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1. 发明授权

US07601515B2 Process of high purity albumin production 失效
标题翻译：高纯白蛋白生产工艺
公开(公告)号：US07601515B2
公开(公告)日：2009-10-13
申请号：US11738582
申请日：2007-04-23
申请人： Andrew Robert Goodey , Darell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
发明人： Andrew Robert Goodey , Darell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
IPC分类号： C12N15/14 , C07K14/00
CPC分类号： C07K14/70571 , C07K14/765 , C07K2319/10
摘要： A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises separating the yeast from the culture medium to yield an albumin solution; subjecting the albumin solution to positive mode cation exchange, affinity, and positive mode anion exchange chromatography; and concentrating and formulating the albumin with sodium octanoate and sodium chloride.
摘要翻译：提供了一种从酵母培养基制备白蛋白的方法，其具有极低水平或基本上不含着色剂，金属离子，人蛋白质，宿主蛋白质，白蛋白片段，白蛋白和病毒聚合物或聚集体，并且其中基本上是非糖化的，游离硫醇相对高且具有完整的C末端。该方法包括将酵母与培养基分离以产生白蛋白溶液; 使白蛋白溶液进行正离子阳离子交换，亲和力和阳性阴离子交换层析; 并用辛酸钠和氯化钠浓缩和配制白蛋白。

2. 发明申请

US20090197316A1 PROCESS FOR PREPARING PARTICLES OF PROTEINACEOUS MATERIAL 有权
标题翻译：制备蛋白质材料颗粒的方法
公开(公告)号：US20090197316A1
公开(公告)日：2009-08-06
申请号：US12373176
申请日：2007-07-13
申请人： Richard Alan Johnson , John Rodney Woodrow
发明人： Richard Alan Johnson , John Rodney Woodrow
IPC分类号： C12N9/98 , C07K1/10
CPC分类号： C07K1/02 , A61K9/1658 , A61K9/5169 , A61K47/64 , A61K47/643 , A61K47/6435 , A61K47/644 , A61K47/6929 , A61K49/0485 , A61K49/085 , A61K49/143 , A61K49/1881 , A61K51/081 , A61K51/1255 , B82Y5/00 , C07K1/08 , C07K1/10
摘要： Protein particles are prepared by causing or allowing protein molecules dispersed in a liquid medium at a concentration of 8 mg.mL-1 or greater to react in the presence of a zero-length crosslinker, so as to produce protein particles comprising protein molecules that are covalently bonded together. The protein particles may be produced with sizes in the sub-micron range with closely defined sizes and size distributions. The particles have applications in many fields, but are useful inter alia for the delivery of therapeutic agents and other agents, eg imaging contrast agents, to the body.
摘要翻译：通过使分散在8mg.mL-1或更高浓度的液体培养基中的蛋白质分子在零长度交联剂的存在下反应来制备蛋白质颗粒，以产生包含蛋白质分子的蛋白质颗粒，共价键合。蛋白质颗粒可以以亚微米范围内的尺寸制造，具有紧密限定的尺寸和尺寸分布。这些颗粒在许多领域中具有应用，但是尤其可用于将治疗剂和其它试剂（例如成像造影剂）递送至身体。

3. 发明授权

US06638740B1 Process of high purity albumin production 失效
标题翻译：高纯白蛋白生产工艺
公开(公告)号：US06638740B1
公开(公告)日：2003-10-28
申请号：US08952558
申请日：1999-02-24
申请人： Andrew Robert Goodey , Darrell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
发明人： Andrew Robert Goodey , Darrell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
IPC分类号： C12N1514
CPC分类号： C07K14/70571 , C07K14/765 , C07K2319/10
摘要： The present invention relates to a process for purifying the protein human serum albumin extracted from serum or recombinant human albumin produced by transforming a microorganism with a nucleotide coding sequence encoding the amino acid sequence of human serum albumin. The present invention provides highly purified albumin.
摘要翻译：本发明涉及一种纯化通过用编码人血清白蛋白氨基酸序列的核苷酸编码序列转化微生物的血清或重组人白蛋白提取的蛋白质人血清白蛋白的方法。本发明提供了高纯度的白蛋白。

4. 发明授权

US6017310A Use of hollow microcapsules 失效
标题翻译：使用空心微胶囊
公开(公告)号：US6017310A
公开(公告)日：2000-01-25
申请号：US724870
申请日：1996-10-04
申请人： Richard Alan Johnson , Nicolaas de Jong , Paulus Antonius van der Wouw
发明人： Richard Alan Johnson , Nicolaas de Jong , Paulus Antonius van der Wouw
IPC分类号： A61B8/00 , A61K49/22
CPC分类号： A61K49/223 , A61B8/481
摘要： A method of generating an ultrasound image comprising the steps of (i) introducing into the location to be imaged an ultrasound contrast agent obtained by spraying a solution or suspension of a wall forming material into a heated gas to form hollow microcapsules, (ii) exposing the microcapsules to ultrasound energy of an intensity of at least 100 kPa and (iii) creating an image based on the scattering of the ultrasound energy by the microcapsules.
摘要翻译：一种产生超声波图像的方法，包括以下步骤：（i）将通过将形成壁的材料的溶液或悬浮液喷雾到加热气体中以形成中空微胶囊而获得的超声造影剂引入待成像的位置，（ii）暴露所述微胶囊具有至少100kPa强度的超声能量，以及（iii）基于所述微胶囊对超声能量的散射产生图像。

5. 发明授权

US5741478A Preparation of hollow microcapsules by spray-drying an aqueous solution of a wall-forming material and a water-miscible solvent 失效
标题翻译：通过喷雾干燥成壁材料和水混溶性溶剂的水溶液制备中空微胶囊
公开(公告)号：US5741478A
公开(公告)日：1998-04-21
申请号：US676344
申请日：1996-07-19
申请人： Nicholas Osborne , Andrew Derek Sutton , Richard Alan Johnson
发明人： Nicholas Osborne , Andrew Derek Sutton , Richard Alan Johnson
IPC分类号： A61K9/50 , A61B8/00 , A61K47/42 , A61K49/00 , A61K49/04 , A61K49/22 , B01J13/04 , A61K9/14 , B01F3/00
CPC分类号： B01J13/043 , A61K49/223
摘要： A process for forming microcapsules comprising (i) providing a solution of a protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules, characterised in that the aqueous solution contains a liquid of greater volatility than water. The protein is preferably albumin and the volatile liquid is preferably ethanol. The microcapsules may be used as ultrasound echogenic contrast agents.
摘要翻译： PCT No.PCT / GB95 / 02673。 371日期：1996年7月19日 102（e）日期1996年7月19日PCT提交1995年11月15日PCT公布。公开号WO96 / 15814 日期1996年5月30日一种形成微胶囊的方法，其包括（i）在水性溶剂中提供蛋白质溶液，和（ii）将所述溶液喷雾到气体中，使得水性溶剂蒸发，从而形成空心微胶囊，其特征在于，水溶液含有比水更大的挥发性的液体。蛋白质优选为白蛋白，挥发性液体优选为乙醇。微胶囊可用作超声回声造影剂。

6. 发明授权

US06623722B1 Spray-drying microcapsules using an aqueous liquid containing a volatile liquid 失效
标题翻译：使用含有挥发性液体的水性液体的喷雾干燥微胶囊
公开(公告)号：US06623722B1
公开(公告)日：2003-09-23
申请号：US09023696
申请日：1998-02-13
申请人： Nicholas Osborne , Andrew Derek Sutton , Richard Alan Johnson
发明人： Nicholas Osborne , Andrew Derek Sutton , Richard Alan Johnson
IPC分类号： A61B800
CPC分类号： B01J13/043 , A61K49/223
摘要： A process for forming microcapsules comprising (i) providing a solution of a protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules, characterised in that the aqueous solution contains a liquid of greater volatility than water. The protein is preferably albumin and the volatile liquid is preferably ethanol. The microcapsules may be used as ultrasound echogenic contrast agents.
摘要翻译：一种形成微胶囊的方法，其包括（i）在水性溶剂中提供蛋白质溶液，和（ii）将所述溶液喷雾到气体中，使得水性溶剂蒸发，从而形成中空微胶囊，其特征在于，所述水溶液含有液体比水更易挥发。蛋白质优选为白蛋白，挥发性液体优选为乙醇。微胶囊可用作超声回声造影剂。

7. 发明授权

US06264918B1 Hollow microcapsules for methods of ultrasound imaging 失效
标题翻译：用于超声成像方法的空心微胶囊
公开(公告)号：US06264918B1
公开(公告)日：2001-07-24
申请号：US09194050
申请日：1999-08-16
申请人： Richard Alan Johnson , Paulus Antonius Van Der Wouw
发明人： Richard Alan Johnson , Paulus Antonius Van Der Wouw
IPC分类号： A61B800
CPC分类号： A61K49/223
摘要： A method of obtaining an image of a part of a patient, comprising: (a) providing microcapsules which have been formed by (i) providing a solution of a material in an aqueous solvent containing water and a liquid of greater volatility than water and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules suitable for use as an echogenic contrast agent, (b) injecting the microcapsules into a patient, and (c) subjecting the patient to ultrasonic energy to obtain an image based on the ultrasound reflectivity transmissibility or resonance of the microcapsules, characterized in that at least 5 minutes elapse between steps (b) and (c). The patient can be exercised between administration and imaging without having to be reinjected.
摘要翻译：一种获得患者部分图像的方法，包括：（a）提供微胶囊，其通过以下方式形成：（i）提供材料在含水溶剂和比水挥发性高的液体中的溶液， ii）将所述溶液喷射到气体中，使得水性溶剂蒸发，从而形成适合用作回声造影剂的中空微胶囊，（b）将微胶囊注射到患者体内，和（c）使患者接受超声能量基于微胶囊的超声反射率传递性或共振获得图像，其特征在于步骤（b）和（c）之间经过至少5分钟。患者可以在行政和成像之间行使，而不必重新注入。

8. 发明授权

US5961459A Use of hollow microcapsules in diagnosis and therapy 失效
标题翻译：中空微胶囊在诊断和治疗中的应用
公开(公告)号：US5961459A
公开(公告)日：1999-10-05
申请号：US953513
申请日：1997-10-17
申请人： Sanjiv Kaul , Richard Alan Johnson
发明人： Sanjiv Kaul , Richard Alan Johnson
IPC分类号： A61K9/50 , A61B8/06 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/22 , A61B8/00
CPC分类号： A61K49/223 , A61K41/0028
摘要： A diagnostic method analyses the effect of intervention, e.g. by surgery, especially in the myocardium. (i) Hollow microcapsules are administered into a blood vessel of a patient having a perfusion defect, (ii) if desired, an ultrasonic image is formed of the tissue, (iii) the occlusion is at least partially removed such that the blood flow in at least one area of the tissue is increased, and (iv) an ultrasonic image of the tissue is obtained after treatment. This is based on the observation of the particular properties of the microcapsules in the myocardium. It is also the basis of providing appropriate drugs to that site.
摘要翻译：诊断方法分析干预的效果，例如通过手术，特别是在心肌中。（i）将空心微胶囊施用于具有灌注缺陷的患者的血管中，（ii）如果需要，由组织形成超声波图像，（iii）至少部分去除闭塞，使得血液流入组织的至少一个区域增加，（iv）处理后获得组织的超声波图像。这是基于观察心肌中微胶囊的特定性质。它也是为该地点提供适当药物的基础。

9. 发明授权

US5955108A Cross-linked microparticles and their use as therapeutic vehicles 失效
标题翻译：交联微粒及其用作治疗载体
公开(公告)号：US5955108A
公开(公告)日：1999-09-21
申请号：US876489
申请日：1997-06-16
申请人： Andrew Derek Sutton , Richard Alan Johnson
发明人： Andrew Derek Sutton , Richard Alan Johnson
IPC分类号： A61K47/48 , A61K9/14 , A61K9/50
CPC分类号： A61K47/48284 , A61K47/48876 , Y10S514/937 , Y10S514/952
摘要： A sterile powder comprising microparticles, 0.1 to 50 .mu.m in diameter, obtainable by spray-drying and cross-linking a water-soluble material having free functional groups, is characterized in that the microparticles are hydrophilic, can be reconstituted in water to give a monodisperse suspension, and have retained said groups available for derivatization. The particles are linked to drugs or other functional molecules, and used as vehicles in therapy.
摘要翻译：一种无菌粉末，其特征在于，微粒是亲水性的，其可以通过喷雾干燥和交联具有游离官能团的水溶性材料而直径为0.1-50μm的微粒，可以在水中重构，得到单分散悬浮液，并保留了可用于衍生化的所述基团。颗粒与药物或其他功能分子连接，并用作治疗中的载体。

10. 发明授权

US07003530B2 Algorithm for selecting audio content 失效
公开(公告)号：US07003530B2
公开(公告)日：2006-02-21
申请号：US10104137
申请日：2002-03-22
申请人： Richard Alan Johnson
发明人： Richard Alan Johnson
IPC分类号： G06F12/00
CPC分类号： G06F17/30017 , Y10S707/916 , Y10S707/99935 , Y10S707/99945
摘要： An algorithm for selecting audio content including an audio database, a user preference learning routine, and an audio selection routine. The user preference learning routine is capable of explicitly learning by a manual entry made by the user concerning his/her favorite audio selections. The user preference learning routine is capable of implicitly learning by recording the selections made by the user through a preference input. The preference input queries the user whether he/she liked or disliked a particular audio selection. Initially, random selections are provided to the user. If the user does not like the audio selection it is skipped. If the user liked the selection it is recorded. As the user listens or doesn't listen to audio selections, a profile is developed that identifies the user's preferences. The audio selection routine chooses the next audio selection to be played for the user. There are at least two methods of making the audio selection. In the first method, a user sends his/her listening history to a central location. In the second method, a table of at least four items is used to determine the user listening preferences.

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