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1. 发明授权

US08333994B2 Stabilized, biocompatible gold nanoparticles and enviro-friendly method for making same 有权
标题翻译：稳定的，生物相容的金纳米颗粒和环境友好的制造方法
公开(公告)号：US08333994B2
公开(公告)日：2012-12-18
申请号：US12283935
申请日：2008-09-17
申请人： Kattesh V. Katti , Raghuraman Kannan , Kavita K. Katti , Satish Kumar Nune
发明人： Kattesh V. Katti , Raghuraman Kannan , Kavita K. Katti , Satish Kumar Nune
IPC分类号： A61K9/14
CPC分类号： A61K49/0093 , A61K9/14 , A61K9/148 , A61K33/24 , A61K41/00 , A61K49/04
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from polyphenols- or flavanoids-rich plant material or reactive phytochemical components of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with polyphenols- or flavanoids-rich plant material. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with black tea, turmeric, curcumin or cinnamon or a similar naturally occurring polyphenols- or flavanoids-rich plant material. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of the polyphenols- or flavanoids-rich plant material. The black tea, turmeric, curcumin or cinnamon or similar naturally occurring polyphenols- or flavanoids-rich plant material can be a powder or can be in its root or bark form.
摘要翻译：本发明提供了稳定的生物相容性金纳米颗粒，其通过来自多酚 - 或富含黄酮的植物材料或植物材料的反应性植物化学成分的材料稳定。本发明的金纳米颗粒可以用用于制备生物相容稳定的金纳米颗粒的环境友好的方法制造。在本发明的方法中，含有金盐的水溶液与富含多酚或富含黄酮的植物材料混合。在优选的实施方案中，提供了含有金盐的水溶液的制备方法。水溶液与红茶，姜黄，姜黄素或肉桂或类似天然存在的多酚或富含黄酮的植物材料混合。金盐反应形成生物相容性金纳米颗粒，其通过多酚或富含黄酮的植物材料的涂层而稳定。红茶，姜黄，姜黄素或肉桂或类似的天然存在的多酚或富含黄酮的植物材料可以是粉末或可以是其根或皮肤形式。

2. 发明申请

US20120134918A1 GUM ARABIC COATED 198GOLD RADIOACTIVE NANOPARTICLES FOR CANCER THERAPY 审中-公开
标题翻译：用于癌症治疗的阿拉伯胶囊198Gold放射性纳米颗粒
公开(公告)号：US20120134918A1
公开(公告)日：2012-05-31
申请号：US13293827
申请日：2011-11-10
申请人： Kattesh V. Katti , Raghuraman Kannan , Cathy S. Cutler
发明人： Kattesh V. Katti , Raghuraman Kannan , Cathy S. Cutler
IPC分类号： A61K51/12 , A61P35/00 , A61M36/06 , B82Y15/00 , B82Y5/00
CPC分类号： A61K51/1244 , B82Y5/00 , B82Y15/00
摘要： The invention provides a cancer therapeutic and imaging agent comprising a solution containing Gum Arabic coated 198Au nanoparticles. The Gum Arabic coated 198Au nanoparticles have been demonstrated experimentally shown to have a surprising efficacy for a single dose direct injection, reducing tumors in analog mice by 82% over a short period of time. The particles of the invention have a believed optimal size for therapy and imaging applications, and can be used as a theranostic agent in the treatment of needle accessible cancers. The invention also provides a method for forming Gum Arabic coated 198Au nanoparticles. A gold foil is irradiated to produce 198Au foil. The foil is dissolved to form radioactive gold salt. The salt is dried, and then reconstituted to form a 198Au nanoparticle precursor. The precursor is reduced with a reducing agent in an aqueous solution including Gum Arabic to form Gum Arabic coated 198Au nanoparticles.
摘要翻译：本发明提供一种癌症治疗和显像剂，其包含含有阿拉伯胶的198Au纳米颗粒的溶液。实验证明，阿拉伯胶包覆的198Au纳米颗粒在单次剂量直接注射中具有令人惊奇的功效，在短时间内将模拟小鼠的肿瘤减少82％。本发明的颗粒具有用于治疗和成像应用的相信最佳尺寸，并且可以用作治疗针可及性癌症的治疗剂。本发明还提供了一种形成阿拉伯胶的198Au纳米颗粒的方法。照射金箔以产生198Au箔。将箔溶解形成放射性金盐。将盐干燥，然后重构形成198Au纳米颗粒前体。在包含阿拉伯胶的水溶液中用还原剂还原前体以形成阿拉伯胶包覆的198Au纳米颗粒。

3. 发明申请

US20100266508A1 STABILIZED GOLD NANOPARTICLE AND CONTRAST AGENT 有权
标题翻译：稳定的金纳米颗粒和对比剂
公开(公告)号：US20100266508A1
公开(公告)日：2010-10-21
申请号：US12665086
申请日：2008-06-27
申请人： Vijaya Kattumuri , Kattesh V. Katti , Evan Boote , Raghuraman Kannan , Stan Casteel , Robert Churchill
发明人： Vijaya Kattumuri , Kattesh V. Katti , Evan Boote , Raghuraman Kannan , Stan Casteel , Robert Churchill
IPC分类号： A61K49/04 , C07K7/08 , C40B40/00 , A61B6/03 , G01N23/04
CPC分类号： A61K49/0428 , A61B6/508 , B82Y5/00
摘要： A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal.
摘要翻译：用于在哺乳动物中提供对比增强剂的试剂盒用于在哺乳动物成像期间进行对比，包括被配置成被引导到哺乳动物的靶器官，组织和损伤中的一个或多个的官能化金纳米颗粒。

4. 发明申请

US20090117045A1 Soy or lentil stabilized gold nanoparticles and method for making same 有权
标题翻译：大豆或扁豆稳定金纳米颗粒及其制备方法
公开(公告)号：US20090117045A1
公开(公告)日：2009-05-07
申请号：US12241904
申请日：2008-09-30
申请人： Kattesh V. Katti , Raghuraman Kannan , Kavita K. Katti , Nripen Chandra , Ravi Shukla
发明人： Kattesh V. Katti , Raghuraman Kannan , Kavita K. Katti , Nripen Chandra , Ravi Shukla
IPC分类号： A61K49/00 , B32B15/04 , H05B6/64 , A61P43/00 , A61K9/14
CPC分类号： A61K33/24 , A61K9/5176 , A61K9/5192 , B82Y5/00 , Y10T428/2991
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with soy or lentil plant material or a reactive extract thereof. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with soy or lentil plant material or a reactive extract thereof. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a robust coating derived of the soy or lentil plant material or a reactive extract thereof.
摘要翻译：本发明提供用来自大豆或扁豆植物材料的材料或其植物材料的反应性提取物稳定的稳定的生物相容性金纳米颗粒。本发明的金纳米颗粒可以用用于制备生物相容稳定的金纳米颗粒的环境友好的方法制造。在本发明的方法中，将含有金盐的水溶液与大豆或扁豆植物材料或其反应性提取物混合。在优选的实施方案中，提供了含有金盐的水溶液的制备方法。将水溶液与大豆或扁豆植物材料或其反应性提取物混合。金盐反应形成生物相容性金纳米颗粒，其由来自大豆或扁豆植物材料的坚固涂层或其反应性提取物稳定。

5. 发明申请

US20090074674A1 Stabilized, biocompatible gold nanoparticles and enviro-friendly method for making same 有权
标题翻译：稳定的，生物相容的金纳米颗粒和环境友好的制造方法
公开(公告)号：US20090074674A1
公开(公告)日：2009-03-19
申请号：US12283935
申请日：2008-09-17
申请人： Kattesh K. Katti , Raghuraman Kannan , Kavita K. Katti
发明人： Kattesh K. Katti , Raghuraman Kannan , Kavita K. Katti
IPC分类号： A61K49/00 , A61K9/14 , A61K33/24
CPC分类号： A61K49/0093 , A61K9/14 , A61K9/148 , A61K33/24 , A61K41/00 , A61K49/04
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from polyphenols- or flavanoids-rich plant material or reactive phytochemical components of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with polyphenols- or flavanoids-rich plant material. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with black tea, turmeric, curcumin or cinnamon or a similar naturally occurring polyphenols- or flavanoids-rich plant material. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of the polyphenols- or flavanoids-rich plant material. The black tea, turmeric, curcumin or cinnamon or similar naturally occurring polyphenols- or flavanoids-rich plant material can be a powder or can be in its root or bark form.
摘要翻译：本发明提供了稳定的生物相容性金纳米颗粒，其通过来自多酚 - 或富含黄酮的植物材料或植物材料的反应性植物化学成分的材料稳定。本发明的金纳米颗粒可以用用于制备生物相容稳定的金纳米颗粒的环境友好的方法制造。在本发明的方法中，含有金盐的水溶液与富含多酚或富含黄酮的植物材料混合。在优选的实施方案中，提供了含有金盐的水溶液的制备方法。水溶液与红茶，姜黄，姜黄素或肉桂或类似天然存在的多酚或富含黄酮的植物材料混合。金盐反应形成生物相容性金纳米颗粒，其通过多酚或富含黄酮的植物材料的涂层而稳定。红茶，姜黄，姜黄素或肉桂或类似的天然存在的多酚或富含黄酮的植物材料可以是粉末或可以是其根或树皮形式。

6. 发明授权

US09549998B2 Stabilized gold nanoparticle and contrast agent 有权
标题翻译：稳定的金纳米颗粒和造影剂
公开(公告)号：US09549998B2
公开(公告)日：2017-01-24
申请号：US12665086
申请日：2008-06-27
申请人： Vijaya Kattumuri , Kattesh V. Katti , Evan Boote , Raghuraman Kannan , Stan Casteel , Robert Churchill
发明人： Vijaya Kattumuri , Kattesh V. Katti , Evan Boote , Raghuraman Kannan , Stan Casteel , Robert Churchill
IPC分类号： A61K49/04 , A61B6/00 , B82Y5/00
CPC分类号： A61K49/0428 , A61B6/508 , B82Y5/00
摘要： A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal.
摘要翻译：用于在哺乳动物中提供对比增强剂的试剂盒用于在哺乳动物成像期间进行对比，包括被配置成被引导到哺乳动物的靶器官，组织和损伤中的一个或多个的官能化金纳米颗粒。

7. 发明申请

US20160363587A1 Magnetic Nanoparticle Conjugate and Use Thereof 审中-公开
标题翻译：磁性纳米粒子共轭体及其用途
公开(公告)号：US20160363587A1
公开(公告)日：2016-12-15
申请号：US15150262
申请日：2016-05-09
申请人： Raghuraman Kannan , Shreya Ghoshdastidar , Dhananjay Suresh , Danny Schust , Anandhi Upendran
发明人： Raghuraman Kannan , Shreya Ghoshdastidar , Dhananjay Suresh , Danny Schust , Anandhi Upendran
IPC分类号： G01N33/543 , G01N33/574 , C12Q1/68 , G01N33/553
CPC分类号： G01N33/54346 , C12Q1/6883 , G01N33/54326 , G01N33/54353 , G01N33/57419 , G01N33/57423 , G01N33/57484 , G01N33/721
摘要： A composition comprising one or more antibodies covalently attached to a magnetic nanoparticle via a linker. The magnetic nanoparticle comprises a magnetic core and a non-magnetic outer surface layer. The one or more antibodies are specific for one or more target cells or one or more target biomolecules in a biological sample. The linker comprises ethylene glycol and/or thiol. The invention also provides methods for fabricating such antibody conjugated nanoparticles and procedures for their applications in selective separation/isolation of target cells or target biomolecules from biological matters.
摘要翻译：包含通过连接体共价连接到磁性纳米颗粒的一种或多种抗体的组合物。磁性纳米颗粒包括磁芯和非磁性外表面层。一种或多种抗体对于生物样品中的一种或多种靶细胞或一种或多种靶生物分子是特异性的。连接体包括乙二醇和/或硫醇。本发明还提供了制备这种抗体共轭纳米颗粒的方法以及用于从生物学物质选择性分离/分离靶细胞或靶生物分子的方法。

8. 发明授权

US08586096B2 Soy or lentil stabilized gold nanoparticles and method for making same 有权
公开(公告)号：US08586096B2
公开(公告)日：2013-11-19
申请号：US12241904
申请日：2008-09-30
申请人： Kattesh K. Katti , Raghuraman Kannan , Kavita K. Katti , Nripen Chanda , Ravi Shukla
发明人： Kattesh K. Katti , Raghuraman Kannan , Kavita K. Katti , Nripen Chanda , Ravi Shukla
IPC分类号： B82Y5/00 , A61K49/00 , B32B15/04 , H05B6/64 , A61P43/00 , A61K9/14
CPC分类号： A61K33/24 , A61K9/5176 , A61K9/5192 , B82Y5/00 , Y10T428/2991
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In methods of the invention, an aqueous solution containing gold salts is mixed with soy or lentil plant material or a reactive extract thereof. In preferred embodiment methods of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with soy or lentil plant material or a reactive extract thereof. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a robust coating derived of the soy or lentil plant material or a reactive extract thereof.

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