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1. 发明授权

US06528516B1 Methods for reducing intraocular pressure using A3 adenosine receptor antagonists 有权
标题翻译：使用A3腺苷受体拮抗剂降低眼内压的方法
公开(公告)号：US06528516B1
公开(公告)日：2003-03-04
申请号：US09743744
申请日：2001-05-04
申请人： Mortimer M. Civan , Richard A. Stone , Claire H. Mitchell , Kenneth A. Jacobson
发明人： Mortimer M. Civan , Richard A. Stone , Claire H. Mitchell , Kenneth A. Jacobson
IPC分类号： A61K31435
CPC分类号： A61K31/5415 , A61K31/00 , A61K31/138 , A61K31/435 , A61K31/4422 , A61K31/4425 , A61K31/455 , A61K31/498 , A61K31/517 , Y10S514/913
摘要： This invention relates to a method of decreasing intraocular pressure by administrating an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen.
摘要翻译：本发明涉及通过施用A3亚型腺苷受体拮抗剂，钙调蛋白拮抗剂或抗雌激素如他莫昔芬来降低眼内压的方法。

2. 发明授权

US5571823A Pharmacological treatment of ocular development 失效
标题翻译：眼科发展的药理治疗
公开(公告)号：US5571823A
公开(公告)日：1996-11-05
申请号：US81469
申请日：1993-06-22
申请人： Richard A. Stone , Alan M. Laties , Paul M. Iuvone
发明人： Richard A. Stone , Alan M. Laties , Paul M. Iuvone
IPC分类号： A61K31/435 , A61K31/00 , A61K31/135 , A61K31/445 , A61K31/47 , A61K45/00 , A61K45/08 , A61P25/00 , A61P27/02
CPC分类号： A61K31/00 , A61K31/445 , A61K31/47 , Y10S514/912
摘要： A method of controlling the abnormal postnatal growth of the eye of a maturing animal which comprises the ocular administration of therapeutically effective amounts of a dopamine antagonist.
摘要翻译：一种控制成熟动物眼睛异常出生后生长的方法，其包括眼部施用治疗有效量的多巴胺拮抗剂。

3. 发明授权

US5356892A Treatment and control of ocular development 失效
标题翻译：治疗和控制眼部发育
公开(公告)号：US5356892A
公开(公告)日：1994-10-18
申请号：US856626
申请日：1992-03-24
申请人： Alan M. Laties , Richard A. Stone
发明人： Alan M. Laties , Richard A. Stone
IPC分类号： C07D405/06 , A61K31/00 , A61K31/14 , A61K31/16 , A61K31/27 , A61K31/415 , A61K31/4178 , A61K31/46 , A61K31/495 , A61K31/55 , A61K31/695 , A61K45/00 , A61P27/02 , A61P27/10 , A61P43/00
CPC分类号： A61K31/415 , A61K31/00 , A61K31/14 , A61K31/27 , A61K31/4178 , A61K31/55 , A61K31/695 , Y10S514/912
摘要： A composition for the inhibition of the abnormal postnatal axial growth of the eye of a maturing animal which comprises a pharmaceutically effective amount of a muscarinic pharmacological antagonist relatively selective for blocking the cholinergic receptors in cells of the brain, neural tissue and/or neural ganglia but less selective for blocking the cholinergic receptors of the cells of smooth muscles at the front of the eye, said antagonist present in a carrier or diluent suitable for ocular administration. A suitable antagonist is pirenzepine. Other suitable antagonists are telenzepine and o-methoxy-sila-hexocyclium.
摘要翻译：用于抑制成熟动物眼睛异常出生后轴向生长的组合物，其包含药学有效量的相对选择性地阻断脑，神经组织和/或神经神经节细胞中的胆碱能受体的毒蕈碱药物拮抗剂，但是较少选择性地阻断眼前方平滑肌细胞的胆碱能受体，所述拮抗剂存在于适合于眼部给药的载体或稀释剂中。合适的拮抗剂是哌仑西平。其他合适的拮抗剂是telenzepine和邻甲氧基 - 硅 - 己内酰胺。

4. 发明授权

US4853375A Method of lowering intraocular (eye) pressure 失效
标题翻译：降低眼内（眼）压力的方法
公开(公告)号：US4853375A
公开(公告)日：1989-08-01
申请号：US97554
申请日：1987-09-16
申请人： Theodore Krupin , Richard A. Stone
发明人： Theodore Krupin , Richard A. Stone
IPC分类号： A61K31/65 , A61P9/12 , A61P27/02 , A61P27/06
CPC分类号： A61K31/65 , Y10S514/913
摘要： A method of lowering intraocular pressure in the eye of a human or an animal, the method involving administering to the eye, an agent comprising an amount of tetracycline or a tetracycline related compound, such as demeclocycline, sufficient to achieve a significant lowering of intraocular pressure.
摘要翻译：一种降低人或动物眼睛眼内压的方法，该方法涉及向眼睛施用包含一定量的四环素或四环素相关化合物的剂量，例如德莫西林，其足以实现眼内压显着降低。

5. 发明授权

US4539097A Method for filtering solvent and tar sand mixtures 失效
标题翻译：过滤溶剂和焦油砂混合物的方法
公开(公告)号：US4539097A
公开(公告)日：1985-09-03
申请号：US584718
申请日：1984-02-29
申请人： Jeffrey C. Kelterborn , Richard A. Stone
发明人： Jeffrey C. Kelterborn , Richard A. Stone
IPC分类号： B01D11/02 , B01D36/00 , B01D37/02 , C10G1/04
CPC分类号： B01D36/00 , B01D11/023 , B01D37/02 , C10G1/045
摘要： A method for filtering spent tar sands from a bitumen and organic solvent solution comprises separating the solution into two streams wherein the bulk of the coarser spent tar sand is in a first stream and has an average particle size of about 10 to about 100 mesh and the bulk of the finer spent tar sand is in a second stream; producing a filter cake by filtering the coarser spent tar sand from the first stream; and filtering the finer spent tar sand from the second stream with the filter cake. The method is particularly useful for filtering solutions of bitumen extracted from bitumen containing diatomite, spent diatomite and organic solvent.
摘要翻译：用于从沥青和有机溶剂溶液中过滤废沥青砂的方法包括将溶液分离成两股流，其中较粗的乏焦油砂的体积处于第一流中，其平均粒度为约10至约100目，更多的废焦油砂的大部分是第二流; 通过从第一流过滤较粗的焦油砂来生产滤饼; 并用滤饼从第二流中过滤更细的废焦油砂。该方法特别适用于从含沥青的硅藻土，废硅藻土和有机溶剂中提取沥青的过滤溶液。

6. 发明授权

US06698885B2 Judging changes in images of the eye 有权
标题翻译：判断眼睛图像的变化
公开(公告)号：US06698885B2
公开(公告)日：2004-03-02
申请号：US10168932
申请日：2002-12-18
申请人： Jeffrey W Berger , Richard A Stone
发明人： Jeffrey W Berger , Richard A Stone
IPC分类号： A61B314
CPC分类号： G06T7/0012 , G06T7/30 , G06T2200/24 , G06T2207/30041
摘要： The invention includes a computer-implemented method, system (100), and computer-readable medium having computer-executable modules for judging changes in components of an eye. The inventive computer-implemented method includes the steps of acquiring (103), displaying (107), and superimposing at least two digital images of the components of the eye. The method further includes the step of processing at least one of the digital images such that the superimposed images may be compared, and the step of flickering among the superimposed digital images. The step of acquiring the images may include the step of converting a photographic representation of the components of the eye to the digital image. The step of processing may include registering, warping, and/or aligning the digital images.
摘要翻译：本发明包括计算机实现的方法，系统（100）和具有用于判断眼睛的分量变化的计算机可执行模块的计算机可读介质。本发明的计算机实现的方法包括以下步骤：获取（103），显示（107）并且叠加眼睛的分量的至少两个数字图像。该方法还包括处理数字图像中的至少一个以使得叠加的图像可以被比较的步骤以及叠加的数字图像之间闪烁的步骤。获取图像的步骤可以包括将眼睛的分量的摄影表现转换为数字图像的步骤。处理步骤可以包括登记，翘曲和/或对准数字图像。

7. 发明授权

US5360801A Pharmacological stimulation of eye growth 失效
标题翻译：药物刺激眼睛生长
公开(公告)号：US5360801A
公开(公告)日：1994-11-01
申请号：US004685
申请日：1993-01-14
申请人： Alan M. Laties , Richard A. Stone
发明人： Alan M. Laties , Richard A. Stone
IPC分类号： A61K31/00 , A61K31/14 , A61K31/27 , A61K31/415 , A61K31/4178 , A61K31/55 , A61K31/695 , A61K31/445
CPC分类号： A61K31/14 , A61K31/00 , A61K31/27 , A61K31/415 , A61K31/4178 , A61K31/55 , A61K31/695 , Y10S514/912
摘要： A method of inducing axial elongation of an eye of an animal comprising contacting a first open animal eye with a cholinergic agonist, detecting the change in axial growth of the first eye, applying a known control agent in a second open animal eye, observing the results of the control agent on the second eye, and comparing the change in axial growth of the first eye with the change in axial growth of the second eye.
摘要翻译：一种诱导动物眼睛轴向伸长的方法包括使第一开放动物眼睛与胆碱能激动剂接触，检测第一只眼睛的轴向生长变化，在第二只开放的动物眼睛中施用已知的控制剂，观察结果并且将第一只眼睛的轴向生长的变化与第二只眼睛的轴向生长的变化进行比较。

8. 发明授权

US5055302A Neuropeptide control of ocular growth 失效
标题翻译：神经生长控制
公开(公告)号：US5055302A
公开(公告)日：1991-10-08
申请号：US483447
申请日：1990-02-22
申请人： Alan M. Laties , Richard A. Stone
发明人： Alan M. Laties , Richard A. Stone
IPC分类号： A61K38/00 , A61K38/22 , A61P25/02 , A61P27/02 , C07K14/575
CPC分类号： C07K14/57563 , A61K38/00 , Y10S514/912 , Y10S514/929 , Y10S530/843 , Y10S530/844
摘要： A method and composition for inhibition of abnormal postnatal ocular growth are disclosed. The composition comprises vasoactive intestinal peptide (VIP), PHI or a analogue of these peptides. The method for inhibition of abnormal postnatal ocular growth comprises administering to the eye of an animal effective amount of VIP, PHI or analogue of these peptides.
摘要翻译：公开了用于抑制异常出生后眼部生长的方法和组合物。该组合物包含血管活性肠肽（VIP），PHI或这些肽的类似物。用于抑制异常出生后眼部生长的方法包括向动物眼睛施用有效量的这些肽的VIP，PHI或类似物。

9. 发明授权

US3982413A King pin lock for semi-trailers 失效
标题翻译：国王针锁半拖车
公开(公告)号：US3982413A
公开(公告)日：1976-09-28
申请号：US559144
申请日：1975-03-17
申请人： Richard A. Stone , Mathias H. Riesgraf
发明人： Richard A. Stone , Mathias H. Riesgraf
IPC分类号： B62D53/08 , F16B41/00
CPC分类号： B62D53/085 , Y10T70/40 , Y10T70/5854 , Y10T70/7661
摘要： This is a lock which can be quickly and easily attached to the locking groove of the king pin of a trailer to block entrance of the king pin into the attaching slot of the "fifth wheel" of a tractor, the lock having a pair of pivotally connected pin-surrounding locking segments with a snap-in lock element to hold the segments in closed position and also incorporating a safety warning sign to indicate the presence of the lock on the king pin and prevent inadvertent damage to the lock or the tractor unit.
摘要翻译：这是一种可以快速方便地连接到拖车的主销的锁定槽的锁，以阻挡主销进入拖拉机的“第五轮”的连接槽中的锁定，该锁具有一对枢转连接的针脚围绕的锁定片段具有卡扣锁定元件，以将片段保持在关闭位置，并且还包括安全警告标志，以指示锁扣在主销上的存在，并防止意外损坏锁或拖拉机单元。

10. 发明授权

US07322698B2 Method for judging changes in images of the eye or its component parts 有权
标题翻译：用于判断眼睛或其组成部分的图像变化的方法
公开(公告)号：US07322698B2
公开(公告)日：2008-01-29
申请号：US11432230
申请日：2006-05-10
申请人： Karen R. Berger, legal representative , Richard A. Stone
发明人： Jeffrey W. Berger, deceased
IPC分类号： A61B3/14
CPC分类号： G06T7/0012 , G06T7/30 , G06T2200/24 , G06T2207/30041
摘要： The invention includes a computer-implemented method, system, and computer-readable medium having computer-executable modules for judging changes in components of an eye. The inventive computer-implemented method includes the steps of acquiring, displaying, and superimposing at least two digital images of the components of the eye. The method further includes the step of processing at least one of the digital images such that the superimposed images may be compared, and the step of flickering among the superimposed digital images. The step of acquiring the images may include the step of converting a photographic representation of the components of the eye to the digital image. The step of processing may include registering, warping, and/or aligning the digital images.
摘要翻译：本发明包括具有计算机可执行模块的计算机实现的方法，系统和计算机可读介质，用于判断眼睛的分量变化。本发明的计算机实现的方法包括以下步骤：获取，显示和叠加眼睛的分量的至少两个数字图像。该方法还包括处理数字图像中的至少一个以使得叠加的图像可以被比较的步骤以及叠加的数字图像之间闪烁的步骤。获取图像的步骤可以包括将眼睛的分量的摄影表现转换为数字图像的步骤。处理步骤可以包括登记，翘曲和/或对准数字图像。

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