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1. 发明授权

US5565366A Kits and ligand assay plates using two-tiered separation for detection of immunoreagent particles 失效
标题翻译：试剂盒和配体测定平板，使用两层分离法检测免疫代谢颗粒
公开(公告)号：US5565366A
公开(公告)日：1996-10-15
申请号：US248835
申请日：1994-05-25
申请人： Raymond F. Akers, Jr.
发明人： Raymond F. Akers, Jr.
IPC分类号： G01N33/545 , G01N33/543 , G01N33/569 , G01N33/58 , G01N33/546
CPC分类号： G01N33/54313 , G01N33/585 , Y10S435/97 , Y10S436/807 , Y10S436/825
摘要： Methods for determining the presence of a ligand in a sample suspected to contain the ligand are provided, along with apparatus suitable for performing the methods. The methods depend upon a color visualization indicating the ligand's presence or absence in the sample. Preferred methods comprise contacting the sample with colored particles which bear on their surface a receptor specific for the ligand, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate. The presence of ligand in the sample is established where the color of the filtrate is substantially different from the color of the receptor-bearing particles.
摘要翻译：提供了用于确定疑似含有配体的样品中配体存在的方法，以及适于执行该方法的设备。方法取决于颜色可视化，表明配体在样品中的存在或不存在。优选的方法包括使样品与着色颗粒接触，所述着色颗粒在其表面上具有对配体特异性的受体，使样品/颗粒混合物通过过滤器，然后分析滤液的颜色。建立样品中配体的存在，其中滤液的颜色与含有受体的颗粒的颜色显着不同。

2. 外观设计

USD261871S Salinity tester 失效
公开(公告)号：USD261871S
公开(公告)日：1981-11-17
申请号：US64334
申请日：1979-08-06
申请人： Raymond F. Akers, Jr.
设计人： Raymond F. Akers, Jr.

3. 发明授权

US08871521B2 Breath ketone detector 有权
标题翻译：呼吸酮探测器
公开(公告)号：US08871521B2
公开(公告)日：2014-10-28
申请号：US13415624
申请日：2012-03-08
申请人： Raymond F. Akers, Jr.
发明人： Raymond F. Akers, Jr.
IPC分类号： G01N31/22 , G01N21/78 , G01N33/64 , G01N33/52 , G01N33/68 , G01N33/18
CPC分类号： G01N33/52 , B01L3/502 , B01L2200/16 , B01L2300/0832 , B01L2300/0835 , G01N33/18 , G01N33/1826 , G01N33/6893 , G01N2800/02 , G01N2800/18 , Y10T436/20 , Y10T436/200833
摘要： Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. Embodiments of this invention test the ketone level of a patient by measuring the ketone bodies in breath condensation. Some embodiments include a device for medical testing comprising a hollow container, comprising powder mixture of sodium nitroferricyanide, ammonium sulfate and silica and a liquid including an ammonium hydroxide solution.
摘要翻译：酮症酸中毒是一种极端和不受控制的酮症形式，这是对长期禁食的正常反应。本发明的实施例通过测量呼吸凝结中的酮体来测试患者的酮水平。一些实施方案包括用于医学测试的装置，其包括中空容器，其包含硝基氰化钠，硫酸铵和二氧化硅的粉末混合物和包含氢氧化铵溶液的液体。

4. 发明授权

US5231035A Latex agglutination assay 失效
标题翻译：乳胶凝集试验
公开(公告)号：US5231035A
公开(公告)日：1993-07-27
申请号：US640037
申请日：1991-01-11
申请人： Raymond F. Akers, Jr.
发明人： Raymond F. Akers, Jr.
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/54313 , G01N33/585 , Y10S436/805 , Y10S436/815 , Y10S436/816 , Y10S436/817 , Y10S436/818
摘要： Methods for determining the presence of a first ligand, preferably a hapten, in a sample suspected to contain the first ligand are provided, along with reagent systems and apparatus suitable for performing the methods. The methods depend upon a color visualization indicating the presence or absence of the first ligand in the sample. Preferred methods comprise contacting the sample with a reagent system which comprises: (1) colored particles which bear on their surface a second ligand which may be the same as or different than the first ligand; and (2) an amount of a receptor which is specific for the first ligand and the second ligand, wherein the amount is sufficient to stabilize the particles. The methods further comprise passing the contacted sample and reagent system through a filter, and then analyzing the color of the filtrate. The presence of ligand in the sample is established where the color of the filtrate is substantially different from the color of the ligand-bearing particles.
摘要翻译：提供了用于确定怀疑含有第一配体的样品中第一配体，优选半抗原存在的方法，以及适用于实施该方法的试剂系统和装置。该方法取决于指示样品中第一配体存在或不存在的颜色可视化。优选的方法包括使样品与试剂系统接触，试剂系统包括：（1）着色颗粒，其表面上具有可与第一配体相同或不同的第二配体; 和（2）对第一配体和第二配体特异的受体的量，其中该量足以使颗粒稳定。所述方法还包括使接触的样品和试剂系统通过过滤器，然后分析滤液的颜色。建立样品中配体的存在，其中滤液的颜色与含配体颗粒的颜色显着不同。

5. 发明授权

US4816415A Cannabinoid detection method 失效
标题翻译：大麻素检测方法
公开(公告)号：US4816415A
公开(公告)日：1989-03-28
申请号：US55438
申请日：1987-05-29
申请人： Susan Akers , Raymond F. Akers, Jr.
发明人： Susan Akers , Raymond F. Akers, Jr.
IPC分类号： G01N33/94 , G01N21/78
CPC分类号： G01N33/948 , Y10S436/901 , Y10T436/142222 , Y10T436/255
摘要： A method for detecting cannabinoids in body fluids which comprises filtering body fluids through a cellulosic filtering means treated with a binding agent for cannabinoids and the filtering means. The binding agent is an arylcarboxylic acid. The cannabinoids are then treated with a subsequent reagent to produce a color reaction. A device for detecting cannabinoids is also disclosed which contains the filtering means treated with the binding agent so as to concentrate the cannabinoid prior to reaction with a suitable indicator.
摘要翻译：一种用于检测体液中的大麻素的方法，其包括通过用大麻素结合剂和过滤装置处理的纤维素过滤装置过滤体液。粘合剂是芳基羧酸。然后用随后的试剂处理大麻素以产生显色反应。还公开了一种用于检测大麻素的装置，其包含用结合剂处理的过滤装置，以便在与合适的指示剂反应之前浓缩大麻素。

6. 发明授权

US4806487A Basic drug detection method 失效
标题翻译：基本药物检测方法
公开(公告)号：US4806487A
公开(公告)日：1989-02-21
申请号：US55437
申请日：1987-05-29
申请人： Susan Akers , Raymond F. Akers, Jr.
发明人： Susan Akers , Raymond F. Akers, Jr.
IPC分类号： G01N33/94 , G01N21/78
CPC分类号： G01N33/94 , Y10S436/901 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/255
摘要： A method for detecting basic narcotics or drugs in body fluids which comprises filtering body fluids through a cellulosic filtering means treated with a binding agent for the narcotics or drugs and the filtering means. The binding agent is a polycarboxylic acid. The narcotics or drugs are then treated with a subsequent reagent to produce a color reaction. A device for detecting basic narcotics or drugs in also disclosed which contains the filtering means treated with the binding agent so as to concentrate the narcotic or drug prior to reaction with a suitable indicator.
摘要翻译：一种用于检测体液中的碱性麻醉剂或药物的方法，其包括通过用麻醉剂或药物和过滤装置的粘合剂处理的纤维素过滤装置过滤体液。粘合剂是多元羧酸。然后用随后的试剂处理麻醉剂或药物以产生显色反应。还公开了用于检测碱性麻醉剂或药物的装置，其中包含用粘合剂处理的过滤装置，以便在与合适的指示剂反应之前浓缩麻醉药或药物。

7. 发明申请

US20120231548A1 BREATH KETONE DETECTOR 有权
标题翻译：西班牙探测器
公开(公告)号：US20120231548A1
公开(公告)日：2012-09-13
申请号：US13415624
申请日：2012-03-08
申请人： Raymond F. Akers, JR.
发明人： Raymond F. Akers, JR.
IPC分类号： G01N33/64 , B01L3/00
CPC分类号： G01N33/52 , B01L3/502 , B01L2200/16 , B01L2300/0832 , B01L2300/0835 , G01N33/18 , G01N33/1826 , G01N33/6893 , G01N2800/02 , G01N2800/18 , Y10T436/20 , Y10T436/200833
摘要： Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. Embodiments of this invention test the ketone level of a patient by measuring the ketone bodies in breath condensation. Some embodiments include a device for medical testing comprising a hollow container, comprising powder mixture of sodium nitroferricyanide, ammonium sulfate and silica and a liquid including an ammonium hydroxide solution.
摘要翻译：酮症酸中毒是一种极端和不受控制的酮症形式，这是对长期禁食的正常反应。本发明的实施例通过测量呼吸凝结中的酮体来测试患者的酮水平。一些实施方案包括用于医学测试的装置，其包括中空容器，其包含硝基氰化钠，硫酸铵和二氧化硅的粉末混合物和包含氢氧化铵溶液的液体。

8. 发明授权

US5827749A Ligand assay method 失效
标题翻译：配体测定法
公开(公告)号：US5827749A
公开(公告)日：1998-10-27
申请号：US730522
申请日：1996-10-11
申请人： Raymond F. Akers, Jr.
发明人： Raymond F. Akers, Jr.
IPC分类号： G01N33/545 , G01N33/543 , G01N33/569 , G01N33/58 , G01N33/546
CPC分类号： G01N33/54313 , G01N33/585 , Y10S435/97 , Y10S436/807 , Y10S436/825
摘要： Methods for determining the presence of a ligand in a sample suspected to contain the ligand are provided, along with apparatus suitable for performing the methods. The methods depend upon a color visualization indicating the ligand's presence or absence in the sample. Preferred methods comprise contacting the sample with colored particles which bear on their surface a receptor specific for the ligand, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate. The presence of ligand in the sample is established where the color of the filtrate is substantially different from the color of the receptor-bearing particles.
摘要翻译：提供了用于确定疑似含有配体的样品中配体存在的方法，以及适于执行该方法的设备。方法取决于颜色可视化，表明配体在样品中的存在或不存在。优选的方法包括使样品与着色颗粒接触，所述着色颗粒在其表面上具有对配体特异性的受体，使样品/颗粒混合物通过过滤器，然后分析滤液的颜色。建立样品中配体的存在，其中滤液的颜色与含有受体的颗粒的颜色显着不同。

9. 发明授权

US4331923A Salts monitoring device 失效
标题翻译：盐监测装置
公开(公告)号：US4331923A
公开(公告)日：1982-05-25
申请号：US64268
申请日：1979-08-06
申请人： Raymond F. Akers, Jr.
发明人： Raymond F. Akers, Jr.
IPC分类号： G01N27/06 , G01R27/22 , G01N27/42
CPC分类号： G01N27/06 , G01R27/22
摘要： Circuitry is disclosed for measuring the quantity of total dissolved ionized salts in an undiluted aqueous sample. A bi-level power supply operating through a square wave generator and voltage follower creates a low amplitude AC signal at a predetermined level above a ground reference. The control voltage is applied through a conductivity probe assembly to two series connected operational amplifiers operating through a bridge assembly and meter movement to provide a reading of the total dissolved ionized salts in the sample as a function of their ionization characteristics.
摘要翻译：公开了用于测量未稀释水样品中的总溶解离子化盐的量的电路。通过方波发生器和电压跟随器操作的双电平电源产生在高于地面基准的预定电平的低幅度AC信号。控制电压通过电导探针组件施加到两个串联连接的运算放大器上，通过桥组件和仪表运动进行操作，以提供样品中溶解的总溶解盐的读数，作为其电离特性的函数。

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