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    • 3. 发明授权
    • NMR glomerular filtration test
    • NMR肾小球滤过试验
    • US5100646A
    • 1992-03-31
    • US557038
    • 1990-07-25
    • Peter L. ChoykeJoseph A. FrankHoward A. Austin
    • Peter L. ChoykeJoseph A. FrankHoward A. Austin
    • A61K49/06
    • A61K49/06Y10S514/836Y10S514/869Y10T436/24
    • A method of determining the glomerular filtration rate of a subject comprises (1) obtaining a serum sample S.sub.pre and a urine sample U.sub.pre from a subject; (2) administering to the subject an amount of a paramagnetic substance that is filtered by the kidneys and is readily detectable by NMR in serum and urine; (3) allowing for the concentration of the substance to equilibrate between the blood and the extravascular spaces; (4) separating an aliquot of the urine sample v.sub.A and obtaining a serum sample from the subject at the time t.sub.A ; (5) calculating a urine rate (v/a).sub.A from the formula (v/a).sub.A =V.sub.A /a.sub.A ; (6) measuring the magnetic resonance relaxation times of the serum and urine samples, (7) obtaining the concentrations of the paramagnetic substance in the serum samples and the urine samples by comparing their relaxation times to a standard; and (8) calculating GFR from the formula ##EQU1##
    • 确定受试者的肾小球滤过率的方法包括:(1)从受试者获得血清样品Spre和尿液样本Upre; (2)向受试者施用一定量的由肾过滤的顺磁性物质,并且可通过血清和尿液中的NMR容易地检测; (3)允许物质的浓度在血液和血管外空间之间平衡; (4)分离尿液样品vA的等分试样并在时间tA从受试者获得血清样品; (5)从公式(v / a)A = VA / aA计算尿率(v / a)A (6)测定血清和尿液样品的磁共振弛豫时间,(7)通过将其放松时间与标准品进行比较,获得血清样品和尿样中顺磁物质的浓度; 和(8)从公式计算GFR