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1. 发明授权

US08329012B2 Method and apparatus for measuring oxidation-reduction potential 有权
标题翻译：测量氧化还原电位的方法和装置
公开(公告)号：US08329012B2
公开(公告)日：2012-12-11
申请号：US13450743
申请日：2012-04-19
申请人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
发明人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
IPC分类号： G01N27/403
CPC分类号： G01N27/3277 , G01N27/301 , G01N27/3272 , G01N27/403 , G01N27/4168 , G01N33/49
摘要： Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
摘要翻译：提供了用于测量流体样品的氧化还原电位的方法和系统。该系统包括具有适于接收流体样品的样品室的测试条。样品室可以与过滤膜相关联。测试条还包括参考单元。放置在样品室中的流体样品的氧化还原电位可以通过互连到与样品室电接触的测试导线的读出装置读取，以及与参考电池电接触的参考引线。放置在样品室中的流体样品与参考单元之间的电接触可通过桥来建立。氧化还原电位可以被读取为测试引线与测试条的参考引线之间的电位。

2. 发明授权

US08317997B2 Method and apparatus for measuring oxidation-reduction potential 有权
公开(公告)号：US08317997B2
公开(公告)日：2012-11-27
申请号：US13407517
申请日：2012-02-28
申请人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
发明人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
IPC分类号： G01N27/327
CPC分类号： G01N27/3277 , G01N27/301 , G01N27/3272 , G01N27/403 , G01N27/4168 , G01N33/49
摘要： Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.

3. 发明申请

US20120217173A1 METHOD AND APPARATUS FOR MEASURING OXIDATION-REDUCTION POTENTIAL 有权
公开(公告)号：US20120217173A1
公开(公告)日：2012-08-30
申请号：US13407517
申请日：2012-02-28
申请人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
发明人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
IPC分类号： G01N33/50 , G01N27/26 , G01N27/403
CPC分类号： G01N27/3277 , G01N27/301 , G01N27/3272 , G01N27/403 , G01N27/4168 , G01N33/49
摘要： Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.

4. 发明申请

US20120217159A1 METHOD AND APPARATUS FOR MEASURING OXIDATION-REDUCTION POTENTIAL 有权
标题翻译：用于测量氧化还原电位的方法和装置
公开(公告)号：US20120217159A1
公开(公告)日：2012-08-30
申请号：US13450743
申请日：2012-04-19
申请人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
发明人： Raphael Bar-Or , David Bar-Or , Leonard T. Rael
IPC分类号： G01N27/327 , G01N33/96
CPC分类号： G01N27/3277 , G01N27/301 , G01N27/3272 , G01N27/403 , G01N27/4168 , G01N33/49
摘要： Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
摘要翻译：提供了用于测量流体样品的氧化还原电位的方法和系统。该系统包括具有适于接收流体样品的样品室的测试条。样品室可以与过滤膜相关联。测试条还包括参考单元。放置在样品室中的流体样品的氧化还原电位可以通过互连到与样品室电接触的测试导线的读出装置读取，以及与参考电池电接触的参考引线。放置在样品室中的流体样品与参考单元之间的电接触可通过桥来建立。氧化还原电位可以被读取为测试引线与测试条的参考引线之间的电位。

5. 发明申请

US20120022004A1 TREATMENT OF T-CELL MEDIATED DISEASES 有权
标题翻译： T细胞介导性疾病的治疗
公开(公告)号：US20120022004A1
公开(公告)日：2012-01-26
申请号：US13247782
申请日：2011-09-28
申请人： David Bar-Or , Raphael Bar-Or , Richard Shimonkevitz
发明人： David Bar-Or , Raphael Bar-Or , Richard Shimonkevitz
IPC分类号： A61K38/12 , A61P37/08 , C07K5/12
CPC分类号： A61K31/495 , A61K9/00 , A61K9/0048 , A61K38/12 , A61K45/06 , C07D241/08 , A61K2300/00
摘要： The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
摘要翻译：本发明提供一种治疗T细胞介导的疾病的方法和使用某些二酮哌嗪抑制T细胞活化的方法。本发明还提供了合成二酮哌嗪和包含某些二酮哌嗪的药物组合物的方法。本发明还提供了通过增加或降低组合物中二酮哌嗪含量和所得改进的药物组合物来制备蛋白质和肽的改进的药物组合物的方法。

6. 发明申请

US20050021235A1 Method and system for optically performing an assay to determine a medical condition 审中-公开
标题翻译：用于光学执行测定以确定医疗状况的方法和系统
公开(公告)号：US20050021235A1
公开(公告)日：2005-01-27
申请号：US10477384
申请日：2002-05-30
申请人： Raphael Bar-Or , David Bar-Or , C. Curtis
发明人： Raphael Bar-Or , David Bar-Or , C. Curtis
IPC分类号： A61B5/00 , G01N21/64 , G01N33/48 , G01N33/68 , G01N33/84
CPC分类号： G01N21/31 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6428 , G01N33/683 , G01N33/84 , G01N2021/6423 , G01N2201/129 , G01N2333/76 , G01N2800/2871 , G01N2800/32
摘要： A method and system are disclosed for detecting a medical condition wherein a blood or plasma sample is combined with a metal such as cobalt and optically analyzed for an optical distinction that identifies the medical condition. The invention is useful for diagnosing medical conditions such as ischemia. Moreover, the diagnoses of patient samples according to the invention may be enhanced by developing a mathematical model based on signal processing techniques such as principal component analysis on the data obtained in patient studies.
摘要翻译：公开了用于检测医疗状况的方法和系统，其中血液或血浆样品与诸如钴的金属组合并且被光学分析以识别医学状况的光学鉴别。本发明对于诊断诸如缺血的医学病症是有用的。此外，通过开发基于信号处理技术的数学模型，例如对患者研究中获得的数据的主成分分析，可以增强根据本发明的患者样品的诊断。

7. 发明授权

US09707227B2 Treatment of T-cell mediated diseases 有权
公开(公告)号：US09707227B2
公开(公告)日：2017-07-18
申请号：US12707942
申请日：2010-02-18
申请人： David Bar-Or , Raphael Bar-Or , Richard Shimonkevitz
发明人： David Bar-Or , Raphael Bar-Or , Richard Shimonkevitz
IPC分类号： A61K38/00 , A61P43/00 , A61K38/12 , A61K31/495 , A61K45/06 , C07D241/08 , A61K9/00
CPC分类号： A61K31/495 , A61K9/00 , A61K9/0048 , A61K38/12 , A61K45/06 , C07D241/08 , A61K2300/00
摘要： The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.

8. 发明申请

US20130171670A1 DIAGNOSIS AND MONITORING OF INFLAMMATION, ISCHEMIA AND APPENDICITIS 审中-公开
标题翻译：诊断和监测炎症，间断和附件
公开(公告)号：US20130171670A1
公开(公告)日：2013-07-04
申请号：US13341608
申请日：2011-12-30
申请人： David Bar-Or , Raphael Bar-Or , James V. Winkler , Richard L. Yukl
发明人： David Bar-Or , Raphael Bar-Or , James V. Winkler , Richard L. Yukl
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , C07K16/18 , C07K16/44 , G01N33/6893 , G01N33/746 , G01N33/76 , G01N2333/4712 , G01N2333/765 , G01N2800/12 , G01N2800/26 , G01N2800/324
摘要： The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal.The invention also provides an improved method and kits for diagnosing appendicitis in an animal. The method comprises determining the quantities of orthohydroxyhippuric acid and of a marker of general inflammation, such as a post-translationally modified protein, present in one or more body fluids of the animal.
摘要翻译：本发明提供用于诊断和监测动物中炎症和/或缺血的方法和试剂盒。所述方法包括确定存在于来自动物的体液中的翻译后修饰的蛋白质（磷酸化tau）以外的量。本发明还提供了用于诊断动物阑尾炎的改进方法和试剂盒。该方法包括确定存在于动物的一种或多种体液中的邻羟基嘌呤酸和一般炎症的标志物如翻译后修饰的蛋白质的量。

9. 发明申请

US20120325685A1 MEASUREMENT AND USES OF OXIDATIVE STRESS 有权
标题翻译：氧化应变的测量和使用
公开(公告)号：US20120325685A1
公开(公告)日：2012-12-27
申请号：US13601586
申请日：2012-08-31
申请人： David Bar-Or , Raphael Bar-Or
发明人： David Bar-Or , Raphael Bar-Or
IPC分类号： G01N27/26
CPC分类号： G01N27/4168 , G01N27/26 , G01N27/327 , G01N33/50
摘要： The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill or who are critically ill, patients who have an infection, and patients suspected of having a myocardial infarction (MI) or who have had an MI. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product.
摘要翻译：本发明提供了一种通过测量体液或组织的氧化还原电位（ORP）来确定患者的体液或组织的整体氧化状态的方法。已经发现该方法可用于诊断，评估和监测患有创伤（例如头部损伤）的患者，怀疑患有危重病人或危重病人，患有感染的患者，以及疑似心肌梗塞（MI）或心肌梗塞的患者。该方法也被发现可用于监测和评估患者的运动表现。此外，已经发现该方法可用于监测和评估将接收这种产品的储存的血液制品和患者。

10. 发明授权

US07732403B2 Treatment of T-cell mediated diseases 有权
标题翻译：治疗T细胞介导的疾病
公开(公告)号：US07732403B2
公开(公告)日：2010-06-08
申请号：US10846482
申请日：2004-05-14
申请人： David Bar-Or , Raphael Bar-Or , Richard Shimonkovitz
发明人： David Bar-Or , Raphael Bar-Or , Richard Shimonkovitz
IPC分类号： A61K38/12
CPC分类号： A61K31/495 , A61K9/00 , A61K9/0048 , A61K38/12 , A61K45/06 , C07D241/08 , A61K2300/00
摘要： The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
摘要翻译：本发明提供一种治疗T细胞介导的疾病的方法和使用某些二酮哌嗪抑制T细胞活化的方法。本发明还提供了合成二酮哌嗪和包含某些二酮哌嗪的药物组合物的方法。本发明还提供了通过增加或降低组合物中二酮哌嗪含量和所得改进的药物组合物来制备蛋白质和肽的改进的药物组合物的方法。

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