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    • 2. 发明申请
    • Blood cells having modified antigenicity
    • 具有改良抗原性的血细胞
    • US20050208655A1
    • 2005-09-22
    • US11049271
    • 2005-02-02
    • Henrik ClausenHumberto de la VegaCheryl HillQiyong Liu
    • Henrik ClausenHumberto de la VegaCheryl HillQiyong Liu
    • A61K35/18A61P7/06C12N1/20C12N1/21C12N5/078C12N9/24C12N9/40C12Q1/34C12N5/08
    • C12N5/0641C12N9/2402C12N9/2465C12Q1/34C12R1/465C12Y302/01022C12Y302/01049
    • This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique alpha N-acetylgalactosaminidases and alpha-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique alpha-N-acetylgalactosaminidases and alpha-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates. The conversion methods of the invention use significantly lower amounts of recombinant glycosidase enzymes than previous and result in complete sero-conversion of all blood group A and B red cells.
    • 本发明涉及从血型A,B,AB型反应性细胞中分离A型和B型抗原,从而将其转化为非A型和非B型细胞。 本发明还涉及使用独特的α-N-乙酰半乳糖胺酶和具有优异动力学性质的α-半乳糖苷酶,用于去除血型A和B抗原的免疫优势单糖,并提高红细胞酶促转化的性能。 优选的独特的α-N-乙酰半乳糖胺酶和α-半乳糖苷酶具有以下特征:(i)相对于简单的单糖和二糖的可测量的活性,对于A型和B型支链多糖结构的排列,优选或不低于10%的底物特异性 结构和糖苷配基衍生物; (ii)在中性pH下用血型寡糖和细胞酶促转化的最佳性能; 和(iii)具有单糖和寡糖底物的有利的动力学常数Km。 本发明的转化方法比以前使用显着更低量的重组糖苷酶,并导致所有血型A和B红细胞的完全血清转化。
    • 4. 发明授权
    • Joint optimization of packetization and error correction for video communication
    • 联合优化视频通信的分组和纠错
    • US08707141B1
    • 2014-04-22
    • US13196359
    • 2011-08-02
    • Rui ZhangQiyong LiuBo LingSiping Tao
    • Rui ZhangQiyong LiuBo LingSiping Tao
    • H03M13/00
    • H03M13/353H04N21/2383
    • In one embodiment, a process determines a size of a video unit (e.g., frame) to transmit from a sender to a receiver across a communication channel for an associated video stream, and also determines an updated packet loss rate on the channel. In response, the process may dynamically determine both a number N of video data packets and a number M of forward error correction (FEC) packets to transmit for the video unit based on the size of the video unit, the updated packet loss rate on the channel, and an error resilience requirement for the video stream. In an illustrative embodiment, N and M are determined during transmission of the video stream through a look-up operation into a table indexed by the size of the video unit and the updated packet loss rate as co-indices, the co-indices co-indexing a pre-determined N and M pair.
    • 在一个实施例中,过程确定通过用于相关联的视频流的通信信道从发送方发送到接收者的视频单元(例如,帧)的大小,并且还确定信道上的更新的丢包率。 作为响应,该过程可以基于视频单元的大小来动态地确定视频数据分组的数量N和数字M的前向纠错(FEC)分组,以便为​​视频单元发送,更新的丢包率 频道和视频流的错误恢复能力要求。 在说明性实施例中,在通过查找操作将视频流传输到由视频单元的大小索引的表和更新的分组丢失率作为共同索引的同时,确定N和M, 索引预定的N和M对。