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1. 发明申请

US20140221384A1 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE 审中-公开
标题翻译： TETRA-O-取代的丁烷修饰的NDGA衍生物，其合成和药物使用
公开(公告)号：US20140221384A1
公开(公告)日：2014-08-07
申请号：US14246741
申请日：2014-04-07
申请人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
发明人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
IPC分类号： C07D295/088 , C07C255/33 , C07C47/27 , C07D277/24 , C07C217/54 , C07C39/21 , C07C43/205
CPC分类号： C07D295/088 , C07C37/50 , C07C39/21 , C07C39/367 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C47/27 , C07C47/273 , C07C217/20 , C07C217/54 , C07C255/33 , C07D277/24 , C07C39/16
摘要： The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
摘要翻译：本发明涉及去甲二氢愈创木酸衍生物化合物，即丁烷桥改性的二氢愈创木酸（NDGA）化合物和丁烷桥改性的四-O-取代的NDGA化合物，含有它们的药物组合物，制备它们的方法及其使用方法和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HPV感染或HSV感染引起的或与病毒感染相关的疾病，诸如各种类型的关节炎和炎症性肠病的炎性疾病，代谢疾病，如糖尿病和高血压，或增殖性疾病，如各种类型的癌症。

2. 发明申请

US20100022528A1 TETRA-SUBSTITUTED NDGA DERIVATIVES VIA ETHER BONDS AND CARBAMATE BONDS AND THEIR SYNTHESIS AND PHARMACEUTICAL USE 有权
标题翻译：通过其他骨骼和碳酸氢钠的四氮替代NDGA衍生物及其合成和药物使用
公开(公告)号：US20100022528A1
公开(公告)日：2010-01-28
申请号：US12443906
申请日：2007-10-02
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/09 , C07D401/14 , C07D403/14 , C07C217/64 , C07C43/23 , C07D413/14 , A61K31/4545 , A61K31/427 , A61K31/138 , A61K31/5377 , A61K31/496 , A61P29/00 , A61P3/00 , A61P7/00
CPC分类号： C07C271/52 , C07C43/225 , C07C43/23 , C07C217/20 , C07D277/24 , C07D295/088 , C07D307/52
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

3. 发明申请

US20170044121A1 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE 审中-公开
标题翻译： TETRA-O-取代的丁烷修饰的NDGA衍生物，其合成和药物使用
公开(公告)号：US20170044121A1
公开(公告)日：2017-02-16
申请号：US15339822
申请日：2016-10-31
申请人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
发明人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
IPC分类号： C07D295/088 , C07D277/24 , C07C217/54 , C07C43/205
CPC分类号： C07D295/088 , C07C37/50 , C07C39/21 , C07C39/367 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C47/27 , C07C47/273 , C07C217/20 , C07C217/54 , C07C255/33 , C07D277/24 , C07C39/16
摘要： The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
摘要翻译：本发明涉及去甲二氢愈创木酸衍生物化合物，即丁烷桥改性的二氢愈创木酸（NDGA）化合物和丁烷桥改性的四-O-取代的NDGA化合物，含有它们的药物组合物，制备它们的方法及其使用方法和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HPV感染或HSV感染引起的或与病毒感染相关的疾病，诸如各种类型的关节炎和炎症性肠病的炎性疾病，代谢疾病，如糖尿病和高血压，或增殖性疾病，如各种类型的癌症。

4. 发明申请

US20140287526A1 Nanotube Based Lateral Flow Device for Biomarker Detection 审中-公开
标题翻译：基于纳米管的侧向流动装置，用于生物标志物检测
公开(公告)号：US20140287526A1
公开(公告)日：2014-09-25
申请号：US13934707
申请日：2013-07-03
申请人： Xue-Feng Wang , Qingqi Chen
发明人： Xue-Feng Wang , Qingqi Chen
IPC分类号： G01N33/543
CPC分类号： G01N33/558
摘要： Nanotube based lateral flow test device described herein is a lateral flow based diagnostic device, which uses arrays of fragments of single wall carbon nanotubes as sensor to detect the biomarkers at ultralow concentration (below picogram per milliliter). The device is consisted of the following components: (1). an lateral flow strip which typically is consisted of a backing film laminated with conjugate/sample pads, nitrocellulose membrane, wicking pad, (2). the arrays of single wall carbon nanotube conjugate with antibody which is immobilized on the membrane of the lateral flow device as the test line, (3). pairs of micro-electrode are installed on top part of the cassette, (4). a cassette which holds the lateral flow strip. The device can be used in clinical environments for biomarker detection.
摘要翻译：本文所述的基于纳米管的横向流动测试装置是基于侧向流动的诊断装置，其使用单壁碳纳米管碎片阵列作为传感器，以超低浓度（低于皮质每毫升）检测生物标志物。该设备由以下组件组成：（1）。横向流动条，其通常由层合有共轭/样品垫，硝酸纤维素膜，芯吸垫（2）的背衬膜组成。与作为测试线固定在侧流装置的膜上的与抗体结合的单壁碳纳米管阵列，（3）。成对的微电极安装在磁带盒的顶部，（4）。保持横向流动条的盒。该装置可用于生物标志物检测的临床环境。

5. 发明申请

US20130303531A1 TETRA-SUBSTITUTED NDGA DERIVATIVES VIA ETHER BONDS AND CARBAMATE BONDS AND THEIR SYNTHESIS AND PHARMACEUTICAL USE 有权
公开(公告)号：US20130303531A1
公开(公告)日：2013-11-14
申请号：US13470779
申请日：2012-05-14
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/09 , A61K31/4545 , C07D277/24 , A61K31/427 , C07C217/20 , A61K31/138 , C07C43/23 , C07C43/225 , A61K31/5377 , A61K31/496 , C07C271/52 , A61K31/27 , C07D295/13 , C07D307/52 , A61K31/341 , A61P31/12 , A61P35/00 , A61P29/00 , A61P3/00 , A61P9/00 , C07D295/088
CPC分类号： A61K31/5377 , A61K31/09 , A61K31/138 , A61K31/325 , A61K31/341 , A61K31/427 , A61K31/4545 , A61K31/496 , C07C43/225 , C07C43/23 , C07C217/20 , C07C217/64 , C07C271/52 , C07C2601/16 , C07D211/14 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/52 , C07D307/54
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

6. 发明申请

US20150141417A9 TETRA-SUBSTITUTED NDGA DERIVATIVES VIA ETHER BONDS AND CARBAMATE BONDS AND THEIR SYNTHESIS AND PHARMACEUTICAL USE 有权
标题翻译：通过其他骨骼和碳酸氢钠的四氮替代NDGA衍生物及其合成和药物使用
公开(公告)号：US20150141417A9
公开(公告)日：2015-05-21
申请号：US13470779
申请日：2012-05-14
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： C07D307/54 , A61K31/09 , C07D277/24 , A61K31/427 , C07C217/20 , A61K31/138 , C07C43/23 , C07C43/225 , A61K31/5377 , A61K31/496 , C07C271/52 , A61K31/27 , C07D295/13 , C07D307/52 , A61K31/341 , A61P31/12 , A61P35/00 , A61P29/00 , A61P3/00 , A61P9/00 , C07D211/14 , C07C217/64 , A61K31/4545 , C07D295/15 , C07D295/088
CPC分类号： A61K31/5377 , A61K31/09 , A61K31/138 , A61K31/325 , A61K31/341 , A61K31/427 , A61K31/4545 , A61K31/496 , C07C43/225 , C07C43/23 , C07C217/20 , C07C217/64 , C07C271/52 , C07C2601/16 , C07D211/14 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/52 , C07D307/54
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

7. 发明授权

US08178527B2 Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use 有权
标题翻译：通过醚键和氨基甲酸酯键的四取代的NDGA衍生物及其合成和药物用途
公开(公告)号：US08178527B2
公开(公告)日：2012-05-15
申请号：US12443906
申请日：2007-10-02
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/495 , A61K31/445 , A61K31/341 , A61K31/426 , A61K31/5375 , A61K31/165 , A61K31/132 , A61K31/085 , C07D277/24 , C07D307/52 , C07D211/06 , C07D241/04 , C07D413/14 , C07C271/46 , C07C271/02
CPC分类号： C07C271/52 , C07C43/225 , C07C43/23 , C07C217/20 , C07D277/24 , C07D295/088 , C07D307/52
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

8. 发明申请

US20060029586A1 Use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates 审中-公开
标题翻译：使用异氰酸酯接头制备可水解的活性剂生物聚合物共轭物
公开(公告)号：US20060029586A1
公开(公告)日：2006-02-09
申请号：US11036259
申请日：2005-01-14
申请人： Qingqi Chen , Damian Sowa , Reinhard Gabathuler
发明人： Qingqi Chen , Damian Sowa , Reinhard Gabathuler
IPC分类号： A61K38/16 , A61K38/43 , C07K14/47 , C12N9/00
CPC分类号： A61K47/60
摘要： The invention provides bioconjugates of the formula: in which A is an active agent comprising an active hydroxy or amino functionality and B is a biopolymer comprising an active hydroxy or amino functionality, and X1 and X2 are independently N or O, and R is substituted alkyl or unsubstituted alkyl or unsubstituted or substituted heteroalkyl from 1 to about 30 atoms in length. The biopolymer may for instance be a transport protein or an antibody directed to a transport protein (e.g., a p97 protein or antibody thereto). The active agent may be a therapeutic agent such as a chemotherapeutic agent or an antineoplastic agent or an enzyme. The bioconjugates find therapeutic usages according to the therapeutic indications of the active agent. Methods of making the bioconjugates and bifunctional isocyanate cross linking reagents of use in making such bioconjugates are provided.
摘要翻译：本发明提供下式的生物缀合物：其中A是包含活性羟基或氨基官能团的活性剂，B是包含活性羟基或氨基官能团的生物聚合物，X 1和X 2， 2个独立地是N或O，R是长度为1至约30个原子的取代的烷基或未取代的烷基或未取代或取代的杂烷基。生物聚合物可以例如是转运蛋白或针对转运蛋白的抗体（例如，p97蛋白或其抗体）。活性剂可以是治疗剂，例如化学治疗剂或抗肿瘤剂或酶。生物缀合物根据活性剂的治疗适应症找到治疗用途。提供了制备用于制备这种生物缀合物的生物共轭物和双功能异氰酸酯交联试剂的方法。

9. 发明授权

US09067875B2 Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use 有权
标题翻译：通过醚键和氨基甲酸酯键的四取代的NDGA衍生物及其合成和药物用途
公开(公告)号：US09067875B2
公开(公告)日：2015-06-30
申请号：US13470779
申请日：2012-05-14
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/27 , A61K31/135 , A61K31/075 , C07D265/30 , C07D241/04 , C07D211/06 , C07D277/02 , C07C271/02 , C07C215/00 , C07C43/02 , C07C43/225 , C07C43/23 , C07C217/20 , C07D277/24 , C07D295/088 , C07D295/13 , C07D307/52 , C07C217/64 , C07C271/52 , C07D211/14 , C07D295/15 , C07D307/54
CPC分类号： A61K31/5377 , A61K31/09 , A61K31/138 , A61K31/325 , A61K31/341 , A61K31/427 , A61K31/4545 , A61K31/496 , C07C43/225 , C07C43/23 , C07C217/20 , C07C217/64 , C07C271/52 , C07C2601/16 , C07D211/14 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/52 , C07D307/54
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

10. 发明申请

US20130053378A1 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMACEUTICAL USE 失效
公开(公告)号：US20130053378A1
公开(公告)日：2013-02-28
申请号：US13561517
申请日：2012-07-30
申请人： Qingqi Chen , Jonathan Daniel Heller , Rocio Alejandra Lopez , Amanda Jean Morris
发明人： Qingqi Chen , Jonathan Daniel Heller , Rocio Alejandra Lopez , Amanda Jean Morris
IPC分类号： C07D295/088 , C07C255/36 , C07C33/46 , A61K31/11 , A61K31/277 , A61K31/05 , C07D277/24 , C07C217/18 , C07D413/14 , A61K31/4545 , A61K31/496 , A61K31/427 , A61K31/138 , A61K31/5377 , A61K31/5375 , A61K31/409 , A61P31/00 , A61P29/00 , A61P3/00 , A61P9/00 , C07C47/27
CPC分类号： C07D295/088 , C07C37/50 , C07C39/21 , C07C39/367 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C47/27 , C07C47/273 , C07C217/20 , C07C217/54 , C07C255/33 , C07D277/24 , C07C39/16
摘要： The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.

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