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1. 发明授权

US4407744A Process for obtaining nerve growth factor 失效
标题翻译：获得神经生长因子的方法
公开(公告)号：US4407744A
公开(公告)日：1983-10-04
申请号：US9017
申请日：1979-02-05
申请人： David M. Young
发明人： David M. Young
IPC分类号： A61K38/00 , C07K14/48 , C07G7/00 , A61K37/00
CPC分类号： C07K14/48 , A61K38/00 , Y10S530/843 , Y10S530/854
摘要： A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.
摘要翻译：从小鼠颌下腺或小鼠唾液中获得分子量为约116,000并且在稀水溶液中稳定的新形式的神经生长因子。将小鼠颌下腺或小鼠唾液的提取物进行离子交换层析以回收富含神经生长因子的腺体或唾液的成分，并含有不降解神经生长因子的蛋白质物质。纯神经生长因子通过将富含神经生长因子的组分进行至少一个另外的色谱步骤（通常为2-4）来获得，以回收分子量为约116,000的纯神经生长因子。

2. 发明授权

US5788967A Composition and method for enhancing wound healing 失效
标题翻译：用于增强伤口愈合的组合物和方法
公开(公告)号：US5788967A
公开(公告)日：1998-08-04
申请号：US480700
申请日：1995-06-07
申请人： R. I. Henkin
发明人： R. I. Henkin
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , A61K39/395 , C07K16/00
CPC分类号： C07K16/18 , C07K14/4705 , A61K38/00 , Y10S514/969 , Y10S530/843
摘要： There is described herein a wound healing enhancing medicinal composition formulated from the salivary protein Lumicarmine. The invention further includes preparation of antibodies of this protein. A culture of salivary gland cells was also grown. Lumicarmine was produced as well as other salivary proteins. The production of Lumicarmine also was blocked by antibodies thereof.
摘要翻译：这里描述了由唾液蛋白质Lumicarmine配制的伤口愈合增强药物组合物。本发明还包括制备该蛋白质的抗体。还种植了唾液腺细胞培养物。产生Lumicarmine以及其他唾液蛋白质。 Lumicarmine的生产也被其抗体阻断。

3. 发明授权

US4185095A Nerve growth factor 失效
标题翻译：神经生长因子
公开(公告)号：US4185095A
公开(公告)日：1980-01-22
申请号：US854194
申请日：1977-11-23
申请人： David M. Young
发明人： David M. Young
IPC分类号： A61K35/37 , A61K38/00 , A61P25/00 , C07K14/48 , A61K35/12 , A61K37/02 , C07G7/00
CPC分类号： C07K14/48 , A61K38/00 , Y10S530/843 , Y10S530/854
摘要： A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.
摘要翻译：从小鼠颌下腺或小鼠唾液中获得分子量为约116,000并且在稀水溶液中稳定的新形式的神经生长因子。将小鼠颌下腺或小鼠唾液的提取物进行离子交换层析以回收富含神经生长因子的腺体或唾液的成分，并含有不降解神经生长因子的蛋白质物质。纯神经生长因子通过将富含神经生长因子的组分进行至少一个另外的色谱步骤（通常为2-4）来获得，以回收分子量为约116,000的纯神经生长因子。

4. 发明授权

US3707531A Method of collecting protein substances having biological activity with respect to the nervous system comprising extraction of protein from submaxillary glands 失效
标题翻译：收集具有生物活性的蛋白质物质的方法，包括从亚细丝提取蛋白质的神经系统
公开(公告)号：US3707531A
公开(公告)日：1972-12-26
申请号：US3707531D
申请日：1970-08-04
申请人： TEIKOKU HORMONE MFG CO LTD
发明人： YAMAMOTO MASAAKI , NAKAZAWA TSUNEYUKI
IPC分类号： A61K38/00 , C07K14/475 , C07G7/00
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/843
摘要： A PROCESS FOR THE RECOVERY OF PROTEIN SUBSTANCES HAVING A BIOLOGICAL ACTIVITY TO PROMOTE THE GROWTH AND DEVELOPMENT OF THE NERVOUS SYSTEM WHICH COMPRISES (A) EXTRACTING THE SUBMAXILLARY GLANDS OF LARGE ANIMALS, I.E. BOVINE, EQUINE AND SWINE, WITH AN AQUEOUS EXTRACTING AGENT SELECTED FROM WATER AND SALINE SOLUTION; (B) ADDING TO THE EXTRACTED SOLUTION SULFOSALICYLIC ACID OR SODIUM SALT TO FORM A SOLUTION HAVING A CONCENTRATION OF 1-2% AND ADJUSTING THE PH OF THE SOLUTION TO 3.0-4.0 AND COLLECTING THE RESULTING PRECIPITATES; (C) DISSOLVING SUCH COLLECTED PRECIPITATES IN AN AQUEOUS SOLUTION; AND (D) SUBJECTING THE AQUEOUS SOLUTION FORMED IN (C) TO FRACTIONAL PRECIPITATION WITH ACETONE OR ALCOHOL IN A CONCENTRATION OF 40-50% AND COLLECTING THE FRACTIONAL PRECIPITATES CONTAINING THE PROTEIN SUBSTANCE. A PROTEIN SUBSTANCE (S) AND A PROTEIN SUBSTANCE (F) CAN BE FURTHER PRODUCED BY ACRINOL PRECIPITATION OF THE REDISSOLVED PROTEIN SUBSTANCE.

5. 发明授权

US3522229A Glycoprotein from saliva or salivary glands having gastric acid secretion inhibitory as well as anti-ulcerative activity and method of collecting the same 失效
标题翻译：来自具有胃酸分泌抑制作用的盐酸或盐酸的甘氨酸，作为抗活性活性及其收集方法
公开(公告)号：US3522229A
公开(公告)日：1970-07-28
申请号：US3522229D
申请日：1968-03-25
申请人： TEIKOKU HORMONE MFG CO LTD
发明人： YAMAMOTO MASAAKI , KOBAYASHI MASAYOSHI , MIKI TOKUTARO
IPC分类号： A61K38/00 , C07K14/47 , A61K17/00 , C07G7/00
CPC分类号： C07K14/4703 , A61K38/00 , Y10S530/843 , Y10S530/854

6. 发明授权

US4921789A Marker for colorectal carcinoma and methods of detecting the same 失效
标题翻译：结直肠癌标记物及其检测方法
公开(公告)号：US4921789A
公开(公告)日：1990-05-01
申请号：US184079
申请日：1988-04-20
申请人： Ronald R. Salem , Peter Thomas , Glenn Steele
发明人： Ronald R. Salem , Peter Thomas , Glenn Steele
IPC分类号： C07K16/30
CPC分类号： C07K16/3046 , Y10S435/81 , Y10S435/96 , Y10S436/808 , Y10S436/813 , Y10S436/815 , Y10S530/828 , Y10S530/843
摘要： A new marker for colorectal carcinoma has been discovered which is a glycoprotein having a molecular weight of approximately 160,000 daltons. Assay methods which can identify this marker are useful indetecting, diagnosing, and monitoring colorectal carcinoma, and in particular, carcinoma of the undifferentiated variety which heretofor were not readily detectible. For example, an assay which utilizes an antibody reacting to this glycoprotein marker is useful in a screening method for the detection and monitoring of colorectal carcinoma cells. Such an antibody can be included as part of a kit for screening a patient for colorectal carcinoma.
摘要翻译：已经发现结肠直肠癌的新标志物是分子量约为160,000道尔顿的糖蛋白。可以鉴定该标记物的测定方法是有益的检索，诊断和监测结肠直肠癌，特别是未分化品种的癌症不容易被检测到。例如，利用与该糖蛋白标记反应的抗体的测定法可用于检测和监测结肠直肠癌细胞的筛选方法。可以将这样的抗体作为用于筛选患者结肠直肠癌的试剂盒的一部分。

7. 发明授权

US3549610A Method of collecting protein substances having biological activity with respect to the nervous system comprising extraction of protein from submaxillary glands with ammonium sulfate or sodium sulfate 失效
标题翻译：收集具有生物活性的蛋白质物质的方法，其中包含从亚硫酸钠或硫酸钠提取蛋白质的神经系统
公开(公告)号：US3549610A
公开(公告)日：1970-12-22
申请号：US3549610D
申请日：1969-06-19
申请人： MASAAKI YAMAMOTO , TSUNEYUKI NAKAZAWA
发明人： YAMAMOTO MASAAKI , NAKAZAWA TSUNEYUKI
IPC分类号： A61K38/00 , C07K14/475 , C07G7/00
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/843

8. 发明授权

US3181997A Process for preparing purified solutions of kallikrein inactivator 失效
标题翻译：制备激肽释放酶的纯化溶液的方法
公开(公告)号：US3181997A
公开(公告)日：1965-05-04
申请号：US22493962
申请日：1962-09-20
申请人： BAYER AG
发明人： FRITZ SCHULTZ
IPC分类号： A61K38/57 , C07K14/81
CPC分类号： C07K14/811 , A61K38/57 , Y10S514/803 , Y10S530/837 , Y10S530/843 , Y10S530/848 , Y10S530/854

9. 发明授权

US2276882A Gastric mucin product and process for producing same 失效
标题翻译：胃粘蛋白产品及其生产方法
公开(公告)号：US2276882A
公开(公告)日：1942-03-17
申请号：US32042040
申请日：1940-02-23
申请人： SCHNEIDERWIRTH HERMAN J
发明人： SCHNEIDERWIRTH HERMAN J
IPC分类号： A61K35/12
CPC分类号： A61K38/1735 , Y10S530/843 , Y10S530/844

10. 发明授权

US5958407A Ileus treatment method 失效
标题翻译：麻醉治疗方法
公开(公告)号：US5958407A
公开(公告)日：1999-09-28
申请号：US49662
申请日：1998-03-27
申请人： Nigel W. Bunnett , Carlos U. Corvera
发明人： Nigel W. Bunnett , Carlos U. Corvera
IPC分类号： A61K36/16 , A61K38/05 , A61K38/48 , A61K38/55 , A61K38/57 , A61K38/58 , A61P1/00 , G01N33/50
CPC分类号： G01N33/5061 , A61K38/05 , A61K38/482 , A61K38/4826 , A61K38/55 , A61K38/57 , A61K38/58 , G01N33/5008 , G01N33/502 , G01N33/5047 , G01N33/5088 , Y10S530/843 , Y10S530/844
摘要： A method of treating or preventing post-operative ileus in a mammalian subject is disclosed. The method involves administering to the subject, a pharmaceutically effective amount of a compound that is effective in (i) preventing mast cell degranulation, (ii) inhibiting tryptase and chymase, and (iii) antagonizing PAR-2. The treatment is based on the discoveries that proteinase-activated receptor 2 is expressed in colonic muscle cells, and that activation of PAR-2 inhibits colonic motility. The PAR-2 receptor is activated, at least in part, by tryptase and chymase, produced by infiltration and degranulation of mast cells.
摘要翻译：公开了一种在哺乳动物受试者中治疗或预防术后肠梗阻的方法。该方法涉及向受试者施用药学有效量的在（i）预防肥大细胞脱粒，（ii）抑制类胰蛋白酶和胃促胰酶，和（iii）拮抗PAR-2中有效的化合物。治疗是基于蛋白酶激活的受体2在结肠肌细胞中表达的发现，并且PAR-2的激活抑制结肠运动。 PAR-2受体至少部分通过由肥大细胞的渗透和脱颗粒产生的类胰蛋白酶和胃促胰酶激活。

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