会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明申请
    • Method for Assembly of Nucleic Acid Sequence Data
    • 核酸序列数据的装配方法
    • US20140249764A1
    • 2014-09-04
    • US14124261
    • 2012-05-24
    • Sunil KumarRandeep SinghNevenka Dimitrova
    • Sunil KumarRandeep SinghNevenka Dimitrova
    • G06F19/22
    • G16B30/00
    • The present invention relates to a method for assembly of nucleic acid sequence data comprising nucleic acid fragment reads into (a) contiguous nucleotide sequence segment(s), comprising the steps of: (a) obtaining a plurality of nucleic acid sequence data from a plurality of nucleic acid fragment reads; (b) aligning said plurality of nucleic acid sequence data to a reference sequence; (c) detecting one or more gaps or regions of non-assembly, or non-matching with the reference sequence in the alignment output of step (b); (d) performing de novo sequence assembly of nucleic acid sequence data mapping to said gaps or regions of non-assembly; and (e) combining the alignment output of step (b) and the assembly output of step (d) in order to obtain (a) contiguous nucleotide sequence segment(s). In addition, a corresponding program element or computer program for assembly of nucleic acid sequence data and a sequence assembly system for transforming nucleic acid sequence data comprising nucleic acid fragment reads into (a) contiguous nucleotide sequence segment(s) is provided.
    • 本发明涉及将包含核酸片段读取的核酸序列数据装配到(a)连续核苷酸序列片段中的方法,包括以下步骤:(a)从多个核酸序列获得多个核酸序列数据 的核酸片段读取; (b)将所述多个核酸序列数据与参考序列对准; (c)检测与步骤(b)的对准输出中的参考序列的非组装或不匹配的一个或多个间隙或区域; (d)执行核酸序列数据的从头序列组装,其映射到所述非组装的间隙或区域; 和(e)组合步骤(b)的比对输出和步骤(d)的组合输出,以获得(a)连续核苷酸序列片段。 此外,提供了用于装配核酸序列数据的相应程序元件或计算机程序和用于将包含核酸片段的核酸序列数据转换成(a)连续核苷酸序列片段的序列组装系统。