专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07223556B1 Targeted proteolysis by recruitment to ubiquitin protein ligases 失效
标题翻译：通过募集到泛素蛋白连接酶的靶向蛋白水解
公开(公告)号：US07223556B1
公开(公告)日：2007-05-29
申请号：US09415795
申请日：1999-10-08
申请人： Pengbo Zhou , Peter M. Howley
发明人： Pengbo Zhou , Peter M. Howley
IPC分类号： C12P21/06 , C12N9/00 , C12N5/16 , C12N5/18 , C12N5/22 , C07H21/04
CPC分类号： C12N15/62 , A61K47/67 , B82Y5/00 , C07K14/005 , C07K14/47 , C07K14/4736 , C07K2319/00 , C07K2319/42 , C07K2319/43 , C07K2319/70 , C07K2319/95 , C12N9/93 , C12N2710/20022
摘要： The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.
摘要翻译：本发明涉及用于通过与泛素蛋白连接酶的顺式或反式结合靶向多肽的蛋白水解的方法和试剂，并且还提供用于抑制泛素蛋白连接酶识别的细胞蛋白的泛素化和蛋白水解的方法和试剂。

2. 发明授权

US5821048A Methods, kits, and compositions for diagnosing papillomavirus infection 失效
标题翻译：用于诊断乳头瘤病毒感染的方法，试剂盒和组合物
公开(公告)号：US5821048A
公开(公告)日：1998-10-13
申请号：US472666
申请日：1995-06-07
申请人： Peter M. Howley , John D. Benson , Toshiharu Yasugi , Hiroyuki Sakai
发明人： Peter M. Howley , John D. Benson , Toshiharu Yasugi , Hiroyuki Sakai
IPC分类号： C12N15/09 , C07K14/025 , C12Q1/70 , G01N33/574 , A01N37/18 , C07K1/00 , C12Q1/68
CPC分类号： C07K14/005 , G01N33/57411 , C12N2710/20022
摘要： Methods, kits, and compositions are provided for diagnosing papillomavirus infections by detecting the interaction between a papillomavirus E1 protein interaction domain and a papillomavirus E2 protein interaction domain.
摘要翻译：提供了方法，试剂盒和组合物，用于通过检测乳头瘤病毒E1蛋白相互作用结构域和乳头瘤病毒E2蛋白质相互作用区域之间的相互作用来诊断乳头瘤病毒感染。

3. 发明授权

US4419446A Recombinant DNA process utilizing a papilloma virus DNA as a vector 失效
标题翻译：使用乳头瘤病毒DNA作为载体的重组DNA方法
公开(公告)号：US4419446A
公开(公告)日：1983-12-06
申请号：US221565
申请日：1980-12-31
申请人： Peter M. Howley , Nava Sarver , Ming-Fan Law
发明人： Peter M. Howley , Nava Sarver , Ming-Fan Law
IPC分类号： C12N15/86 , C12P21/00 , C12N1/00 , C12N15/00 , C12P19/34
CPC分类号： C12N15/86 , C12N2710/20043
摘要： A novel method and composition are provided for the replication and expression of exogenous genes in eukaryotic cells. A segment of a papilloma virus genome capable of extrachromosomal replication is linked to the foreign gene(s) using recombinant DNA techniques to provide a biologically functional replicon with a desired phenotypical property. The replicon is inserted into a eukaryotic cell by transformation, and the isolation of transformant provides cells for replication and expression of the DNA molecules present in the modified plasmid. The transforming region of the bovine papilloma virus provides a unique vector in that it provides both the capability of autonomous extrachromosomal replication but also the malignant transformed phenotype. Thus, genes which of themselves provide no selectable phenotypical property can be conveniently and efficiently introduced into eukaryotic cells and the transformants selected. The method is useful in that the foreign DNA is faithfully expressed and the gene products (proteins), such as pro-insulin (an insulin precursor) is synthesized.
摘要翻译：提供了一种新颖的方法和组合物，用于在真核细胞中复制和表达外源基因。使用重组DNA技术将能够染色体外复制的乳头瘤病毒基因片段与外源基因连接，以提供具有所需表型性质的生物功能复制子。通过转化将复制子插入真核细胞，转化体的分离提供用于复制和表达修饰质粒中存在的DNA分子的细胞。牛乳头瘤病毒的转化区域提供了独特的载体，因为它提供了自主染色体外复制的能力，而且提供了恶性转化的表型。因此，本身不提供选择性表型性质的基因可以方便且有效地引入真核细胞并选择转化体。该方法可用于外来DNA被忠实表达，并且合成基因产物（蛋白质），例如胰岛素前体（胰岛素前体）。

4. 发明授权

US06673354B2 Compositions and methods for treating papillomavirus-infected cells 失效
标题翻译：用于治疗乳头瘤病毒感染细胞的组合物和方法
公开(公告)号：US06673354B2
公开(公告)日：2004-01-06
申请号：US10161499
申请日：2002-06-03
申请人： Peter M. Howley , John Benson , Hiroaki Kasukawa
发明人： Peter M. Howley , John Benson , Hiroaki Kasukawa
IPC分类号： A61K3912
CPC分类号： G01N33/5011 , A61K38/00 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/20022 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/68
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译：根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。根据本发明，通过药学上可接受的施用E2肽模拟物治疗哺乳动物以减少特异性乳头瘤病毒相关疾病的症状，或防止其复发。

5. 发明授权

US5532348A E6 associated protein and methods of use thereof 失效
标题翻译： E6相关蛋白及其使用方法
公开(公告)号：US5532348A
公开(公告)日：1996-07-02
申请号：US100692
申请日：1993-07-30
申请人： Jon M. Huibregtse , Martin Scheffner , Peter M. Howley
发明人： Jon M. Huibregtse , Martin Scheffner , Peter M. Howley
IPC分类号： C07K14/47 , C07H21/04
CPC分类号： C07K14/47 , C07K14/4746 , C07K2319/00
摘要： The present invention provides compositions of isolated and purified E6 Associated Protein and fragments thereof. Also provided are nucleic acid constructs encoding E6 Associated Protein. These compositions may be employed to identify compounds which inhibit binding of high risk HPV E6 to p53. The compositions of the present invention may also be used in methods to detect the presence of high risk HPV in biological samples.
摘要翻译：本发明提供了分离和纯化的E6相关蛋白及其片段的组合物。还提供编码E6相关蛋白的核酸构建体。这些组合物可用于鉴定抑制高危HPV E6与p53结合的化合物。本发明的组合物也可用于检测生物样品中高危HPV存在的方法。

6. 发明授权

US07235244B2 Compositions and methods for treating papillomavirus-infected cells 失效
标题翻译：用于治疗乳头瘤病毒感染细胞的组合物和方法
公开(公告)号：US07235244B2
公开(公告)日：2007-06-26
申请号：US10744964
申请日：2003-12-23
申请人： Peter M. Howley , John Benson , Hiroaki Kasukawa
发明人： Peter M. Howley , John Benson , Hiroaki Kasukawa
IPC分类号： A61K39/12
CPC分类号： G01N33/5011 , A61K38/00 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/20022 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/68
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译：根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。根据本发明，通过药学上可接受的施用E2肽模拟物治疗哺乳动物以减少特异性乳头瘤病毒相关疾病的症状，或防止其复发。

7. 发明授权

US06432926B1 Compositions and methods for treating papillomavirus-infected cells 失效
标题翻译：用于治疗乳头瘤病毒感染细胞的组合物和方法
公开(公告)号：US06432926B1
公开(公告)日：2002-08-13
申请号：US09362012
申请日：1999-07-27
申请人： Peter M. Howley , Jennifer J. Dowhanick-Morrissette , John D. Benson , Hiroyuki Sakai
发明人： Peter M. Howley , Jennifer J. Dowhanick-Morrissette , John D. Benson , Hiroyuki Sakai
IPC分类号： A61K4800
CPC分类号： A61K48/00 , A61K38/162
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2ad/db protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译：根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。根据本发明，通过直接或通过基因转移技术的药学上可接受的E2ad / db蛋白质的施用来治疗哺乳动物，以减少特异性乳头瘤病毒相关疾病的症状或防止其复发。

8. 发明授权

US5491064A HTS-1 gene, a human tumor suppressor gene 失效
标题翻译： HTS-1基因，一种人肿瘤抑制基因
公开(公告)号：US5491064A
公开(公告)日：1996-02-13
申请号：US369043
申请日：1995-01-05
申请人： Jack H. Lichy , Peter M. Howley
发明人： Jack H. Lichy , Peter M. Howley
IPC分类号： C07K14/82 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/82 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： A gene which is associated with tumor suppression and is localized on chromosome 11 has now been identified. The identification, localization and sequence of a gene which demonstrates differential expression in a manner that correlates with tumorigenicity suggests that this gene could potentially be used for gene therapy in cancers deleted or altered in their expression of the gene. Furthermore, a gene which is localized on chromosome 11p15, with identified polymorphisms, could be used for analysis of tumor DNA for loss of heterozygosity at chromosome 11p15. This region of chromosome 11 shows frequent loss of heterozygosity (LOH) in many human malignancies. Thus, the determination of LOH at chromosome 11p15 may be useful in predicting the prognosis of that tumor.
摘要翻译：与肿瘤抑制相关并位于第11号染色体上的基因已被鉴定。以与致瘤性相关的方式表达差异表达的基因的鉴定，定位和序列表明该基因可潜在地用于在其基因表达中被删除或改变的癌症中的基因治疗。此外，位于染色体11p15上的基因，具有确定的多态性，可用于分析染色体11p15上杂合性丧失的肿瘤DNA。染色体11的这个区域在许多人类恶性肿瘤中表现出频繁的杂合性损失（LOH）。因此，染色体11p15上的LOH的测定可用于预测该肿瘤的预后。

9. 发明授权

US07423138B2 Compositions and methods for treating papillomavirus-infected cells 失效
标题翻译：用于治疗乳头瘤病毒感染细胞的组合物和方法
公开(公告)号：US07423138B2
公开(公告)日：2008-09-09
申请号：US10187536
申请日：2002-07-01
申请人： Peter M. Howley , Jennifer J. Dowhanick-Morrissette , John D. Benson , Hiroyuki Sakai
发明人： Peter M. Howley , Jennifer J. Dowhanick-Morrissette , John D. Benson , Hiroyuki Sakai
IPC分类号： A61K39/12
CPC分类号： A61K48/00 , A61K38/162
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2ad/db protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译：根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。根据本发明，通过直接或通过基因转移技术的药学上可接受的E2A / db蛋白的施用来治疗哺乳动物，以减少特异性乳头瘤病毒相关疾病的症状，或者防止其复发。

10. 发明授权

US06399075B1 Compositions and methods for treating Papillomavirus-infected cells 失效
标题翻译：用于治疗乳头瘤病毒感染细胞的组合物和方法
公开(公告)号：US06399075B1
公开(公告)日：2002-06-04
申请号：US09347504
申请日：1999-07-02
申请人： Peter M. Howley , John Benson , Hiroaki Kasukawa
发明人： Peter M. Howley , John Benson , Hiroaki Kasukawa
IPC分类号： A61K3912
CPC分类号： G01N33/5011 , A61K38/00 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/20022 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/68
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译：根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。根据本发明，通过药学上可接受的施用E2肽模拟物治疗哺乳动物以减少特异性乳头瘤病毒相关疾病的症状，或防止其复发。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式