专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5491064A HTS-1 gene, a human tumor suppressor gene 失效
标题翻译： HTS-1基因，一种人肿瘤抑制基因
公开(公告)号：US5491064A
公开(公告)日：1996-02-13
申请号：US369043
申请日：1995-01-05
申请人： Jack H. Lichy , Peter M. Howley
发明人： Jack H. Lichy , Peter M. Howley
IPC分类号： C07K14/82 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/82 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： A gene which is associated with tumor suppression and is localized on chromosome 11 has now been identified. The identification, localization and sequence of a gene which demonstrates differential expression in a manner that correlates with tumorigenicity suggests that this gene could potentially be used for gene therapy in cancers deleted or altered in their expression of the gene. Furthermore, a gene which is localized on chromosome 11p15, with identified polymorphisms, could be used for analysis of tumor DNA for loss of heterozygosity at chromosome 11p15. This region of chromosome 11 shows frequent loss of heterozygosity (LOH) in many human malignancies. Thus, the determination of LOH at chromosome 11p15 may be useful in predicting the prognosis of that tumor.
摘要翻译：与肿瘤抑制相关并位于第11号染色体上的基因已被鉴定。以与致瘤性相关的方式表达差异表达的基因的鉴定，定位和序列表明该基因可潜在地用于在其基因表达中被删除或改变的癌症中的基因治疗。此外，位于染色体11p15上的基因，具有确定的多态性，可用于分析染色体11p15上杂合性丧失的肿瘤DNA。染色体11的这个区域在许多人类恶性肿瘤中表现出频繁的杂合性损失（LOH）。因此，染色体11p15上的LOH的测定可用于预测该肿瘤的预后。

IPRDB

热门服务

关于我们

友情链接

联系方式