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1. 发明申请

US20120121702A1 Controlled Release Azithromycin Solid Dosage Forms 审中-公开
标题翻译：控制释放阿奇霉素固体剂型
公开(公告)号：US20120121702A1
公开(公告)日：2012-05-17
申请号：US13357722
申请日：2012-01-25
申请人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
发明人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
IPC分类号： A61K31/7052 , A61K9/00 , B05D5/00 , A61K9/26 , A61K9/54 , A61P31/04 , C07H17/08 , A61K9/50
CPC分类号： A61K31/7052 , A61K9/2081 , A61K9/2846 , A61K9/2886 , A61K9/4858 , A61K9/4891
摘要： A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
摘要翻译：一种用于口服给药的固体剂型，其含量低于引起胃肠道副作用的阿奇霉素，该剂型为控释剂型。

2. 发明申请

US20090060994A1 Controlled release azithromycin solid dosages forms 有权
标题翻译：控制释放的阿奇霉素固体剂型
公开(公告)号：US20090060994A1
公开(公告)日：2009-03-05
申请号：US12002417
申请日：2007-12-17
申请人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
发明人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
IPC分类号： A61K9/52 , A61K31/7052 , A61K9/54 , A61P31/00 , A61K9/28 , A61K9/22
CPC分类号： A61K31/7052 , A61K9/2081 , A61K9/2846 , A61K9/2886 , A61K9/4858 , A61K9/4891
摘要： A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
摘要翻译：一种用于口服给药的固体剂型，其含量低于引起胃肠道副作用的阿奇霉素，该剂型为控释剂型。

3. 发明授权

US5628981A Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents 失效
标题翻译：口服胃肠道诊断X线造影剂和口服胃肠道治疗剂的配方
公开(公告)号：US5628981A
公开(公告)日：1997-05-13
申请号：US366841
申请日：1994-12-30
申请人： Gary Liversidge , W. Mark Eickhoff , Kathleen J. Illig , Pramod Sarpotdar , Stephen B. Ruddy
发明人： Gary Liversidge , W. Mark Eickhoff , Kathleen J. Illig , Pramod Sarpotdar , Stephen B. Ruddy
IPC分类号： A61K9/14 , A61K9/51 , A61K49/04 , A61M36/14
CPC分类号： A61K49/049 , A61K49/0423 , A61K9/146 , A61K9/5146 , B82Y5/00 , Y10S514/975 , Y10S977/906
摘要： Nanoparticulate crystalline x-ray contrast agents are formulated with stabilizers to enhance contact between the crystalline x-ray contrast agents and the gastrointestinal tract.Nanoparticulate crystalline therapeutic substances also formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
摘要翻译：用稳定剂配制纳米颗粒结晶x射线造影剂以增强结晶x射线造影剂与胃肠道之间的接触。纳米颗粒结晶治疗物质也与稳定剂配制以增强结晶治疗物质与胃肠道之间的接触并提供延长的治疗效果。

4. 发明授权

US5518187A Method of grinding pharmaceutical substances 失效
标题翻译：药物物质的研磨方法
公开(公告)号：US5518187A
公开(公告)日：1996-05-21
申请号：US180827
申请日：1994-01-12
申请人： Joseph A. Bruno , Brian D. Doty , Evan Gustow , Kathleen J. Illig , Nats Rajagopalan , Pramod Sarpotdar
发明人： Joseph A. Bruno , Brian D. Doty , Evan Gustow , Kathleen J. Illig , Nats Rajagopalan , Pramod Sarpotdar
IPC分类号： A61J3/02 , A61K9/14 , A61K9/16 , A61K9/26 , A61K31/19 , A61K31/192 , A61K49/00 , A61K49/04 , A61K51/00 , B02C17/00 , B02C17/20 , B02C19/00 , G03C1/005 , B02C23/18
CPC分类号： A61K9/146 , A61K9/14 , A61K9/1688 , G03C1/005 , Y10S977/775 , Y10S977/788 , Y10S977/90 , Y10S977/928
摘要： A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
摘要翻译：一种制备药物或诊断显像剂的颗粒的方法，其包括在包含聚合物树脂的研磨介质的存在下研磨药物或显像剂。该方法提供表现出减少污染的颗粒。

5. 发明授权

US08124123B2 Controlled release azithromycin solid dosages forms 有权
标题翻译：控制释放的阿奇霉素固体剂型
公开(公告)号：US08124123B2
公开(公告)日：2012-02-28
申请号：US12002417
申请日：2007-12-17
申请人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
发明人： Radhakrishnan Pillai , Pramod Sarpotdar , David W. Osborne , Gordon J. Dow
IPC分类号： A61K9/54 , A61K9/52 , A61K31/7052 , A61K9/28 , A61K9/22 , A61P31/00
CPC分类号： A61K31/7052 , A61K9/2081 , A61K9/2846 , A61K9/2886 , A61K9/4858 , A61K9/4891
摘要： A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
摘要翻译：一种用于口服给药的固体剂型，其含量低于引起胃肠道副作用的阿奇霉素，该剂型为控释剂型。

6. 发明授权

US06432381B1 Methods for targeting drug delivery to the upper and/or lower gastrointestinal tract 失效
公开(公告)号：US06432381B1
公开(公告)日：2002-08-13
申请号：US08815346
申请日：1997-03-11
申请人： Gary G. Liversidge , W. Mark Eickhoff , Kathleen J. Illig , Pramod Sarpotdar , Stephen B. Ruddy
发明人： Gary G. Liversidge , W. Mark Eickhoff , Kathleen J. Illig , Pramod Sarpotdar , Stephen B. Ruddy
IPC分类号： A61K4900
摘要： Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.

7. 发明授权

US5340564A Formulations comprising olin 10-G to prevent particle aggregation and increase stability 失效
标题翻译：包含奥林10-G以防止颗粒聚集并增加稳定性的制剂
公开(公告)号：US5340564A
公开(公告)日：1994-08-23
申请号：US988564
申请日：1992-12-10
申请人： Kathleen J. Illig , Pramod Sarpotdar
发明人： Kathleen J. Illig , Pramod Sarpotdar
IPC分类号： A61K9/14 , A61K49/04 , A61K31/075
CPC分类号： B82Y5/00 , A61K49/049 , A61K9/145 , Y10S514/975 , Y10S977/773 , Y10S977/89
摘要： This invention discloses a composition comprised of nanoparticles having p-isononylphenoxypoly (glycidol) as a surface modifier adsorbed on the surface thereof. In preferred embodiments, the p-isononylphenoxypoly (glycidol) provides resistance to particle aggregation during heat sterilization. In another preferred embodiment, those nanoparticles also comprise a stability enhancing compound. A preferred stability enhancing compound is albumin. This invention further discloses a method of making nanoparticles having p-isononylphenoxypoly(glycidol) as a surface modifier adsorbed on the surface, comprised of contacting said nanoparticles with p-isononylphenoxypoly(glycidol) for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle. In a preferred embodiment, the p-isononylphenoxypoly (glycidol) surface modified nanoparticle is further contacted with a stability enhancing compound for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle with a stability enhancing compound associated therewith.
摘要翻译：本发明公开了一种由在其表面吸附了作为表面改性剂的对 - 异壬基苯氧基聚（缩水甘油）的纳米粒子组成的组合物。在优选的实施方案中，对 - 异壬基苯氧基聚（缩水甘油）在加热灭菌期间提供对颗粒聚集的抗性。在另一个优选的实施方案中，那些纳米颗粒还包含稳定性增强化合物。优选的稳定性增强化合物是白蛋白。本发明进一步公开了一种制备具有对 - 异壬基苯氧基聚（缩水甘油）作为吸附在表面上的表面改性剂的纳米颗粒的方法，其包括使所述纳米颗粒与对 - 异壬基苯氧基聚（缩水甘油）接触一段时间并在足以形成对 - 异壬基苯氧基聚（缩水甘油）表面改性纳米粒子。在优选的实施方案中，对 - 异壬基苯氧基聚（缩水甘油）表面改性的纳米颗粒进一步与稳定性增强化合物接触足以形成具有与其相关的稳定性增强化合物的对 - 异壬基苯氧基聚（缩水甘油）表面改性纳米颗粒的时间和条件。

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