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1. 发明授权

US08163499B2 Drug selection for breast cancer therapy using antibody-based arrays 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US08163499B2
公开(公告)日：2012-04-24
申请号：US12511017
申请日：2009-07-28
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： G01N33/53 , G01N33/58 , G01N33/68 , G01N33/545 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

2. 发明申请

US20110281748A1 DRUG SELECTION FOR GASTRIC CANCER THERAPY USING ANTIBODY-BASED ARRAYS 审中-公开
标题翻译：使用基于抗体的阵列进行胃癌治疗的药物选择
公开(公告)号：US20110281748A1
公开(公告)日：2011-11-17
申请号：US13014674
申请日：2011-01-26
申请人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
发明人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
IPC分类号： C40B30/04
CPC分类号： G01N33/5011 , G01N33/5041
摘要： The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer.
摘要翻译：本发明提供了选择合适的抗癌疗法以及鉴定和预测胃癌治疗反应的方法。

3. 发明申请

US20100167945A1 DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US20100167945A1
公开(公告)日：2010-07-01
申请号：US12511017
申请日：2009-07-28
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： C40B30/04 , C12Q1/26 , G01N33/566 , C12Q1/28 , C40B40/10
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

4. 发明授权

US09726669B2 Biomarkers for determining sensitivity of breast cancer cells to HER2-targeted therapy 有权
公开(公告)号：US09726669B2
公开(公告)日：2017-08-08
申请号：US12854144
申请日：2010-08-10
申请人： Phillip Kim , Xinjun Liu , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Phillip Kim , Xinjun Liu , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

5. 发明授权

US09488654B2 Methods for predicting response of triple-negative breast cancer to therapy 有权
标题翻译：预测三阴性乳腺癌治疗反应的方法
公开(公告)号：US09488654B2
公开(公告)日：2016-11-08
申请号：US13545947
申请日：2012-07-10
申请人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N2333/71 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。

6. 发明申请

US20140372169A1 SYSTEMS AND METHODS FOR PROVIDING BUSINESS RATINGS 审中-公开
标题翻译：提供业务评级的系统和方法
公开(公告)号：US20140372169A1
公开(公告)日：2014-12-18
申请号：US14308268
申请日：2014-06-18
申请人： Phillip KIM , Alex HASHA , Jaidev SHERGILL , Homin LEE , Simon FREEDMAN
发明人： Phillip KIM , Alex HASHA , Jaidev SHERGILL , Homin LEE , Simon FREEDMAN
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0201
摘要： The disclosed embodiments include methods, systems, and articles of manufacture for providing business ratings. The disclosed embodiments include, for example, a system that may be configured to access spending transaction data including at least a unique payor identifier, a payee description, a payee category code, and a postal code. The system may determine a payee identification for the spending transaction data by comparing the spending transaction data to a plurality of known payees having the same payee category code as the spending transaction data. Further, the system may access one or more historical spending transactions matching the payee category code, and generate a business rating score for a payee associated with the determined payee identification based on at least the determined one or more historical spending transactions.
摘要翻译：所公开的实施例包括用于提供商业评级的方法，系统和制品。所公开的实施例包括例如可被配置为访问消费交易数据的系统，该系统至少包括唯一的付款人标识符，收款人描述，收款人类别代码和邮政编码。该系统可以通过将消费交易数据与具有与消费交易数据相同的收款人类别代码的多个已知收款人进行比较来确定支出交易数据的收款人标识。此外，系统可以访问与收款人类别代码相匹配的一个或多个历史支出交易，并且基于至少所确定的一个或多个历史支出交易来生成与确定的收款人标识相关联的收款人的商业评级分数。

7. 发明授权

US08609349B2 Drug selection for breast cancer therapy using antibody-based arrays 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US08609349B2
公开(公告)日：2013-12-17
申请号：US13439737
申请日：2012-04-04
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： G01N33/50 , G01N33/548 , C12Q1/26 , C12Q1/28
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

8. 发明申请

US20130012407A1 METHODS FOR PREDICTING RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER TO THERAPY 有权
标题翻译：预防三阴性乳腺癌治疗反应的方法
公开(公告)号：US20130012407A1
公开(公告)日：2013-01-10
申请号：US13545947
申请日：2012-07-10
申请人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： C40B30/04
CPC分类号： G01N33/57415 , G01N2333/71 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。

9. 发明授权

US08658388B2 Antibody-based arrays for detecting multiple signal transducers in rate circulating cells 有权
标题翻译：用于在稀有循环细胞中检测多个信号传感器的基于抗体的阵列
公开(公告)号：US08658388B2
公开(公告)日：2014-02-25
申请号：US12046381
申请日：2008-03-11
申请人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
发明人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
IPC分类号： G01N33/573 , C07H21/04
CPC分类号： G01N33/574 , C40B30/08 , C40B40/10 , G01N33/542 , G01N33/57415 , G01N33/582 , G01N33/6845 , G01N33/6854 , G01N2333/902 , G01N2333/908
摘要： The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.
摘要翻译：本发明提供用于检测稀有循环细胞中多个信号转导分子的活化状态和/或总量的基于抗体的阵列及其用于促进癌症预后和诊断以及个性化靶向治疗的设计的方法。

10. 发明申请

US20130237436A9 DRUG SELECTION FOR GASTRIC CANCER THERAPY USING ANTIBODY-BASED ARRAYS 审中-公开
标题翻译：使用基于抗体的阵列进行胃癌治疗的药物选择
公开(公告)号：US20130237436A9
公开(公告)日：2013-09-12
申请号：US13014674
申请日：2011-01-26
申请人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
发明人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
IPC分类号： C40B30/04
CPC分类号： G01N33/5011 , G01N33/5041
摘要： The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer.
摘要翻译：本发明提供了选择合适的抗癌疗法以及鉴定和预测胃癌治疗反应的方法。

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