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1. 发明授权

US6068600A Use of hollow microcapsules 失效
标题翻译：使用空心微胶囊
公开(公告)号：US6068600A
公开(公告)日：2000-05-30
申请号：US761600
申请日：1996-12-06
申请人： Richard Alan Johnson , Paulus Antonius van der Wouw
发明人： Richard Alan Johnson , Paulus Antonius van der Wouw
IPC分类号： A61B8/00 , A61K9/16 , A61K49/22
CPC分类号： A61K49/223 , A61B8/4281 , A61B8/543 , A61K9/1658
摘要： A method of generating an ultrasound image comprising the steps of (i) introducing into the location to be imaged an ultrasound contrast agent obtained by spraying a solution or suspension of a wall forming material into a heated gas to form hollow microcapsules, (ii) exposing the microcapsules to ultrasound energy at an insonation frequency of less than 3.5 MHz and (iii) creating an image based on the scattering of the ultrasound energy by the microcapsules.
摘要翻译：一种产生超声波图像的方法，包括以下步骤：（i）将通过将形成壁的材料的溶液或悬浮液喷雾到加热气体中以形成中空微胶囊而获得的超声造影剂引入待成像的位置，（ii）暴露所述微胶囊以小于3.5MHz的振动频率进行超声能量，以及（iii）基于所述微胶囊的超声能量的散射来产生图像。

2. 发明授权

US06264918B1 Hollow microcapsules for methods of ultrasound imaging 失效
标题翻译：用于超声成像方法的空心微胶囊
公开(公告)号：US06264918B1
公开(公告)日：2001-07-24
申请号：US09194050
申请日：1999-08-16
申请人： Richard Alan Johnson , Paulus Antonius Van Der Wouw
发明人： Richard Alan Johnson , Paulus Antonius Van Der Wouw
IPC分类号： A61B800
CPC分类号： A61K49/223
摘要： A method of obtaining an image of a part of a patient, comprising: (a) providing microcapsules which have been formed by (i) providing a solution of a material in an aqueous solvent containing water and a liquid of greater volatility than water and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates, thereby forming hollow microcapsules suitable for use as an echogenic contrast agent, (b) injecting the microcapsules into a patient, and (c) subjecting the patient to ultrasonic energy to obtain an image based on the ultrasound reflectivity transmissibility or resonance of the microcapsules, characterized in that at least 5 minutes elapse between steps (b) and (c). The patient can be exercised between administration and imaging without having to be reinjected.
摘要翻译：一种获得患者部分图像的方法，包括：（a）提供微胶囊，其通过以下方式形成：（i）提供材料在含水溶剂和比水挥发性高的液体中的溶液， ii）将所述溶液喷射到气体中，使得水性溶剂蒸发，从而形成适合用作回声造影剂的中空微胶囊，（b）将微胶囊注射到患者体内，和（c）使患者接受超声能量基于微胶囊的超声反射率传递性或共振获得图像，其特征在于步骤（b）和（c）之间经过至少5分钟。患者可以在行政和成像之间行使，而不必重新注入。

3. 发明授权

US6017310A Use of hollow microcapsules 失效
标题翻译：使用空心微胶囊
公开(公告)号：US6017310A
公开(公告)日：2000-01-25
申请号：US724870
申请日：1996-10-04
申请人： Richard Alan Johnson , Nicolaas de Jong , Paulus Antonius van der Wouw
发明人： Richard Alan Johnson , Nicolaas de Jong , Paulus Antonius van der Wouw
IPC分类号： A61B8/00 , A61K49/22
CPC分类号： A61K49/223 , A61B8/481
摘要： A method of generating an ultrasound image comprising the steps of (i) introducing into the location to be imaged an ultrasound contrast agent obtained by spraying a solution or suspension of a wall forming material into a heated gas to form hollow microcapsules, (ii) exposing the microcapsules to ultrasound energy of an intensity of at least 100 kPa and (iii) creating an image based on the scattering of the ultrasound energy by the microcapsules.
摘要翻译：一种产生超声波图像的方法，包括以下步骤：（i）将通过将形成壁的材料的溶液或悬浮液喷雾到加热气体中以形成中空微胶囊而获得的超声造影剂引入待成像的位置，（ii）暴露所述微胶囊具有至少100kPa强度的超声能量，以及（iii）基于所述微胶囊对超声能量的散射产生图像。

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