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    • 5. 发明授权
    • Clasp for jewelry
    • 珠宝首饰
    • US5628095A
    • 1997-05-13
    • US411524
    • 1995-03-28
    • Richard AppelEginhard Wichelhaus
    • Richard AppelEginhard Wichelhaus
    • A44C5/20A44C11/02A44B11/25A44C13/00
    • A44C5/2071A44D2200/12Y10S24/38Y10T24/45188Y10T24/47Y10T24/4745Y10T403/58
    • A jewelry clasp has a first and a second clasp member connected to one another for closing the clasp. At least the first clasp member has a spring-weighed element for achieving a fixation of a closed position of the clasp. The first clasp member has a first end portion with a first end face and further has a first receiving opening extending transverse to the longitudinal extension of the first clasp member. The second clasp member has a second end portion with a second end face and further has a second receiving opening extending transverse to a longitudinal extension of the second clasp member. The first receiving opening is oriented oppositely to the second receiving opening. The first and the second end portions are insertable into one another such that in a closed position of the clasp the spring-weighed element is forced against the second end face of the second clasp member.
    • 珠宝扣具有彼此连接的第一和第二扣环构件,用于封闭扣环。 至少第一扣环构件具有弹簧加重元件,用于实现扣环的闭合位置的固定。 第一扣环构件具有第一端部,其具有第一端面并且还具有横向于第一扣环构件的纵向延伸部延伸的第一接收开口。 第二搭扣构件具有带有第二端面的第二端部,并且还具有横向于第二搭扣构件的纵向延伸部延伸的第二容纳开口。 第一接收开口与第二接收开口相反地定向。 第一和第二端部可彼此插入,使得在扣环的关闭位置,弹簧称重的元件被迫抵靠第二扣环构件的第二端面。
    • 8. 发明授权
    • Inhibiting furin with polybasic peptides
    • 用多碱性肽抑制弗林蛋白酶
    • US07569547B2
    • 2009-08-04
    • US11408519
    • 2006-04-21
    • Iris LindbergAngus CameronRichard A. HoughtenJon Richard Appel
    • Iris LindbergAngus CameronRichard A. HoughtenJon Richard Appel
    • A61K38/00C07K16/00
    • A61K38/55A61K38/07
    • Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can improve inhibition of furin. High inhibition was seen in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, had a Ki against furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred furin inhibitors for therapeutic uses, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides should be non-immunogenic. These peptides are efficiently transported across cell membranes.
    • 公开了作为弗林蛋白酶抑制剂有效的小的多元肽,例如。 在大多数位置具有L-Arg或L-Lys的六元至十肽。 去除肽末端基团可以改善对弗林蛋白酶的抑制。 在一系列非酰胺化和非乙酰化聚精氨酸中观察到高抑制。 迄今为止确定的最有效的抑制剂,即非-L-精氨酸,具有40nM的对抗弗林蛋白酶的Ki。 非乙酰化的聚-D-精氨酸衍生的分子是优选的用于治疗用途的弗林蛋白酶抑制剂,例如抑制某些细菌感染,病毒感染和癌症。 由于它们相对较小的尺寸,这些肽应该是非免疫原性的。 这些肽有效地通过细胞膜传输。