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1. 发明授权

US10525129B2 Combined use of Fc gamma RIIb (CD32B) and CD20-specific antibodies 有权
公开(公告)号：US10525129B2
公开(公告)日：2020-01-07
申请号：US13817744
申请日：2011-08-19
申请人： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Bjorn Frendeus , Ingrid Teige
发明人： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Bjorn Frendeus , Ingrid Teige
IPC分类号： A61K39/395 , A61K39/40 , C07K16/28 , G01N33/68 , C07K16/00 , A61K39/00
摘要： The invention provides a method of treating a patient having target cells that express FcyRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcyRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcyRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcyRIIb.

2. 发明授权

US09428464B2 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof 有权
标题翻译：犬奈宁-3-单加氧酶抑制剂，药物组合物及其使用方法
公开(公告)号：US09428464B2
公开(公告)日：2016-08-30
申请号：US14241699
申请日：2012-08-28
申请人： Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson , Celia Dominguez , Leticia M. Toledo-Sherman , Ignacio Muñoz-Sanjuan
发明人： Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson , Celia Dominguez , Leticia M. Toledo-Sherman , Ignacio Muñoz-Sanjuan
IPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D403/12 , C07D403/06 , C07D405/12 , C07D413/12 , C07D491/048 , C07D239/42 , C07D401/04 , C07D401/12 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D239/28 , A61K31/506 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , Y02A50/401 , Y02A50/411 , Y02A50/465
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

3. 发明申请

US20150257454A1 Form Contouring Lingerie 审中-公开
标题翻译：形状轮廓内衣
公开(公告)号：US20150257454A1
公开(公告)日：2015-09-17
申请号：US14208440
申请日：2014-03-13
申请人： Peter Johnson
发明人： Peter Johnson
IPC分类号： A41C1/02
CPC分类号： A41C1/02 , A41B2400/38
摘要： The invention relates to a form contouring lingerie having a left and a right laterally disposed members and a front and rear medially disposed members that are elastic or inelastic and are releasably connected to each other, wherein the elastic members have a different color from the nonelastic members and wherein the elastic members and the nonelastic members form a one piece shape correcting inner or outer garment.
摘要翻译：本发明涉及一种具有左和右横向设置的构件的形状轮廓内衣，以及具有弹性或非弹性并且可释放地彼此连接的前后中间设置的构件，其中弹性构件具有与非弹性构件不同的颜色并且其中所述弹性构件和所述非弹性构件形成校正内衣或外衣的单件形状。

4. 发明申请

US20140329816A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 有权
标题翻译：某些京那奈因-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：US20140329816A1
公开(公告)日：2014-11-06
申请号：US14235253
申请日：2012-07-26
申请人： Celia Dominguez , Leticia M. Toledo-Sherman , Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson
发明人： Celia Dominguez , Leticia M. Toledo-Sherman , Stephen Martin Courtney , Michael Prime , William Mitchell , Christopher John Brown , Paula C. De Aguiar Pena , Peter Johnson
IPC分类号： C07D417/04 , C07D401/04 , C07D413/04 , C07D413/14 , C07D239/28 , C07D403/04
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/5377 , C07D239/26 , C07D239/28 , C07D239/42 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

5. 发明授权

US08533676B2 Single development test environment 失效
标题翻译：单一开发测试环境
公开(公告)号：US08533676B2
公开(公告)日：2013-09-10
申请号：US13339880
申请日：2011-12-29
申请人： Christina Watters , Peter Johnson , Robert S. Baker
发明人： Christina Watters , Peter Johnson , Robert S. Baker
IPC分类号： G06F9/44
CPC分类号： G06F11/3664 , G06F8/71
摘要： System and method for forming a cloud appliance. The system includes a management server, an artifact repository, a continuous integration server, and build managers. The management server includes source code and a project script for forming the cloud appliance. The artifact repository stores artifacts required to build the cloud appliance and artifacts that comprise the built cloud appliance. The continuous integration server manages a build process, unit test process, and deployment process based on the project script. The build managers build the source code for customizing the virtual machine and store the built source code as the second artifacts in the artifact repository. The continuous integration server instantiates the virtual machine from template and customizes the virtual machine to form a customized virtual machine using the artifacts specified in the project script, a customization process for each of the artifacts based on a type of the artifact.
摘要翻译：用于形成云设备的系统和方法。该系统包括管理服务器，工件存储库，持续集成服务器和构建管理器。管理服务器包括用于形成云设备的源代码和项目脚本。工件存储库存储构建云设备所需的工件，以及组成构建的云设备的工件。持续集成服务器根据项目脚本管理构建过程，单元测试过程和部署过程。构建管理器构建用于自定义虚拟机的源代码，并将构建的源代码作为第二个工件存储在工件存储库中。持续集成服务器从模板中实例化虚拟机，并使用项目脚本中指定的工件，基于工件类型的每个工件的自定义过程来自定义虚拟机以形成自定义虚拟机。

6. 发明授权

US08455963B1 Low frequency CMUT with vent holes 有权
标题翻译：低频CMUT带通风孔
公开(公告)号：US08455963B1
公开(公告)日：2013-06-04
申请号：US13309773
申请日：2011-12-02
申请人： Steven Adler , Peter Johnson , Ira Oaktree Wygant
发明人： Steven Adler , Peter Johnson , Ira Oaktree Wygant
IPC分类号： H01L29/84 , H02K41/02 , A61B8/00
CPC分类号： H01L29/84 , B06B1/0292 , H01L29/66007
摘要： A capacitive micromachined ultrasonic transducer (CMUT), which has a conductive structure that can vibrate over a cavity, has a number of vent holes that are formed in the bottom surface of the cavity. The vent holes eliminate the deflection of the CMUT membrane due to atmospheric pressure which, in turn, allows the CMUT to receive and transmit low frequency ultrasonic waves.
摘要翻译：具有能够在空腔上振动的导电结构的电容式微加工超声波换能器（CMUT）具有形成在空腔的底表面中的多个通气孔。通气孔消除了由于大气压力导致的CMUT膜的挠曲，这进一步允许CMUT接收和传输低频超声波。

7. 发明申请

US20130086205A1 DATA GATHERING USING A MOBILE COMPUTING DEVICE 有权
标题翻译：使用移动计算设备进行数据采集
公开(公告)号：US20130086205A1
公开(公告)日：2013-04-04
申请号：US13250108
申请日：2011-09-30
申请人： James St. Clair , Jon Watts , Karl Schulze , Peter Johnson
发明人： James St. Clair , Jon Watts , Karl Schulze , Peter Johnson
IPC分类号： G06F15/16
CPC分类号： H04W4/00 , G06Q10/00 , G06Q10/06 , H04L12/189 , H04L67/04 , H04L67/22
摘要： Systems and methods for field data gathering and which provide flexible configuration options for a central office. The system, run from, mobile computing devices, provides a free-flowing data gathering experience while only requiring what the central office needs from the field. The central office can configure the system to accept different types of data by way of different data input means available to the mobile computing device. Only the data needed by the central office need be collected by the mobile device operator. The data format is defined by the central office and is uploaded to each of the relevant mobile computing devices for use by the operators. Once each data set has been collected by an operator, the data package with the data set is scheduled for transmission to the central office once a connection with the central office can be made.
摘要翻译：用于现场数据采集的系统和方法，并为中心局提供灵活的配置选项。该系统从移动计算设备运行，提供了一个自由流动的数据收集体验，同时只需要中心局从现场需要的。中央办公室可以通过移动计算设备可用的不同数据输入手段，将系统配置为接受不同类型的数据。只有中央办公室需要的数据需要由移动设备运营商收集。数据格式由中心局定义，并被上传到每个相关的移动计算设备供操作者使用。一旦每个数据集已被操作员收集，与数据集的数据包一起可以一旦与中心局建立连接就被安排传送到中心局。

8. 发明授权

US08407883B2 Magnetically enhanced power inductor with self-aligned hard axis magnetic core produced in an applied magnetic field using a damascene process sequence 有权
标题翻译：使用大马士革过程序列在施加的磁场中产生的具有自对准硬轴磁芯的磁性增强型功率电感器
公开(公告)号：US08407883B2
公开(公告)日：2013-04-02
申请号：US13486195
申请日：2012-06-01
申请人： Peter Smeys , Peter Johnson , Andrei Papou
发明人： Peter Smeys , Peter Johnson , Andrei Papou
IPC分类号： H01F3/00 , H01F41/02
CPC分类号： H01F17/0006 , H01F41/046 , H01F2017/0066 , H01L23/5227 , H01L2924/0002 , Y10T29/49005 , Y10T29/4902 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073 , Y10T29/49144 , H01L2924/00
摘要： A damascene process is utilized to fabricate the segmented magnetic core elements of an integrated circuit inductor structure. The magnetic core is electroplated from a seed layer that is conformal with a permanent dielectric mold that results in sidewall plating defining an easy magnetic axis. The hard axis runs parallel to the longitudinal axis of the core and the inductor coils are orthogonal to the core's longitudinal axis. The magnetic field generated by the inductor coils is, therefore, parallel and self-aligned to the hard magnetic axis. The easy axis is enhanced by electroplating in an applied magnetic field parallel to the easy axis.
摘要翻译：利用镶嵌工艺来制造集成电路电感器结构的分段磁芯元件。磁芯从与保持永久介电模具的种子层电镀，导致侧壁镀层限定易磁轴。硬轴平行于芯的纵轴延伸，并且电感线圈与芯的纵向轴线正交。因此，由电感线圈产生的磁场与硬磁轴平行和自对准。通过在平行于容易轴的施加磁场中电镀来增强易轴。

9. 发明申请

US20120284144A1 System and Method for Evaluating Computerized Product Customization Tool and Associated Database(s) 审中-公开
标题翻译：用于评估计算机化产品定制工具和关联数据库的系统和方法
公开(公告)号：US20120284144A1
公开(公告)日：2012-11-08
申请号：US13365765
申请日：2012-02-03
申请人： Nathan Herbst , Peter Johnson
发明人： Nathan Herbst , Peter Johnson
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0601 , G06Q50/08
摘要： A computer-implemented method for assessing fidelity of a product customization tool for an electronic catalog including electronic records representing a plurality of customizable products, the customizable products including a plurality of configurable option selections is described. The method includes identifying a plurality of test case grouping including one or more customizable products having defined ranges of the configurable option selection that do not affect a key output parameter for the grouping and identifying a set of test cases selected from the test case groupings, the test cases having selections associated with the configurable option selection. The method further includes evaluating the set of test cases relative to identify instances of products in the electronic catalog conforming to the selections associated with the configurable option selection and generating a report providing differences between what was expected with the number of rules and actual results of the evaluating act.
摘要翻译：描述了一种用于评估电子目录的产品定制工具的保真度的计算机实现的方法，包括代表多个可定制产品的电子记录，包括多个可配置选项选择的可定制产品。该方法包括识别多个测试用例分组，其包括一个或多个可定制的可配置选项选择范围的可定制产品，其不影响用于分组的键输出参数，并且识别从测试用例组中选择的一组测试用例，具有与可配置选项选择相关联的选择的测试用例。该方法还包括评估该组测试用例，以相对于识别符合与可配置选项选择相关联的选择的电子目录中的产品的实例，并且生成提供与期望数量与规则数量和实际结果之间的差异的报告评估行为。

10. 发明授权

US08274129B2 Power transistor with improved high-side operating characteristics and reduced resistance and related apparatus and method 有权
标题翻译：功率晶体管具有改善的高端工作特性和降低电阻及相关设备和方法
公开(公告)号：US08274129B2
公开(公告)日：2012-09-25
申请号：US12589491
申请日：2009-10-23
申请人： William French , Peter Smeys , Peter J. Hopper , Peter Johnson
发明人： William French , Peter Smeys , Peter J. Hopper , Peter Johnson
IPC分类号： H01L23/58
CPC分类号： H01L29/7835 , H01L21/76898 , H01L29/407 , H01L29/66659
摘要： A method includes forming a transistor device on a first side of a semiconductor-on-insulator structure. The semiconductor-on-insulator structure includes a substrate, a dielectric layer, and a buried layer between the substrate and the dielectric layer. The method also includes forming a conductive plug through the semiconductor-on-insulator structure. The conductive plug is in electrical connection with the transistor device. The method further includes forming a field plate on a second side of the semiconductor-on-insulator structure, where the field plate is in electrical connection with the conductive plug. The transistor device could have a breakdown voltage of at least 600V, and the field plate could extend along at least 40% of a length of the transistor device.
摘要翻译：一种方法包括在绝缘体上半导体结构的第一侧上形成晶体管器件。绝缘体上半导体结构包括衬底，电介质层和衬底和电介质层之间的掩埋层。该方法还包括通过绝缘体上半导体结构形成导电插塞。导电插头与晶体管器件电连接。该方法还包括在绝缘体上半导体结构的第二侧上形成场板，其中场板与导电插头电连接。晶体管器件可以具有至少600V的击穿电压，并且场板可以沿着晶体管器件的长度的至少40％延伸。

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