or 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine, that is useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention. The present invention further includes a method of preventing destabilizing or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention.
摘要翻译：本发明包括包含化合物如2,4,6-三氨基-1,3,5-三嗪，2,4,6-三氨基嘧啶，2,4-二氨基-6,7-二氢-5H - 吡咯并[2,3-d]嘧啶或2,4-二氨基-7H-吡咯并[2,3-d]嘧啶，其可用于治疗有需要的受试者的呼吸控制疾病或病症。本发明还包括治疗有需要的受试者的呼吸系统疾病或病症的方法，其包括向受试者施用治疗有效量的本发明的药物组合物。本发明还包括一种在有需要的受试者中防止不稳定或稳定呼吸节律的方法，包括向受试者施用治疗有效量的本发明的药物组合物。

2. 发明申请

US20050052071A1 Disc type wheel 审中-公开
标题翻译：盘式轮
公开(公告)号：US20050052071A1
公开(公告)日：2005-03-10
申请号：US10657566
申请日：2003-09-08
申请人： Richard Woodward , Gregory Kluwe
发明人： Richard Woodward , Gregory Kluwe
IPC分类号： B60B19/00 , B60B21/00 , B60C7/14
CPC分类号： B60C7/14 , B60B3/001 , B60B3/005 , B60B3/02 , B60B5/02 , B60B9/00 , B60B21/00 , B60B2310/226 , B60B2360/104 , B60B2360/32 , B60B2360/50 , B60B2900/112 , B60B2900/113 , B60Y2200/13
摘要： The present invention resides in a wheel formed from a flat sheet with the outer edge of the center portion changing into many beams extending to and forming the outer diameter in a manner to permit the beams to flex with changing loads on the outer diameter. The outer diameter may be covered with a rubber like material. The disc wheel may have dimples for strength and stiffness. Two sheets and other materials may be used.
摘要翻译：本发明在于由平板形成的车轮，其中心部分的外缘改变成许多梁，以允许梁以外径变化的载荷挠曲并形成外径。外径可以用橡胶状材料覆盖。盘轮可能具有用于强度和刚度的凹坑。可以使用两张纸和其他材料。

3. 外观设计

USD385130S Hexagonal rotating display rack 失效
公开(公告)号：USD385130S
公开(公告)日：1997-10-21
申请号：US53814
申请日：1996-04-30
申请人： Richard Woodward
设计人： Richard Woodward

4. 外观设计

USD382420S Square rotating display rack 失效
公开(公告)号：USD382420S
公开(公告)日：1997-08-19
申请号：US53812
申请日：1996-05-07
申请人： Richard Woodward
设计人： Richard Woodward

5. 发明申请

US20120101073A1 Novel Method For Treating Breathing Disorders or Diseases 审中-公开
标题翻译：治疗呼吸障碍或疾病的新方法
公开(公告)号：US20120101073A1
公开(公告)日：2012-04-26
申请号：US12910490
申请日：2010-10-22
申请人： James C. Mannion , Scott L. Dax , Richard Woodward
发明人： James C. Mannion , Scott L. Dax , Richard Woodward
IPC分类号： A61K31/57 , A61P11/00 , A61K31/5377
CPC分类号： A61K31/5377 , A61K31/57 , A61K2300/00
摘要： The present invention includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising (+)-doxapram or a salt thereof, and a pharmaceutically acceptable carrier, wherein the formulation is essentially free of (−)-doxapram or a salt thereof.
摘要翻译：本发明包括治疗有需要的受试者的呼吸系统疾病或病症的方法，其包括向受试者施用治疗有效量的包含（+） - 多沙普兰或其盐的药物制剂和药学上可接受的载体，其中所述制剂基本上不含（ - ） - 多沙帕姆或其盐。

6. 发明授权

US08191032B1 Budgeting global constraints on local constraints in an autorouter 有权
标题翻译：在自动布线器中预算对局部约束的全局约束
公开(公告)号：US08191032B1
公开(公告)日：2012-05-29
申请号：US12500191
申请日：2009-07-09
申请人： Ken Wadland , Sean Bergan , Randall Lawson , Keith Woodword , Richard Woodward
发明人： Ken Wadland , Sean Bergan , Randall Lawson , Keith Woodword , Richard Woodward
IPC分类号： G06F17/50
CPC分类号： G06F17/5077 , G06F17/5072
摘要： Local constraints on placement of routing objects for direct connections between terminals in a circuit layout are determined from global constraints on the placement of the routing objects in a process referred to as global constraint budgeting. An autorouter finds paths in the layout to satisfy the local constraints and ignores the global constraints. The local constraints are updated before each routing pass to ensure that routes are completed on individual direct connections while also satisfying the global constraint.
摘要翻译：在电路布局中的终端之间的直接连接的路由对象布局的局部约束是从被称为全局约束预算的过程中的路由对象的布局的全局约束来确定的。自动布线器查找布局中的路径以满足局部约束并忽略全局约束。在每个路由传递之前更新本地约束，以确保在单个直接连接上完成路由，同时也满足全局约束。

7. 发明授权

US07620922B1 Method and system for optimized circuit autorouting 有权
标题翻译：优化电路自动布线的方法和系统
公开(公告)号：US07620922B1
公开(公告)日：2009-11-17
申请号：US11556999
申请日：2006-11-06
申请人： Ken Wadland , Richard Woodward , Randall Lawson , Greg Horlick
发明人： Ken Wadland , Richard Woodward , Randall Lawson , Greg Horlick
IPC分类号： G06F17/50 , G06F9/45
CPC分类号： G06F17/5077
摘要： An approach is provided for selectively optimizing a circuit design, including generating a circuit routing solution according to a plurality of constraints for parametric resources of the circuit design, with the constraints being defined respectively by a plurality of corresponding constraint instances. Each constraint instance variably indicates an effective constraining limit and degree of consumption for at least one of the parametric resources. At least one of the constraints is selectively adjusted by a predetermined over-constraining amount, and the circuit routing solution is preliminarily modified by applying at least one routing action selected responsive to the constraint adjustment. The potential impact upon constraint compliance is evaluated, including generating a relative cost measure for the preliminary modification of the circuit routing solution, based at least partially upon each of the constraint instances. Thereafter, the preliminary modification of the circuit routing solution is either discarded or accepted responsive to the evaluation.
摘要翻译：提供了一种用于选择性地优化电路设计的方法，包括根据电路设计的参数资源的多个约束生成电路布线解决方案，其中约束分别由多个相应的约束实例定义。每个约束实例可变地指示至少一个参数资源的有效约束极限和消耗程度。通过预定的过约束量选择性地调节约束中的至少一个，并且通过应用响应于约束调整选择的至少一个路由动作来初步修改电路路由解决方案。评估对约束约束的潜在影响，包括至少部分地基于每个约束实例来生成用于电路路由解决方案的初步修改的相对成本度量。此后，响应于评估，电路布线解决方案的初步修改被丢弃或接受。

8. 发明授权

US06448270B1 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists 失效
标题翻译： 4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
公开(公告)号：US06448270B1
公开(公告)日：2002-09-10
申请号：US09592883
申请日：2000-06-13
申请人： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F.W. Keana
发明人： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F.W. Keana
IPC分类号： A61K31445
CPC分类号： C07D401/06 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/54 , C07D211/58 , C07D405/06
摘要： Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as cerebral ischemia, central nervous system trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headaches, convulsions, aminoglycoside antibiotics-induced hearing loss, chronic pain, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, urinary incontinence and neurodegenerative disorders such as lathyrism, Alzheimers' Disease, Parkinsonism, and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.
摘要翻译：新的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如脑缺血，中枢神经系统性创伤，低血糖症，神经退行性疾病，焦虑症，偏头痛，惊厥，氨基糖苷类抗生素诱发的听力损失，慢性疼痛，精神病，青光眼，CMV视网膜炎，阿片样物质耐受或戒断，尿失禁和神经退行性疾病，如莱姆里斯，阿尔茨海默病，描述了帕金森综合征和亨廷顿氏病。还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

9. 发明授权

US6130234A 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists 失效
标题翻译： 4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
公开(公告)号：US6130234A
公开(公告)日：2000-10-10
申请号：US91594
申请日：1996-12-20
申请人： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana
发明人： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/4535 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/00 , A61P25/02 , A61P25/04 , A61P43/00 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/70 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D235/08
CPC分类号： C07D401/06 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/54 , C07D211/58 , C07D405/06
摘要： Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.
摘要翻译： PCT No.PCT / US96 / 20766 Sec。 371日期：1998年9月16日 102（e）1998年9月16日PCT PCT 1996年12月20日PCT公布。公开号WO97 / 23214 PCT 日期1997年7月3日新颖的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风，脑缺血，中枢神经系统创伤，低血糖症，焦虑症，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，青光眼，CMV视网膜炎，慢性疼痛，阿片样物质耐受或戒断，或神经退行性疾病，如幻影，阿尔茨海默病，帕金森综合征并描述亨廷顿氏病。还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

10. 外观设计

USD401083S Eyeglass display rack 失效
公开(公告)号：USD401083S
公开(公告)日：1998-11-17
申请号：US78539
申请日：1997-10-20
申请人： Richard Woodward
设计人： Richard Woodward

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